103 research outputs found
Algorithms for quadratic matrix and vector equations
No full textThis book is devoted to studying algorithms for the solution of a class of quadratic matrix and vector equations. These equations appear, in different forms, in several practical applications, especially in applied probability and control theory. The equations are first presented using a novel unifying approach; then, specific numerical methods are presented for the cases most relevant for applications, and new algorithms and theoretical results developed by the author are presented. The book focuses on “matrix multiplication-rich” iterations such as cyclic reduction and the structured doubling algorithm (SDA) and contains a variety of new research results which, as of today, are only available in articles or preprints
The case of gente Rutheni, natione Poloni in Galicia
No full textIn this article, the author seeks to answer the question, since when the term gente Rutheni, natione
Poloni was used in public space in Galicia. This is the starting point to search for the answer
to the question of when the Ruthenians of Polish nationality in Galicia produced the idea defi ning
their identity and worldview. The author tries to reveal when the Ruthenians of Polish nationality
made an unsuccessful attempt to carry out their political demands, and how they were perceived
in the Polish-Ruthenian society of Galicia. Eventually gente Rutheni, natione Poloni disappeared
in the historical process because they had not created an explicit ideology and had not developed
a compact elite representing the group of Ruthenians of Polish nationality in the public space.
Outstanding individuals from this group functioned within Galician society, but they were more of
a tool (the subject) of the Polish policy, rather than an entity
Degrees of irreducible morphisms in generalized standard coherent almost cyclic components
No full textWe study the degrees of irreducible morphisms between indecomposablemodules lying in generalized standard coherent almost cyclic componentsof Auslander-Reiten quivers of artin algebras.Fil: Chaio, Claudia Alicia. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Malicki, Piotr. Nicolaus Copernicus University. Faculty of Mathematics and Computer Science; Poloni
Degrees and composition of irreducible morphisms in coils
No full textWe characterize the finiteness of degrees of irreducible morphisms between indecomposable modules lying in coils of the Auslander–Reiten quivers of artin algebras. We mainly study non-zero compositions of irreducible morphisms between indecomposable modules lying in coils in relation to powers of the radical of their module category.Fil: Chaio, Claudia Alicia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Malicki, Piotr. Uniwersytet Mikołaja Kopernika; Poloni
The role of cocaine in heroin-related deaths. Hypothesis on the interaction between heroin and cocaine
No full textIn recent years, there has been an increase in cocaine-related deaths at the Department of Legal Medicine and Public Health of Pavia, probably reflecting the rising trend in cocaine use in Western Europe. Deaths from cocaine alone have increased from 6 cases in 1979-1991 (1.5% of drug-of-abuse deaths) to 13 in 1992-2002 (3.2%) and comparing the same periods, heroin-related deaths (HRDs) involving cocaine more than doubled from 8 (1.9%) to 22 (5.4%). In an attempt to investigate the role of cocaine in HRDs, acute narcotic death cases testing positive for cocaine use (blood cocaine or metabolite concentration >0.01 mg/l, COC+) were examined. Only cases from 1997 to 2001 were considered as in this period all data were obtained using the same analytical procedures (free morphine and total morphine by DPC Coat-A-Count radioimmunoassay before and after enzymatic hydrolysis, cocaine and metabolites in blood by SPE, TMS derivatization and gas chromatography-mass spectrometry (GC-MS)). The median, minimum and maximum concentrations of free morphine in blood (FM) and total morphine in blood (TM), urine (UM) and bile (BM) in the COC+ group (n = 9) were compared with those calculated in the group of "pure" HRDs (no other drugs detected in blood, COC-, n = 30). Differences among the medians in the two groups were statistically evaluated using the two-tailed Mann-Whitney U-Test. Statistical analysis was also carried out including in both groups cases with a blood alcohol concentration (BAC) > 20 mg/L (COC+, n = 19; COC-, n = 76). For the COC+ group, median TM was lower (0.32 mg/l versus 0.90 mg/l, P = 0.0214), median FM was lower, but not statistically significant (0.08 mg/l versus 0.28 mg/l, P = 0.1064), FM/TM ratio was similar (0.33 and 0.35), UM was also similar (21.0 mg/l and 18.0 mg/l), and BM was higher (90.0 mg/l versus 49.0 mg/l, P = 0.0268). Similar comparison results were obtained by repeating statistical analyses after including in the two groups cases with positive BAC. The picture observed for HRD cases involving cocaine is very different from what was previously observed for HRD cases involving ethanol [A. Polettini, A. Groppi, M. Montagna, The role of alcohol abuse in the etiology of heroin related deaths: evidence for pharmacokinetic interactions between heroin and alcohol, J. Anal. Toxicol. 23 (1999) 570-576], and updated with more recent data; in the high-ethanol (HE, BAC > 1000 mg/l) group, TM was lower than in the low-ethanol (LE, BAC <= 1000 mg/l) group (0.59 mg/l versus 0.90 mg/l, P = 0.0180), FM/TM ratio was higher (0.66 versus 0.43, P = 0.0038), FM was equal, UM was lower (0.21 mg/l versus 13.0 mg/l, P = 0.0001), as was BM (10.0 mg/l versus 26.5 mg/l, P = 0.0156). The observed lower TM in the COC+ group supports the hypothesis of an interaction of cocaine with heroin in the cause of death, as previously observed for the heroin-ethanol interaction. However, ethanol results suggested that a pharmacokinetic interaction is prevalent (inhibition of heroin metabolism, as suggested by the increased FM/TM ratio, resulting in reduced urinary and biliary excretion). In the case of cocaine, a pharmacodynamic interaction seems to prevail, as the FM/TM ratio remains unchanged and UM and BM are not lower in the COC+ group. The hypothesis of a pharmacodynamic interaction of cocaine with heroin could not be confirmed owing to the paucity of data and the many uncontrolled variables involved
Mowa miana w Senacie polskim: nieznane staropolskie tłumaczenie Equitis Poloni in Jesuitas actio prima – wprowadzenie, tekst i komentarze
No full textThe text is a critical edition of a previously unknown early modern Polish translation of Equitis Poloni in Jesuitas actio prima (1590), one of the most controversial polemical texts in the history of the Polish Reformation. The translation is published in the transcribed form, based on a recently discovered manuscript in The Princes Czartoryski Library, and accompanied by a commentary that elucidates the text’s historical and literary context. This edition aims to make this significant artefact of Polish political and religious culture accessible as well as to contribute to further interpretive and attributional studies of Actio prima. This is particularly important considering the Polish manuscript’s identification of the text’s author, previously overlooked in scholarship – Jan Drohojewski, Castellan of Sanok.Artykuł zawiera edycję krytyczną dotychczas nieznanego staropolskiego przekładu Equitis Poloni in Jesuitas actio prima (1590), jednego z najbardziej kontrowersyjnych tekstów polemicznych w dziejach polskiej reformacji. Transkrypcja tego tłumaczenia została przygotowana na podstawie odnalezionego w Bibliotece Książąt Czartoryskich rękopisu oraz opatrzona komentarzem, objaśniającym kontekst historyczny i literacki dzieła. Wydanie ma na celu udostępnienie tego ważnego dla polskiej kultury politycznej i religijnej zabytku oraz zachęcenie do dalszych interpretacyjnych i atrybucyjnych studiów nad Actio prima, zwłaszcza wobec identyfikacji przez polski rękopis autora dotychczas w badaniach nieuwzględnianego, czyli kasztelana sanockiego Jana Drohojewskiego
Comparative Study of Photoswitchable Zinc-Finger Domain and AT-Hook Motif for Light-Controlled Peptide-DNA Binding
No full textDNA-peptide interactions are involved in key life processes, including DNA recognition, replication, transcription, repair, organization, and modification. Development of tools that can influence DNA-peptide binding non-invasively with high spatiotemporal precision could aid in determining its role in cells and tissues. Here, the design, synthesis, and study of photocontrolled tools for sequence-specific small peptide-DNA major and minor groove interactions are reported, shedding light on DNA binding by transcriptionally active peptides. In particular, photoswitchable moieties were implemented in the peptide backbone or turn region. In each case, DNA binding was affected by photochemical isomerization, as determined in fluorescent displacement assays on model DNA strands, which provides promising tools for DNA modulation
Application of a Multi Objective Genetic Algorithm and a Neural Network to the Optimisation of Foundry Processes
No full textSintesi, caratterizzazione e studi conformazionali della tilopeptina B, Un peptide naturale attivo sulle membrane biologiche
No full textopenTESI 362
- …
