14 research outputs found
Оцінка ремоделювання кісткової тканини щелеп у динаміці ортодонтичного лікування скупченості зубів = Evaluation of remodelling of jaw bone tissue in the dynamics of orthodontic treatment of tooth crowding
No full textSuslova O. V., Shpak S. V., Plotnikova V .G., Stecenko D. V. Оцінка ремоделювання кісткової тканини щелеп у динаміці ортодонтичного лікування скупченості зубів = Evaluation of remodelling of jaw bone tissue in the dynamics of orthodontic treatment of tooth crowding. Journal of Education, Health and Sport. 2016;6(9):637-642. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.158907
http://ojs.ukw.edu.pl/index.php/johs/article/view/3889
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.09.2016. Revised 24.09.2016. Accepted: 24.09.2016.
УДК 616.311.2-002-053.2/6+616.314-089.29
Оцінка ремоделювання кісткової тканини щелеп у динаміці ортодонтичного лікування скупченості зубів
О. В. Суслова, С. В. Шпак, В. Г. Плотнікова, Д. В. Стеценко
Одеський національний медичний університет
Evaluation of remodelling of jaw bone tissue in the dynamics of orthodontic treatment of tooth crowding
O. V. Suslova, S. V. Shpak, V .G. Plotnikova, D. V. Stecenko
Odessa National Medical University, Odessa, Ukraine
Rearrangement of bone tissue occurs during the orthodontic treatment of tooth crowding due to the processes of resorption and apposition, the ability to influence these processes will allow to reduce the complications of orthodontic treatment purposefully. The aim: to investigate the processes of resorption and osteogenesis of jaw bone tissue during the orthodontic treatment of children with nonremovable devices. Materials and methods of the study. The research of mineral density of jaws has been held among 19 orthodontic patients between the ages of 12-14 with a tooth crowding. Dental sanation and professional oral hygiene have been made in children before the orthodontic treatment. Mineral density of bone tissue, volumetric part of bone trabecules, has been determined by estimation of spread rate of ultrasound waves of upper and lower jaws. Results. Conclusions. The received results confirm the data, in the dynamics of active orthodontic treatment, especially in the beginning, the processes of bone resorption dominates, while in a period of stabilization the synthesis of bone tissue is more active.
Keywords: jaw bone tissue, crowding of teeth, ultrasound wave, echo osteometry
Oligonucleotides containing 2-aminoadenine and 5-methylcytosine are more effective as primers for PCR amplification than their nonmodified counterparts
No full textEvaluation of remodelling of jaw bone tissue in the dynamics of orthodontic treatment of tooth crowding
No full textДля лікування дітей зі скупченням зубів найчастіше використовується незнімна ортодонтична техніка, яка крім багаточисельних переваг може спричинити погіршення гігієнічного стану ротової порожнини, зниження неспецифічної резистентності і функціональних реакцій організму, сприяти запальним процесам у тканинах пародонту. Оскільки, під час ортодонтичного лікування відбувається перебудова кісткової тканини за рахунок процесів резорбції і аппозиції, можливість впливати на ці процеси дозволить цілеспрямовано зменшити ці ускладнення. Метою дослідження було вивчення процесів резорбції та остеогенезу кісткової тканини щелеп під час ортодонтичного лікування дітей незнімними апаратами.Rearrangement of bone tissue occurs during the orthodontic treatment of tooth crowding due to the processes of resorption and apposition, the ability to influence these processes will allow to reduce the complications of orthodontic treatment purposefully. The aim: to investigate the processes of resorption and osteogenesis of jaw bone tissue during the orthodontic treatment of children with nonremovable devices. Materials and methods of the study. The research of
mineral density of jaws has been held among 19 orthodontic patients between the ages of 12–14 with a tooth crowding. Dental sanation and professional oral hygiene have been made in children before the orthodontic treatment. Mineral density of bone tissue, volumetric part of bone trabecules, has been determined by estimation of spread rate of ultrasound waves of upper and lower jaws. Results. Conclusions. The received results confirm the data, in the dynamics of
active orthodontic treatment, especially in the beginning, the processes of bone resorption dominates, while in a period of stabilization the synthesis of bone tissue is more active
New aspects of pedagogical activity in the distant form of pathological physiology teaching to medical university students
No full textDistance learning (DL) is a completely new and unique form of education, which got
forced to switch to by the current pandemic of coronavirus disease.
Note that until now, distance learning technologies have been used at the department
of general and clinical pathological physiology and some other departments of the Odessa
National Medical University (ONMedU).
The aim of this analytical article is to analyze the efficacy of ONMedU General and
Clinical Pathological Physiology Department staff during the one and a half year period of the
coronavirus infection pandemic with an accent to psychological approach to students
modified teaching. The urgent need of time and the primary desire to protect students and
their own lives during 2020-2021 requires us to improve our own pedagogical approaches in
the further on-line teaching of students. We see success in systematic methodological work with students, the implementation
of which will make it possible to evoke and increase their motivation to study histology. The
importance of this methodological technique, supported in the senior years of medical
universities by the integration of teaching theoretical and clinical disciplines, the
approximation of teaching to specific clinical cases will help optimize the assimilation of
morphological knowledge by students at least and, undoubtedly, in the near future will lead to
a better assimilation of clinical disciplines.
In connection with the ideas of individualized and developmental learning, the use of
psychological capabilities of learning tools in the virtual environment brings both pedagogy and
psychology to a new level of understanding the mediation of mental, creative, communicative
and executive learning and learning activities.
The use of distance learning helps the students to acquire skills of independent work,
creates comfortable conditions for creativity, increases the creative and intellectual potential
of the student through self-organization, the ability to interact with computer technology and
make responsible decisions, creates favorable conditions for individual creative expression in
the process of learning, for the development of the student's personality.
The authors are convinced that the optimization and improvement of the educational
process in medical universities is to draw students' attention to the problems that the medical
community is dealing with on a daily basis today
Аномалії зубних рядів в структурі зубощелепних аномалій у дітей 7-18 років
No full textЦель исследования. Сведения о распространенности и
структуре зубочелюстных аномалий помогут определить
нуждаемость детского населения в ортодонтической помощи и рассчитать объем лечебно-профилактических мероприятий. Поэтому сведения о распространенности аномалий зубных рядов требуют постоянного обновления.
Материалы и методы. Для определения структуры зубочелюстных аномалий нами было обследовано 346 пациентов в возрасте 7-18 лет, проживающих в городе Одессе и
Одесской области и обратившихся за ортодонтической
помощью. Все дети были поделены на 4 возрастные группы в
соответствии с периодом формирования прикуса. Анализ полученных результатов проводился по классификации Д.А. Калвелиса, комбинированную патологию отдельно не выделяли.
Результаты исследований. Результаты проведенных исследований показали, что структура зубочелюстных аномалий в различные возрастные периоды различна и зубочелюстные аномалии имеют сочетанный характер.
В структуре зубочелюстных аномалий преобладали случаи
прогнатии. Наименьшая доля прогнатии была зафиксирована в раннем сменном прикусе. В позднем сменном прикусе
она увеличилась более чем на 19,3 %. В период формирования постоянного прикуса и в постоянном прикусе частота
прогнатии приблизительно находилась на одном уровне.
Глубокий прикус наблюдался в 18,4 % случаев осмотренных.
Причем наибольшее количество детей с глубоким прикусом
зафиксировано в раннем сменном прикусе, что можно объяснить частым сочетанием глубокого прикуса с ростом
прогнатии в этом же возрасте. Распространенность глубокого прикуса в позднем сменном и в период формирования
постоянного прикуса колеблется на одном уровне, а в постоянном прикусе опять резко вырастает.
Частота открытого прикуса с возрастом практически не
изменялась. Наибольшая частота косого прикуса наблюдалась в позднем сменном прикусе. Прогения наблюдалась у
6,7 % случаев обследованных и наблюдалась тенденция к ее
увеличению с возрастом обследованных детей, что возможно связано с половым созреванием.
Выводы. Полученные данные помогут определить объем
лечебно-профилактических мероприятий.
Ключевые слова: зубочелюстные аномалии, распространенность, скученность зубов, аномалии зубных рядов.Purpose of research. Information on the prevalence and structure of dentoalveolar anomalies will help to determine the need
of the child population in orthodontic care and to calculate the
volume of therapeutic and preventive measures. Therefore, information about the prevalence of anomalies of dentition require constant updating.
Materials and methods. To determine the structure of
dentoalveolar anomalies, we examined 346 patients aged 7-18
years living in the city of Odessa and Odessa region and seeking
orthodontic care. All children were divided into 4 age groups
according to the period of bite formation. The analysis of the
obtained results was carried out according to the classification
of D. A. Kalvelis, the combined pathology was not singled out
separately.
Research result. The results of the studies showed that the structure of dentoalveolar anomalies in different age periods is different and dentoalveolar anomalies have a combined character.
In the structure of dentoalveolar anomalies prevailed cases
pregnate. The smallest proportion of prognathia was recorded
in the early changeable bite. In the late shift bite, it increased by
more than 19.3 %. During the formation of a permanent bite
and in a permanent bite, the frequency of prognathia was approximately at the same level.
Deep bite was observed in 18.4 % of cases examined. Moreover,
the largest number of children with deep bite is recorded in the
early changeable bite, which can be explained by the frequent
combination of deep bite with the growth of prognathia at the
same age. The prevalence of deep bite in the late shift and during the formation of a permanent bite varies at the same level,
and in the constant bite again grows sharply.
The frequency of open bite did not change with age. The highest
frequency of oblique occlusion was observed in the late changeable occlusion.
Progeny was observed in 6.7 % of the cases surveyed and there
was a tendency to increase with age surveyed children, possibly
due to puberty.
Summary. The data obtained will help to determine the volume
of therapeutic and preventive measures.Мета дослідження. Відомості про поширеність і структуру зубощелепних аномалій допоможуть визначити потребу дитячого населення в ортодонтичній допомозі і розрахувати обсяг лікувально-профілактичних заходів. Тому відомості про поширеність аномалій зубних рядів вимагають
постійного оновлення.
Матеріали і методи. Для визначення структури зубощелепних аномалій нами було обстежено 346 пацієнтів у віці 7-
18 років, які проживають у місті Одесі та Одеській області і звернулися за ортодонтичною допомогою. Всіх дітей
було поділено на 4 вікові групи відповідно до періоду формування прикусу. Аналіз отриманих результатів проводився за
класифікацією Д. А. Калвеліса, комбіновану патологію
окремо не виділяли.
Результати досліджень. Результати проведених досліджень показали, що структура зубощелепних аномалій у різні вікові періоди різна і зубощелепні аномалії мають поєднаний характер.
У структурі зубощелепних аномалій переважали випадки
прогнатії. Найменшу частку прогнатії було зафіксовано в
ранньому змінному прикусі. У пізньому змінному прикусі вона збільшилася більш ніж на 19,3 %. У період формування
постійного прикусу і в постійному прикусі частота прогнатії приблизно перебувала на одному рівні.
Глибокий прикус спостерігався в 18,4 % випадків оглянутих.
Причому найбільшу кількість дітей з глибоким прикусом
зафіксовано в ранньому змінному прикусі, що можна пояснити частим поєднанням глибокого прикусу з ростом прогнатії в цьому ж віці. Поширеність глибокого прикусу у пізньому змінному і в період формування постійного прикусу
коливається на одному рівні, а в постійному прикусі знову
різко зростає.
Частота відкритого прикусу з віком практично не змінювалася. Найбільша частота косого прикусу спостерігалася
в пізньому змінному прикусі. Прогенія спостерігалася у 6,7
% випадків обстежених і спостерігалася тенденція до її
збільшення з віком обстежених дітей, що можливо пов'язано з статевим дозріванням.
Висновок. Отримані дані допоможуть визначити обсяг лікувально-профілактичних заходів
Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production
No full textLevels of prostaglandin E-2 (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2). To further investigate the relative importance of COX-2 and PGE2 in the development of fibrosis we have used a selective COX-2 inhibitor and COX-2-deficient ((-/-) and (+/-)) mice in studies of bleomycin-induced lung fibrosis. We demonstrate in wild-type mice that bleomycin-induced. p lung PGE(2) production is predominantly COX-2 mediated. Furthermore, COX-2(+/-) mice show limited induction of PGE2 and an enhanced fibrotic response with increased lung collagen content compared with wild-type mice after bleomycin injury (P < 0.001). In contrast, COX-2(-/-) mice show increased levels of lung PGE(2), compared with wild-type mice after injury (P < 0.05), because of compensatory up-regulation of COX-1, which appears to be associated with macrophage/monocytes but not fibroblasts derived from these mice. COX-2(-/-) mice show an enhanced and persistent inflammatory response to bleomycin, however the fibrotic response to injury was unaltered compared with wild-type animals. These data provide further direct evidence for the importance of up-regulating COX-2 and PGE(2) expression in protecting against the development of fibrosis after lung injury
Measures of noncompactness in locally convex spaces and fixed point theory for the sum of two operators on unbounded convex sets
No full textsummary:In this paper we prove a collection of new fixed point theorems for operators of the form on an unbounded closed convex subset of a Hausdorff topological vector space . We also introduce the concept of demi--compact operator and -semi-closed operator at the origin. Moreover, a series of new fixed point theorems of Krasnosel'skii type is proved for the sum of two operators, where is -sequentially continuous and -compact while is -sequentially continuous (and -condensing, -nonexpansive or nonlinear contraction or nonexpansive). The main condition in our results is formulated in terms of axiomatic -measures of noncompactness. Apart from that we show the applicability of some our results to the theory of integral equations in the Lebesgue space
Controversies In Cystic Fibrosis - From Pediatrician To Specialist [controvérsias Na Fibrose Cística - Do Pediatra Ao Especialista]
No full textObjective: Cystic fibrosis has become, in the last 70 years, the most important potentially fatal inherited disease that affects white individuals around the world. Although it is considered a genetic disorder, which strikes cells of different organs, not all patients present similar clinical response. Many clinical manifestations, mainly pulmonary and gastrointestinal, may develop in cystic fibrosis patients. The aim of this article is to offer pediatricians an updated review of the controversies and recent advances in the treatment of cystic fibrosis. Sources: systematic review in the Medline database. Summary of the findings: seventy-nine articles about cystic fibrosis published in international journals were reviewed. This article presents an updated and critical review of the main events related to the incidence, pathophysiology, diagnosis and treatment of cystic fibrosis. Conclusions: even though no treatment is available for this disease, new findings about its etiology and pathophysiology have been discovered in the last two decades, improving treatment and survival of cystic fibrosis patients.78SUPPL. 2S171S186Lyczak, J.B., Cannon, C.L., Pier, G.B., Lung infections associated with cystic fibrosis (2002) Clin Microbiol Rev, 15 (2), pp. 194-222Doull, I.J., Recent advances in Cystic Fibrosis (2001) Arch Dis Child, 85 (1), pp. 62-66Super, M., Milestones in Cystic Fibrosis (1992) Br Med Bull, 48 (4), pp. 713-737Temkate, L.P., Cystic fibrosis in the Netherlands (1977) Int J Epidemiol, 6, pp. 23-34Brunechy, Z., The incidence and genetics of cystic fibrosis (1972) J Med Genet, 9, pp. 33-37Dodge, J.A., Morison, S., Lewis, P.A., Cystic fibrosis in the United Kingdom, 1968-1988: Incidence, population and survival (1993) Pediatr Perinat Epidemiol, 7, pp. 157-166Nevanlinna, H.R., The Finnish population structure, a genetic and genealogical study (1972) Hereditas, 71, pp. 195-236Nielsen, E.L., Cystic Fibrosis: Incidence in Denmark (1972) Acta Paediatr Scand, 61, pp. 377-379Raskin, S., Phillips J.A. III, Krishnamani, M.R., Vnencak-Jones, C., Parker, R.A., Rozov, T., DNA analysis of cystic fibrosis in Brazil by direct PCR amplification from Guthrie cards (1993) Am J Med Gen, 46, pp. 665-669Tsui, L.C., Rommens, J., Kerem, B., Rozmahel, R., Zielenski, J., Kennedy, D., Molecular genetics of cystic fibrosis (1991) Adv Exp Med Biol, 290, pp. 9-17Collins, F.S., Cystic fibrosis: Molecular biology and therapeutic implications (1992) Science, 256, pp. 774-779Santis, G., Basic molecular genetics (1995) Cystic Fibrosis, pp. 15-39. , Hodson M, Gueddes D. London: Chapman & Hall MedicalMorral, N., Bertranpetit, J., Estivill, X., Nunes, V., Casals, T., Giménez, J., The origin of the major cystic fibrosis mutation (DF508) in European populations (1994) Nat Genet, 7, pp. 169-175Martins, C.S.B., Ribeiro, A.F., Costa, F.F., Frequency of the cystic fibrosis DF508 mutation in a population from São Paulo State, Brazil (1993) Braz J Med Biol Res, 26, pp. 1037-1040Knowles, M.R., Stutts, M.J., Yankaskas, J.R., Gatzy, J.T., Boucher R.C., Jr., Abnormal respiratory epithelial ion transport in cystic fibrosis (1986) Clin Chest Med, 7, pp. 285-297Esterley, J.R., Oppenheimer, E.H., Cystic fibrosis of the pancreas: Structural changes in peripheral airways (1968) Thorax, 23, pp. 270-275Oppenheimer, E.R., Esterly, J.R., Pathology of cystic fibrosis: Review of the literature and comparison with 146 autopsied cases (1975) Perspect Pediatr Pathol, 2, pp. 241-278Bedrossian, C.W., Greenberg, S.D., Singer, D.B., Hansen, J.J., Rosenberg, H.S., The lung in cystic fibrosis: A quantitative study including prevalence of pathological finding among different age groups (1976) Hum Pathol, 7 (2), pp. 195-204Tomashefski J.F., Jr., Bruce, M., Goldberg, H.I., Dearborn, D.G., Regional distribution of macroscopic lung disease in cystic fibrosis (1986) Am Rev Respir Dis, 133 (4), pp. 535-540Mack, J.F., Moss, A.J., Harper, W.H., The bronchial arteries in cystic fibrosis (1965) Br J Radiol, 38, pp. 422-429Rose, V., Mechanisms and markers of airway inflammation in cystic fibrosis (2002) Eur Respir J, 19 (2), pp. 333-340Muhlebach, M.S., Stewart, P.W., Leigh, M.W., Noah, T.L., Quantification of inflammatory responses to bacteria in young cystic fibrosis and control patients (1999) Am J Respir Crit Care Med, 160, pp. 186-191Park, R.W., Grand, R.J., Gastrointestinal manifestations of cystic fibrosis: A review (1981) Gastroenterology, 81, pp. 1143-1161Evans, A.K., Fitzgerald, D.A., Mckay, K.O., The impact of meconium ileus on the clinical course of children with cystic fibrosis (2001) Eur Respir J, 18 (5), pp. 784-789Colombo, C., Apostolo, M.G., Ferrari, M., Analysis of risk factors for the development of liver disease associated with Cystic Fibrosis (1994) J Pediatr, 124, pp. 393-399Friedman, S.L., The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies (1993) N Eng J Med, 328, pp. 1828-1835(1997) Clinical Practice Guidelines for Cystic Fibrosis Committee, pp. 1-54(1996) Consensus Conferences. The Diagnosis of Cystic Fibrosis: Consensus Statement, 7 (1)Storni, V., Claustres, M., Chinet, T., Ravilly, S., Diagnostic de la Mucoviscidose (2001) Arch Pédiat, 8 (SUPPL. 5), pp. 818-832Gibson, L.E., Cooke, R.E., A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis (1959) Pediatrics, 23, pp. 545-549Denning, C.R., Huang, N.N., Cuasay, L.R., Shwachman, H., Tocci, P., Warwick, W.J., Cooperative study comparing three methods of performing sweat tests to diagnose cystic fibrosis (1980) Pediatrics, 66, pp. 752-757Mastella, G., Di Cesare, G., Borruso, A., Menin, L., Zanolla, L., Reliability of sweat-testing by the Macroduct collection method combined with conductivity analysis in comparison with the classic Gibson and Cooke technique (2000) Acta Paediatr, 89 (8), pp. 933-937Tsui, L.C., The cystic fibrosis transmenbrane conductance regulator gene (1995) Am J Respir Crit Care Med, 151 (3 PART 2), pp. 47-53Leus, J., Van Bieruliet, S., Robberecht, E., Detection and follow up of exocrine pancreatic insufficiency in Cystic fibrosis: A review (2000) Eur J Pediatr, 159, pp. 563-568Crossley, J.R., Elliott, R.B., Smith, P.A., Dried-blood spot screening for Cystic Fibrosis in the newborn (1979) Lancet, 1 (8114), pp. 472-474King, D.N., Heeley, A.F., Walsh, M.P., Kusenko, J.A., Sensitive trypsin assay for dried-blood specimens as a screening procedure for early detection of cystic fibrosis (1979) Lancet, 2 (8154), pp. 1217-1219Merelle, M.E., Nagelkerke, A.F., Lees, C.M., Dezateux, C., Newborn Screening for Cystic Fibrosis (2001) Cochrane Database Syst Rev, (3). , CD001402Wilcken, B., Brow, A.R.D., Urwin, R., Brown, D.A., Cystic Fibrosis screening by dried blood spot trypsin assay: Results in 75.000 newborn infants (1983) J Pediatr, 102, pp. 383-387Verlinsky, Y., Kuliev, A., Preimplantation genetic diagnosis (1999) Reprod Med Rev, 7, pp. 1-14Massie, R.J., Olsen, M., Glazner, J., Robertson, C.F., Francis, I., Newborn screening for cystic fibrosis in Victoria: 10 Years experience (1989-1998) (2000) Med J Aust, 172 (12), pp. 584-587McCaffery, K., Olver, R.E., Franklin, M., Mukhopadhyay, S., Systematic review of antistaphilococcal antibiotic therapy in cystic fibrosis (1999) Thorax, 54, pp. 380-383Doring, G., Conway, S.P., Heijennan, H.G.M., Hodson, M.E., Hoiby, N., Smyth, A., Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: A European consensus (2000) Eur Respir J, 16 (4), pp. 749-767Frederiksen, B., Koch, C., Hoiby, N., Changing epidemiology of Pseudomonas aeruginosa infection in Danish cystic fibrosis patients (1974-1995) (1999) Pediatr Pulmonol, 28, pp. 159-166Elborn, J.S., Prescott, R.J., Stack, B.H., Goodchild, M.C., Bates, J., Pantin, C., Elective versus symptomatic antibiotic treatment in cystic fibrosis patients with chronic Pseudomonas infection of the lungs (2000) Thorax, 55, pp. 355-358Mukhopadhyay, S., Singh, M., Carter, J.I., Ogston, S., Franklin, M., Olver, R.E., Nebulized anti-pseudomonal antibiotic therapy in cystic fibrosis: A meta-analysis of benefits and risks (1996) Thorax, 51, pp. 364-368Ramsey, B.W., Pepe, M.S., Quan, J.M., Otto, K.L., Montgomery, A.B., Williams-Warren, J., Intermittent administration of inhaled tobramycin in patients with cystic fibrosis (1999) N Engl J Med, 340, pp. 23-30Jones, A.M., Dodd, M.E., Webb, A.K., Burkholderia cepacia: Current clinical issues, environmental controversies and ethical dilemmas (2001) Eur Respir J, 17 (2), pp. 295-301Cohn, R.C., Rudziensky, L., Further observations on amiloridetobramycin synergy in Cystic Fibrosis (1991) Pediatr Pulmonol Suppl, (SUPPL. 6), p. 279Bush, A., Gedds, D., Cystic fibrosis in adolescence (2002) European Respiratory Monograph, 7 (19), pp. 225-253Dezateux, C., Crighton, A., Oral non-steroidal anti-inflammatory drug therapy for cystic fibrosis (2000) Cochrane Database Syst Rev, (2). , CD001505Dezateux, C., Walters, S., Balfour-Lynn, I., Inhaled Corticosteroids for Cystic Fibrosis (2000) Cochrane Database Syst Rev, (2). , CD001915Wolter, J., Seeney, S., Bell, S., Bowler, S., Masel, P., McCormack, J., Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: A randomised trial (2002) Thorax, 57 (3), pp. 212-216Jaffe, A., Bush, A., Anti-inflammatory effects of macrolides in lung disease. Sate of the art (2001) Pediatr Pulmonol, 31, pp. 464-473Wall, M.A., LaGesse, P.C., Istvan, J.A., The worth of routine spirometry in a Cystic Fibrosis Clinic (1998) Pediatr Pulmonol, 25, pp. 231-237Fuchs, H.J., Borowitz, D.S., Christiansen, D.H., Morris, E.M., Nash, M.L., Ramsey, B.W., Effect of aerosolized recombinant DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis (1994) N Engl J Med, 331, pp. 637-642Shah, P.I., Bush, A., Canny, G.J., Colin, A.A., Fuchs, H.J., Geddes, D.M., Recombinant human DNase 1 in cystic fibrosis patients with severe pulmonary disease: A short-term, double-blind study followed by six months of open label treatment (1995) Eur Respir J, 8, pp. 954-958McCoy, C., Hamilton, S., Johson, C., Effects of 12 week administration of dornasealfa in patients with advanced cystic fibrosis lung disease (1996) Chest, 110, pp. 889-895Eng, P.A., Morton, J., Douglass, J.A., Riedler, J., Wilson, J., Robertson, C., Short term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis (1996) Pediatr Pulmonol, 21, pp. 77-83Borsje, P., Jongste, J.C., Mouton, J.W., Tiddens, H.A.W.M., Aerosol therapy in cystic fibrosis: A survey of 54 CF centers (2000) Pediatr Pulmonol, 30, pp. 368-376King, M., Dasgupta, B., Tomkiewicz, R.P., Brown, N.E., Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I (1997) Am J Respir Crit Care Med, 156 (1), pp. 173-177Wark, P.A., McDonald, V., Nebulised hypertonic saline for cystic fibrosis (2000) Cochrane Database Syst Rev, (2). , CD001506Wills, P., Greenstone, M., Inhaled hyperosmolar agents for bronchiectasis (2002) Cochrane Database Syst Rev, (1), pp. CD002996Van Der Schans, C., Prasad, A., Main, E., Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis (2000) Cochrane Database Syst Rev, (2). , CD001401Kerem, E., Reisman, J., Corey, M., Canny, G.J., Levison, H., Prediction of mortality in patients with Cystic Fibrosis (1992) N Engl J Med, 326, pp. 1187-1191Bridges, N.D., Mallory G.B., Jr., Huddleston, C.B., Canter, C.E., Sweet, S.C., Spray, T.L., Pediatric lung transplantation at St. Louis Children's Hospital, 1990-1995 (1997) Am J Repir Crit Care Med, 155, pp. 1027-1035Moss, R.B., Passive immunotherapy for treatment of endobronchitis in Cystic Fibrosis (1993) Infusionsther Transfusionsmed, 20 (SUPPL. 1), pp. 42-46Kraisinger, M., Hochhaus, G., Stecenko, A., Bowser, E., Hendeles, L., Clinical pharmacology of pancreatic enzymes in patients with Cystic Fibrosis and in vitro performance of microencapsulated formulations (1994) J Clin Pharmacol, 34, pp. 158-166Lebenthal, E., David, D.K., Holclaw, D.J., Enzyme therapy for pancreatic insufficiency. Present status and future needs (1994) Pancreas, 9 (1), pp. 1-112(1995) Cystic Fibrosis Foundation Consensus Conference, , Appendix IX, Vol VI, Section I MarchRansey, B.W., Farrell, P.M., Pencharg, P., Nutritional assessment and management in Cystic Fibrosis: A Consensus Conference Statement (1998) Chest, 55, pp. 108-116Geiss, S.K., Hobbs, S.A., Hammers, L.Y., Maercklein, G., Psychosocial factors related to perceived compliance with cystic fibrosis treatment (1992) J Clin Psychol, 48, pp. 99-103Alton, E.W., Guedds, D.M., Gene therapy for Cystic Fibrosis: A clinical prospective (1995) Gene Ther, 2, pp. 88-95Implementation of cystic fibrosis services in developing countries: Memorandum from a joint WHO/ICF(M)A meeting (1997) Bulletin of the World Health Organization, 75 (1), pp. 1-10. , World Health Organization/ International Cystic Fibrosis AssociationMickle, J.E., Cutting, G.R., Genotype-phenotype relationships in cystic fibrosis (2000) Med Clin North Am, 84 (3), pp. 597-607Collins, C.E., Macdonald-Wicks, L., Rowe, S., O'loughlin, E.V., Henry, R.L., Normal growth in cystic fibrosis associated with a specialized center (1999) Arch. Dis. Child, 81 (3), pp. 241-246Corey, M., Farewell, V., Determinants of mortality from cystic fibrosis in Canada, 1970-1989 (1996) Am J Epidemiol, 143, pp. 1007-1017Macri, C.N., De Gentile, A.S., Manterola, A., Tomezzoli, S., Reis, F.C., Largo Garcia, I., Epidemiology of Cystic Fibrosis in Latin America. Preliminary communication (1991) Pediatr Pulmonol, 10, pp. 249-253Camargos, P.A.M., Guimarães, M.D.C., Reis, F.C., Prognostic aspects of Cystic Fibrosis in Brazil (2000) Ann Trop Pediatr, 20 (4), pp. 287-29
Resposta inflamatória, estado nutricional e função pulmonar em crianças e adolescentes como fibrose cística
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pos-Graduação em Nutrição.Introdução: as infecções das vias respiratórias e a ativação de processos inflamatórios promovem depleção nutricional e declínio da função pulmonar, representando as principais consequências da Fibrose Cística (FC). Objetivo: avaliar a relação entre resposta inflamatória, estado nutricional e função pulmonar em crianças e adolescentes com FC. Sujeitos e Métodos: estudo clínico-transversal realizado com 86 sujeitos distribuídos em Grupo Controle (GC, n= 31) e Grupo FC (GFC, n= 55), redistribuído em GFC bacteriologia negativa (GFCB?) ou GFC bacteriologia positiva (GFCB+) e GFC Pseudomonas aeruginosa negativa (GFCPa?) ou GFC Pseudomonas aeruginosa positiva (GFCPa+). A função pulmonar foi avaliada pelo Volume Expiratório Forçado no primeiro segundo (VEF1) e o estado nutricional pelo z-escore de peso-para-idade (zP/I), estatura-para-idade (zE/I), índice de massa corporal-para-idade (zIMC/I), área muscular do braço (zAMB), área gordurosa do braço (zAGB) e percentual de gordura corporal (%GC). A resposta inflamatória foi avaliada pela dosagem de mieloperoxidase (MPO), interleucina-1beta (IL-1?), fator de necrose tumoral-alfa (TNF-?), proteína C-reativa (PCR), metabólitos de óxido nítrico (NOx), adenosina deaminase (ADA) e contagem de leucócitos, neutrófilos, linfócitos e monócitos. A análise bacteriológica foi avaliada na secreção da cavidade orofaríngea. Foi adotado um nível de significância p< 0,05. Resultados: o VEF1 foi significativamente maior no GC (88,57%) comparado com GFC (66,77%; p=0,001), GFCB+ (57,87%; p<0,001) e GFCPa+ (54,82%; p<0,001). Comparados ao GC e após análise ajustada para variáveis de confusão observou-se: redução do zIMC/I e zAMB no GFC (p=0,030; p=0,019), GFCB+ (p=0,030; p=0,029), e GFCPa+ (p=0,047; p=0,026). Aumento da MPO (p<0,001, todos subgrupos), IL-1? (p<0,001, todos subgrupos) e PCR (GFC: p=0,002; GFCB?: p=0,007; GFCB+: p=0,009; GFCPa?: p=0,004 e GFCPa+: p=0,020). Nos GFCB+ e GFCPa+ o NOx (p=0,001; p<0,001), leucócitos (p=0,002; p=0,001) e neutrófilos (p=0,003; p<0,001) estavam aumentados. No GFC foi observada correlação positiva entre VEF1 e zP/I (p=0,009), zE/I (p=0,006), zIMC/I (p=0,028) e zAMB (p=0,027) e negativa com leucócitos (p=0,008) e neutrófilos (p=0,031), correlação negativa entre zAMB e NOx (p=0,028). Conclusão: sujeitos com FC independente do tipo de infecção acometida apresentam resposta inflamatória importante caracterizada por aumento de MPO, IL-1? e PCR. A bacteriologia positiva apresentou efeito aditivo na resposta inflamatória levando ao aumento do NOx, leucócitos e neutrófilos. A desnutrição, leucocitose e neutrofilia estão correlacionadas com a redução da função pulmonar.Background: the infections of the airways and the activation of immune and inflammatory process promote nutritional depletion and decline in lung function, representing the main consequences of cystic fibrosis (CF). Aim: evaluate the relationship between inflammatory response, nutritional status and pulmonary function in children and adolescents with CF. Subjects andMethods: clinical-cross-sectional study was conducted with 86 subjects distributed in Control Group (CG, n= 31) and CF Group (CFG, n= 55), redistributed in CFG bacteriology negative (CFGB.) or CFG bacteriology positive (CFGB+) and CFG Pseudomonas aeruginosa negative (CFGPa.) or CFG Pseudomonas aeruginosa positive (CFGPa+). Pulmonary function was assessed by Forced Expiratory Volume in the first second (FEV1) and the nutritional status by indicators in Z-escore weight-for-age (zW/A), height-for-age (zH/A), body mass index-for-age (zBMI/A), arm muscle area (zAMA), arm fat area (zAFA) and percentage of body fat (%BF). Inflammatory response was assessed by measurement of myeloperoxidase (MPO), interleukin-1beta (IL-1â), tumor necrosis factor-alpha (TNF-á), C-reative protein (CRP), nitric oxide metabolites (NOx), adenosine deaminase (ADA) and leukocytes, neutrophils, lymphocytes, monocytes counts. Bacteriological analysis was assessed in the secretion of the oropharyngeal cavity. Was adopted a significance level of p<0.05. Results: the FEV1 was significantly higher in CG (88.57%) compared with CFG (66.77%, p=0.001), CFGB+ (57.87, p<0.001) and CFGPa+ (54.82, p<0.001). Compared to CG and after adjustment for confounding variables was observed: reduction the zBMI/A and zAMA in CFG (p=0.030; p=0.019), CFGB+ (p=0.030; p=0.029), and CFGPa+ (p=0.047; p=0.026). Increased to MPO (p<0.001, all subgroups), IL-1â (p<0.001, all subgroups) and CRP (CFG: p=0.002; CFGB.: p=0.007; CFGB+: p=0.009; CFGPa.: p=0.004 and CFGPa+: p=0.020). In the CFGB+ and CFGPa+, the NOx (p=0.001; p<0.001), leukocytes (p=0.002; p=0.001) and neutrophils (p=0.003; p<0.001) was increased. In the CFG was observed positive correlation between FEV1 and zW/A (p=0.009), zH/A (p=0.006), zBMI/A (p=0.028) and zAMA (p=0.027) and negative with leukocytes (p=0.008) and neutrophils (p=0.031), negative correlation between zAMA and NOx (p=0.028). Conclusion: subjects with CF independent of infection involved showed important inflammatory response characterized by increased MPO, IL-1â and CRP. The bacteriology positive had additive effect on the inflammatory response by increasing the NOx, leukocytes and neutrophils. Malnutrition, leukocytosis and neutrophilia are correlated with reduced lung function
