1,721,106 research outputs found
Hable con él: Leopoldo Zea's last interview
No full textLeopoldo Zea, one of the most important and original thinkers in contemporary Latin-American thinking, analyzed through his very long and fruitful career, the problem of cultural identity, focusing in particular on the complex relationship that has arisen between Latin-American culture and Western culture. This article presents, after a brief analysis of the most characteristic aspects of Zea's thought, an interview, which I did with Zea in 2001. In this interview, probably the last that the Mexican philosopher was to give (Zea died in June 2004), some of the fundamental passages of his philosophy are re-examined and explored in greater depth
Induction of the mitochondrial permeability transition pore by N-Ethylmaleimide depends on secondary oxidation of critical thiols groups. Potentiation by copper-ortho-phenanthroline without dimerization of the adenine nucleotide translocator.
No full textAddition to energized rat liver mitochondria of low micromolar concentrations of the thiol oxidant, copper-ophenanthroline
Addition to energized rat liver mitochondria of low micromolar concentrations of the thiol oxidant, copper-o-phenanthroline [Cu(OP)2], causes opening of the permeability transition pore, a cyclosporin A-sensitive channel. The effects of Cu(OP)2 can be reversed by reduction with dithiothreitol (DTT), suggesting that a dithiol-disulfide interconversion is involved. However, at variance with all pore inducers known to act through dithiol oxidation, the effects of Cu(OP)2 are not prevented by treatment of mitochondria with low (10-20 microM) concentrations of N-ethylmaleimide (NEM). Rather, these concentrations of NEM potentiate the inducing effects of Cu(OP)2. We show that this enhancing effect of NEM is blocked by the subsequent addition of DTT, indicating that potentiation by NEM is mediated by an oxidative event rather than by substitution as such. We find that also pore induction by high (0.5-1.0 mM) concentrations of NEM in the absence of oxidants is completely blocked by reduction with DTT or beta-mercaptoethanol. These results underscore the unexpected importance of oxidative events in pore opening by substituting agents. Since we find that pore opening by Cu(OP)2 or by high concentrations of NEM is not accompanied by dimerization of the adenine nucleotide translocase, we conclude that the translocase itself is not the target of the pore-inducing oxidative events triggered by Cu(OP)2 and NEM
Gerbi, lo storicista
Full text linkAntonello Gerbi’s Americanistic studies are rooted in that historicist culture that has its most important reference in Benedetto Croce. However, starting from his most important book, La disputa del nuovo mondo. Storia di una polemica, 1750-1900, Gerbi will be increasingly influenced also by authors such as Humboldt and especially Meinecke. This article will concern this last aspect with the intention of representing the first step of a more complete work about the thought of Antonello Gerbi.Gli studi di americanistica di Antonello Gerbi sono profondamente radicati
in quella cultura storicistica che ha in Benedetto Croce il suo riferimento più
importante. Tuttavia, soprattutto nella sua opera più importante, La disputa del
nuovo mondo. Storia di una polemica, 1750-1900, Gerbi sarà sempre più influenzato
da autori come Humboldt e soprattutto Meinecke. Questo articolo sarà dedicato a
quest’ultimo aspetto e rappresenta il primo tassello di un lavoro più ampio e
articolato sul pensiero di Gerbi che vedrà la luce nei prossimi anni
Influence of granulosa cells and of different somatic cell types on mammalian oocyte development in vitro
No full textMechanisms of amino acid uptake in cumulus-enclosed mouse oocytes. Biology of Reproduction 28, 797-803 (1983).
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Role of antral follicle development and cumulus cells on in vitro fertilization of mouse oocytes
No full textThe phosphorylation of a 21 kda polypeptide is differentially regulated in mouse oocytes during antral follicle development
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