1,037 research outputs found
Control and Filtering for Discrete Linear Repetitive Processes with H infty and ell 2--ell infty Performance
No full textRepetitive processes are characterized by a series of sweeps, termed passes, through a set of dynamics defined over a finite duration known as the pass length. On each pass an output, termed the pass profile, is produced which acts as a forcing function on, and hence contributes to, the dynamics of the next pass profile. This can lead to oscillations which increase in amplitude in the pass to pass direction and cannot be controlled by standard control laws. Here we give new results on the design of physically based control laws for the sub-class of so-called discrete linear repetitive processes which arise in applications areas such as iterative learning control. The main contribution is to show how control law design can be undertaken within the framework of a general robust filtering problem with guaranteed levels of performance. In particular, we develop algorithms for the design of an H? and dynamic output feedback controller and filter which guarantees that the resulting controlled (filtering error) process, respectively, is stable along the pass and has prescribed disturbance attenuation performance as measured by and – norms
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
Get PDFThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Nonlinear filtering for state delayed systems with Markovian switching
Get PDFCopyright [2003] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to [email protected]. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.This paper deals with the filtering problem for a general class of nonlinear time-delay systems with Markovian jumping parameters. The nonlinear time-delay stochastic systems may switch from one to the others according to the behavior of a Markov chain. The purpose of the problem addressed is to design a nonlinear full-order filter such that the dynamics of the estimation error is guaranteed to be stochastically exponentially stable in the mean square. Both filter analysis and synthesis problems are investigated. Sufficient conditions are established for the existence of the desired exponential filters, which are expressed in terms of the solutions to a set of linear matrix inequalities (LMIs). The explicit expression of the desired filters is also provided. A simulation example is given to illustrate the design procedures and performances of the proposed method
Utility of novel diagnostic tests for tuberculosis using human urine
No full textIncludes abstract.Includes bibliographical references.Two thirds of new TB cases in sub-Saharan Africa are HIV coinfected. HIV-TB co-infection increases the incidence of extra-pulmonary, sputum smear-negative and sputum-scarce TB. In these vulnerable patientgroups with high mortality rates, sputum-based diagnostic tools are unhelpful. Urine-based diagnostics offer an attractive, easily available alternative for rapid diagnosis. We evaluated the point-of-care urine LAM strip test (Determine TB LAM Ag test, Alere) and urine-based Xpert MTB/RIF for TB diagnosis in two patient cohorts with high HIV prevalence. A spot urine sample was collected from two cohorts of persons with suspected TB. The first cohort consisted of ambulatory primary care clinic patients suspected of having TB (group 1) whilst the second comprised hospitalised patients with suspected HIV co-infection (group 2). The urine LAM ELISA, LAM strip test and Xpert MTB/RIF were performed according to the manufacturer’s instructions. In addition, the effects of using an alternative ‘rulein’ cut-point for the urine LAM strip test and a pelleted (2-10ml) urine sample for Xpert MTB/RIF testing on diagnostic accuracy and inter-reader reliability was assessed. The diagnostic reference standard was M. tuberculosis culture positivity
Effects of biased irradiation on charge trapping in HfO<inf>2</inf> dielectric thin films
Get PDF© 2017 Author(s). This paper reports the low-dose-rate radiation response of Al-HfO 2 /SiO 2 -Si MOS devices, in which the gate dielectric was formed by atomic layer deposition (ALD) with 5-nm equivalent oxide thickness. The degradation of the devices was characterized by a pulse capacitance-voltage (CV) and on-site radiation response technique under continuous gamma (γ) ray exposure at a relatively low dose rate of 0.116 rad (HfO 2 )/s. Compared with conventional CV measurements, the proposed measurements extract significant variations of flat-band voltage shift of the hafnium based MOS devices. The large flat-band voltage shift is mainly attributed to the radiation-induced oxide trapped charges, which are not readily compensated by bias-induced charges produced over the measurement timescales (for timescales less than 5 ms). A negative flat-band voltage shift up to -1.02 V was observed under a positive biased irradiation with the total dose up to 40 krad (HfO 2 ) and with the electric field of 0.5 MV/cm. This is attributed to net positive charge generation in the HfO 2 oxide layer. The generated charges are transported towards the HfO 2 /SiO 2 interface, and then form effective trapped holes in the HfO 2 . Similarly, a positive flat-band voltage shift up to 1.1 V was observed from irradiation under negative bias with an electric field of -0.5 MV/cm. The positive shift is mainly due to the accumulation of trapped electrons. Analyses of the experimental results suggest that both hole and electron trapping can dominate the radiation response performance of the HfO 2 -based MOS devices depending upon the applied bias. It was also found there was no distinct border traps with irradiation in all cases
Correction: Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells
No full textPresent: Due to an omission on the part of the author, the affliations of the first author are incomplete.
Corrected: Additional affliation information for the first author is listed below. The authors sincerely apologize for this error.
Original article: Oncotarget. 2016; 7(10):11397-11411. DOI:10.18632/oncotarget.7242.
PRESENT LIST:
Yanli Zhang1, Jamie Sui-Lam Kwok2, Pui-Wah Choi1, Minghua Liu2, Junzheng Yang1, Margit Singh1, Shu-Kay Ng4, William R. Welch5, Michael G. Muto1, Stephen KW Tsui2, Stephen P. Sugrue3, Ross S. Berkowitz1, Shu-Wing Ng1
1 Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA
2 School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
3 Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA
4 School of Medicine and Menzies Health Institute Queensland, Griffith University, Meadowbrook, Australia
5 Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
UPDATED LIST:
Yanli Zhang1,6, Jamie Sui-Lam Kwok2, Pui-Wah Choi1, Minghua Liu2, Junzheng Yang1, Margit Singh1, Shu-Kay Ng4, William R. Welch5, Michael G. Muto1, Stephen KW Tsui2, Stephen P. Sugrue3, Ross S. Berkowitz1, Shu-Wing Ng1
1 Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA
2 School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
3 Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA
4 School of Medicine and Menzies Health Institute Queensland, Griffith University, Meadowbrook, Australia
5 Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
6 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaFull Tex
Increasing surface ozone concentrations in the background atmosphere of southern China, 1994-2007
No full textAuthor name used in this publication: Wang, T.Author name used in this publication: Poon, C. N.Author name used in this publication: Lam, K. S.Author name used in this publication: Li. Y. S.2009-2010 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedC
Local government and leisure:: A study of two local authorities and their responses to the growth of leisure
Get PDFLocal authorities have a long history of providing recreation and leisure services, but since the 1970s leisure departments have expanded with a corresponding growth in the number and importance of professional officers to run them. Growing affluence and improvements in the quality of life have led to a recognition of the social importance of leisure provision, and more recently its economic importance has been established with the introduction of schemes aimed at rejuvenating local areas. This thesis investigates the internal workings of two neighbouring local authorities in the North East of England. It is a comparative study of the District Councils of Wear Valley and Chester-le-Street, focusing primarily on the importance of leisure services in the public sector. It draws attention to the importance of leisure to justify local government as elected bodies concerned with the overall well-being of their local communities. After considering historical, philosophical and sociological perspectives on leisure, and examining the role of public bodies in the provision of leisure, the thesis proceeds with a detailed analysis of leisure services in Wear Valley and Chester-le-Street in a period of dramatic change. An evaluation of the differences in each District and their responses leads to a consideration of the 'Enabling' role now expected of all local authorities. Although local government is an important element in the British political system, it has been subjected to a plethora of legislation since 1979, aimed at reducing public spending and questioning and controlling the role and purpose of local authorities. The comparison of the two Districts involves an investigation of their internal conduct and business. It finds that leisure services are an increasingly important reasons for maintaining elected local authorities
Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome
Get PDF© 2018 The Author(s).Background. Initiation of antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected individuals with cryptococcal meningitis places them at risk for Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS). The relationship between antibody immunity and C-IRIS risk has not been investigated. Methods. We compared plasma levels of immunoglobulins, C. neoformans glucuronoxylomannan (GXM) capsule-specific and laminarin (Lam)-binding IgM and IgG, and percentages of peripheral blood total and memory B cells between 27 HIV-infected patients with CM who developed C-IRIS and 63 who did not, and evaluated associations of these parameters with risk of C-IRIS. Results. Prior to initiation of ART, plasma IgM, Lam-binding IgM (Lam-IgM), Lam-IgG, and GXM-IgM levels were significantly lower in patients who developed C-IRIS than those who did not. Multivariate analysis revealed significant inverse associations between C-IRIS and IgM (P = .0003
Multiple-sprint sport exercise and carbohydrate-protein ingestion in humans
Get PDFThe aim of the present thesis was to examine the potential for acute carbohydrate-protein (CHO-P) ingestion to enhance performance and recovery from exercise designed to simulate the demands of multiple-sprint sports (MSSs). Chapter 3 of the thesis explored the inter- and intra-day reliability and concurrent validity of non-motorised treadmill ergometry (NMT) for the assessment of short-distance sprint performance [i.e. 10-30 m). There were no significant mean differences between NMT variables recorded on the same day or between days. Ratio limits of agreement indicated that the best agreement was in 20 [1.02 */-=- 1.09) and 30 m [1.02 */* 1.07) sprint times, peak [1.00 */T 1.06) and mean (0.99 */+ 1.07) running speed and step length (0.99 */-=- 1.09) and frequency (1.01 */+ 1.06). The poorest agreement was observed for time to peak running speed (1.10 */* 1.47). Significant differences were observed between NMT and over-ground sprint times across all distances, with times being lower (faster) by approximately 25-30% over-ground. The correlations between NMT and over-ground variables were generally modest (r5 = 0.44 - 0.67), and optimal for time to cover 30 m on Day 2 (rs = 0.8). Chapter 4 sought to examine the efficacy of CHO-P ingestion during 4 h of recovery from the Loughborough Intermittent Shuttle Test (LIST) when compared to CHO matched for energy (ISOEN) or CHO (ISOCHO) in a typical CHO beverage. There were significant increases over time in muscle soreness, and reductions in extensor and flexor peak torque (by approximately 9%, 9% and 8%, and 13 %, 13% and 11% at 60 deg-s-1) and jump performance (10%, 7% and 5%) with the ingestion of CHO-P, ISOEN and ISOCHO, respectively. Beverage type x time interactions were not significant for any of these variables, indicating that changes in each variable were similar for all groups. Decrements in sprint performance assessed on the NMT were typically small and not different between beverage types (<4%), although sprint times over 20 and 30 m remained elevated for 48 h post-exercise. Accordingly, Chapter 4 provided no clear evidence for a benefit of ingesting CHO-P in the hours after exercise to enhance recovery of muscle function and selected performance variables following MSS activity. Chapters 5 and 6 of the thesis aimed to examine the effect of CHO-P ingestion during simulated MSS exercise. In Chapter 5, it was observed that sprint times, HR and gut fullness increased over the course of the LIST, with no influence of consuming each of the different beverages. In contrast, there was a main effect of time (P < 0.001), and drink (P = 0.042) observed for RPE, which was lower (P < 0.001) during the LIST in the CHO-P condition (16.9 ± 1.4) than in either the ISOCHO (17.8 ± 1.1) or ISOEN (17.7 ± 1.3). However, time to exhaustion was not different (P = 0.29) between CHO-P (468.3 ± 268.5 s), ISOCHO (443.4 ± 286.3 s) and ISOEN (446.2 ± 282.08 s), although these times did equate to a non-significant mean improvement of 4% in the CHO-P trial. Chapter 6 demonstrated that during a modified version of the LIST with two self-regulated blocks of exercise intensity, participants had a higher average speed (8.1 ± 0.3 cf. 7.9 ± 0.5 knvlr1) during the final (self-regulated) 15 min block of the LIST in the CHO-P condition compared to CHO. Whilst the mechanisms for such an improvement are not certain, the attenuated rise in RPE observed in Chapter 5, and increased blood urea concentration observed in Chapter 6, with CHO-P ingestion may suggest altered central fatigue and/or increased protein oxidation enhances performance during MSSs
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