31,367 research outputs found
Twelve. A Poema in a new translation
No full textThe final edited version of this work appears at http://www.russiasgreatwar.orgAleksandr Blok’s (1880-1921) Twelve is a major literary document of Russia’s Bolshevik Revolution of October 1917. More powerfully than any historical text, Blok’s work captures the social chaos, the cultural fragmentation, the aspirations, the fears, the ambiguity, and the ambivalence of this cataclysmic event for the Russian psyche. Maria Carlson prepared this new translation of Blok’s Twelve for the outreach site “Russia’s Great War and Revolution” . The site contains not only this translation, but also extensive annotations to the work, illustrations, and her short essay about the poem.The translation was commissioned for the Russia's Great War & Revolution project: http://www.russiasgreatwar.or
Culture and History Matter: Russia's Search for Identity after the Fall
No full textMaria Carlson, professor and associate chair of Slavic Languages and Literatures at KU, presented the lecture “Culture and History Matter: Russia’s Search for Identity After the Fall” as the 2007 KU faculty speaker in the Hall Center Humanities Lecture Series at 7:30 p.m. on 10 April 2007 in the Woodruff Auditorium, Kansas Union. Carlson teaches Russian culture and intellectual history, 18th and 20th century Russian literature and Russian symbolism. Her publications include a book on Russian theosophy, No Religion Higher than Truth (Princeton Univeristy Press1993). She holds a courtesy appointment in the Department of History and is the 2005 recipient of the American Association of Teachers of Slavic and Eastern European Languages Award for Excellence in Post-Secondary Teaching.Friends of the Hall Center, Hall Center for the Humanitie
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Variable Latency Speculative Han-Carlson Adder
No full textVariable latency adders have been recently proposed in literature. A variable latency adder employs speculation: the exact arithmetic function is replaced with an approximated one that is faster and gives the correct result most of the time, but not always. The approximated adder is augmented with an error detection network that asserts an error signal when speculation fails. Speculative variable latency adders have attracted strong interest thanks to their capability to reduce average delay compared to traditional architectures.
This paper proposes a novel variable latency speculative adder based on Han-Carlson parallel-prefix topology that resulted more effective than variable latency Kogge Stone topology.
The paper describes the stages in which variable latency speculative prefix adders can be subdivided and presents a novel error detection network that reduces error probability compared to previous approaches.
Several variable latency speculative adders, for various operand lengths, using both Han-Carlson and Kogge-Stone topology, have been synthesized using the UMC 65nm library. Obtained results show that proposed variable latency Han Carlson adder outperforms both previously proposed speculative Kogge-Stone architectures and non speculative adders, when high-speed is required. It is also shown that non speculative adders remain the best choice when the speed constraint is relaxed
Interactions between neuroblastoma and the immune system : cellular pathways and mediators
No full textNeuroblastoma (NB) is an embryonal tumor of early childhood arising in tissues of the sympathetic nervous system, such as the adrenal gland and paraspinal ganglia. It is the most common extra-cranial solid tumor of childhood, and 10-20 children are diagnosed with NB each year in Sweden. The overall survival rate is about 70%, but 50% of the children in the high-risk group succumb in spite of intense multimodal therapy. This warrants the search for alternative treatment strategies. One upcoming treatment option is immunotherapy, which represents a specific treatment modality with the possibility of minimizing long-term side effects in survivors.Cellular therapies for NB have previously been discouraged due to the notion that NB is a tumor of low immunogenicity. This thesis demonstrates that differentiating agents alter the immune phenotype of primary NB tumors and cell lines such as to enhance the expression of classical HLA molecules and the adhesion molecule ICAM-1. This was paralleled by an increased ability of differentiated NB cells to bind granzyme B at the cell surface and translated into enhanced killing by natural killer (NK) cells and T-cells. These results argue in favor of differentiation and cellular immunotherapy as a combined auxiliary approach for NB patients (paper I). Furthermore, the work presented in this thesis demonstrates that tumor-non-specific activated cytotoxic T lymphocytes (CTLs) release effector molecules which facilitate immune-mediated recognition of NB. Effector molecules from CTLs upregulated HLA class I, ICAM-1 and Fas at the cell surface and restored the expression and activity of caspase-8 in primary NB tumors and cell lines. This rendered NB cells more susceptible to death receptor-mediated killing (paper II).This thesis also demonstrates that primary human NB samples, representing all genetical subtypes, harbor tumor-infiltrating T-cells which proliferate in situ. Tumor-infiltrating lymphocytes were preferentially CD8+, expressed high levels of the activation marker CD25 and exhibited a phenotype of memory cells. Autologous peripheral blood lymphocytes were exposed to tumor cells in vitro and their production of IFN-γ and TNF-α was increased, while an activated phenotype was obtained. This indicates that human NB cells do not prevent the generation of active T-cell responses (paper III). In the transgenic TH-MYCN mouse model of NB, tumor-associated inflammation was investigated and NB tumor progression was shown to be paralleled by a gradual suppression of intratumoral T-cell responses in favor of immature cells of the innate immune system. Anti-inflammatory treatment with low-dose aspirin displayed a promising efficacy in delaying tumor outgrowth with a concomitant abrogation of an inflammatory switch (paper IV).Taken together, the work presented in this thesis demonstrates that NB can serve as a proper target for cellular immunotherapy. It argues for an early implementation of immunotherapy in clinical protocols, where differentiating agents and/or the attraction of activated CTLs to the NB microenvironment could enhance immune-mediated tumor recognition.List of scientific papersI. Lena-Maria Carlson, Sven Påhlman, Anna De Geer, Per Kogner and Jelena Levitskaya. Differentiation induced by physiological and pharmacological stimuli leads to increased antigenicity of human neuroblastoma cells. Cell Research. 2008, 18:398-411. https://doi.org/10.1038/cr.2008.27 II. Anna De Geer, Lena-Maria Carlson, Per Kogner and Jelena Levitskaya. Soluble factors released by activated cytotoxic T lymphocytes interfere with death receptor pathways in neuroblastoma. Cancer Immunology, Immunotherapy. 2008, 57:731-743. https://doi.org/10.1007/s00262-007-0412-2 III. Lena-Maria Carlson*, Anna De Geer*, Baldur Sveinbjörnsson, Abiel Orrego, Tommy Martinsson, Per Kogner and Jelena Levitskaya. Human neuroblastoma microenvironment supports T-cell activation in tumor-associated lymphocytes. [Manuscript]IV. Lena-Maria Carlson, Agnes Rasmuson, Lova Segerström, Baldur Sveinbjörnsson and Per Kogner. Progressive tumor-associated inflammation as a potential therapeutic target in neuroblastoma. [Manuscript]</p
O curso de licenciatura em educação física da Universidade Federal de Santa Catarina: suas concepções de ensino e de educação física
No full textDissertação (mestrado) - Universidade Federal de Santa Maria. Centro de Educação Fisica e Desporto
Santa Maria di Loreto a Milano: i progetti di Francesco Maria Richino e i "sacri ragionamenti" di Federico Borromeo
No full textFederico Borromeo asked Francesco Maria Richino for some projects for the new church dedicated to Santa Maria di Loreto outside the Porta Orientale in Milan. The author debates the connections between the omely wrote by Federico Borromeo and the plans of the church
Comunicação organizacional na Yahoo!: um modelo polêmico.
No full textResenha do livro: CARLSON, Nicholas. Marissa Mayer: a CEO que revolucionou o Yahoo! Tradução de Maria Silvia Mourão Netto. São Paulo: Benvirá, 2015, 336 p.Resenha
Lifelong pursuit of lace
No full textNewspaper articles from The Coloradoan about the lace collection of Ruth Payne Hellmann, donated to CSU by daughter, Margaret Hellmann. Includes photographs of lace being examined by Linda Carlson
Imagens de Otto Maria Carpeaux: esboço de biografia
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em História, Florianópolis, 2015.Este esboço de biografia procura citar algumas imagens de Otto Maria Carpeaux: construções biográficas de naturezas múltiplas, elaboradas em contextos, por atores e sob condições igualmente díspares. Está constituído a partir de uma visão crítica da História, o que permite que ?outras imagens?, fragmentárias e não monumentais, também tenham espaço. Em diálogo com o princípio da montagem, este esboço apresenta-se em duas partes. Na primeira, Imagens possíveis, estão citadas as imagens elaboradas em vida e post mortem acerca do austríaco-brasileiro que nasceu em Viena em 1900, se exilou no Brasil em 1939 e morreu no Rio de Janeiro, em 1978. Na segunda, Montagens possíveis, apresentam-se duas possibilidades de exercício biográfico: pela leitura alegórica do documentário O velho e o Novo (Otto Maria Carpeaux), entendido como instrumento de intervenção no contexto ditatorial brasileiro e de uma reelaboração biográfica concernentes às suas experiências europeias; e pelo Caderno de imagens críticas, registro dos encontros em Carpeaux pelo meio de imagens críticas produzidas a partir da cesura do presente.Abstract : This biographical sketch attempts to quote some images of Otto Maria Carpeaux: various types of biographical constructions, carried out in different contexts by disparate authors under conditions just as distinct. It stems from a critical view of history, allowing for ?other images? fragmented and non-monumental ? to share the space.In dialogue with the montage principle, this sketch has two parts. The first, Possible Images, quotes the images produced during and after the life of the Austrian-Brazilian, who was born in Vienna in 1900, went to Brazil in exile in 1939 and died in Rio de Janeiro in 1978. The second part, Possible Montages, presents two possibilities of a biographical exercise: through the allegorical reading of documentary O Velho e o Novo (Otto Maria Carpeaux), understood as an instrument of intervention in the Brazilian dictatorship context and as a biographical retelling of the author?s European experiences; and through my Scrapbook of Critical Images, a record of the encounters in Carpeaux through critical images produced from the caesura of the present
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