24 research outputs found
Irritable bowel syndrome and basal serum tryptase: correlation between subtype, severity, and comorbidities. A pilot study
No full text20.500.12530/87855Introduction: the activation of mast cells causes alterations in epithelial and neuromuscular function and is involved in visceral hypersensitivity and dysmotility in gastrointestinal functional disorders.Objectives: primary: to evaluate differences in basal serum tryptase (BST) between patients with irritable bowel syndrome (IBS) and healthy controls. Secondary: BST depending on IBS subtype ( diarrhea: IBS-D; constipation: IBS-C), comorbidities and correlation with IBS severity and quality of life.Material and methods: a prospective control-case study in IBS patients (Rome IV criteria). BST (ImmunoCAP-Phadia, Sweden (R)), IBS Severity Score (IBSSS), pain, bloating and flatulence analogue scales, IBS quality of life (IBSQOL), and patient health status (PHQ-9) were determined. BST is the primary variable to achieve the primary endpoint.Results: thirty-two patients were included, 21 (65.6 %) with IBS-D and 11 (34.4 %) with IBS-C; 32 controls were also included. Mean IBSSSS: 326.6 (+/- 71.4), IBSQOL: 76 (+/- 20.3), and PHQ9: 10.2 (+/- 5.9). BST was 4.8 +/- 2.6 in IBS and 4.7 +/- 2.6 in controls (p = 0.875). There were no differences in BST between IBS subtypes (4.7 +/- 2.9 in IBS-D and 5 +/- 1.8 in IBS-C; p = 0.315) or IBS severity (p = 0.662). However, BST was higher in patients with IBS and extraintestinal comorbidities compared to other patients and controls (p = 0.029). This subgroup also has more severe bloating (p = 0.021). There was no correlation between BST, quality of life (p = 0.9260), and health status (p = 0.3985).Conclusion: BST does not discriminate between IBS patients and controls. However, BST was higher in patients with IBS with extraintestinal comorbidities, which had more severe bloating. This finding is worthy of investigation
Relevance of infections on the outcomes of patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia treated with hypomethylating agents: a cohort study from the GESMD
No full textHypomethylating agent; Infection; Myelodysplastic syndromeAgente hipometilante; Infección; Síndrome mielodisplásicoAgent hipometilant; Infecció; Síndrome mielodisplàsticBackground:
The consequences of infectious toxicity of hypomethylating agents (HMAs) on overall survival (OS) of patients diagnosed with high-risk myeloid neoplasms have not been thoroughly investigated.
Objectives:
We aimed to evaluate whether infectious events (IEs) negatively influenced the results of HMA treatment in a real-world setting.
Design:
Observational study.
Methods:
We obtained data from 412 non-selected consecutive patients from 23 Spanish hospitals who were diagnosed with high-risk myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia and were treated with HMA. HMAs received after chemotherapy or stem cell transplant were excluded. All IEs were recorded. Outcomes included OS, modifications to the pre-planned treatment, incidence and characteristics of IEs, hospitalization, red blood cell transfusions, and factors associated with infection.
Results:
The rate of infection was 1.2 per patient/year. Next-cycle delay (p = 0.001) and hospitalizations (p = 0.001) were significantly influenced by IEs. Transfusion requirements during each cycle were significantly higher after infection compared with cycles without infection (coefficient = 1.55 [95% confidence interval (CI) = 1.26–1.84], p 20% (HR = 1.57 [95% CI = 1.19–2.01], p 9 g/dl (HR = 0.65 [95% CI = 0.51–0.82], p < 0.001) and higher platelet count (HR = 0.997 [95% CI = 0.996–0.998], p = 0.016) protected from it.
Conclusion:
HMA infectious toxicity worsens OS, hinders the adherence to antineoplastic treatment and results in significant morbidity. Preventive strategies are fundamental in vulnerable patients
Multicentre international trial of laparoscopic lavage for Hinchey III acute diverticulitis (LLO Study)
No full textBackground: Laparoscopic lavage was proposed in the 1990s to treat purulent peritonitis in patients with perforated acute diverticulitis. Prospective randomized trials had mixed results. The aim of this study was to determine the success rate of laparoscopic lavage in sepsis control and to identify a group of patients that could potentially benefit from this treatment. Methods: This retrospective multicentre international study included consecutive patients from 24 centres who underwent laparoscopic lavage from 2005 to 2015. Results: A total of 404 patients were included, 231 of whom had Hinchey III acute diverticulitis. Sepsis control was achieved in 172 patients (74·5 per cent), and was associated with lower Mannheim Peritonitis Index score and ASA grade, no evidence of free perforation, absence of extensive adhesiolysis and previous episodes of diverticulitis. The operation was immediately converted to open surgery in 19 patients. Among 212 patients who underwent laparoscopic lavage, the morbidity rate was 33·0 per cent; the reoperation rate was 13·7 per cent and the 30-day mortality rate 1·9 per cent. Twenty-one patients required readmission for early complications, of whom 11 underwent further surgery and one died. Of the 172 patients discharged uneventfully after laparoscopic lavage, a recurrent episode of acute diverticulitis was registered in 46 (26·7 per cent), at a mean of 11 (range 2–108) months. Relapse was associated with younger age, female sex and previous episodes of acute diverticulitis. Conclusion: Laparoscopic lavage showed a high rate of successful sepsis control in selected patients with perforated Hinchey III acute diverticulitis affected by peritonitis, with low rates of operative mortality, reoperation and stoma formation
Evaluation of a Quality Improvement Intervention To Reduce Anastomotic Leak Following Right Colectomy (eagle): Pragmatic, Batched Stepped-Wedge, Cluster-Randomized Trial in 64 Countries
No full textMagill, Laura/0000-0003-2498-8407; Chitul, Andrei/0000-0001-5991-3443; Taha, Mohamed Hassan Ali Ahmed/0000-0001-6503-2239; Soria Aledo, Victoriano/0000-0003-0159-4034; Fiume, Diego/0000-0001-9483-4783; Yonekura, Hiroshi/0000-0003-0523-2997; yadev, IP/0000-0002-5086-6246; ALVAREZ PADILLA, FRANCISCO EMILIANO/0009-0000-8197-3274; Maurya, Ajeet/0000-0002-5845-7236; Mutlu, Arda Ulas/0000-0001-7499-7155; Marino, Fabio/0000-0002-7535-436X; Fernandez-Hevia, Maria/0000-0002-2147-1317; Espin-Basany, Eloy/0000-0002-9139-4548; Rashed, Amier Mohamed/0009-0003-3671-2042; Atanasov, Boyko/0000-0003-3000-681X; Ibrahimli, Arturan/0000-0002-5527-4434; Alvarez-Bautista, Francisco Emmanuel/0000-0003-2645-832X; Elshami, Mohamedraed/0000-0002-9977-0923; Theodoropoulos, Charalampos/0000-0002-7393-1987; Abdou, Khaled/0000-0001-9777-080X; SANLI, AHMET NECATI/0000-0002-1483-8176; Ferrario, Luca/0000-0002-3652-3255; Garcia Botello, Stephanie Anne/0000-0001-6921-4902; Lule, Herman/0000-0002-0647-9716; Colak, Elif/0000-0002-1893-6427; Rey Valcarcel, Cristina/0000-0001-9762-9742; Pantoja Pachajoa, Diana Alejandra/0000-0002-3968-4206; Balaban, Vladimir/0000-0002-7226-4641; Tidjane, Anisse/0000-0002-3264-2441; Duzgun, Ozgul/0000-0001-7214-2276; JIMENEZ-GOMEZ, LUIS MIGUEL/0000-0003-1390-0473; Mastriale, Francesco/0000-0003-3586-2826; Fleres, Francesco/0000-0002-1092-8975; Garzali, Ibrahim Umar/0000-0002-9797-851X; Isik, Ozgen/0000-0002-9541-5035; Paniagua Garcia-Senorans, Marta/0000-0003-2402-4106; Marson, Fernando Augusto Lima/0000-0003-4955-4234; Stijns, Jasper/0000-0002-5256-6167; Mourad, Mohamed/0000-0003-4714-7192; Zayakov, Georgi/0000-0002-8796-8350; Glasbey, James/0000-0001-7688-5018; Arabadzhiev, Angel/0000-0003-2186-3799; KOSTEK, MEHMET/0000-0001-7259-2461; Blanca, Ana/0000-0002-4360-4352; Bozbiyik, Osman/0000-0002-1827-2720; Pizanias, Michail/0000-0002-5270-3555; Waqar, Usama/0000-0002-9447-5810; Karamanliev, Martin/0000-0001-5166-0752; Mariani, Nicolo Maria/0000-0003-4360-187X; Burlov, Nikita/0000-0003-3407-4406; Shudrak, Anatolii/0000-0003-2760-8780; Quintanilha, Rui/0000-0002-5367-4872; KARA, YASIN/0000-0002-9723-1774; , Mikael/0000-0002-5189-2251; Biswas, Jyotirmoy/0000-0001-9357-0448; Garcia Florez, Luis Joaquin/0000-0003-1231-9126; Waledziak, Maciej/0000-0003-4311-9995; Bayhan, Zulfu/0000-0002-7587-7267; Manatakis, Dimitrios K./0000-0002-1263-8488; Sulen, Nina/0000-0002-2012-8090; Sena, Giuseppe/0000-0001-9793-3250; Isaacs Beron, Reinaldo/0000-0002-3539-9985; Minaya Bravo, Ana Maria/0000-0002-7982-5499; Baili, Efstratia/0000-0001-8745-2269; Garcia Urena, Miguel Angel/0000-0002-7356-6211; Gallo, Gaetano/0000-0003-1066-4671; Chowdhury, Sharfuddin/0000-0002-3794-4158; Gribnev, Petar/0000-0001-9459-7095; Palomba, Giuseppe/0000-0003-3954-5166; Bedzhanyan, Arkady/0000-0002-4377-0035; Litvin, Andrey/0000-0002-9330-6513; Baelum, Jens Kristian/0000-0003-0135-2430; fakhradiyev, ildar/0000-0003-0528-3874; Azhar, Najia/0000-0001-6709-4441; Shahu, Juliana/0000-0003-1908-6601; Resendiz Aguilar, Hogla Aridai/0000-0002-3416-2775; Douba, Zain/0000-0001-9662-9492; CHISTHI, MEER/0000-0003-2794-0062; Bisgin, Tayfun/0000-0001-7040-4228; FENNER LYRA JUNIOR, HUMBERTO/0000-0001-8649-802X; Valdes-Hernandez, Javier/0000-0002-0837-8986; Zimmerman, David/0000-0002-0393-9350; Kulimbet, Mukhtar/0000-0003-4399-700X; Triantafyllou, Alexandra/0000-0001-8232-2203; Mantoglu, Baris/0000-0002-2161-3629; Romano, Francesco Maria/0000-0002-9491-748X; Castaldi, Antonio/0000-0003-3084-7942; Bhangu, Aneel/0000-0001-5999-4618; Slavchev, Mihail/0000-0003-4412-7604; Dhar, Puneet/0000-0003-3141-5447; Hamdan, Fatma/0000-0002-0276-1343; Biondo, Santino Antonio/0000-0002-4720-3345; GONULLU, Emre/0000-0001-6391-4414; Perivoliotis, Konstantinos/0000-0002-6622-5734; Tokidis, Evripidis/0000-0001-8594-0007; Negoi, Ionut/0000-0002-6950-9599; Pellino, Gianluca/0000-0002-8322-6421; Elmore, Ugo/0000-0001-9652-1502; Kashchenko, Victor/0000-0002-4958-5850; El Sorogy, Mohamed/0000-0002-5922-3917; Kovacevic, Bojan/0000-0001-6595-337X; Sokolov, Manol/0000-0002-2608-333X; Ulasi, Ikechukwu/0000-0001-7387-2713; Manigrasso, Michele/0000-0001-8204-7942; Metwally, Islam Hany/0000-0002-5981-9614; Bains, Lovenish/0000-0002-8627-0452; Mazzeo, Carmelo/0000-0001-9893-7480; Drozdov, Evgeniy/0000-0003-4157-9744; Perra, Teresa/0000-0001-7032-1289; Akin, Emrah/0000-0003-0224-3834; Ekwesianya, Andrew Chiagozie/0000-0001-5064-681X; Akay, Omer/0000-0002-0824-2077; Jakhar, Subham/0000-0002-1980-3175; Li, Elizabeth/0000-0001-5961-2894; Bintintan, Vasile/0000-0002-1435-6791; BALALIS, DIMITRIOS/0000-0001-8879-2804; Abd-erRazik, Mohammad/0000-0002-8498-9957; Poskus, Tomas/0000-0002-6931-6041; Selvaggi, Lucio/0000-0001-6920-3103; MANDI, DRAGA-MARIA/0000-0002-5070-217X; Curro, Giuseppe/0000-0001-9566-1378; Beznosenko, Andriy/0000-0003-2293-3488; De Deken, Julie/0000-0002-7788-0881; Sarakatsianou, Chamaidi/0000-0002-9509-581X; Ciftci, Ahmet Burak/0000-0002-1814-4008; Egwuonwu, Ochonma Amobi/0000-0001-5978-6392; ozgen, utku/0000-0002-6481-1473; /0000-0003-4645-6655; Dushimova, Zaure/0000-0003-0791-4246; Hamza, Amr/0000-0001-6520-3595; Altintoprak, Fatih/0000-0002-3939-8293; Shehta, Ahmed/0000-0002-9184-8597; Belev, Nikolay/0000-0001-9248-8194; Ballah, Abubakar/0000-0002-7988-5993; Munoz, Jose/0000-0001-9529-6980Background: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods: The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results: A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion: Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov).ESCP; National Institutes of Health Research (NIHR) [NIHR133364] Funding Source: National Institutes of Health Research (NIHR)The EAGLE study was funded by the ESCP. Ethicon provided an unrestricted educational grant to the ESCP which was used in supporting the development of the online education materials. The NIHR Global Health Research Unit on Global Surgery (NIHR133364) provided support, notably in accessing and supporting collaborating teams in low-and middle-income countries. The funders had no role in the design, set-up, running or analysis of this study, or writing of this report. The views expressed are those of the authors and not necessarily those of the ESCP, Ethicon, or NIHR
Incorporating external effects in economic evaluation: The case of smoking
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The aim of this thesis is to explore methods to incorporate external effects on decision making of public health programmes in a UK setting, using smoking cessation as an example. The National Institute for Health and Clinical Excellence (NICE) methodological guidance for evaluating public health programmes is missing the incorporation of external effects. Therefore there is a need for considering their incorporation in such evaluations and to assess what are the appropiate methods to do so. Smoking cessation is an example where epidemiological evidence of external effects exists but has not generally been incorporated into economic evaluation.
This thesis therefore focused in measuring the impact, in terms of costs and QALYs lost, of the incorporation of passive smoking, smoking during pregnancy and transmission of smoking behavior into economic evaluation of smoking cessation programmes previously developed to inform policy. A static Markov model is used to incorporate passive smoking and smoking during pregnancy, whereas transmisison of smoking behaviour is incorporated through a dynamic model.
The findings show that some external effects can be incorporated without a system dynamic model, when this does occur, a static Markov model may be used to account for external effects in economic evaluation. Sometimes, to incorporate external effects, the model needs a change of population. Because smoking cessation interventions are generally highly cost-effective, the incorporation of external effects does not appear to change policy decisions, but there is a clear impact on the magnitude of the ICER. Passive smoking and smoking during pregnancy have higher impact in terms of costs and QALYs lost than transmission of smoking behaviour. Our discussion considers the validity of the methods used; how much the decision making process would be affected considering or not external effects on economic evaluation of smoking cessation interventions; and other valuation approaches for external effects, such as contingent valuation
Identifying and addressing mentorship gaps in European trauma and emergency surgical training. Results from the Young European Society of Trauma and Emergency Surgery (yESTES) mentorship survey
No full textPURPOSE: European training pathways for surgeons dedicated to treating severely injured and critically ill surgical patients lack a standardized approach and are significantly influenced by diverse organizational and cultural backgrounds. This variation extends into the realm of mentorship, a vital component for the holistic development of surgeons beyond mere technical proficiency. Currently, a comprehensive understanding of the mentorship landscape within the European trauma care (visceral or skeletal) and emergency general surgery (EGS) communities is lacking. This study aims to identify within the current mentorship environment prevalent practices, discern existing gaps, and propose structured interventions to enhance mentorship quality and accessibility led by the European Society for Trauma and Emergency Surgery (ESTES). METHODS: Utilizing a structured survey conceived and promoted by the Young section of the European Society of Trauma and Emergency Surgery (yESTES), we collected and analyzed responses from 123 ESTES members (both surgeons in practice and in training) across 20 European countries. The survey focused on mentorship experiences, challenges faced by early-career and female surgeons, the integration of non-technical skills (NTS) in mentorship, and the perceived role of surgical societies in facilitating mentorship. RESULTS: Findings highlighted a substantial mentorship experience gap, with 74% of respondents engaging in mostly informal mentorship, predominantly centered on surgical training. Notably, mentorship among early-career surgeons and trainees was less reported, uncovering a significant early-career gap. Female surgeons, representing a minority within respondents, reported a disproportionately poorer access to mentorship. Moreover, while respondents recognized the importance of NTS, these were inadequately addressed in current mentorship practices. The current mentorship input of surgical societies, like ESTES, is viewed as insufficient, with a call for structured programs and initiatives such as traveling fellowships and remote mentoring. CONCLUSIONS: Our survey underscores critical gaps in the current mentorship landscape for trauma and EGS in Europe, particularly for early-career and female surgeons. A clear need exists for more formalized, inclusive mentorship programs that adequately cover both technical and non-technical skills. ESTES could play a pivotal role in addressing these gaps through structured interventions, fostering a more supportive, inclusive, and well-rounded surgical community
5ᵃ Feria Estudiantil de Ciencias
No full text1. Hipoavitaminosis D3 y cuarentena por SARS-CoV-2: la tormenta perfecta para la desmejoría clínica de Osteonecrosis maxilar por medicamentos / Beltramo, Agostina; Céspedes, Guadalupe; Sanfedele, Agustina. Tutor: Gilligan Gerardo
2. Construcción estudio de algunas variables de riesgo fisiológico y comorbilidad asociadas a SARS-COV-2 / Sagardia Celeste, Peralta Denis, Fernández Santiago. Tutoras: Rhys Karen y Bachmeier Evelin
3. Prevención en acción / La Nasa Ferreiro Jonás, Marenco Yepes Agustin. Tutores: Caciva Ricardo, Mercado Silvia
4. Entrevista virtual sobre enfermedades de la boca y cáncer bucal en contexto actual de Covid-19 / Berns, Agustina; Gauna, Eugenia; Klocker, María Florencia. Tutor: Lazos Jerónimo
5. Telemedicina como herramienta actual / Conti Merlina, Manera Valentina. Tutor: Lazos Jerónimo
6. COVID-19 y enfermedades autoinmunes: una actividad virtual / María Valentina Loza. Tutor: Tomasi Ramiro, Cisneros Mónica
7. Evaluar los conocimientos de la población de la ciudad de Córdoba sobre enfermedad periodontal, su relación con la salud general y la calidad de vida utilizando un cuestionario formulario google, durante la pandemia COVID 19 / Filsinger Andreana. Tutor: Usín María M, Rubio Silvia
8. Entrevista sobre consumo de mate y su relación con el Cáncer Oro faríngeo en tiempos de pandemia / Frete Cavalli, Juan Pablo y Gauna, María Eugenia. Tutor: Lazos Jerónimo
9. COVID-19 de boca en boca / Herrera María J, Martinez Ramello Clarisa, Panza Marianela V, Reyes Florencia M. Tutores: Migueles Goitea María E, Tomasi Ramiro A
10. Confinamiento adolescente e impacto psicológico en tiempos de pandemia. / Aredes Martina, Baravalle Camila, Camacho Paula, Guari Cintia Gabriela, Serdán Jazmín. Tutor: Bono Alejandra
11. COVID-19 y pacientes con cáncer / Costamagna Emilia, Díaz Olmedo Rocío Lourdes, Krasko Mariana, Martínez Cadenas Lucas, Pedano Giuliana. Tutor: Bono Alejandra
12. Pensando y (re) pensando el impacto del aislamiento desde las realidades actuales de los niños / Andrade Martina, Maldonado Leonela, Ramos Ruoroch Ana Luz, Serramia, Candela. Tutor: Bono Alejandra
13. Es posible concluir el aprendizaje de una materia práctica-clínica, mediante cursado virtual? / Gaggioli, Ana Carolina, Garbarino, Brunella, Mendizabal, Lucia, Sánchez Bertoni, Sol, Veci De Haes, María Lourdes. Tutor: Bono, Alejandra
14. Opinión de los médicos sobre la eficacia de la telemedicina y el incremento de su uso durante la cuarentena / Gerbaudo Candela, Segovia Alarcón Augusto Nazareno, Yañez Bruera Ana Mia, Bonino Agustina Belén, Natali Ornella, Ramón Lara Sofía. Tutor: Bono Alejandra
15. Impacto de la pandemia (COVID 19) en el acceso a la atención odontológica / Arceo Lola, Daniel Baltazar, Grangetto Agustina, Izaurralde Valentin, Liverata Rengifo Yesica, Vaca Alejandro. Tutor: Bono Alejandra
16. La importancia de cada gota / Keselman, Tali, Ruiz Luque, Victoria, Salomón Duran, Regean María Constanza, Svetliza, Delfina, Vega Portela, Juan Martin, Visconti Rionda, Selena Giuliana. Tutor: Bono, Alejandra
17. COVID-9, un antes y un después para los trabajadores de la salud en Argentina / Gonzales Lourdes Sofía, Leyria Luciana Carolina, Rosa Florencia, Vergara Yamila Micaela, Yáñez Guadalupe Mailén. Tutor: Bono Alejandra
18. Cambios anímicos en niños argentinos de 7 a 10 años durante la pandemia / Aliaga, Micaela Aylén, Capeans, Pablo Joaquín, Mamani, Roxana Natalia, Ponce, Fátima Aylén, Zurschmitten Moya, Agustín Emilio. Tutor: Murúa, Julia
19. Desempeño de los deportistas de alto rendimiento en confinamiento por Covid-19 / Borghello Ocaña, Agostina, De Pascua, Agostina, Ferrero, Florencia, Gaillez, María Paula, Martinez Paz, Juan Bautista. Tutor: Murúa, Julia
20. El efecto de la cuarentena obligatoria sobre el consumo de sustancias adictivas en jóvenes argentinos / Fernández, Daniela Valentina, Barolo, Agustina, Gómez, Olivera, Rocío Candelaria, Mansilla Juárez, Julián Federico, Berthalet, Tomás. Tutor: Murúa Julia
21. Las consecuencias de la cuarentena en la alimentación y actividad física en Argentina, España y Estados Unidos / Degiovanni Lescano, Bianca, Lamas, Melina Lujan, Rodríguez, Ignacio, Stiepovich, Abril Luana, Valcarcel, Nahir Anais, Zamitto, María luz. Tutor: Murúa, Julia
22. Analizar el ingreso a la Universidad / Cordeiro Macarena, Dalmasso Valentina, Ferreyra Mateo, Miranda Candela, Ibarra Lucrecia del Milagro, Vila Mariel. Tutor: Laura Lagnarini
23. Construcción y reconstrucción de conocimientos en un espacio virtual / Mili Oriana,Carrera Martina,Camacho Rocio, Quinteros Florencia y Vidarte Pilar. Tutor: Laura Lagnarini
24. Evaluar el contexto en pandemia de los comerciantes / Barroso Morata B, Moro C, Venturini F, Villanueva M. Tutor: Laura Lagnarini
25. Determinar los recursos digitales en el aula / Martinich J, Omullane L, Jara N, Bonomo M, Gutierrez M. Tutor: Laura Lagnarini
26. Analizar cómo influye el protocolo de higiene en la vida cotidiana y el desarrollo laboral de los trabajadores / Díaz J. Martínez V. Noel E. Suárez M. Vergara A. Tutor: Lagnarini Laura
27. Aislamiento social transformado en soledad / Abudi Flores Constanza; Dias Bogarin Abigail; Maldonado Flavia; Pundang Yazmin; Villosio Stefanía. Tutor: Lagnarini Laura
28. Los fármacos en tiempos de pandemia / De Haes F. Dendarys Pizarro O. Maltagliati M. Molinero J. Pfister. Tutor: Lagnarini Laura
29. Determinar el estilo de vida de trabajadores argentinos por la pandemia del covid-19 / Pedone Felipe, Baroni Joaquín, Bruno Baldoncini, Cecchini Catalina, Borgogno Julián. Lagnarini Laura
30. El trabajo del odontólogo en tiempo de pandemia / Latorre Agustina, Romero Candela, Falcone Candela Galina, Romero Yesica Daiana, Cardoso Anael Araceli. Tutor: Laura Lagnarini
31. Analizar El Cursado Universitario En Tiempo De Pandemia / Valentina Bagli, Canela Garcia, Ana Juy, Martina Malnis. Tutor: Laura Lagnarini
32. Estudio de los Estado de ánimo de los estudiantes jujeños frente a la suspensión de la cena blanca por el ASPO. / Morales, Aballay Rocio, Ponso Pedro, Ruiz, Hector, Vargas,Marcos , Vignolo,Valentina Selene. Tutor: Laura Lagnarini
33. Preocupaciones referidas por pacientes jóvenes de las provincias de Jujuy, La Rioja, Salta, San Luis y Santa Cruz, para la asistencia a la consulta odontológica en tiempos de pandemia. / Asis Numa Nahir, Fernandez Joaquin Lautaro, Bustos Abi Sabrina, Vargas Mirko Zain Imanol
Dora Martínez y Pablo Gigena.
34. Rendimiento académico en la modalidad de dictado virtual de la asignatura Biología Celular A en los alumnos de la FO-UNC en tiempos de pandemia COVID 19. / Bisotti Noe Maximiliano, Bojanich Lucia Milena, Crotti Ana Paula, López Leonel Agustin, Sombra Milena Priscila. Agustín Zamar, Pablo Gigena
35. Prevalencia de lumbalgia autopercibida por los alumnos de primer año de la Facultad de Odontología de la UNC, en tiempos de pandemia por COVID-19 / Caraballo Marcos, Domínguez Lucía, Estrada María Victoria, Orozco Arcerito Juan Ignacio y Pelinski Sofía. Tutores: Dra. Romina Kohan, Dr. Pablo Gigena
36. Disponibilidad de recursos tecnológicos personales para la educación virtual de estudiantes de 1° y 6° año del nivel secundario de cuatro localidades de la Provincia de Córdoba, durante el aislamiento social, preventivo y obligatorio. / Masino juliana, Alessandri Roma, Bollati Luque Luciana, Guzman Sofía, Murua Melani. Tutores: Gigena Pablo y Lila Susana Cornejo
37. Síntomas de alteraciones temporo articulares autopercibidos en habitantes de dos localidades de la provincia de Córdoba (Pozo del Molle y Villa del Totoral), durante el aislamiento social, preventivo y obligatorio, en tiempo de pandemia Covid-19 / Allende Fonseca, Carla. Basualdo, Lucas Luciano. Bustos, Rocio Ailen. Flores, Lucas. Riachi, Fatima Martina. Tutores: Martínez Florencia y Gigena, Pablo.
38. Estrés académico y hábitos de alimentación en estudiantes universitarios UNC, en tiempos de pandemia en el año 2020 / Avaca Sol Valentina, Cufre María Victoria, Giampaoli María Constanza, Mauro Evelyn Soledad, Lloubel Pedro Lara Lucía. Tutores: Susana Cornejo y Gigena, Pablo
39. Emociones frente al aislamiento social, preventivo y obligatorio en estudiantes de primer año de la carrera de Odontología en la Universidad Nacional de Córdoba 2020 / Casco Juliana Belen, Gigena Lizo Melina Rocio, Guitian Florencia Magali, Loyola Furque Ana Paula, Pintos Bielous Laura Julieta. Tutores: Franchisena Mónica, Pablo Cristian Gigena
40. Rendimiento en parciales y condiciones finales de los estudiantes de la Comisión B1 de la Cátedra de Biología Celular B de la Facultad de Odontología (UNC) durante la pandemia en relación al Ciclo Lectivo 2019 / Chávez Candela, Rey Valentina, González Cecilia, Torres Malena, Villarroel Felipe. Tutores: Barembaum Silvina y Gigena Pablo
41. Identificación de parámetros alimenticios saludables, durante el aislamiento social, preventivo y obligatorio por la pandemia de Covid-19, en estudiantes de primer año que asisten a la Cátedra de Anatomía “A” de la Facultad de Odontología de la UNC / Chialvo, Josefina; Cornejo, Luciana; Gabriel Solorza, María; Ramirez Quijada, Anderson Moisés; Schwab, Delfina. Tutor: María Julia Cambiasso y Pablo Gigena.
42. Herramientas tecnológicas para la enseñanza en estudiantes universitarios de primer año de la facultad de odontología de la unc en tiempos de covid 19 / Bima Giuliana Fátima; Gazzera Ana Laura; Galli Giuliano Valentín; Cabrera Santiago Emmanuel; Ñañez Ludmila Carola. Tutor: Castillo Graciela y Gigena Pablo.
43. Influencia de la cuarentena en el ejercicio físico en estudiantes de la cátedra B de primer año de la carrera de odontología de la UNC del ciclo lectivo 2020 / Jazmin Claribel, Dobler Guillermina, Ivetta Facundo, Sequeria Andrés, Vivas Esteban. Tutor: Rocamundi Maria Raquel, Pablo Cristian Gigena
44. Comparación del estrés académico en alumnos de primer año de la facultad de odontología unc durante el ciclo lectivo 2019 y el 2020 durante el tiempo de aislamiento social, preventivo y obligatorio causado por el SARS-COV-2. / Loser Sofia, María Eugenia Poeta, Porte María Celeste, Lucia Marusich, Agustina Salto Grimaldi. Tutores: Carla Cisternas y Pablo Gigena
45. Motivos de deserción estudiantil expresados por alumnos de la cátedra de Biología celular B de la Facultad de Odontología de la Universidad Nacional de Córdoba, durante el cursado en pandemia mundial por Covid-19” / Martínez Ariel, Ruiz Julieta, Sosa Ariadna, Giraudo Fabricio, Ceballos Federico. Tutor: Martínez Dora y Gigena Pablo
46. Alcance de la difusión de la VIIº campaña de prevención del cáncer bucal, en el marco de la pandemia por COVID-19. / Martínez Bezzato Leonela, Lanz Bertorello Lucia, Luque Jazmín, Oropeza Cubillan Débora Anais y Osorio Carpio Adrián Alexander. Tutores: Pablo Gigena y Natalia Agüero
47. Infecciones de transmisión sexual (ITS) y el grado de conocimiento que poseen los adolescentes de nivel secundario / Cáceres Martina Aimé, Cisneros Nadia Natalia, Murúa Ortiz Rocío, Pistoletti Milagros Candelaria. Tutores: Soto Sabrina, Fontanetti Pablo
48. Adaptación de profesores de la facultad de odontología a la tecnología y virtualidad / Beraldi Delfina, Brunori Tatiana Nicolle, Peve Bueno Stefani, Rivalta Luana, Zürcher Florencia Oriana. Tutores: Adrián Allende y Pablo A. Fontanetti.
49. Adaptación de profesores de la facultad de odontología a la tecnología y virtualidad. / Benito V, Cabrera AV, Canto A, Ramirez DN, Romero F, Tomaselli O. Tutores: Fontanetti PA, Berasategui L, Elías W.
50. Adaptación de profesores de la facultad de odontología a la tecnología y virtualidad. / Castillo Villegas M, D’Uva Hernández L, Han Palacios L, Mela E, Monte J. Tutores: Fontanetti PA, Basanta C, Gorrino R.
51. Nivel de conocimiento que poseen los estudiantes de primer año de las Facultades de Odontología y Arquitectura de la UNC sobre ITS. / Díaz M, Foresto G, Gómez Maldonado V, Storello Montes L, Testa Asnal V, Tutores: Allende A, Fontanetti P.
52. RENDIMIENTO DEPORTIVO A NIVEL PROFESIONAL EN TIEMPOS DE PANDEMIA. / Fernández Pugliese Dolores, Gervasoni Ana Malena, Giménez Pistone Valentina, Molina Constanza, Varela Valentina, Veliz Lobato Agustina. Tutores: Pablo A. Fontanetti, Guadalupe Chaguri.
53. Impacto en el cursado de estomatología de alumnos de 4° de la Facultad de Odontología de la UNC en épocas de COVID-19 / Avaca SA, Díaz EA, Garay G, Nieto C, Olmos D. Tutores: Flores D, Fontanetti PA, Limpitay A
54. La pandemia y su influencia en la deserción de los estudios terciarios en la enseñanza superior / Aguirre AS, Colicheo Del Prado CR, Díaz Antonio AL, Gutiérrez AM, Núñez RC, Tranamil MN. Tutor: Fontanetti PA.
55. Jóvenes adolescentes impulsando emprendimientos en épocas de pandemia como una solución a la crisis y como una oportunidad de desarrollo / Baudino S, Tolaba Perotti C, Corigliani D, Fara Requena R y Chartier Saldivia R. Tutor a cargo: Fontanetti PA
56. Los trastornos alimentarios de los adolescentes y su relación con las redes sociales en el contexto de aislamiento social / Avakian L, Capdevila De Puerta AG, Di Cola B, Gerbaldo Werlen L. Tutor a cargo: Fontanetti PA
57. Enseñar y aprender en tiempos de pandemia; un desafío para padres, alumnos y docentes / Fernández C, Jara A, Raspa VR, Flores Illanes OA, Garcia Tessicino M, Geri Lozano MS. Tutor: Fontanetti, Pablo.
58. Influencia del aislamiento social preventivo y obligatorio (aspo) en el tratamiento y seguimiento de enfermedades preexistentes en los estudiantes de la FO-UNC. / Condorí F. Giolitto G. Moyano CA. Padilla A. Sosa Dulcich N. Tutor: Fontanetti PA
59. Inmunización en tiempos de pandemia: mitos y verdades sobre la vacunación / Vázquez Pellegrini Julia, Fernández Gutiérrez Martina, Santa Andrea Giuliano, Agüero Caballero Federico Gabriel. Tutor: Fontanetti PA
60. Conocimiento de los estudiantes de la Facultad de Odontología de la UNC sobre la violencia en córdoba en tiempo de pandemia / Álvarez NF, Barraza MG, Clua ME, González MA, López AV. Tutor: Fontanetti PA
61. La práctica de ejercicio físico y la salud mental de jóvenes adultos en pandemia. / Fernández AAA, Inostrosa AL, Mercado NMD, Moro LA, Valenzuela AG. Tutor: Fontanetti PA.
62. Aislamiento social y preventivo: ¿cómo afecta a la salud mental de las personas? / Irico AC, Lipari M, Paron P, Pellin F, Ponsetti D, Toledo M. Tutor: Fontanetti PA
63. Análisis y resultados sobre las modalidades evaluativas en instancia virtual / Benito P, Cechetto J, Demarchi M, Ramón casas J, Quelas B, Zapata M. Tutor: Pablo Fontanetti.
64. Efecto de la pandemia en el bienestar de los profesionales de la salud de Argentina. / Bevacqua F; Rada V; De Bairos Moura M; Cuestas C; Vega A; Cabrera C. Tutor: Fontanetti, Pablo.Fil: Actis, Adriana Beatriz. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.Trabajos presentados por alumnos de grado integrantes de equipos de investigación, becarios y ex becariosFil: Actis, Adriana Beatriz. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina
The HLA-B associated transcript 1 (BAT1) expression in human adipose tissue : BAT1 modulation with increasing adiposity and diabetes
No full textObesity and type 2 diabetes (T2DM) are both inflammatory disorders with parallel escalating epidemics. Novel insights provided by the new biology suggest common pathways by which several pathogenic components of obesity affect glucose metabolism and cellular responsiveness to insulin leading eventually to the development of T2DM; inflammation is considered critical for the development of the above metabolic disorders and is directly influenced by weight gain. Adipose tissue (AT), particularly the abdominal fat depot is currently considered source of inflammatory agents that fuel whole body’s low grade inflammatory state. The HLA-B Associated Transcript 1 (BAT1) is a cellular member of the DExD/H-box RNA-helicases with essential role for cellular mRNA export, that also attains anti-inflammatory properties, as it was shown by studies investigating monocytes and T-cell lines. Furthermore, BAT1 polymorphisms were linked to predisposition to immunopathologic disorders including type 1 diabetes. These findings suggest a potential protective role of BAT1 against the obesity-associated lowgrade inflammatory state that contributes to T2DM development. The role of BAT1 in the adipocytes has not been investigated so far. Therefore, this thesis examined BAT1 expression and regulation within specific human AT depots and the adipocyte itself. Initial studies indicated BAT1 expression in ex vivo human AT but also the repressing effect of increasing adiposity and T2DM on BAT 1 expression. Remarkably, there was no difference in BAT1 expression between obese subjects and patients with T2DM indicating that BAT1 becomes suppressed with increasing adiposity and remains suppressed through to the development of T2DM and thereafter; this could in turn reduce the capacity to response to the inflammatory insults. As human AT contains many different types of cells besides adipocytes, including fibroblasts, macrophages, lymphocytes, pre-adipocytes and endothelial cells, some of which actually increase with increasing adiposity (e.g. macrophages and lymphocytes) subsequent studies determined the expression of BAT1 particularly in isolated human primary pre-adipocytes and mature adipocytes; the human pre adipocyte cell line Chub- S7 was used for this purpose. It was shown that BAT1 (mRNA and protein) was expressed in both cell types with maximum expression in mature (lipid accumulating) adipocytes. At the stage of complete maturation, the effects of nutrients and inflammatory factors on BAT1 expression were examined. Both glucose and non-esterified fatty acids (NEFA) were shown to repress BAT 1; these findings were in keeping with the ex vivo data determined in terms of AT from obese and T2DM subjects. Furthermore, these studies indicated a synergistic action of both JNK and NFκB when used in combination to reduce BAT1 expression, indicating interconnectivity between JNK and NFκB pathways, as noted in other human AT studies examining other molecules. Regarding NEFA however, the JNK pathway seemed to mediate its repressing effect on BAT1. These studies also showed that the potent inflammatory agent lipopolysacharide (LPS) also significantly reduced BAT1 expression which was again in keeping with the previous ex vivo AT data since LPS is raised in conditions of metabolic disease. Finally, the investigation of the paracrine influences of leptin and resistin on differentiated primary adipocytes highlighted BAT 1 repression whilst adiponectin appeared to have no significant effect alone to alter BAT 1 expression or inhibit LPS-induced BAT1 repression. Taken together, BAT1 was more susceptible to the repressing effects of nutritional factors (glucose and NEFA) in excess than paracrine inflammatory or antiinflammatory adipokines. The fact that several factors modulate BAT1 expression may suggest that BAT1 represents a first line, non-selective, cellular protective agent, which is therefore influenced by several different factors through common inflammatory pathways. Thus, BAT1 suppression may be an early key event in the pathogenesis of a low chronic inflammatory state. As such BAT1 could represent an important target to manipulate to combat the low chronic inflammatory state observed in both obese and T2DM patients
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.
No full textBACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas
