2,238 research outputs found
Methylotetracoccus oryzae Strain C50C1 Is a Novel Type Ib Gammaproteobacterial Methanotroph Adapted to Freshwater Environments
No full textMethane-oxidizing microorganisms perform an important role in reducing emissions of the greenhouse gas methane to the atmosphere. To date, known bacterial methanotrophs belong to the Proteobacteria, Verrucomicrobia, and NC10 phyla. Within the Proteobacteria phylum, they can be divided into type Ia, type Ib, and type II methanotrophs. Type Ia and type II are well represented by isolates. Contrastingly, the vast majority of type Ib methanotrophs have not been able to be cultivated so far. Here, we compared the distributions of type Ib lineages in different environments. Whereas the cultivated type Ib methanotrophs (Methylococcus and Methylocaldum) are found in landfill and upland soils, lineages that are not represented by isolates are mostly dominant in freshwater environments, such as paddy fields and lake sediments. Thus, we observed a clear niche differentiation within type Ib methanotrophs. Our subsequent isolation attempts resulted in obtaining a pure culture of a novel type Ib methanotroph, tentatively named “Methylotetracoccus oryzae” C50C1. Strain C50C1 was further characterized to be an obligate methanotroph, containing C_(16:1)ω9c as the major membrane phospholipid fatty acid, which has not been found in other methanotrophs. Genome analysis of strain C50C1 showed the presence of two pmoCAB operon copies and XoxF5-type methanol dehydrogenase in addition to MxaFI. The genome also contained genes involved in nitrogen and sulfur cycling, but it remains to be demonstrated if and how these help this type Ib methanotroph to adapt to fluctuating environmental conditions in freshwater ecosystems
Early Ibāḍī Theology
No full textEarly Ibāḍī Theology presents the critical edition of six Arabic theological texts recently discovered in two manuscripts in Mzāb in Algeria dating from the middle of the 8th century. The texts were sent by their author, the prominent Kūfan Ibāḍī kalām theologian ?Abd Allāh b. Yazīd al-Fazārī to North Africa where he had a large following in the Ibāḍī community later known as the Nukkār. They constitute the earliest extant body of Muslim kalām theology and are vital for the study of the initial development of rational theology in Islam. The sophisticated treatment of the divine attributes in these texts indicates that this subject developed considerably earlier in Islamic theology than previously accepted in modern scholarship
Skylab 4 Gerald Carr at Launch Complex 39 November 8, 1973
No full textThis image reflects a view of Skylab 4 Gerald Carr at Launch Complex 39 November 8, 1973.
Skylab 4 was the third manned Skylab mission and placed the third and final crew aboard the first American space station.
The mission started on November 16, 1973 with the launch of three astronauts on a Saturn IB rocket from the Kennedy Space Center, Florida and lasted 84 days, one hour and 16 minutes. A total of 6,051 astronaut-utilization hours were tallied by Skylab 4 astronauts performing scientific experiments in the areas of medical activities, solar observations, Earth resources, observation of the Comet Kohoutek and other experiments
A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo
No full textIn vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses. Until now, invasive surgery has been required for microscopic access to lymph nodes (LNs), making repeated imaging of the same animal impractical and potentially affecting lymphocyte behavior. To allow longitudinal in vivo imaging, we conceived the novel approach of transplanting LNs into
the mouse ear pinna. Transplanted LNs maintain the structural and cellular organization of conventional secondary lymphoid organs. They participate in lymphocyte
recirculation and exhibit the capacity to receive and respond to local antigenic challenge. The same LN could be repeatedly imaged through time without the requirement for surgical exposure, and the dynamic behavior of the cells within the transplanted LN could be characterized. Crucially, the use of blood vessels as fiducial markers also allowed precise re-registration of the same regions for
longitudinal imaging. Thus, we provide the first demonstration of a method for repeated, noninvasive, in vivo imaging of lymphocyte behavior
Identity-based non-interactive key distribution with forward security
No full textThe second author acknowledges support of FICYT (project IB-08-147) and Spanish MEC (project MEC-07-MTM2007-67884-C04-01 and FPU grant AP2007-03141, cofinanced by the European Social Fund)
Efficacy and safety of empagliflozin in glycogen storage disease type Ib: Data from an international questionnaire
No full textPurpose: This paper aims to report collective information on safety and efficacy of empagliflozin drug repurposing in individuals with glycogen storage disease type Ib (GSD Ib). Methods: This is an international retrospective questionnaire study on the safety and efficacy of empagliflozin use for management of neutropenia/neutrophil dysfunction in patients with GSD Ib, conducted among the respective health care providers from 24 countries across the globe. Results: Clinical data from 112 individuals with GSD Ib were evaluated, representing a total of 94 treatment years. The median age at start of empagliflozin treatment was 10.5 years (range = 0-38 years). Empagliflozin showed positive effects on all neutrophil dysfunction–related symptoms, including oral and urogenital mucosal lesions, recurrent infections, skin abscesses, inflammatory bowel disease, and anemia. Before initiating empagliflozin, most patients with GSD Ib were on G-CSF (94/112; 84%). At the time of the survey, 49 of 89 (55%) patients previously treated with G-CSF had completely stopped G-CSF, and another 15 (17%) were able to reduce the dose. The most common adverse event during empagliflozin treatment was hypoglycemia, occurring in 18% of individuals. Conclusion: Empagliflozin has a favorable effect on neutropenia/neutrophil dysfunction–related symptoms and safety profile in individuals with GSD Ib. © 2022 The Author
ANALISIS MEKANISME PERHITUNGAN BAGI HASIL AKAD MUDHARABAH PADA PRODUK TABUNGAN TAAT iB DI BPRS DAYA ARTHA MENTARI KANTOR CABANG GEMPOL KABUPATEN PASURUAN
No full textThe banking industry is currently competing to provide convenience in meeting the needs of a growing community. One of them is the community's need for lifestyle changes that are increasingly modern, which is one of the banking opportunities to help, namely through fundraising called Savings. BPRS Daya Artha Mentari KC Gempol as a pioneer of Islamic banking in Indonesia has also created products to help its customers obtain fundraising services with various types of programs, one of which is the iB TaaT Savings. In this study, using a descriptive method. The data collection method that the author uses is literature study, observation, recording, and interviews. Based on the research conducted by the author, the author can conclude that this study is entitled Analysis of the Mechanism of Calculation of Profit Sharing for Mudharabah Contracts on TaaT iB Savings Products at BPRS Daya Artha Mentari KC Gempol according to an Islamic Economics review. TaaT iB Savings is a savings product with the mudharabah principle. Therefore, the authors are interested in further researching how exactly the iB TaaT Savings is, and how the function of the Education Savings is for both the bank and the customer and how the Islamic economy reviews the iB TaaT Savings
The antibacterial mode of action and properties of Ib-AMP1, a plant-derived antimicrobial peptide, against Escherichia coli O157:H7
No full textThe continual occurrence of foodborne outbreaks along with the consumer demand for use of fewer traditional antimicrobial agents in foods has driven research interests in development of plant-derived antimicrobial agents (pAMPs) for use in food and food processing. Ib-AMP1 is a pAMP isolated from seeds of Impatiens balsamina. Previous studies indicated that it is a broad spectrum pAMP and the therapeutic index against eight human pathogens was 23.5; however, for future utilization, other antibacterial properties and mode of action must be elucidated. The purpose of this dissertation was to investigate the antibacterial properties and mode of action of Ib-AMP1 against Escherichia coli O157:H7, a foodborne pathogen that has been continually associated with foodborne outbreaks. The study design provided insight on the implantation and potential application of Ib-AMP1; a specific docking site or ligand-receptor relationship was not studied. The results demonstrated that Ib-AMP1 exhibited bactericidal activity against E. coli O157:H7, Salmonella enterica serovar Newport, Pseudomonas aeruginosa and Staphylococcus aureus. Ib-AMP1 at lethal concentrations (1X and 2X MIC) resulted in 1.46 to 2.69 log reduction of viable cells and prevented outgrowth when tested against low (103 CFU/mL) and medium (106 CFU/mL) E. coli O157:H7 populations. Ib-AMP1 at 2X MIC failed to inhibit and prevent outgrowth when cell numbers were 109 CFU/mL. No residual activity of Ib-AMP1 was apparent following interaction of the peptide with bacteria or the medium. Ib-AMP1 concentration less than 100 µg/mL showed little or no inhibition of human cell proliferation including human small intestine, colon and liver cells, which are associated with oral consumption of an AMP. The mode of action study demonstrated that a concentration dependent effect of Ib-AMP1 on the E. coli O157:H7 cell membrane occurred. Ib-AMP1 treatments resulted in efflux of K+ and ATP, suggesting pores of sufficient size to allow efflux of large molecules. The efflux of intracellular components may be associated with damage to the outer membrane and dissipation of cytoplasmic membrane potential. Results of this study suggest Ib-AMP1 is bactericidal interfering within outer and inner membrane integrity permitting efflux of ATP and interfering with intracellular biosynthesis of DNA, RNA, and protein.Ph. D.Includes bibliographical referencesIncludes vitaby Wen-Hsuan W
19.1 A 300MHz-BW, 27-to-38dBm In-Band OIP3 sub-7GHz Receiver for 5G Local Area Base Station Applications
No full textRecently, the so-called sub-6GHz band of the 5G new radio (NR) has been extended to 7.125GHz to address the relentless customer demand for higher data-rate communication. This demands a new design approach for the local area base-station (LA-BS) receivers (RXs) to cover a wide operating frequency range of 0.41 to 7.125GHz. Moreover, for NR bands above 3GHz, the maximum RF bandwidth (BW) is as high as 400MHz, in which a -35dBm modulated in-band (IB) blocker can be present. These impose stringent BW and IB linearity requirements for the baseband amplifiers in the LA-BS receivers. In addition to IB interferences, a -15dBm continuous-wave (CW) out-of-band (OOB) close-in blocker can also be present at 60MHz offset frequency from the passband edges, thus demanding a highly selective RX. Finally, the blocker 1dB compression point (B1textdB) becomes a key parameter for local area co-location applications in which the power of the far-out OOB blocker can be as large as -4dBm.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic
OC5 Project Phase Ib: Validation of Hydrodynamic Loading on a Fixed, Flexible Cylinder for Offshore Wind Applications
No full textAbstractThis paper summarizes the findings from Phase Ib of the Offshore Code Comparison, Collaboration, Continued with Correlation (OC5) project. OC5 is a project run under the International Energy Agency (IEA) Wind Research Task 30, and is focused on validating the tools used for modelling offshore wind systems through the comparison of simulated responses of select offshore wind systems (and components) to physical test data. For Phase Ib of the project, simulated hydrodynamic loads on a flexible cylinder fixed to a sloped bed were validated against test measurements made in the shallow water basin at the Danish Hydraulic Institute (DHI) with support from the Technical University of Denmark (DTU). The first phase of OC5 examined two simple cylinder structures (Phase Ia and Ib) to focus on validation of hydrodynamic models used in the various tools before moving on to more complex offshore wind systems and the associated coupled physics. Verification and validation activities such as these lead to improvement of offshore wind modelling tools, which will enable the development of more innovative and cost-effective offshore wind designs
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