1,355,101 research outputs found
Curro González arte y creación
No full textEsta tesis doctoral se ha escrito con la intención de contribuir al esclarecimiento y a la sistematización de la producción artística del artista sevillano Curro González, cuyas aportaciones a la vida artística española y, sobre todo, hispalense han sid
K+ channels as potential targets for the treatment of gastrointestinal motor disorders
No full textK+ channels play important functional roles in excitable cells, as neurons and muscle cells. The activation or inhibition of K+ channels hyperpolarizes or depolarizes the cell membrane, respectively. These effects determine in the smooth muscle decrease or increase in Ca2+ influx through voltage-gated Ca2þ (CaV1.2) channels and relaxation or contraction, respectively. Recent studies highlight the importance of voltage-dependent type 7 K+ (KV7 or KCNQ) channels in regulating muscle tone and contractility in stomach and colon. KV7 channels, that include 5 subtypes (KV7.1–7.5), are activated at relatively negative potential values, close to those of the resting membrane potential for the smooth muscle cells of some segments of the gastrointestinal tract. Thus, they contribute to set the resting membrane potential and their blockade induces increase in smooth muscle contractility in stomach and colon. In addition, KV7 channel activation produces profound relaxations of gastric and colonic smooth muscle. Therefore, KV7 channel activators could be used to relax the smooth muscle and relieve symptoms in diseases such as functional dyspepsia and irritable bowel syndrome with prevalent diarrhea. The discovery of activators selective for the channel subtypes present in the smooth muscle, mainly KV7.4 and 7.5, would allow avoiding adverse cardiac and nervous system effects. A further step forward would be characterizing putative differences among the KV7 channel subtypes expressed in the various smooth muscles and synthesizing molecules specific for the gastrointestinal smooth muscle
Curro Claret: il design è politico
No full textIl lavoro del designer catalano Curro Claret apre a una considerazione critica sul ruolo sociale del fare design
The Modulation of Potassium Channels in the Smooth Muscle as a Therapeutic Strategy for Disorders of the Gastrointestinal Tract
No full textAlterations of smooth muscle contractility contribute to the pathophysiology of important functional gastrointestinal disorders (FGIDs) such as functional dyspepsia and irritable bowel syndrome. Consequently, drugs that decrease smooth muscle contractility are effective treatments for these diseases. Smooth muscle contraction is mainly triggered by Ca(2+) influx through voltage-dependent channels located in the plasma membrane. Thus, the modulation of the membrane potential results in the regulation of Ca(2+) influx and cytosolic levels. K(+) channels play fundamental roles in these processes. The open probability of K(+) channels increases in response to various stimuli, including membrane depolarization (voltage-gated K(+) [KV] channels) and the increase in cytosolic Ca(2+) levels (Ca(2+)-dependent K(+) [KCa] channels). K(+) channel activation is mostly associated with outward K(+) currents that hyperpolarize the membrane and reduce cell excitability and contractility. In addition, some K(+) channels are open at the resting membrane potential values of the smooth muscle cells in some gut segments and contribute to set the resting membrane potential itself. The closure of these channels induces membrane depolarization and smooth muscle contraction. KV1.2, 1.5, 2.2, 4.3, 7.4 and 11.1, KCa1.1 and 2.3, and inwardly rectifying type 6K(+) (Kir6) channels play the most important functional roles in the gastrointestinal smooth muscle. Activators of all these channels may theoretically relax the gastrointestinal smooth muscle and could therefore be promising new therapeutic options for FGID. The challenge of future drug research and development in this area will be to synthesize molecules selective for the channel assemblies expressed in the gastrointestinal smooth muscle
Riabilitazione implantoprotesica con impianti passivati nel paziente totalmente edentulo
No full textRuo y curro, dos formas de correr en lat\uedn
No full textEl prop\uf3sito del siguiente estudio es demostrar la compleja
realidad ling\ufc\uedstica que ata\uf1e a los verbos ruo y curro. Entre estos
dos verbos de movimiento existe una diferenciaci\uf3n sem\ue1ntica
que las traducciones no pueden expresar de forma sint\ue9tica y que
a menudo no recogen. Para poner de manifiesto que la elecci\uf3n de
un verbo u otro no es arbitraria recurrimos a un estudio ling\ufc\uedstico
basado en un corpus de ejemplos extra\ueddos de Plauto, Livio y Virgilio,
autores representativos de los g\ue9neros literarios que cultivan.
Mediante el an\ue1lisis comparativo de ruo y curro y los elementos
centrales que intervienen en una situaci\uf3n de movimiento se determinan
unos marcos predicativos distintos para cada verbo. Cabe poner \ue9nfasis en la posibilidad de ruo y curro de expresar un movimiento metaf\uf3rico, m\ue1s all\ue1 de la expresi\uf3n de un desplazamiento
real o f\uedsic
Iconographic key points of Curro González pictorial universe
No full textEste artículo se ha escrito con la intención de contribuir al esclarecimiento y a la sistematización de la producción pictórica del artista sevillano Curro González (Sevilla, 1960), cuyas aportaciones a la vida artística española y, sobre todo, hispalense han sido tan diversas como importantes. La finalidad más específica de este estudio es, pues, profundizar en el conocimiento del universo simbólico e iconográfico de su obra, llegando a conclusiones que clarifiquen su ingente producción creativa.This article has been written with the intention of contributing to the clarification and systematization of pictorial production Sevillian artist Curro Gonzalez (Seville,1960), whose contributions to the Spanish artistic life and, above all, Seville have been as diverse as important. The specific purpose of this study is therefore to deepen the knowledge of the symbolic and iconographic universe Curro González’s work, reaching conclusions that clarify their enormous creative output
From a survey on accidents in the downstream oil industry to the development of a detailed near-miss reporting system
No full textA historical analysis with statistical investigation on accidental events in the oil industry from the beginning of the XX century till now, was performed in order to identify historical trend and go deeper into accident causes. The classification
methodology was developed referring to three headings, namely plant/process, environment and organization
and trying to go deeper into the analysis of the causes of the accidents reported and understand more of what is probably
behind the accidents. The accident types and severity were studied, plotting the accumulated frequency–fatality
curve for each item. In the subsequent applicative phase, we applied a similar classification approach to near-misses
directly collected over nine years observation in a large downstream oil firm. The historical analysis was extended
on each section of the refinery, paying a careful attention to all causes and consequences of the event. Data were
structured for analyzing trends and identifying possible precursors of unwanted events. According to the step-bystep
approach we try to evidence how immediate causes of a near-miss could be linked in some kind of causal chain
to underlying causes that should be controlled by middle or higher management, or are part of the corporate safety
culture
Gala Flamenca de Navidad. Actuacion de Curro Piñana (al cante) y Antonio Piñana ( a la guitarra).
No full textGala Flamenca de Navidad. Actuacion de Curro Piñana (al cante) y Antonio Piñana ( a la guitarra)
CLAVES ICONOGRÁFICAS DEL UNIVERSO PICTÓRICO DE CURRO GONZÁLEZ
No full textThis article has been written with the intention of contributing to the clarification and systematization of pictorial production Sevillian artist Curro Gonzalez (Seville,1960), whose contributions to the Spanish artistic life and, above all, Seville have been as diverse as important. The specific purpose of this study is therefore to deepen the knowledge of the symbolic and iconographic universe Curro González’s work, reaching conclusions that clarify their enormous creative output.Este artículo se ha escrito con la intención de contribuir al esclarecimiento y a la sistematización de la producción pictórica del artista sevillano Curro González (Sevilla, 1960), cuyas aportaciones a la vida artística española y, sobre todo, hispalense han sido tan diversas como importantes. La finalidad más específica de este estudio es, pues, profundizar en el conocimiento del universo simbólico e iconográfico de su obra, llegando a conclusiones que clarifiquen su ingente producción creativa
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