328,243 research outputs found
Pharmacological characterization of [I-125]CHIBA-1006 binding, a new radioligand for alpha 7 nicotinic acetylcholine receptors, to rat brain membranes
No full textThe alpha 7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease. However, there are currently no suitable small molecule radioligands for imaging alpha 7 nAChRs in the brain. In this study, we synthesized the novel radioligand [I-125]4-iodophenyl 1,4-diazaicyclo[3.2.2]nonane-4-carboxylate ([I-125]CHIBA-1006), a iodine-derivative of the selective alpha 7 nAChR agonist SSR180711, and studied the characterization of [I-125]CHIBA-1006 binding to rat brain membranes. The assays of [I-125]CHIBA-1006 binding to rat brain membranes were performed at 4 degrees C. The presence of a single saturable high-affinity binding component for [I-125] CHIBA-1006 in the rat brain was shown. Scatchard analysis revealed an apparent equilibrium dissociation constant (K-d) of 88.2 +/- 21.4 nM and a maximal number of binding sites (B-max) of 65.4 +/- 6.8 fmol/mg protein (mean +/- SEM, n=4). The specific binding of [I-125]CHIBA-1006 was inhibited by a number of alpha 7 nAChR-selective ligands (e.g., unlabeled CHIBA-1006, SSR180711, CHIBA-1001, MG624 and A844606), suggesting a similarity among 7 nAChR pharmacological profiles. In contrast, alpha-bungarotoxin, MLA, and nicotine showed very weak affinity for [I-125]CHIBA-1006 binding. The regional distribution of [I-125]CHIBA-1006 binding to crude membranes from dissected regions of the rat brain was different from that of [I-125] alpha-bungarotoxin binding, suggesting that [I-125]CHIBA-1006 binding sites may not be identical to [I-125]alpha-bungarotoxin binding sites in the rat brain. The present findings suggest that [I-125]CHIBA-1006 would be a useful new small molecule radioligand for alpha 7 nAChRs in the brain. (C) 2010 Elsevier B.V. All rights reserved.NeurosciencesSCI(E)2ARTICLE130-137136
Natural Inductive Theorems for Higher-Order Rewriting
No full textThe notion of inductive theorems is well-established in first-order term rewriting. In higher-order term rewriting, in contrast, it is not straightforward to extend this notion because of extensionality (Meinke, 1992). When extending the term rewriting based program transformation of Chiba et al. (2005) to higher-order term rewriting, we need extensibility, a property stating that inductive theorems are preserved by adding new functions via macros. In this paper, we propose and study a new notion of inductive theorems for higher-order rewriting, natural inductive theorems. This allows to incorporate properties such as extensionality and extensibility, based on simply typed S-expression rewriting (Yamada, 2001)
Jade, amber, obsidian and serpentinite: the social context of exotic stone exchange networks in central Japan during the late middle Jômon period
No full textThis dissertation presents a holistic, contextual approach to long-distance exchange networks in Central Japan ca. 4000BP, by focussing on the conditions behind consumption, circulation and production of exotic materials-particularly jadeite and amber, derived from unique and spatially limited source areas: the Japan Sea Coast and the Pacific Coast, respectively. Analysis is based on a sample of 175 sites located in Nagano, Yamanashi, Tokyo, Kanagawa and Chiba prefectures. Analysis of consumption patterns shows that (compared to other artefact categories) stone ornaments, particularly jadeite and amber pendants, are far more frequently associated with 'intentional deposition', namely mortuary contexts. This indicates that a different value was ascribed to jadeite and amber pendants. However, other evidence of social differentiation during the Middle Jômon is absent. Statistical analysis of wider distribution patterns, focusing on the variability of site characteristics, supports the hypothesis that the presence of jadeite and/or amber pendants is strongly associated with 'core' settlements sites characterised by large house numbers, continuous habitation throughout the Middle Jômon period, and evidence of ritual practices. Contrary to some hypotheses, evidence for related distribution between jadeite pendants and serpentinite adzes (from the same production sites) was lacking, whereas association with relatively high quantities of obsidian (used for arrowheads) proved to be strong. It is suggested that exploitation and export of nearby high-quality obsidian resources contributed to the prosperity and longevity of Japan Alps settlements. In the greater Tokyo Plains area, settlements stable and influential enough to participate in the exchange networks are located at major rivers or coastal areas. Preliminary assessment of the conditions at production sites suggests different motives for part-time ornament production. It is hypothesised that inhabitants of the Japan Sea area-a hostile and isolated environment-may have engaged in fairly regular production and export of jadeite pendants and serpentinite ground adzes, in order to maintain interregional relations, possibly as a socio-economic safety net. Perhaps-in the absence of obvious environmental or subsistence constraints-Pacific Coast inhabitants produced amber pendants occasionally, exchanging them as hunting amulets between specialist hunters. However, further research involving subsistence patterns is essential for a deeper understanding of long-distance exchange network membership. Finally, it is suggested that instead of being individually-owned valuables, jadeite pendants (as 'esoteric', inalienable items) circulated among certain settlements in an interregional exchange network, regulating relationships and creating a social context for different types of exchange. Perhaps mortuary contexts indicate exchange relations with 'the other world'
The 1930' s beginning peasant movement of Chiba Pref.
No full textThe universal suffrage of Japan was carried out in 1928 for the first time. Peasants have expected universal suffrage and supported the proletarian party. Furthermore they fought well in the universal suffrage. The peasant union was disuniting in that time. However, the peasant union unified it after the universal suffrage. And they orgnized the National Peasant Union. The National Peasant Union received a big suppression by the April 16 Incident. The biggest subject of the National Peasant Union was the relation with the proletarian party. This paper examines the 1930's beginning peasant movement of Chiba Pref.KJ00007850891departmental bulletin pape
Cultural Heritage Digitisation Through European Funding
No full textMagistrska naloga je pregled kratke zgodovine kulturne dediščine, od prvih pobud ohranjanja, ustanavljanja muzejev, do različnih politik, ki so bile predlagane na ravni Evropske unije in pobud ter možnosti sofinanciranja, z namenom ohranjanja in varovanja, ki jih je EU vzpostavila za in v sodelovanju z državami članicami.
Kultuna dediščina se sooča z grožnjami kot so podnebne spremembe, vojne in ne nazadnje tudi masovni turizem, kar je rezultirano v težnji po ponovni opredelitvi politik kulturne dediščine, z namenom njenega ohranjanja, razširjanja in približanja ljudem, da bi vsi začutili odgovornost do skupne zgodovine.
Na podlagi tega in tudi čedalje hitrejšega vstopa sveta v digitalno dobo so se začele razvijati politike digitalizacije kulturne dediščine in vzpostavitve skupnih podatkovnih prostorov, kjer bo digitalizirana dediščina na voljo za spoznavanje, raziskovanje in izobraževanje vsem, hkrati pa se je začel z vpeljavo digitalnega razvijati povsem nov odnos med ustanovami kulturne dediščine in obiskovalci.
Evropska unija je prepoznala kulturno dediščino kot pomemben del skupne zgodovine in kot pomemben sektor povezovanja, kar pomeni, da mu je v zadnjih petnajstih letih z usmerjenim financiranjem pomagala do preporoda in ponovne oživitve.
Magistrska naloga raziskuje dobre primere projektov in implementacije različnih novih tehnologij, hkrati pa ob koncu ponudi tudi določene smernice sofinanciranja podobnih projektov v novem finančnem obdobju 2021-2027 ter med programi sofinanciranja in politikami potegne vzporednice, ki so lahko v pomoč novim prijaviteljem.This Master\u27s thesis is a short overview of the history of cultural heritage, from the first conservation initiatives, the establishment of museums, to the various policies proposed at European Union level in regards to co-financing possibilities for conservation and protection of cultural heritage established by the EU for and in cooperation with Member States.
Cultural heritage faces threats such as climate change, wars and, last but not least, mass tourism, resulting in a desire to redefine cultural heritage policies in order to preserve, disseminate and bring them closer to the people so that everyone can feel responsibility for common history.
Based on this, as well as the increasingly rapid entry of the world into the digital age, policies have begun to develop about the digitization of cultural heritage and the establishment of common data spaces where digitized heritage will be available for learning, research and education for all. With the introduction of digital, a completely new relationship began to develop between cultural heritage institutions and their visitors.
The European Union has recognized cultural heritage as an important part of its common history and as an important sector of integration, which means that it has helped it to revive and revitalize itself over the last fifteen years through targeted funding.
The Master\u27s thesis explores good examples of projects and implementations of various new technologies, while also providing certain guidelines for co-financing similar projects in the new financial period 2021-2027. In its final chapter, the thesis draws parallels between co-financing programmes and newly established policies that could help new applicants
Ford Motor Co. Shipment Arrives via Ship Named Chiba, S
No full textA shipment of Ford Motor Co. vehicles arrives via a ship named Chiba in Tampa, Florida.https://digitalcommons.usf.edu/gandy_commercial/9568/thumbnail.jp
SI:IME-13 Chiba : 13th International Meeting on Electrochromism, August 27-31, 2018, Chiba, Japan
No full textElectrochromic materials are able to change their optical properties reversibly upon the application of a DC voltage or current. The field of electrochromics spans a large and diverse class of materials including metal oxides, metal hexacyanometallates, metal hydrides, metal deposit, organic molecules such as viologens, conjugated polymers, transition-metal complexes and polymers, just to name a few. The systematic study on these materials was motivated by the research conducted by Dr. S. K. Deb, who published two seminal papers on tungsten oxide films in 1969 and 1973 [1,2]. Apart from the astonishing success of the 250 million Gentex automatic-dimming mirrors that have been sold since 1987 and the recent dimmable cabin windows of the Boeing 787 Dream-liner and some business aircrafts, commercial electrochromic applications have been limited [3,4]. This means that there is a substantial need for better understanding electrochromism from the scientific point of view. In fact, this was realized by Prof. B. Scrosati, who organized the First International Meeting on Electrochromism (IME-1) in Murano, Venice, Italy in 1994. Since then, IME has been held every two years around the globe, IME-2 (1996 in San Diego, CA, USA), IME-3 (1998 in London, UK), IME-4 (2000 in Uppsala, Sweden), IME-5 (2002 in Golden, CO, USA), IME-6 (2004 in Brno, Czech Republic), IME-7 (2006 in Istanbul, Turkey), IME-8 (2008 in Seoul, Korea), IME-9 (2010 in Bordeaux, France), IME-10 (2012 in Holland, MI, USA), IME-11 (2014 in Taipei, Taiwan), IME-12 (2016 in Delft, Netherlands) and IME-13 (2018 in Chiba, Japan).The proceedings of previous IME can be found in literature [[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]]. The meeting in Chiba can also be viewed as continuation of the biennial historical symposia dedicated solely to this topic. The technical program of IME-13 includes 11 invited lectures, 35 oral and 65 poster presentations. This meeting not only provided us the opportunity to re-assess the future potential on the advanced electrochromic materials and devices but also opened the window for all participants to seek for research partners and to exchange friendship. There were 151 attendees from 18 countries, covering both academic circle and industrial sectors. The participants ranged from the pioneer of electrochromics to young students. New participants were attracted from the neighbouring fields of thermochromism, photochromism and gasochromism. The meeting organizers would like to acknowledge the participants, members of the international advisory board, members of the local organizing committee, and our student volunteers, without whom the success of this meeting would have been impossible. We would also like to extend special thanks to all the sponsors for their generous donations. We feel very fortunate to receive financial support from Gentex Corporation, Chromogenic Research Group of Electrochemical Society Japan, Chiba Convention Bureau, Tokuyama Science Foundation, Hokuto Denko Corporation, KAKENHI on Innovative Areas “Soft Crystals” and Chiba University. The present volume of Solar Energy Materials and Solar Cells contains only some of the contributions presented at IME-13. All manuscripts were subjected to the standard peer-reviewing procedure involving at least two referees. The guest editors would like to thank all the reviewers and the scientific committee for their professional help as well as the contributors for submitting their manuscripts. The next meeting, IME-14, will be held in Atlanta, USA (http://ime-14.chemistry.gatech.edu/). It is expected that this important and fascinating topic will have taken a large step forward
Growth-promoting factors for yeast cells of Paracoccidioides brasiliensis
No full textLow-density seedings of yeast cells of Paracoccidioides brasiliensis give poor growth (as assessed by plating efficiency test) on conventional mycological agar media, and therefore growth-promoting factors for this fungus were sought. Water-extracts of yeast cells of six P. brasiliensis isolates were all considerably effective in promoting the growth of low-density seedings of P. brasiliensis isolates Pb-18 and Hachisuga, but had little effect on isolate Bt-4. Horse serum, at a concentration range of 2-4%, moderately or considerably promoted the growth of these P. brasiliensis isolates. Combinations of the fungus cell extracts with horse serum were highly effective in promoting the growth of all of the fungal isolates. The fungus cell extracts showed siderophore (microbial iron carrier) activity. An iron-chelator, ethylenediaminetetraacetic acid, at a concentration of 100 μM also highly promoted the growth of the fungal isolates in the presence of horse serum, and ferric ion added to culture medium was considerably effective in the growth promotion. These results suggest that deficient utilization of external iron by the fungus cell is one of the growth-limiting processes for low-density seedings of yeast cells of P. brasiliensis on conventional mycological agar media.Res. Ctr. Pathogenic Fungi/M.T. Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-shi, Chiba 260Institute of Biosciences Univ. of the State of S. Paulo, 18618-000 Botucatu, Sao PauloBotucatú Medical School Univ. of the State of S. Paulo, 18618-000 Botucatu, Sao Paul
Sharp Recanalization of the Hepatic Vein Using a Chiba Needle in Budd–Chiari Syndrome
No full textHepatic vein recanalization in Budd–Chiari syndrome may require procedural modification if the endovascular approach fails. Sharp recanalization using the stiff end of a guidewire or a thin Chiba needle remains an effective technique in difficult-to-cross hepatic vein stricture. Of note, this technique requires utmost precaution to avoid catastrophic hemorrhage. The present case describes the successful recanalization of the middle hepatic vein using a 21-gauge Chiba needle through the percutaneous transhepatic route
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
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