183,397 research outputs found
Celebration of the Life of Edward K. T. Chen
No full textEdward C. M. Chen is the son of Edward K. T. Chen
A possible mechanism of superconductivity in high-T-c cuprates
No full textThis paper derives a generic T-c formula by using the long-range phase coherence condition in quantum phase fluctuation of the order parameter. Taking the two-local-spin-mediated interaction (TLSMI) proposed by Liu and Chen [Phys. Rev. B 58 (1998) 8812] as a Cooper pair potential, and the T-c formula, this paper explains five basic experimental facts in high-T-c cuprates. The aim of this paper is to show that TLSMI is a possible pairing mechanism of superconductivity in high-T-c cuprates. (C) 2000 Elsevier Science B.V. All rights reserved.Physics, AppliedSCI(E)EI0ARTICLE4276-28434
Corrigendum to “General reduced vehicle model for simulating truck-bridge pier collisions” [Dev. Built. Environ. 16 (2023) 100233] (Developments in the Built Environment (2023) 16, (S2666165923001151), (10.1016/j.dibe.2023.100233))
No full textThe authors regret there were two errors in the authors' affiliation in the published article. First, the affiliation of the first author (Daogang Ou) should only be the School of Civil Engineering, Hunan University of Science and Technology, Xiangtan, 411201, China. Second, the corresponding author (Lin Chen) should have two affiliations; the first one should be: School of Civil Engineering, Hunan University of Science and Technology, Xiangtan, 411201, China; and the second one should be: Key Laboratory of Building Safety and Energy Efficiency of Ministry of Education, Hunan University, Changsha, 410082, China. The authors would like to apologise for any inconvenience caused
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
No full textCellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of caspase-8 and is required for macrophage survival. Recent studies have revealed a selective role of caspase-8 in noncanonical IL-1 beta production that is independent of caspase-1 or inflammasome. Here we demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1 beta. Hemizygotic deletion of c-FLIP impaired ATP-and monosodium uric acid (MSU)-induced IL-1 beta production in macrophages primed through Toll-like receptors (TLRs). Decreased IL-1 beta expression was attributed to a reduced activation of caspase-1 in c-FLIP hemizygotic cells. In contrast, the production of TNF-alpha was not affected by downregulation in c-FLIP. c-FLIPL interacted with NLRP3 or procaspase-1. c-FLIP is required for the full NLRP3 inflammasome assembly and NLRP3 mitochondrial localization, and c-FLIP is associated with NLRP3 inflammasome. c-FLIP downregulation also reduced AIM2 inflammasome activation. In contrast, c-FLIP inhibited SMAC mimetic-, FasL-, or Dectin-1-induced IL-1 beta generation that is caspase-8-mediated. Our results demonstrate a prominent role of c-FLIPL in the optimal activation of the NLRP3 and AIM2 inflammasomes, and suggest that c-FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflammasomes
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
Full text linkThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Amynthas mamillaris Chen 1938
No full textAmynthas mamillaris (Chen, 1938) Pheretima mamillaris Chen, 1938: 413, Fig. 15; Le 1995a: 33; Nakamura 1999: 35. Amynthas mamillaris— Sims & Easton 1972: 236, 244; Blakemore 2007a: 62. Type locality. China (Hainan Isl.). Type material. Unknown. Examined material. 8 C (SORC-V.149.01) near stream, Viet Lam, Vi Xuyen, Ha Giang, 5/12/1993, coll. Le Van Trien. Records from Vietnam. Ha Giang (Vi Xuyen) (Le 1995a). Distribution. China (Chen 1938). Vietnamese name. Giun núm vú.Published as part of Nguyen, Tung T., Nguyen, Anh D., Tran, Binh T. T. & Blakemore, Robert J., 2016, A comprehensive checklist of earthworm species and subspecies from Vietnam (Annelida: Clitellata: Oligochaeta: Almidae, Eudrilidae, Glossoscolecidae, Lumbricidae, Megascolecidae, Moniligastridae, Ocnerodrilidae, Octochaetidae), pp. 1-92 in Zootaxa 4140 (1) on page 38, DOI: 10.11646/zootaxa.4140.1.1, http://zenodo.org/record/25650
Sputtering Process of Carbon Nitride Films by Using a Novel Bio-Molecular C-N Containing Target
No full textPhortica FLOCCIPES CAO & CHEN 2009, SP. NOV.
No full textPHORTICA FLOCCIPES CAO & CHEN SP. NOV. (FIGS 1, 8, 13–15) Material examined: Holotype male, CHINA: Dajiuhu, Shennongjia, Hubei, 3.viii.2005, H. W. Chen (SCAU, No. 120020). Paratypes: CHINA: four males, three females, same data as holotype except 3–5.viii.2005, H. Z. Cao, H. W. Chen, and M. F. Xu (one male and one female in KIZ; the rest in SCAU, Nos 120021–25); two males, two females, Miyaluo, Lixian, Sichuan, 8–10.ix.2005, M. F. Xu and H. L. Cao (SCAU, Nos 120026–29). Description: Male and female. Head: frons black, with grey pollinosity. Thorax: scutum almost black, with grey pollinose pattern. Scutellum black, with a pair of yellow patches submedially. Legs: hind tibiae with three black rings, three irregular rows of suberect setae on ventral surface, which are slightly shorter than tibia width (Fig. 2A), apically with one long curved seta (Fig. 2B). All fourth and fifth tarsomeres black, the rest grey-yellow. Male terminalia: cercus with two strong setae (Fig. 14). Surstylus medially protrudent, with two rows of about seven to eight prensisetae, apically round, with four prensisetae (Fig. 14). Paramere submedially with three small processes, two of them with sensillum, apically with one sensillum; basal process with fine sawteeth (Fig. 15). A KEY TO SPECIES OF THE PHORTICA HANI SPECIES COMPLEX (MALES) 1. Arista with only short dorsal branches; wing R 4+5 and M 1 veins nearly parallel; fifth sternite notched posteromedially; cercus ventrally with two to three long, strong setae; paramere with one spike-like process basally; aedeagus nearly membranous (Phortica hani complex)..........................................................................................2 2. Hindleg tibia lacking a long seta apically (males only known); surstylus with one prensiseta apically; basal spike-like process of paramere lacking fine sawteeth............................................................................... 3 – Hindleg tibia with a long seta apically; surstylus apically with two prensisetae at least; basal process of paramere with fine sawteeth.............................................................................................................................4 3. Surstylus apically truncate; cercus ventrally with three long setae......................................................................................................................................................... Phortica longicauda Cao & Chen sp. nov. – Surstylus apically pointed; cercus ventrally with two long setae......... Phortica longiseta Cao & Chen sp. nov. 4. Hindleg tibia apically with one row of short, scopiform setae on ventral surfaces (male only known); surstylus with two prensisetae apically.................................................................. Phortica panda Cao & Chen sp. nov. – Hindleg tibia lacking scopiform setae apically; surstylus with three prensisetae at least................................5 5. Hindleg tibiae with three black rings and two to three rows of suberect setae on ventral surface, lacking long setae on posteroventral surface; surstylus not covered by epandrium..................................................................6 – Hindleg tibiae with two rings, lacking fringe-like setae on ventral surface, with one row of long setae on posteroventral surface, surstylus covered by epandrium........................................................................... 7 6. Fringe-like setae of hindleg tibiae as long as 1.5¥ of tibia width; surstylus medially not protrudent, with two prensisetae.................................................................................................. Phortica hani (Zhang & Shi) – Fringe-like setae of hindleg tibiae shorter than tibia width; surstylus medially protrudent, with seven to eight prensisetae arranged in two rows.................................................. Phortica floccipes Cao & Chen sp. nov. 7. Scutellum orange-brown, black along margin; hindleg tibia basally to apically with one row of about 11 long setae on anteroventral surface which are about as long as the tibia width......................................................................................................................................................... Phortica hirtotibia Cao & Chen sp. nov. – Scutellum entirety blackish; hind tibiae distally with one row of about eight strong setae on anteroventral surface, most of which are shorter than the tibia width............................. Phortica pinguiseta Cao & Chen sp. nov. A KEY TO PHORTICA HANI SPECIES COMPLEX BASED ON ND2 AND COI SEQUENCES In the following key to seven species of the P. hani complex, character statuses at diagnostic sites were compared between a given pair of taxa. Each status depiction starts with a letter denoting its affiliated gene (N: ND2; C: COI), followed by a number (in subscript) indicating the site positions in the sequences of the affiliated gene, and then by the codon position of the site (in parentheses and in subscript), the nucleotide type (after a colon), and the corresponding amino acid type (after a slash, all shown by standard three-letter abbreviations). No character was found to diagnose between P. floccipes and P. panda based on their ND2 or COI sequences. 1. N 330 (3rd): A/Leu; N 627 (3rd): A/Leu; N 919 (1st): A/Met; C 204 (3rd): A/Val; C 534 (3rd): T/Arg; C 574 (1st): C/Leu; C 627 (3rd): T/Thr; C 705 (3rd): T/Phe; C819 (3rd):T/Tyr; C 894 (3rd): C/Asp; C1002 (3rd): A/Pro................................................................................2 – N330 (3rd): T/Phe; N627 (3rd): T/Phe; N919 (1st): G/Val; C204 (3rd): T/Val; C534 (3rd): A/Arg; C574 (1st): T/Leu; C627 (3rd): A/Thr; C705 (3rd): C/Phe; C819 (3rd): C/Tyr; C 894 (3rd): T/Asp; C1002 (3rd): G/Pro.............................................................................. 4 2. N292 (1st): G/Val; N605 (2nd): C/Thr; N996 (3rd): A/Met; C72 (3rd): C/Ala; C279 (3rd): T/Pro; C402 (3rd): C/Ile; C573 (3rd): T/Phe; C756 (3rd): T/Ile; C805 (1st): C/Leu; C1083 (3rd): C/Val; C1201 (1st): T/Leu; C1335 (3rd): T/Tyr........................................................................................................................................................... Phortica longiseta Cao & Chen sp. nov. – N 292 (1st): A/Met; N 605 (2nd): T/Ile; N 996 (3rd): T/Ile; C 72 (3rd): T/Ala; C 279 (3rd): C/Pro; C 402 (3rd): T/Ile; C 573 (3rd): C/Phe; C 756 (3rd): C/Ile; C805 (1st): T/Leu; C1083 (3rd): T/Val; C1201 (1st): C/Leu; C1335 (3rd): C/Tyr................................................................... 3 3. N144 (3rd): C/Asn; N333 (3rd): T/His; C1023 (3rd): A/Gly; C1089 (3rd): T/Ile........... Phortica pinguiseta Cao & Chen sp. nov. – N144 (3rd): T/Asn; N333 (3rd): C/His; C1023 (3rd): G/Gly; C1089 (3rd): C/Ile............ Phortica hirtotibia Cao & Chen sp. nov. 4. N441 (3rd): A/Lys; N444 (3rd): T/Pro; N795 (3rd): A/Gln; N810 (3rd): C/Asn; C201 (3rd): A/Met; C456 (3rd): T/Gly; C474 (3rd): A/Gly; C537 (3rd): A/Met; C 648 (3rd): C/Ser; C 747 (3rd): T/Phe............................................................................................................................................... Phortica floccipes Cao & Chen sp. nov. / Phortica panda Cao & Chen sp. nov. – N 441 (3rd): G/Lys; N 444 (3rd): C/Pro; N 795 (3rd): G/Gln; N 810 (3rd): T/Asn; C 201 (3rd): G/Met; C 456 (3rd): A/Gly; C 474 (3rd): G/Gly; C 537 (3rd): G/Met; C648 (3rd): T/Ser; C747 (3rd): C/Phe.....................................................................................................5 5. N405 (3rd): C/Ile; N 603 (3rd): C/Phe; N651 (3rd): C/Thr; N774 (3rd): T/Pro; N915 (3rd): T/Asn; C513 (3rd): C/Ala; C594 (3rd): T/Pro; C855 (3rd): G/Val; C1218 (3rd): A/Lys.................................................................................... Phortica hani (Zhang & Shi) – N405 (3rd): T/Ile; N 603 (3rd): T/Phe; N651 (3rd): T/Thr; N774 (3rd): A/Pro; N915 (3rd): C/Asn; C513 (3rd): T/Ala; C594 (3rd): G/Pro; C855 (3rd): T/Val; C 1218 (3rd): G/Lys............................................................... Phortica longicauda Cao & Chen sp. nov. Measurements: BL = 3.70 mm in holotype (range in four male and five female paratypes: 3.50–4.20); ThL = 1.75 mm (1.60–2.00); WL = 3.30 mm (3.05– 3.60); WW = 1.35 mm (1.30–1.75). Indices: arb = 3/0 (3–6/0), adf = 0.79 (0.53–0.79), flw = 1.64 (1.54–2.00), FW/HW = 0.50 (0.49–0.53), ch/o = 0.13 (0.12–0.14), prorb = 1.21 (1.00–1.33), rcorb = 0.52 (0.38–0.53), vb = 0.36 (0.32–0.59), dcl = 0.52 (0.49– 0.62), presctl = 0.44 (0.44–0.57), sctl = 1.05 (1.03– 1.07), sterno = 0.81 (0.65–0.94), orbito = 1.70 (1.46–1.67), dcp = 0.26 (0.19–0.30), sctlp = 0.87 (0.72– 0.96), C = 2.54 (2.57–3.24), 4c = 1.37 (1.07–1.26), 4v = 2.50 (2.25–2.65), 5x = 0.88 (0.68–1.10), ac = 2.25 (1.69–2.08), M = 0.65 (0.49–0.76), C3F = 0.56 (0.43– 0.60). Etymology: A combination of the Latin words floccus and pes, referring to the hindleg tibia with suberect setae. Distribution: China (Hubei, Sichuan). A KEY TO SPECIES OF THE PHORTICA HANI SPECIES COMPLEX (MALES) 1. Arista with only short dorsal branches; wing R 4+5 and M 1 veins nearly parallel; fifth sternite notched posteromedially; cercus ventrally with two to three long, strong setae; paramere with one spike-like process basally; aedeagus nearly membranous (Phortica hani complex)..........................................................................................2 2. Hindleg tibia lacking a long seta apically (males only known); surstylus with one prensiseta apically; basal spike-like process of paramere lacking fine sawteeth............................................................................... 3 – Hindleg tibia with a long seta apically; surstylus apically with two prensisetae at least; basal process of paramere with fine sawteeth.............................................................................................................................4 3. Surstylus apically truncate; cercus ventrally with three long setae......................................................................................................................................................... Phortica longicauda Cao & Chen sp. nov. – Surstylus apically pointed; cercus ventrally with two long setae......... Phortica longiseta Cao & Chen sp. nov. 4. Hindleg tibia apically with one row of short, scopiform setae on ventral surfaces (male only known); surstylus with two prensisetae apically.................................................................. Phortica panda Cao & Chen sp. nov. – Hindleg tibia lacking scopiform setae apically; surstylus with three prensisetae at least................................5 5. Hindleg tibiae with three black rings and two to three rows of suberect setae on ventral surface, lacking long setae on posteroventral surface; surstylus not covered by epandrium..................................................................6 – Hindleg tibiae with two rings, lacking fringe-like setae on ventral surface, with one row of long setae on posteroventral surface, surstylus covered by epandrium........................................................................... 7 6. Fringe-like setae of hindleg tibiae as long as 1.5¥ of tibia width; surstylus medially not protrudent, with two prensisetae.................................................................................................. Phortica hani (Zhang & Shi) – Fringe-like setae of hindleg tibiae shorter than tibia width; surstylus medially protrudent, with seven to eight prensisetae arranged in two rows.................................................. Phortica floccipes Cao & Chen sp. nov. 7. Scutellum orange-brown, black along margin; hindleg tibia basally to apically with one row of about 11 long setae on anteroventral surface which are about as long as the tibia width......................................................................................................................................................... Phortica hirtotibia Cao & Chen sp. nov. – Scutellum entirety blackish; hind tibiae distally with one row of about eight strong setae on anteroventral surface, most of which are shorter than the tibia width............................. Phortica pinguiseta Cao & Chen sp. nov.Published as part of He, Xiaofang, Gao, Jianjun, Cao, Huazhi, Zhang, Xiaolei & Chen, Hongwei, 2009, Taxonomy and molecular phylogeny of the Phortica hani species complex (Diptera: Drosophilidae), pp. 359-372 in Zoological Journal of the Linnean Society 157 (2) on pages 362-364, DOI: 10.1111/j.1096-3642.2009.00516.x, http://zenodo.org/record/468781
MPTP/MPP+ suppresses activation of protein C in Parkinson's disease
No full textEndothelial dysfunction and disruption of the blood-brain barrier have been found to be associated with Parkinson's disease (PD). However, the mechanisms underlying these effects have yet to be elucidated. It has also been found that activated protein C (APC) displays neuroprotective properties. Presently, the effects of APC on PD remain unknown. Using a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) neurotoxin rodent model of PD, we found that administration of MPTP can reduce expression of endothelial protein C receptor (EPCR), an N-glycosylated type I membrane protein that has the ability to enhance protein C activation. However, the use of MPTP does not alter levels of thrombomodulin. These findings were verified in an in vitro study showing that 1-methyl-4-phenylpyridinium (MPP+) treatment leads to suppression of EPCR along with reduction of protein C activation in human primary endothelial cells. Importantly, our results display that activation of the transcriptional factor SP1 is involved in the inhibitory effects of MPTP/MPP+ on EPCR expression. We found that using 300 nM of the SP1 inhibitor MIT can abolish the effects of MPP+ on EPCR expression. Consistently, SP1 silencing using small RNA interference was able to prevent the inhibitory effects of MPTP/MPP+ on the reduction of EPCR expression and impairment of protein C activation. Importantly, our results indicate that overexpression of SP1 inhibits EPCR promoter activity. Our study suggests that EPCR-APC may be a potential therapeutic target for endothelial dysfunction in P
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