44,330 research outputs found
Nuovi dati sulla Flora del bosco comunale “Difesa Grande” – Gravina in Puglia (Bari – Italia)
No full textAnalisi floristica del territorio comunale di Palagianello (Taranto) compreso nel Parco naturale regionale “Terra delle gravine”. Dati preliminari
No full text
Neuroprotezione : the next step nella terapia del glaucoma
No full textScientific researches are aimed to reduce the
glaucoma by means of neuroprotection since
an optical nerve damage could determine visual
loss. Actually, there are neuroprotective drugs
such as i) blood flow enhancers such as Ca2+
blockers; ii) glutamate inhibitors; iii) nitric
oxide inhibitors; iv) free radical scavengers/
antioxidant. Moreover, experimental studies
have shown that growth factors such as
bFGF (basic fibroblastic growth factor), brain
neurotrophic factor (BDNF), neutrophin-4 and
ciliary neurotrophic (CNTF) greatly reduce
retinal ganglion cell death rates after axotomy.
Recent molecular genetic studies have identified
the bax and bad genes as stimulators and
bcl-x and bcl-2 genes as suppressor of retinal
glanglion cell apoptosis
Analisi delle specie indicatrici applicata alle comunità a Stipa austroitalica Martinovsky e relative problematiche sin tassonomiche.
No full textA method for the classification of the guide species of the different dry grassland communities characterised by Stipa austroitalica is proposed
“Research on heterocyclic compounds. XXXVI. Imidazo[1,2-a]pyrimidine-2-acetic derivatives: synthesis and antiinflammatory activity”.
No full textMessa a punto della Galleria del Vento Ambientale dell’Università Politecnica delle Marche per prove di aerodinamica ambientale su edifici
No full textEvidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
No full textSummaryThe anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase and core component of the cell-cycle oscillator. During G1 phase, APC/C binds to its substrate receptor Cdh1 and APC/CCdh1 plays an important role in restricting S-phase entry and maintaining genome integrity. We describe a reciprocal feedback circuit between APC/C and a second ubiquitin ligase, the SCF (Skp1-Cul1-F box). We show that cyclin F, a cell-cycle-regulated substrate receptor (F-box protein) for the SCF, is targeted for degradation by APC/C. Furthermore, we establish that Cdh1 is itself a substrate of SCFcyclin F. Cyclin F loss impairs Cdh1 degradation and delays S-phase entry, and this delay is reversed by simultaneous removal of Cdh1. These data indicate that the coordinated, temporal ordering of cyclin F and Cdh1 degradation, organized in a double-negative feedback loop, represents a fundamental aspect of cell-cycle control. This mutual antagonism could be a feature of other oscillating systems
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