24,119 research outputs found
Addressing User Engagement With an Interactive Reading Model by Innovative Digital Expansion
No full textThe paper presents the research results aimed to design and realize an innovative prototype of user’s interactions method, based on the digital impact that Digital Transformation (DT) has on society. The experimentation presented takes as an example some good practices identified in the Victoria & Albert Museum (V&A), London: challenging, unconventional cultural goods could attract new users. Based on this assumption, we have observed a target users’ impact on a cultural good generally considered little appeal, transforming the user into a prosumer. The first tests were made in 2019. The University of Bari Aldo Moro and the De Sanctis Classical Linguistic High School of Human Sciences in Trani started a collaboration as part of a PON project titled "Comunicare e promuovere un evento culturale". High School students have been identified as an important target of study. Subsequently, in the paper, we examined a project created by D.A.BI.MUS S.r.l. and Quorum Italia S.r.l, working on niche cultural goods also in this case. In this project, an anastatic printed book became a potential endless book capable of intercepting the interest of even large groups of digital users
Measurement of the time-dependent CP asymmetry in B0 -> J/ψ KS0 decays
No full textThis Letter reports a measurement of the CP violation observables SJ/ψK0S and CJ/ψK0S in the decay channel B0→J/ψK0S performed with 1.0 fb−1 of pp collisions at s√=7 TeV collected by the LHCb experiment. The fit to the data yields SJ/ψK0S=0.73±0.07(stat)±0.04(syst) and CJ/ψK0S=0.03±0.09(stat)±0.01(syst). Both values are consistent with the current world averages and within
expectations from the Standard Model
Università e città gateway. Il caso studio di Bari/University and gateway city. The case study of Bari
No full textThe paper starts from the marking of banch DATAR (2003) in which only two indicators Bari brought to a level of European competitiveness: population dynamics and size of the local university. The contribution by looking at the relationship between universities and cities to Bari reconnects to one of the themes of the author
Dualsteric activation of M2 muscarinic acetylcholine receptors inhibits cell proliferation in human glioblastoma cell lines
No full textMuscarinic acetylcholine receptors (mAChRs) are expressed in several primary and metastatic tumours. ACh synthesized by the tumour cells can modulate cell proliferation by an autocrine mechanism which involves cholinergic receptors. Although a direct or indirect role of transduction pathways activated by cholinergic receptors has not yet been demonstrated, the inhibition of ACh synthesis as well as the release or use of cholinergic antagonists are able to counteract tumour cell growth and slow down the tumour progression in small cell lung carcinoma [1]. In mammary adenocarcinoma and melanoma cell lines, mAChRs can also modulate cell migration and angiogenesis, suggesting their involvement in the metastases formation [2]. The characterization of mAChR effects on more aggressive brain tumours is still poorly investigated. Glioblastomas are the most common brain tumours in humans. Recently, Tata et al. demonstrated that M2 receptor activation inhibits glioma cell growth and survival, suggesting that this receptor subtype may represent a new putative target for glioblastoma therapy [3,4]. Therefore, the identification of more selective ligands for M2 mAChRs may be of clinical significance. Here we report the results on the effects of the muscarinic orthosteric superagonist Iperoxo [5] and its related dualsteric agonists P-6-Iper and N-8-Iper [6]. Our data demonstrate that cell proliferation as well as cell survival of the U251 and U87 stable cell lines were unaffected by treatment with Iperoxo and P-6-Iper. Conversely, N-8-Iper decreased cell proliferation in a time and dose dependent manner. Similarly, N-8-Iper (100 uM) was also able to counteract cell proliferation in glioblastoma cancer stem cells (GB7) obtained from human biopsy. The antiproliferative effect shown by N-8-Iper was significantly counteracted by the selective M2 antagonist methoctramine (10^-7 M), suggesting an actual contribution of the M2 selective activation.
References:
1) Song P, Sekhon HS, Jia Y, Keller JA, Blusztajn JK, Mark GP, Spindel ER. Cancer Res. 2003, 63(1), 214-221
2) Boss A, Oppitz M, Lippert G, Drews U. Clin Exp Dermatol. 2005, 30(5), 557-564
3) Ferretti M, Fabbiano C, Di Bari M, Ponti D, Calogero A, Tata AM. Life Sci. 2012, 91(21-22), 1134-1137
4) Ferretti M, Fabbiano C, Di Bari M, Conte C, Castigli E, Sciaccaluga M, Ponti D, Ruggieri P, Raco A, Ricordy R, Calogero A, Tata AM. J Cell Mol Med. 2013, 17(4), 552-566
5) Schrage R, Seemann WK, Klöckner J, Dallanoce C, Racké K, Kostenis E, De Amici M, Holzgrabe U, Mohr K. Br J Pharmacol. 2013, 169(2), 357-370
6) Matera C, Flammini L, Quadri M, Vivo V, Ballabeni V, Holzgrabe U, Mohr K, De Amici M, Barocelli E, Bertoni S, Dallanoce C. Eur J Med Chem. 2014, 75, 222-23
Measurement of the D+/- production asymmetry in 7 TeV pp collisions
No full textThe asymmetry in the production cross-section \sigma of D+/- mesons, A_P = (\sigma(D+) - \sigma(D-))/(\sigma(D+) + \sigma(D-)), is measured in bins of pseudorapidity \eta and transverse momentum p_T within the acceptance of the LHCb detector. The result is obtained with a sample of D+ -> K_S pi+ decays corresponding to an integrated luminosity of 1.0 fb^-1, collected in pp collisions at a centre of mass energy of 7 TeV at the Large Hadron Collider. When integrated over the kinematic range 2.0 K_S pi+ decay is negligible. No significant dependence on \eta or p_T is observed
First observation of Bs → J/ψf0(980) decays
No full textUsing data collected with the LHCb detector in proton–proton collisions at a centre-of-mass energy of 7 TeV, the hadronic decay is observed. This CP eigenstate mode could be used to measure mixing-induced CP violation in the system. Using a fit to the π+π− mass spectrum with interfering resonances gives . In the interval ±90 MeV around 980 MeV, corresponding to approximately two full f0 widths we also find , where in both cases the uncertainties are statistical and systematic, respectively
Digitalizzazione e Patrimonio Culturale Digitale: ambiguità, ipotesi, definizioni.
No full textSince the beginning of the Digital Transformation, the eu has classified the Cultural Heritage into the three categories: tangible, intangible and digital, the latter declined in digitized and born digital. However, which requirements should characterize digital for allowing us to identify it as cultural heritage is still an open issue. In Italy, both all the processes linked to the dt and the resources produced by these processes are confusedly identified as digitalizzazione. English language distinguishes digitization and digitalization concepts for defining with the one the process for creating digital entities, with the other the innovation of administrative and business processes. Starting
by clarifying the Italian digitalizzazione faced to English digitization both applied to cultural heritage, this paper aims to outline the requirements of digitization process for
creating the new Digital Cultural Heritage. As case study we present the experience of the Victorian & Albert Museum of London
The power system lat Politecnico di Bari
No full textModern education in the area of power systems cannot be based only on theoretical knowledge. The main problem of education in this areas is due to the continuous and fast development of technology. The curricula must adapt themselves to technological development and, consequently, principles of laboratory education have to follow this trend as well. In this paper, the approach of a "multi-functional" lab utilized by the power system group at the Politecnico di Bari is described. This approach has been adopted at the Power System Laboratory (PS Lab) of Politecnico di Bari both for hystorical reason and an optimal exploitation of the available space. The main features of this lab are described in terms of organization and facilities on three different educational level
The DCH in the Italian Cultural System. The Necessity of a Change
No full textDigital Transformation is changing the daily life of the communities, but a clear definition of what can be defined as Digital Cultural Heritage (DCH) still misses. Moreover, in this period, Cultural Institutions (CI) have been under pressure because of the COVID-19 pandemic. This paper proposes a digital strategy based on a central role of the cultural heritage users. To this goal, a first-rate need is to hire new professionals provided with digital knowledge and skills
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