1,721,046 research outputs found
Innovative policy of european institutes in solving cancer problems. The General Assembly of OECI, Genoa, Italy, May 21–24
Get PDFThe General Assembly and Scientific week of OECI (Organization of European Cancer Institutes) took place in Genoa (Italy) on 21–24 of May. The membership of OECI comprises 58 European cancer institutions, including R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine as the only representative from Ukraine. In the frames of Scientific week several important events took place: meeting on translational oncogenomics, workshop on cancer biotherapy, symposium on nanotechnology application in oncology, seminar on accreditation. OECI General Assembly closed the Scientific week
Innovative policy of european institutes in solving cancer problems. The General Assembly of OECI, Genoa, Italy, May 21–24
No full textThe General Assembly and Scientific week of OECI (Organization of European Cancer Institutes) took place in Genoa (Italy) on 21–24 of May. The membership of OECI comprises 58 European cancer institutions, including R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine as the only representative from Ukraine. In the frames of Scientific week several important events took place: meeting on translational oncogenomics, workshop on cancer biotherapy, symposium on nanotechnology application in oncology, seminar on accreditation. OECI General Assembly closed the Scientific week
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells
No full textBackground: The mechanisms of drug resistance of cancer have not been yet elucidated in details. Recently, the role of mast cells (MCs) in the development of drug resistance has been brought in the limelight. The aim of the study was to examine the morphological features of doxorubicin (DOX)-resistant Walker 256 carcinosarcoma and to assess the response of MCs and histamine content in these cells in relation to the development of resistance to DOX as well as in DOX-resistant tumors. Materials and Methods: The DOX resistance was induced by serial passages of Walker 256 carcinosarcoma in rats in the setting of DOX treatment in vivo. MCs in tumors were detected in the sections by staining with Toluidine Blue O. Histamine content in MCs stained with solution of Water Blue-Orcein was assessed by Astaldi semiquantitative method taking into account different staining intensity. Results: Formation of DOX resistance in the course of serial passages of Walker 256 carcinosarcoma was accompanied by the increase in the number of MCs in tumors and histamine content. Nevertheless, in tumors with phenotype of complete DOX resistance the number of histamine-containing MCs decreased to the same level as in tumors of the original strain that are DOX-sensitive. Conclusion: MCs are involved in formation of DOX resistance in Walker 256 carcinosarcoma
Нанокомпозити медикобіологічного призначення: реальність і перспективи для онкології
No full textAnalysis is given of the ways of creation of polyfunctional medicobiologic nanocomposites with multilevel hierarchic architecture that would be applicable for recognition of microbiological objects in biologic media, targeted delivery and deposition of drugs in target organs, diagnostics and therapy of diseases on the cellular level. The physicochemical experimental data, as well as medicobiological studies, confirm their perspective for preparation of new medicinal forms with complex (cytotoxic, immunotherapeutic and hyperthermic) activity
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