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John C. Lamoreaux (trad.), Theodore Abū Qurrah
No full textConticello Vassa. John C. Lamoreaux (trad.), Theodore Abū Qurrah . In: Revue des études byzantines, tome 66, 2008. pp. 281-282
La théologie byzantine et sa tradition, II (XIIIe-XIXe s.)
No full textInternational audienceLe volume collectif La Théologie byzantine et sa tradition, II (XIIIe-XIXe s.), dirigé par Vassa Kontouma-Conticello et C. G. Conticello, rassemble des articles substantiels consacrés à des personnalités majeures de la théologie byzantine et post-byzantine. Les contributions, en anglais, français, italien, allemand et espagnol sont les suivantes :1. Gregorio il Sinaita (par Antonio Rigo), 2. Gregory Palamas (par Robert E. Sinckewicz), 3. Gregorio Akíndinos (par Juan Nadal Cañellas), 4. Nicola Cabasilas Chamaetos (par Yannis Spiteris, C. G. Conticello), 5. Mark Eugenikos (par Nicholas Constas), 6. Georgios Gennadios Scholarios (par Franz Tinnefeld), 7. Jérémie II Tranos (par Christian Hannick, Klaus-Peter Todt), 8. Kyrillos Loukaris (par Klaus-Peter Todt), 9. Dositheos II. von Jerusalem (par Klaus-Peter Todt), 10. Eugène Boulgaris (par Daniel Stiernon), 11. Nicéphore Théotokès (par Vasilios Makrides, Vassa Conticello), 12. Nicodemo Agiorita (par Elia Citterio), 13. La Philocalie et L’ambition première de l’ouvrage est d’aborder le domaine théologique byzantin à travers ses forces vives, les théologiens, perçus comme des sujets porteurs d’une expérience spirituelle riche et vivante, dont la production compte parfois parmi les chefs-d’oeuvre de la littérature théologique universelle. Sa seconde ambition est de considérer ce domaine dans toute son extension, aussi bien chronologique que géographique, la coupure historique de 1453, date de la chute de Constantinople, ne marquant pas la fin de cet univers de pensée qui continue de vivre dans l’Orthodoxie moderne et contemporaine.Dans chaque chapitre, un soin particulier a été accordé à la prosopographie, à la constitution d’un répertoire complet des oeuvres de chaque théologien considéré — cette section constitue l’esquisse d’une Clavis Auctorum Byzantinorum, sur le modèle de la Clavis Patrum Graecorum de M. Geerard —, au repérage des manuscrits pour les oeuvres inédites, à l’exhaustivité et à la présentation critique des bibliographies en langues occidentales et orientales. Pour illustrer l’exposé sur la doctrine des auteurs présentés, partie centrale de chaque contribution, l’ouvrage rassemble également plusieurs textes, traduits pour la première fois ou édités critiquement
La théologie byzantine et sa tradition, II (XIIIe-XIXe s.)
No full textInternational audienceLe volume collectif La Théologie byzantine et sa tradition, II (XIIIe-XIXe s.), dirigé par Vassa Kontouma-Conticello et C. G. Conticello, rassemble des articles substantiels consacrés à des personnalités majeures de la théologie byzantine et post-byzantine. Les contributions, en anglais, français, italien, allemand et espagnol sont les suivantes :1. Gregorio il Sinaita (par Antonio Rigo), 2. Gregory Palamas (par Robert E. Sinckewicz), 3. Gregorio Akíndinos (par Juan Nadal Cañellas), 4. Nicola Cabasilas Chamaetos (par Yannis Spiteris, C. G. Conticello), 5. Mark Eugenikos (par Nicholas Constas), 6. Georgios Gennadios Scholarios (par Franz Tinnefeld), 7. Jérémie II Tranos (par Christian Hannick, Klaus-Peter Todt), 8. Kyrillos Loukaris (par Klaus-Peter Todt), 9. Dositheos II. von Jerusalem (par Klaus-Peter Todt), 10. Eugène Boulgaris (par Daniel Stiernon), 11. Nicéphore Théotokès (par Vasilios Makrides, Vassa Conticello), 12. Nicodemo Agiorita (par Elia Citterio), 13. La Philocalie et L’ambition première de l’ouvrage est d’aborder le domaine théologique byzantin à travers ses forces vives, les théologiens, perçus comme des sujets porteurs d’une expérience spirituelle riche et vivante, dont la production compte parfois parmi les chefs-d’oeuvre de la littérature théologique universelle. Sa seconde ambition est de considérer ce domaine dans toute son extension, aussi bien chronologique que géographique, la coupure historique de 1453, date de la chute de Constantinople, ne marquant pas la fin de cet univers de pensée qui continue de vivre dans l’Orthodoxie moderne et contemporaine.Dans chaque chapitre, un soin particulier a été accordé à la prosopographie, à la constitution d’un répertoire complet des oeuvres de chaque théologien considéré — cette section constitue l’esquisse d’une Clavis Auctorum Byzantinorum, sur le modèle de la Clavis Patrum Graecorum de M. Geerard —, au repérage des manuscrits pour les oeuvres inédites, à l’exhaustivité et à la présentation critique des bibliographies en langues occidentales et orientales. Pour illustrer l’exposé sur la doctrine des auteurs présentés, partie centrale de chaque contribution, l’ouvrage rassemble également plusieurs textes, traduits pour la première fois ou édités critiquement
Nasal and lung function in competitive swimmers
No full textNasal and sinusal complaints are considered common among swimmers. Aim of the present study was to evaluate the nasal and bronchial functions, before and after swimming, and the relationship between nasal resistances and FEV1 in competitive swimmers. A group of 30 competitive swimmers were examined: spirometry and nasal respiratory tests were carried out before and after swimming. Moreover, both the competitive swimmers and the 150 visitors of a swimming pool were asked to complete a specific questionnaire. In this questionnaire, 18% of the population reported nasal-sinusal symptoms after swimming. The differences between nasal volumes and resistances before and after swimming were not statistically significant. Nasal patency increased or remained unchanged in 21/30 athletes. The variations in FEV1 were not statistically significant. In conclusion, results showed that swimming is able to increase nasal patency or to leave it unchanged. Temporary worsening of the nasal patency was observed in only a few hyper-reactive patients. In the whole group, no variations, at bronchial level, were found
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
No full textWe conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis
Nasal and lung function in competitive swimmers
No full textAIM
Nasal and sinusal complaints are considered common among swimmers. Aim of the present study was to evaluate the nasal and bronchial functions, before and after swimming, and the relationship between nasal resistances and FEV1 in competitive swimmers.
SUBJECTS AND METHODS
A group of 30 competitive swimmers were examined: spirometry and nasal respiratory tests were carried out before and after swimming. Moreover, both competitive swimmers and 150 visitors of a swimming pool were asked to complete a specific questionnaire.
RESULTS
In the questionnaire, 18% of the population reported nasal-sinusal symptoms after swimming. The differences between nasal volumes and resistances before and after swimming were not statistically significant. Nasal patency increased or remained unchanged in 21/30 athletes. The variations in FEV1 were not statistically significant.
CONCLUSIONS
Results showed that swimming is able to increase nasal patency or to leave it unchanged. Temporary worsening of the nasal patency was observed in only a few hyper-reactive patients. In the whole group, no variations, at bronchial level, were found
John C. Lamoreaux (trad.), Theodore Abū Qurrah
No full textConticello Vassa. John C. Lamoreaux (trad.), Theodore Abū Qurrah . In: Revue des études byzantines, tome 66, 2008. pp. 281-282
Minimal Residual Disease Assessment Within the Bone Marrow of Multiple Myeloma: A Review of Caveats, Clinical Significance and Future Perspectives
No full textThere is an increasing clinical interest in the measure and achievement of minimal residual disease (MRD) negativity in the bone marrow of Multiple Myeloma (MM) patients, as defined equally either by Multicolor Flow Cytometry (MFC) or by Next Generation Sequencing (NGS) technologies. At present, modern technologies allow to detect up to one on 104 or on 105 or even on 106 cells, depending on their throughput. MFC approaches, which have been progressively improved up to the so-called Next Generation Flow (NGF), and NGS, which proved clear advantages over ASO-PCR, can detect very low levels of residual disease in the BM. These methods are actually almost superimposable, in terms of MRD detection power, supporting the lack of unanimous preference for either technique on basis of local availability. However, some technical issues are still open: the optimal assay to use to detect either phenotype (e.g., next generation multidimensional flow cytometry, imaging) or genotype aberrations (e.g., ASO-RQ PCR, digital droplet PCR, NGS) and their standardization, the sample source (BM or peripheral blood, PB) and its pre-processing (red-cell lysis vs. Ficoll, fresh vs. frozen samples, requirement of CD138+ cells enrichment). Overall, MRD negativity is considered as the most powerful predictor of favorable long-term outcomes in MM and is likely to represent the major driver of treatment strategies in the near future. In this manuscript, we reviewed the main pitfalls and caveats of MRD detection within bone marrow in MM patients after front-line therapy, highlighting the improving of the currently employed technology and describing alternative methods for MRD testing in MM, such as liquid biopsy
Unraveling C-to-U RNA editing events from direct RNA sequencing
No full textIn mammals, RNA editing events involve the conversion of adenosine (A) in inosine (I) by ADAR enzymes or the hydrolytic deamination of cytosine (C) in uracil (U) by the APOBEC family of enzymes, mostly APOBEC1. RNA editing has a plethora of biological functions, and its deregulation has been associated with various human disorders. While the large-scale detection of A-to-I is quite straightforward using the Illumina RNAseq technology, the identification of C-to-U events is a non-trivial task. This difficulty arises from the rarity of such events in eukaryotic genomes and the challenge of distinguishing them from background noise. Direct RNA sequencing by Oxford Nanopore Technology (ONT) permits the direct detection of Us on sequenced RNA reads. Surprisingly, using ONT reads from wild-type (WT) and APOBEC1-knock-out (KO) murine cell lines as well as in vitro synthesized RNA without any modification, we identified a systematic error affecting the accuracy of the Cs call, thereby leading to incorrect identifications of C-to-U events. To overcome this issue in direct RNA reads, here we introduce a novel machine learning strategy based on the isolation Forest (iForest) algorithm in which C-to-U editing events are considered as sequencing anomalies. Using in vitro synthesized and human ONT reads, our model optimizes the signal-to-noise ratio improving the detection of C-to-U editing sites with high accuracy, over 90% in all samples tested. Our results suggest that iForest, known for its rapid implementation and minimal memory requirements, is a promising tool to denoise ONT reads and reliably identify RNA modifications
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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