34,987 research outputs found
P.2.f.004 Effects of combined treatment between trazodone and selective serotonin reuptake inhibitors
No full text
Stress Analysis of Bulk Carrier Hatch Corners
No full textOne of the most frequent damage cause for bulk carrier ships is represented by high stress
concentrations occurring in deck plating close to hatch corners in way of coaming stay. In this
area many fractures are found during surveys which are generated mainly by three types of
problems:
• stress concentration in correspondence of deck large openings;
• bad design of stays;
• different thickness between transversal and external deck plates.
The typical approach followed by IACS classification societies consists in a wide range of
qualitative suggestion (transversal stiffening for transversal deck strip, elliptical hatch corner
etc.) and a very simple formula providing the extra thickness of the hatch corner compulsory
insert.
This solution seems to be inadequate to face this phenomenon and a better knowledge is
mandatory to understand which parameters are more influent on stress distribution and
concentration.
The purpose of the analysis herein presented is to identify most important parameters and to
study their influence, in order to develop a more sophisticate procedure to be used in
preliminary design stage.
The investigation has been developed starting from the analysis of five different bulk carriers,
selected on the basis of their geometric and structural properties, and modeled with FEM
software Leonardo hull 3D v. 2.4.1.
The analysis has been divided into two sub-problems:
• study of b/B ratio influence (hatch breadth versus ship breadth);
• study of lw/b ratio influence (cross deck length versus hatch breadt)..
Two different series of FEM models have been realized:
Global models of the hull extended to a portion of three cargo holds;
Simplified models with increasing refinement degree.
All global models have a relatively coarse mesh and are loaded with a wide number of
loading condition (homogeneous, heavy and light ballast, alternate ore) corresponding to
relevant RINA load cases in order to maximize the effects. For what simplified models are concerned four different types of models have been analysed:
a) The first model consists in a simple plate with a rectangular opening and two longitudinal
box structures simulating the wing tanks. All the parts of the model have a constant thickness.
b) A second series of models has then been created, similar to the first one, adding a coaming
around the hatch opening. As in the first case the thickness has been maintained constant.
c) The third series is similar to the first one but the thicknesses of the lateral deck strip and of
the cross deck have different values, according to the real case.
d) The fourth series is similar to the second one. Again deck plates have different thicknesses. For all the models the results have been processed to calculate stress concentration factors “k”
(defined as longitudinal stress close to hatch corner versus theoretical hull girder stress) for all
selected loading conditions.
From the “k” coefficients obtained for every model, a “stress concentration surface”, as a
function of b/B and w/b, has been drawn and expressed by a simplified formula
Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection
No full textWe report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Off-Label Uses of Trazodone: a Review
No full textIntroduction: Trazodone is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors. It is approved by the FDA for the treatment of depression. Insomnia is the most frequent reason for prescription of trazodone. It has also been proven useful in the treatment of anxiety disorders. Other off-label uses include the treatment of bulimia, benzodiazepine/alcohol dependence, fibromyalgia, central nervous system degenerative diseases (behavioral disorders in dementia and other organic disorders), schizophrenia, chronic pain disease and diabetic neuropathy, sexual dysfunction. Areas covered: This paper evaluates trazodone's efficacy and safety in its off-label uses. It also discusses the possibility that a combination of trazodone with SSRIs may prevent or treat some of the SSRI side effects, such as anxiety, insomnia and sexual dysfunction, in addition to synergically increasing SSRIs' antidepressant activity. Expert opinion: Few clinical trials have been conducted to evaluate trazodone's efficacy in the treatment of the diseases and symptoms for which it is often used in clinical practice. More studies are necessary to investigate possible new therapeutic indications, and to scientifically demonstrate the risk/benefit ratio for the many conditions for which trazodone is used, but not approved by the FDA. © 2012 Informa UK, Ltd
Tomografie sismiche a rifrazione su Monte Testaccio (Roma).
No full textViene presentato il risultato di una prospezione sismica effettuata su Monte Testaccio per determinare struttura, geometria, densità dell'ammasso di anfore olearie, per delineare le strutture di sostruzione e comprendere l'evoluzione della sua crescita nel tempo. Questa prospezione va ad integrare il rilievo microgravimetrico effettuato sempre su Monte Testaccio, dove con la gravimetria sono state individuate alcune aree di minimo gravimetrico, causate dalla scarsa compattazione dei frammenti di anfore, e aree di massimo gravimetrico dovute alla presenza di sostruzioni caratterizzate da una maggiore compattazione e conseguente maggiore densità1. Le prospezioni sismiche hanno avuto come scopo di tracciare la sismostratigrafìa dell'area e di individuare strutture di sostruzione e determinare la quota di base dei livelli archeologici. Sono state realizzate tre tomografìe sismiche a rifrazione
Diagnostic mistakes in post-traumatic stress disorder. The problem of symptom overlap with depression [Błędy popełniane w diagnostyce zaburzenia stresowego pourazowego – problem nakładania się objawów tego zaburzenia i depresji]
No full textObjectives. The overlap between symptoms of PTSD and MDD is substantial. PTSD symptoms arise after a traumatic experience and the trauma is present in all of the diagnostic clusters. In individuals who have experienced a trauma a long time before, it is difficult to establish the exact moment of onset of their symptoms in relation to the trauma suffered. We proposed to raise awareness among operators who may encounter this problem, with the aim of providing them with valuable help in order to achieve a correct differential diagnosis. Methods. A sample of subjects suffering from PTSD without comorbidity was assessed to confirm the diagnosis and the severity of post-traumatic symptoms. The Kruskal-Wallis test was used to compare any modifications in the parameters analyzed through the Davidson Trauma Scale with the presence and severity of depressive symptoms as evaluated by the Hamilton-D scale. Results. Half of the PSTD patients recruited showed values of HAM-D > 18, although an active Major Depressive Episode was clinically excluded. Symptom of "numbing", despite being different from the apathy experienced in depression, is identified as a depressive symptom by the HAM-D. Conclusions. Giving prevalence to depressive symptoms may be misleading for diagnosis and may ultimately result in inappropriate treatment
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
- …
