279,890 research outputs found
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
CHO microRNA engineering is growing up : recent successes and future challenges
No full textmicroRNAs with their ability to regulate complex pathways that control cellular behavior and phenotype have been proposed as potential targets for cell engineering in the context of optimization of biopharmaceutical production cell lines, specifically of Chinese Hamster Ovary cells. However, until recently, research was limited by a lack of genomic sequence information on this industrially important cell line. With the publication of the genomic sequence and other relevant data sets for CHO cells since 2011, the doors have been opened for an improved understanding of CHO cell physiology and for the development of the necessary tools for novel engineering strategies. In the present review we discuss both knowledge on the regulatory mechanisms of microRNAs obtained from other biological models and proof of concepts already performed on CHO cells, thus providing an outlook of potential applications of microRNA engineering in production cell lines
Measurement of J/Ψ production in pp collisions at √s=7 TeV
No full textThe production of J/psi mesons in proton-proton collisions at root s = 7 TeV is studied with the LHCb detector at the LHC. The differential cross-section for prompt J/psi production is measured as a function of the J/psi transverse momentum p(T) and rapidity y in the fiducial region p(T) is an element of [0; 14] GeV/c and y is an element of [2.0; 4.5]. The differential cross-section and fraction of J/psi from b-hadron decays are also measured in the same p(T) and y ranges. The analysis is based on a data sample corresponding to an integrated luminosity of 5.2 pb(-1). The measured cross-sections integrated over the fiducial region are 10.52 +/- 0.04 +/- 1.40(-2.20)(+1.64) mu b for prompt J/psi production and 1.14 +/- 0.01 +/- 0.16 mu b for J/psi from b-hadron decays, where the first uncertainty is statistical and the second systematic. The prompt J/psi production cross-section is obtained assuming no J/psi polarisation and the third error indicates the acceptance uncertainty due to this assumption
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
sj-docx-2-cho-10.1177_18632521241229954 – Supplemental material for Optimizing calibration of modern skeletal maturity systems
No full textSupplemental material, sj-docx-2-cho-10.1177_18632521241229954 for Optimizing calibration of modern skeletal maturity systems by Ryan J Furdock, Andrew J Moyal, Alexander Benedick, Feng-Chang Lin, Yajing Hao, Daniel R Cooperman, James O Sanders and Raymond W Liu in Journal of Children’s Orthopaedics</p
TG, T-cho, H-cho, and cortisol levels in the serum.
No full text<p>CMS group, chronic mild stress group; C group, control group; TG, triglyceride; T-cho, total cholesterol; H-cho, HDL-cholesterol; SD, standard deviation.</p><p>TG, T-cho, H-cho, and cortisol levels in the serum.</p
sj-docx-1-cho-10.1177_18632521241232301 – Supplemental material for Outcomes of treatment of patella fractures in children and adolescents
No full textSupplemental material, sj-docx-1-cho-10.1177_18632521241232301 for Outcomes of treatment of patella fractures in children and adolescents by Evan W. Beatty, Mathilde Hupin, Dennis E. Kramer, Benjamin J. Shore and Benton E. Heyworth in Journal of Children’s Orthopaedics</p
1H NMR Spectroscopy Profiling of Metabolic Reprogramming of Chinese Hamster Ovary Cells upon a Temperature Shift during Culture
No full textWe report an NMR based approach to determine the metabolic reprogramming of Chinese hamster ovary cells upon
a temperature shift during culture by investigating the extracellular cell culture media and intracellular metabolome of
CHOK1 and CHO-S cells during culture and in response to cold-shock and subsequent recovery from hypothermic
culturing. A total of 24 components were identified for CHOK1 and 29 components identified for CHO-S cell systems
including the observation that CHO-S media contains 5.6 times the level of glucose of CHOK1 media at time zero.
We confirm that an NMR metabolic approach provides quantitative analysis of components such as glucose and
alanine with both cell lines responding in a similar manner and comparable to previously reported data. However,
analysis of lactate confirms a differentiation between CHOK1 and CHO-S and that reprogramming of metabolism in
response to temperature was cell line specific. The significance of our results is presented using principal component
analysis (PCA) that confirms changes in metabolite profile in response to temperature and recovery. Ultimately, our
approach demonstrates the capability of NMR providing real-time analysis to detect reprogramming of metabolism
upon cellular perception of cold-shock/sub-physiological temperatures. This has the potential to allow manipulation of
metabolites in culture supernatant to improve growth or productivity
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
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