479 research outputs found
Deux chansons de Mme Mathilde Chevallier-Potier
No full textChevallier-Potier Mathilde. Deux chansons de Mme Mathilde Chevallier-Potier. In: La Révolution de 1848. Bulletin de la Société d'histoire de la Révolution de 1848, Tome 5, Numéro 25, Mars-avril 1908. pp. 431-432
Deux chansons de Mme Mathilde Chevallier-Potier
No full textChevallier-Potier Mathilde. Deux chansons de Mme Mathilde Chevallier-Potier. In: La Révolution de 1848. Bulletin de la Société d'histoire de la Révolution de 1848, Tome 5, Numéro 25, Mars-avril 1908. pp. 431-432
Author's gift inscription, in The heather on fire; a tale of the Highland clearances
No full textThis edition includes an author's gift inscription, "To Mrs John Dillon with sincere esteem Mathilde Blind".Blind, Mathilde, 1841-189
Gender and pedagogics - Mathilde Vaerting, professor of educational science (Jena, 1923-1933)
No full textDer Aufsatz skizziert Leben und Karriere von Mathilde Vaerting (1884-1977), der ersten Professorin für Erziehungswissenschaft in Deutschland, Jena 1923-1933. Ihr Hauptwerk „Neubegründung der Psychologie von Mann und Weib", 1921ff., wird unter Aspekten der Forschungslogik analysiert und auf Konsequenzen für die Erziehungswissenschaft befragt. Ihre Forderung nach Gleichberechtigung und Abwehr jeglicher Herrschaft werden vor dem Hintergrund heutiger feministischer Forderungen diskutiert. Im Anschluß an die Betrachtung der zeitgenössischen Rezeption Mathilde Vaertings wird die Frage aufgeworfen, inwieweit ihr Leben und ihre Karriere die Stellung der Frau in der Wissenschaft während der zwanziger Jahre (und auch später?) spiegeln. (DIPF/Orig.)The author outlines the biography and career of Mathilde Vaerting (1884-1977), the first woman to hold a chair in educational science in Germany. Her major work - Neubegründung der Psychologie von Mannund Weib (1921 fol.) - is analyzed from a methodological point of view and with respect to its implications for educational research. Vaerting\u27s demands for equal rights for women and her rejection of any kind of domination are discussed within the framework of present feminist positions. After having studied how contemporaries reacted to Mathilde Vaerting\u27s writings, the author raises the question of whether Vaerting\u27s life and career reflect the Status of women in science during the 1920s (and later on?). (DIPF/Orig.
Effi Briest, Mathilde Möhring. The Development of Theodor Fontane's Female Characters on the Background of Women Emancipation.
No full textTheodore Fontane is best known as the author of numerous women's novels, which he wrote in the last ten years of his life. This diploma thesis deals with the topic of women's emancipation on the basis of textual analysis of two latter novels by Theodore Fontane - Effi Briest and Mathilde Möhring. In the first part, it characterizes the topic of the period women's emancipation and puts the author's biography into context. In the second part, it creates the picture of position of the main women characters. The last part describes the personal development of the women characters, on the basis of which I determine how much the women's emancipation reflects in the author's work and what is his attitude towards it. This thesis deals with the interpretation of the author's intent to illustrate the creation of an advanced character like Mathilde Möhring. Key words: Theodore Fontane, women's emancipation, Effi Briest, Mathilde Möhring, development of women's characters, women's novels, interpretation, author's intent, counterpoin
Correction to: Idelalisib treatment prior to allogeneic stem cell transplantation for patients with chronic lymphocytic leukemia: a report from the EBMT chronic malignancies working party (Bone Marrow Transplantation, (2021), 56, 3, (605-613), 10.1038/s41409-020-01069-w)
No full textThe Idelalisib treatment prior to allogeneic stem cell transplantation for patients with chronic lymphocytic leukemia: a report from the EBMT chronic malignancies working party, written by Johannes Schetelig, Patrice Chevallier, Michel van Gelder, Jennifer Hoek, Olivier Hermine, Ronjon Chakraverty, Paul Browne, Noel Milpied, Michele Malagola, Gerard Socié, Julio Delgado, Eric Deconinck, Ghandi Damaj, Sebastian Maury, Dietrich Beelen, Stéphanie Nguyen Quoc, Paneesha Shankara, Arne Brecht, Jiri Mayer, Mathilde Hunault-Berger, Jörg Bittenbring, Catherine Thieblemont, Stéphane Lepretre, Henning Baldauf, Liesbeth C. de Wreede, Olivier Tournilhac, Ibrahim Yakoub-Agha, Nicolaus Kröger, Peter Dreger was originally published Online First without Open Access. After publication in volume 56, issue 3, page 605–613 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2020 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0. Open access funding enabled and organized by Projekt DEAL
Effi Briest, Mathilde Möhring. Vývoj postavy žen na pozadí dobové emancipace ve stejnojmenných románech Theodora Fontana.
No full textTheodore Fontane is best known as the author of numerous women's novels, which he wrote in the last ten years of his life. This diploma thesis deals with the topic of women's emancipation on the basis of textual analysis of two latter novels by Theodore Fontane - Effi Briest and Mathilde Möhring. In the first part, it characterizes the topic of the period women's emancipation and puts the author's biography into context. In the second part, it creates the picture of position of the main women characters. The last part describes the personal development of the women characters, on the basis of which I determine how much the women's emancipation reflects in the author's work and what is his attitude towards it. This thesis deals with the interpretation of the author's intent to illustrate the creation of an advanced character like Mathilde Möhring. Key words: Theodore Fontane, women's emancipation, Effi Briest, Mathilde Möhring, development of women's characters, women's novels, interpretation, author's intent, counterpointTheodor Fontane je známý především jako autor četných ženských románů, které psal ve svém pokročilém věku. Tato práce zpracovává na základě analýzy textu téma ženské emancipace v jeho dvou pozdějších románech - Manželství Effi Briestové a Mathilda Möhringová. V první části charakterizuje téma dobové ženské emancipace a zasazuje autorovu biografii do kontextu. V druhé části utváří obraz pozice hlavních románových hrdinek. V poslední části je shrnut osobní vývoj ženských postav, na jejímž základě má být zodpovězena otázka, nakolik se ženská emancipace odráží v autorově díle a jaký je jeho postoj k ní. Práce se zároveň zabývá intepretací autorova záměru, který vytvořil postavu pokročilé Mathildy Möhringové, čímž dosáhl kontrapunktu k tomu, co doposud psal. Klíčová slova: Theodor Fontane, ženská emancipace, Effi Briest, Mathilde Möhring, vývoj ženských postav, interpretace, ženské romány, záměr autora, kontrapunktInstitute of Germanic StudiesÚstav germánských studiíFilozofická fakultaFaculty of Art
Evaluating the role of glucose and its potential therapeutic use in intervertebral disc degeneration
No full textLe mal de dos, première cause d'années vécues avec invalidité, représente un problème de santé publique majeur, qui touche au moins une fois dans leur vie environ 80% de la population mondiale. Bien que multifactoriel, l'une des causes principales du mal de dos est la dégénérescence du disque intervertébral (DIV). Le DIV est composé de trois éléments: (i) le noyau pulpeux, le centre gélatineux, riche en eau, du disque (ii) l'anneau fibreux, une bande fibreuse et élastique entourant le noyau pulpeux, et (iii) les plateaux cartilagineux situés à l'interface avec les corps vertébraux. Les DIV ont pour fonction d'assurer la mobilité et la stabilité de la colonne vertébrale et sont la plus grande structure avasculaire du corps humain. De ce fait, l'apport en nutriments et l'évacuation des déchets métaboliques ne se font que par diffusion à travers les plateaux cartilagineux essentiellement, ce qui résulte en de faibles concentrations en oxygène et en glucose et en un faible pH au centre du DIV. La dégénérescence discale débute dans le noyau pulpeux et se caractérise par une perte cellulaire, un changement phénotypique des cellules survivantes, une dégradation de la matrice extracellulaire, et une libération de médiateurs de l'inflammation. Bien que l'étiologie de la dégénérescence discale reste actuellement incertaine, l'une des causes suspectée de jouer un grand rôle et étudiée ici est une carence en nutriments. L'apport nutritif déjà modeste du disque, en effet, est perturbé lors de la dégénérescence discale, avec une diminution de l'afflux sanguin à la périphérie du DIV et l'occlusion des plateaux cartilagineux. Ainsi, la carence en nutriments pourrait jouer un rôle central dans la survie et la fonctionnalité des cellules du noyau pulpeux, essentielles pour le maintien de l'hydratation de la matrice extracellulaire et des fonctions du DIV qui y sont liées. Si la carence en oxygène n'a montré que peu ou pas d'effet, les études réalisées sur la carence en glucose, principalement faites sur cellules de noyau pulpeux isolées, relatent des effets contradictoires. Ces études, cependant, ne conservent pas la matrice extracellulaire reconnue comme modulant la survie, la prolifération et la fonctionnalité cellulaires. Dans le but d'étudier l'effet d'une carence en glucose dans un environnement physiologiquement pertinent, le premier objectif de ce travail est donc la mise en place d'un modèle 3D d'explant de noyau pulpeux bovin cultivé dans des conditions représentatives de l'environnement discal. La deuxième (et principale) partie de ce travail vise à caractériser le rôle d'une carence en glucose dans l'homéostasie du noyau pulpeux. En utilisant le modèle d'explant préalablement développé, j'ai ainsi montré qu'une concentration de glucose telle que retrouvée lors de la dégénérescence discale conduit à une diminution importante de la viabilité et à une altération phénotypique des cellules du noyau pulpeux, bien qu'elle n'affecte pas la sénescence, le catabolisme matriciel ou l'inflammation, autres traits typiques de la dégénérescence discale. Cette étude montre donc l'implication majeure de la carence en glucose dans l'homéostasie du noyau pulpeux mais suggère également que d'autres facteurs micro-environnementaux peuvent être en jeu lors de la dégénérescence discale. Basée sur ces résultats, la dernière partie de ce travail a pour objectif le développement d'un hydrogel capable de délivrer du glucose dans le but de restaurer la concentration de glucose à un niveau sain et ainsi promouvoir la survie et la fonctionnalité des cellules du noyau pulpeux dans un environnement discal dégénéré. Dans l'ensemble, ces travaux contribuent à une meilleure compréhension des acteurs en jeu lors de la dégénérescence discale. Ils suggèrent également que la supplémentation en glucose, utilisée seule ou en association avec d'autres thérapies régénératives, pourrait aider à la réparation du DIV.Back pain, leading cause of years lived with disability, represents a major public health problem, affecting approximately 80% of the worldwide populationat least once in their lifetime. Although multifactorial, one of the main causes of back pain is the intervertebral disc (IVD) degeneration. The IVD is composed of three components: the nucleus pulposus, the gelatinous, water-rich core of the disc, surrounded by the annulus fibrosus, a fibrous and elastic ring, both sandwiched by the cartilaginous endplates present on the vertebrae. The IVDs ensure the mobility and stability of the spine and are the largest avascular structure in the human body. As a result, nutrient supply and metabolic waste removal are solely relying on diffusion through the cartilaginous endplates, resulting in low oxygen and glucose concentrations and a low pH in the nucleus pulposus. Disc degeneration starts in the nucleus pulposus and is characterized by cell loss, change in surviving cell phenotype, extracellular matrix degradation, and release of inflammatory mediators. Although the etiology of disc degeneration still remains unclear, one of the causes suspected to play a major role and studied here is nutrient depletion. The already modest nutrient supply of the disc is, indeed, disrupted during disc degeneration, with a decrease in blood flow at IVD periphery and occlusion of the cartilaginous endplates. Thus, nutrient depletion may play a crucial part in nucleus pulposus cell survival and functionality, which are essential for maintaining extracellular matrix hydration and related IVD functions. While oxygen depletiononly exhibited little or no effect, studies on glucose depletion, mostly done on nucleus pulposus cells isolated from their environment, revealed contradictory effects. Those studies, however, did not preserve the extracellular matrix, known to modulate cell survival, proliferation and functionality. In order to study the effect of glucose depletion in a physiologically relevant environment, the first objective of this work is therefore the establishment of a 3D model of bovine nucleus pulposus explant cultured under conditions representative of the disc environment. The second (and main) part of this work aims at characterizing the impact of glucose depletionon the nucleus pulposus homeostasis. Using the explant model previously developed, I have shown that a glucose concentration such as found during disc degeneration leads to a significant decrease in the viability and to a phenotypic alteration of the nucleus pulposus cells, although it does not affect senescence, matrix catabolism or inflammation, other typical features of disc degeneration. This study showed the major implication of glucose depletion in nucleus pulposus homeostasis but also suggested that other micro-environmental factor(s) may be at play during disc degeneration. Based on these results, the last part of this work aims at developing a hydrogel capable of delivering glucose in order to restore glucose concentration to a healthy level and thus promote the survival and functionality of nucleus pulposus cells in a degenerated disc environment. Overall, this work contributes to a better understanding of the players involved in disc degeneration. It also suggests that glucose supplementation, used alone or in combination with other regenerative therapies, may help repair IVD
Tunisian Politics in France: Long-Distance Activism since the 1980s
No full textInternational audienceWhat does it mean to oppose or support an authoritarian regime from afar? During the years of Ben Ali's dictatorship in Tunisia between 1987 and 2011, diaspora activism played a key role in the developments of post-independence Tunisian politics. Centring this study on long-distance activism in France, where the majority of leftist and Islamist exile groups took refuge, Mathilde Zederman explores how this activism helps to shed new light on Tunisia's political history. Tunisian Politics in France closely explores the interactions and conflicts between different constellations of pro-regime and oppositional actors in France, examining the dynamics of what the author persuasively describes as a 'trans-state space of mobilisation'. In doing so, Zederman draws attention to the constraints and possibilities of long-distance activism. Utilising material gathered from extensive fieldwork in France and Tunisia, this study considers how the evolution of diaspora activism both challenges and reinforces the boundaries of Tunisian politics
Book review: Photography of protest and community: the radical collectives of the 1970s by Noni Stacey
No full textIn Photography of Protest and Community: The Radical Collectives of the 1970s, Noni Stacey shows how a 1970s network of London-based photography collectives raised fundamental questions about the politics of photography, the role and responsibilities of photographers in relation to local communities and the uses of photography in the context of social activism. This book is a welcome addition to the expanding field of research on the photography of protest, writes Mathilde Bertrand, contributing to the ongoing documentation of this strong current in British photographic history. If you are interested in this book review, you can read an LSE RB interview with author Dr Noni Stacey. The archive of the Exit Photography Group is held at LSE Library; readers can find out more about the archive and the catalogue. Photography of Protest and Community: The Radical Collectives of the 1970s. Noni Stacey. Lund Humphries. 2020
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