64 research outputs found
Management of movement disorders in primary care
No full textMovement disorders (MDs), are a spectrum of neurological diseases consisting of motor and non-motor symptoms regarding the dysfunctional motor control circuitry and some parts of the nervous system including the basal ganglia, thalamus, cortex, cerebellum besides peripheral autonomic nervous system. Usually, movement disorders are a clinical syndrome which is a specific movement disorder with some other disorders besides neurological and non-neurological abnormalities. The clinical manifestations that should be considered as MDs are complex and heterogeneous. These conditions include symptoms of motor functions like tremor, myoclonus or dystonia, so-called hyperkinetic movements, problems with cognitive functioning like attention problems, prediction error, and sometimes emotion hyper-responsiveness. It is estimated that more than 500,000 individuals in Europe were affected by rare neurological diseases according to the European Reference Network for Rare Neurological Diseases - ERN-RND. Parkinson's Disease is the most common disease in the large spectrum of neurodegenerative disorders characterized by movement disorder and this affected more than 1 million persons over 55 years old in the United States. In response to the COVID-19 pandemic, movement disorders followed up by all forms of telemedicine usage increased across almost all of the countries in the world. In most countries, the patient's first contact is the primary care physician and it is important to disseminate the knowledge of primary care among movement disorders. It is important to be aware of and be an expert in neurological symptoms for diagnosing rare movement disorders. Due to technological improvements, it is feasible to implement continuing medical education and on-the-job training programs among MDs to exchange information, training, and skill
Management of movement disorders in primary care
No full textMovement disorders (MDs), are a spectrum of neurological diseases consisting of motor and non-motor symptoms regarding the dysfunctional motor control circuitry and some parts of the nervous system including the basal ganglia, thalamus, cortex, cerebellum besides peripheral autonomic nervous system. Usually, movement disorders are a clinical syndrome which is a specific movement disorder with some other disorders besides neurological and non-neurological abnormalities. The clinical manifestations that should be considered as MDs are complex and heterogeneous. These conditions include symptoms of motor functions like tremor, myoclonus or dystonia, so-called hyperkinetic movements, problems with cognitive functioning like attention problems, prediction error, and sometimes emotion hyper-responsiveness. It is estimated that more than 500,000 individuals in Europe were affected by rare neurological diseases according to the European Reference Network for Rare Neurological Diseases - ERN-RND. Parkinson's Disease is the most common disease in the large spectrum of neurodegenerative disorders characterized by movement disorder and this affected more than 1 million persons over 55 years old in the United States. In response to the COVID-19 pandemic, movement disorders followed up by all forms of telemedicine usage increased across almost all of the countries in the world. In most countries, the patient's first contact is the primary care physician and it is important to disseminate the knowledge of primary care among movement disorders. It is important to be aware of and be an expert in neurological symptoms for diagnosing rare movement disorders. Due to technological improvements, it is feasible to implement continuing medical education and on-the-job training programs among MDs to exchange information, training, and skill
Effect of nimesulide against indomethacin- induced oxidative liver damage in rats
No full textIndomethacin is used in the treatment of ankylosing spondylitis, osteoarthritis, tendinitis, and other inflammations. However, it has been reported indomethacin has nephrotoxic, gastrotoxic, and hep-atotoxic effects. The aim of this study is to investigate the effect of nimesulide on indomethacin-induced liver damage in rats biochemically and histopathologically. Experimental animals (21 rats) were divided into 3 groups: the healthy (HG) group receiving distilled water as a solvent, the 25 mg/kg indomethacin administered (IDO) group, and the 50 mg/kg nimesulide + 25 mg/kg indomethacin administered (NIDO) group. Malondialdehyde (MDA), total glutathione (GSH) levels and cyclooxygenase-1 (COX-1), cyclo-oxygenase (COX-2) enzyme activities were determined from liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were also measured in serum. The data obtained in the IDO group were compared with the data obtained from the NIDO and MDA and decreased tGSH levels with indomethacin HG groups. Increased application in liver tissue approached the HG group with nimesulide application, and the difference was found to be insignificant. Nimesulide prevented the decrease in COX -1 and COX-2 levels observed with indomethacin administration. Again, the increase in ALT and AST levels, which increased with indomethacin administration, was prevented by nimesulide. As a result of the histopathological evaluation, it was observed that nimesulide reduced the damage caused by indometha-cin. Nimesulide at 50 mg/kg prevented oxidative liver damage induced with indomethacin at 25 mg/kg. Our results suggest that nimesulide may be useful in the treatment of hepatotoxicity and COX-1 inhibi-tion side effects without suppressing analgesic and anti-inflammatory activity due to indomethacin us
Toprakta oluşturulan tuz stresi koşullarında hümik asit ve hidrojel uygulamasının bazı toprak özellikleri ile bazı fizyolojik bitki parametreleri üzerine etkisi
No full textBuçalışmada farklı tuz stresi koşullarında toprağa uygulanan hümik asit vehidrojelin bazı toprak özellikleri ile fasulye (Phaseolus vulgaris L.)bitkisinin gelişimi ve tuz stresine tepkisi incelenmiştir. Bu amaçla toprağauygulanan farklı (0, 30, 60 ve 120 mM) konsantrasyonlardaki tuzların (CaCl2,CaSO4, MgCl2, MgSO4, NaCl, Na2SO4, KCl, K2SO4) oluşturduğu stres koşullarındahümik asit ve hidrojel (0; %0,05; %0,1) uygulamasının topraktaki tuz stresiniazaltmadaki etkisi, 2kg toprak kullanılarak sera koşullarında tam şansa bağlıbloklar deneme deseninde (8x4x2x3x3=576 saksıda) yürütülmüştür. Canlı bitkidokularında katalaz (CAT), peroksidaz (POD), süperoksitdismutaz (SOD),klorofil, prolin, nitrat, hücre geçirgenliği, yaprak alan indeksi ve tuztolerans indeksi gibi parametreler ile bitki kuru madde miktarı ve bitkimineral içeriği üzerine hümik asit ve hidrojel ilavesinin etkisi incelenmiştir.Deneme sonucunda elde edilen bulgulara göre, farklı tuz stresi koşullarınasahip topraklarda, topakların elektriki iletkenlik (EC), doygunluk yüzdesi(DY), tarla kapasitesi (TK), daimi solma noktası (DSN) ve yarayışlı nemkapasitesi (YNK) gibi özelliklerine hümik asit ve hidrojel uygulamasınınistatistiksel olarak etkili olduğu bulunmuştur. Bitki parametreleri (CAT, POD,SOD, klorofil, prolin, nitrat, hücre geçirgenliği vs.) üzerinde tuz stresiniazaltmada hümük asit ve hidrojeller istatistiksel olarak etkili olmuştur. Bitkigelişimi ve kuru madde miktarını tuz stresi negatif yönde etkilerken, humikasit ve hidrojel uygulaması tuz stresinin negatif etkisini azaltmıştır. Tuzstresini azaltmada en etkili doz %0,1 hidrojel dozudur. Tuz stresininazaltılmasında hem toprak özellikleri hem de bitki parametreleri üzerindehidrojel uygulamalarının, hümik asit uygulamalarından daha etkili olduğubelirlenmiştir. Bu sonuçlara göre, fasulye gibi tuza hassas bitkilerinyetiştirilmesinde, toprakta tuz stresinin azaltılmasında ve toprak nemininbitki tarafından daha etkin kullanımında hidrojel kullanımının daha yararlıolacağı, ancak hidrojellerin pahalı olması nedeniyle, hümik asitin de bu amaçdoğrultusunda kullanılabileceği önerilebilir.</p
Plio-Quaternary extensional tectonics of the Central Anatolian Plateau: A case study from the Tuz Gölü Basin, Turkey
No full textThe Tuz Gölü Basin is the largest sedimentary depression located at the center of the Central Anatolian Plateau, an extensive, low-relief region with elevations of ca. 1 km located between the Pontide and Tauride mountains. Presently, the basin morphology and sedimentation processes are mainly controlled by the extensional Tuz Gölü Fault Zone in the east and the transtensional ?nönü–Eski?ehir Fault System in the west. The purpose of this study is to contribute to the understanding of the Plio-Quaternary deformation history and to refine the timing of the latest extensional phase of the Tuz Gölü Basin. Field observations, kinematic analyses, interpretations of seismic reflection lines, and 40Ar/39Ar dating of a key ignimbrite layer suggest that a regional phase of NNW–SSE to NE–SW contraction ended by 6.81 ± 0.24 Ma and was followed by N–S to NE–SW extension during the Pliocene–Quaternary periods. Based on sedimentological and chronostratigraphic markers, the average vertical displacement rates over the past 5 or 3 Ma with respect to the central part of Tuz Gölü Lake are 0.03 to 0.05 mm/year for the fault system at the western flank of the basin and 0.08 to 0.13 mm/year at the eastern flank. Paleo-shorelines of the Tuz Gölü Lake, vestiges of higher lake levels related to Quaternary climate change, are important strain markers and were formed during Last Glacial Maximum conditions as indicated by a radiocarbon age of 21.8 ± 0.4 ka BP obtained from a stromatolitic crust. Geomorphic observations and deformed lacustrine shorelines suggest that the main strand of the Tuz Gölü Fault Zone straddling the foothills of the ?ereflikoçhisar–Aksaray range has not been active during the Holocene. Instead, deformation appears to have migrated towards the interior of the basin along an offshore fault that runs immediately west of ?ereflikoçhisar Peninsula. This basinward migration of deformation is probably associated with various processes acting at the lithospheric scale, such as plateau uplift and/or microplate extrusion.Geoscience & EngineeringCivil Engineering and Geoscience
Perspectives of Turkish family physicians towards refugee patients and primary health care: A qualitative study
No full textObjectives: The increasing number of refugees in various regions of our country has led to socio-economic issues and challenges in the healthcare system. This study aims to investigate family physicians' perspectives in Turkey regarding refugees' social lives and healthcare services. Design: This is a qualitative cross-sectional study using phenomenological research design. The study was carried out with family physicians in health care centers. Three online focus group interviews were conducted to collect the data. The interviews proceeded with semistructured questions about their perceptions of refugee health and their challenges while working with refugee patients. The research data were descriptively presented and supported by quotes obtained from interviews with the participants. Results: A total of 24 family physicians were reached through three online sessions for data collection. Of the 24 participating family physicians, 10 were men and 14 were women. On average, the physicians had eight years of medical experience, and the average number of registered immigrant populations in the family health units was around 100 patients. After consulting the domain experts, a final determination of 4 different themes was made. These themes were identified as follows: experience, emotions, and thoughts; encountered challenges, and proposed solutions. Conclusions: Family physicians face difficulties adapting to healthcare systems and face challenges in scheduling appointments and accessing advanced medical investigations when seeking hospital services
The role of primary health care in long-term care facilities during the COVID-19 pandemic in 30 European countries : a retrospective descriptive study (Eurodata study)
No full textBackground and aim:Primary health care (PHC) supported long-term care facilities (LTCFs) in attending COVID-19 patients. The aim of this study is to describe the role of PHC in LTCFs in Europe during the early phase of the pandemic.Methods:Retrospective descriptive study from 30 European countries using data from September 2020 collected with an ad hoc semi-structured questionnaire. Related variables are SARS-CoV-2 testing, contact tracing, follow-up, additional testing, and patient care.Results:Twenty-six out of the 30 European countries had PHC involvement in LTCFs during the COVID-19 pandemic. PHC participated in initial medical care in 22 countries, while, in 15, PHC was responsible for SARS-CoV-2 test along with other institutions. Supervision of individuals in isolation was carried out mostly by LTCF staff, but physical examination or symptom's follow-up was performed mainly by PHC.Conclusion:PHC has participated in COVID-19 pandemic assistance in LTCFs in coordination with LTCF staff, public health officers, and hospitals.Peer reviewe
Intımate partner –sexual vıolence and relatıonshıp between depressıon symptoms among collage women A sample from A unıversıty
No full textThe aim of this studywas to identify the prevalence of sexual violence among collage women of Ankara University. The risk factors of intimate violence-sexual version- was investigated, the depression symptoms of the respondents were compared with the history oftheir sexual abuse in the past and in six months. Methods: The screening model was used in the study. A questionnaire consisting three subscales (personal information, determining the sexual violence and depression symptoms) were administered to collage women in the first built university of Turkey. The subscales were Intİmate Partner Violence – Victim Version and Personal Health Questionnaire-9. Both of the scales were validity and reliably in Turkish language. Results: Forty hundred healthy collage women, who were students in Ankara Universityandaccepted to participate were includedin the study.Of the participants,97.3% were single (n = 389) and average age was 20.70 ± 2.12. The average year of the attendance to the collage was %30.8 of them were in her third year. Most of the individuals were grown up in towns by the range of % 81.8 (n=327). Of the individuals 55.8% of them were graduated from Anatolian High Schools (n=223). According to the study, the rate of sexual violence among collage women is %17. It is found that the %17 of the individuals have been sexually violence at least once in their lives. Also, the prevelance of sexual violence in six months is 9% (n=36). It is compared that the mother of collage women has a job and the collage women have more risk of being sexual violence ( p=0.005 ). It is found that the romantic relationships time that collage woman was involved in is another risk factor for sexual violence ( p=0,122 ).The results of logistics regression is attending a science or communication faculty, being a witness to domestic violence, alcohol abuse, substance abuse are risk factors that affect sexual violence. Depression is another issue that is found high among collage women who were sexually abused. Conclusion: In this study, it was demonstrated that there was a positive correlationbetween sexual violence among collage women and alcohol abuse, drug abuse, depression. It should also be emphasized how childhood histories are important. In addition, collage women should be aware of being sexually abused while dating with men.Ankara Üniversitesi'nde öğrenim görmekte olan kadın üniversite öğrencilerinde flört ilişkilerinde cinsel şiddete uğrama prevalansları ile bu kadınlarda cinsel şiddetin bağımsız risk faktörlerini araştırmak, üniversiteye devam etmekte olan kadın öğrencilerin depresyon prevalanslarını ve olası depresyonları ile cinsel şiddete uğrama durumlarını karşılaştırmak amaçlanmıştır. Gereç-yöntem: Çalışmada tarama modeli kullanılmıştır.Araştırma örneklemini oluşturan Ankara Üniversitesinde öğrenim görmekte kadın öğrencilereyerleşke içindeki sosyal alanlarda gönüllülük esası ile anket uygulanmıştır. Anket sosyodemografik bilgilerden, Mağdurların Cinsel Deneyimleri Ölçeği' nden, Hasta Sağlık Anketi-9 formundan oluşmaktaydı. Konunun mahremiyeti sebebiyle anketler kapalı zarf içinde isimsiz olarak büyük bir kutu içinde toplandı.Kullanılan ölçeklerin tümünün Türkçe geçerlilik ve güvenilirliği yapılmıştı. Bulgular: Çalışmaya,katılmayı kabul eden sağlıklı400 kadın üniversite öğrencisi alınmıştır. Katılımcılarınortalama yaşı 20.70 ± 2.12 dur. Üniversiteli olma yıllarına bakıldığında %30,8'inin üçüncü sınıfta olduğu belirlenmiştir (n=134). Katılımcıların %97,3'ü bekar (n=389 ); %2,8'i ise evlidir (n=11). Katılımcıların %18,3'ü şehirde büyümüş olup (n=73) % 81,8'i kırsal bölgeden gelmektedir (n=327). Öğrencilerin en son mezun oldukları lise sorulduğunda % 55,8 ile en sık Anadolu lisesi(n=223), ikinci sıklıkla %21 ile lise (n=84); en az olarak da %0,3 ile imam hatip lisesi (n=1) olduğu belirlenmiştir. Bu verilere göre cinsel şiddet prevalansı %17 olarak bulunmuştur. Öğrencilerin %17'sinin hayatlarında en az bir kez cinsel şiddete maruz kaldıkları tespit edilmiştir.Evli olanların hiçbiri cinsel şiddete maruz kalmamıştır. Son altı ay içinde cinsel şiddete maruz kalan kız öğrenci oranı %9 (n=36)' dir.Kişilerin annelerinin çalışıp çalışmama durumuna göre önceki ve şimdiki cinsel şiddet öyküleri istatiksel olarak anlamlı farklılık göstermekteydi ( p=0.005 ). Cinsel şiddet mağduriyet öyküsü olan kadın öğrencilerden %24'ünün annesi herhangi bir işte çalışıyorken, %13'ü çalışmıyor veya emekli olarak hesaplanmıştır. Flört süresi ile cinsel şiddete uğrama durumu arasında istatiksel olarak anlamlı bir fark bulunmadı ( p=0,122 ). İstatiksel olarak anlamlı olmasa da cinsel şiddete uğrayan kadın öğrencilerin flört ilişkilerini sonlandırma eğiliminde olduğu tespit edildi. Cinsel şiddet öyküsü bulunmayan ancak flörtü olan kadın öğrencilerin flört sürelerinin medianı 11 iken, cinsel şiddet öyküsü bulunan öğrencilerin flört sürelerinin medianı 6 olarak hesaplanmıştır. Lojistik regresyon yapıldığında fen fakültesi ve iletişim fakültesinin cinsel şiddete uğramak açısından riskli olduğu, aile içi şiddete tanık olmanın cinsel şiddete uğramayı 2,5 kat arttırdığını, alkol kullanımın cinsel şiddete uğrama oranını 3,4 kat artırdığını ve madde kullanımının ise 7,5 kat artırdığı hesaplandı. Depresyonun da cinsel şiddete uğrama oranını 2,03 kat artırdığı bulundu. Sonuç: Bu çalışmada, bir üniversite örneklemindeki kadın öğrencilerin cinsel şiddet prevalansının literatürle uyumlu olduğu, genç erişkinlerde depresyon sıklığının literatürle benzer olduğu bulundu. Sigara, alkol ve bağımlılık yapıcı madde kullanımının, ailede şiddete tanık olma öyküsünün, flört edinme ve flörtün zararlı alışkanlıkları olmasının yakın ilişkilerde cinsel şiddete uğrama riskini artırdığı bulunmuştur. Ayrıca, yakın ilişkilerinde cinsel şiddete uğramış kadın öğrencilerin depresyon tanısı alma ihtimalinin normal populasyona göre daha yüksek olduğu saptanmıştır
Investigation of the effects of different applications on salt stress in strawberry
No full textLisansüstü Eğitim Enstitüsü, Bahçe Bitkileri Ana Bilim DalıTuz stresi, çilekte bitki gelişimini, yapısal, fizyolojik, biyokimyasal ve moleküler olarak olumsuz yönde etkileyen önemli bir abiyotik stres çeşididir. Toprakta çözünebilir tuzların miktarı, bitkinin tölerans sınırının üzerine çıktığında tuz stresi başlar. Çilek saçak köklü ve köklerinin toprak içerisinde yüzeysel gelişmesi sebebiyle çevre koşullarından oldukça fazla etkilenmektedir. Dolayısıyla tuz stresi çilek yetiştiriciliğinde önemli bir sorundur. Son yıllarda yağış miktarındaki azalmalar ve yüksek sıcaklıkların tuz stresinin etkilerini daha da artıracağı düşünülmektedir. Bu çalışma, Malatya Turgut Özal Üniversitesi Ziraat Fakültesi Bahçe Bitkileri Bölümüne ait ısıtmasız cam sera şartlarında Albin çilek çeşidiyle saksı denemesi şeklinde, üç tekerrürlü ve her tekerrürde 6 bitki (saksı) olacak şekilde yürütülmüştür. Çalışmada çilek bitkilerine 35 mM tuz uygulaması yapılmıştır. Çalışmada tuz stresi altında yetiştirilen çileklere, sıvı formda solucan gübresi, potasyum silikat ve organik içerikli ticari preperat uygulamaları yapılarak bu uygulamaların tuz stresi üzerine etkileri ortaya konulmaya çalışılmıştır. Tuz stresi altındaki bitkilere yapılan uygulamaların klorofil miktarı, yaprak oransal su içerği, taç yaş ve kuru ağırlığı, yaprak sayısı, kök derinliği ve gövde çapı artarken; membran geçirgenliği, prolin ve lipid peroksidasyon miktarının ise azaldığı tespit edilmiştir.Salt stress is an important type of abiotic stress that adversely affects plant growth in strawberry structurally, physiologically, biochemically and molecularly. Salt stress begins when the amount of soluble salts in the soil exceeds the tolerance limit of the plant. Strawberry is highly affected by environmental conditions due to its fibrous root system and superficial development of its roots in the soil. Therefore, salt stress is an important problem in strawberry cultivation. It is thought that the decrease in precipitation and high temperatures in recent years will further increase the effects of salt stress. This study was carried out in unheated glass greenhouse conditions in Malatya Turgut Özal University, Faculty of Agriculture, Department of Horticulture, as a pot experiment with Albion strawberry variety, with three replications and 6 plants (pot) in each replication. In the experiment, salt dosage of 35 mM was applied to strawberry plants. Liquid vermicompost, potassium silicate and organic-containing commercial preparations were applied to strawberries grown under salt stress, and the effects of these applications on salt stress were tried to be revealed. In the study, it was determined that the applications increased the amount of chlorophyll, the relative water content of the leaves, the fresh and dry weight of plant and roots, the number of leaves, therootdepthandthestemdiameter, and decreased the amount of membrane permeability, proline and lipid peroxidation
Attilâ İlhan’ın Yaraya Tuz Basmak Romanında Kalıp Sözler Üzerine Bir Değerlendirme
No full textThis study is about the formulaic expressions used in Attilâ İlhan's novel Yaraya Tuz Basmak. Turkish vocabulary is formed of idioms, proverbs, reduplications, slang, terms, formulaic expressions, etc. Structures are formed. It is seen that the formulaic expressions within this wide vocabulary of Turkish are just beginning to gain value. Formulaic expressions used in most communication languages are also used in literary works. For this reason, the subject of to what extend and how successfully the formulaic words are handled in Attilâ İlhan's novel Yaraya Tuz Basmak constitutes the universe of this piece. This research was conducted in line with the assumption that the author used formulaic expressions in the Turkish vocabulary in the context of communication language in his work. Formulaic expressions in the work were found by scanning method. It has been observed that 354 formulaic expressions are used in the entire novel. This shows that there is only one formulaic expression per page. Based on this, it can be said that the author successfully uses formulaic words as a means of communication in his novel. With this study, it has been revealed to what extent and in what situations the formulaic expressions, which have an important place in the vocabulary of Turkish, especially in terms of communication language, are used in the novel in questionBu çalışma, Attilâ İlhan’ın Yaraya Tuz Basmak romanında kullanılan kalıp sözler üzerinedir. Türkçenin söz varlığı; deyim, atasözü, ikileme, argo, terim, kalıp sözler vb. yapılardan oluşmaktadır. Türkçenin bu geniş söz varlığı içerisinde yer alan kalıp sözlerin, yeni yeni değer kazanmaya başladığı görülmektedir. Çoğu iletişim dilinde kullanılan kalıp sözler, edebi eserlerde de kullanılmaktadır. Bundan dolayıdır ki Attilâ İlhan’ın Yaraya Tuz Basmak romanında kalıp sözleri ne ölçüde ve ne kadar başarılı kullandığı konusu, bu çalışmanın evrenini oluşturmaktadır. Yazarın, Türkçe söz varlığında bulunan kalıp sözleri eserinde iletişim dili bağlamında kullanmış olma varsayımı doğrultusunda bu araştırmaya yönelinmiştir. Tarama yöntemiyle eserdeki kalıp sözler bulunmuştur. Romanın tamamında, 354 kalıp sözün kullanıldığı görülmüştür. Bu da göstermektedir ki sayfa başına bir kalıp söz düşmektedir. Buradan hareketle yazarın, kalıp sözleri bir iletişim aracı olarak romanında başarılı bir şekilde kullandığı söylenebilir. Bu çalışmayla Türkçenin söz varlığında, özellikle iletişim dili bakımından önemli bir yere sahip olan kalıp sözlerin, söz konusu romanda ne ölçüde ve hangi durumlarda kullanıldığı ortaya konmuştur
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