284 research outputs found
Mis encuentros con Ángel Valbuena Prat
Get PDFThe author remembers how he met Valbuena Prat, so much through his History of Literature as for, later, in a personal way.El autor recuerda cómo conoció a Valbuena Prat, tanto a través de su Historia de la Literatura, como posteriormente de forma personal
Expression pattern diversity and functional conservation between retroposed PRAT genes from drosophila melanogaster and drosophila virilis
No full textGene duplication by retrotransposition duplicates only the coding and untranslated regions of a gene and, thus, biases retroduplicated genes toward having different expression patterns from their parental genes. As such, genes duplicated by retrotransposition are more likely to develop novel expression domains. To explore this idea further, we used the Prat/Prat2 gene duplication in Drosophila as a case study to examine the aftermath of a retrotransposition event that resulted in both the parent and the child gene becoming essential for survival. We used the Gal4-UAS transgene system with EGFP as a reporter to determine the developmental expression patterns of Prat and Prat2 from D. melanogaster (DmPrat and DmPrat2) and Prat from D. virilis (DvPrat). We also tested the functional equivalence of the protein products of DmPrat and DmPrat2. We found that each of the proteins could rescue DmPrat mutations, showing that the requirement for both Prat and Prat2 in Drosophila is not simply due to differences in protein function. In contrast, we found that the DmPrat and DmPrat2 genes have developed nonoverlapping patterns of expression, which correlate with their respective loss-of-function phenotypes. We further found that DvPrat expression is similar to DmPrat during development but differs in adult gonads. Thus, the function of the Prat retrogene has not diverged in the D. melanogaster and D. virilis lineages, while some aspects of its expression pattern have evolved. Finally, we have identified promoter elements, conserved upstream of DmPrat and DvPrat, that this retrogene has acquired to drive its expression
A Spanish Dominican in Modern China: Manuel Prat Pujoldevall and His Mission
No full textThe Catholic missions in early twentieth-century Xiamen represent a complex intersection between Western religious ambitions and the cultural intricacies of Southern Fujian, China. Here, the author examines the missionary work of Manuel Prat Pujoldevall, a Spanish Dominican active in Xiamen, including the Kulangsu International Settlement. Drawing on primary archival records and historical sources, this study assesses Prat’s strategies for governance, cultural adaptation, and resource allocation. The findings reveal that Prat’s pragmatic methods significantly influenced local community dynamics while highlighting the challenges he faced in reconciling religious objectives with shifting political and social conditions. Overall, this paper underscores that the long-term success of cross-cultural missionary work depends on a delicate balance between steadfast religious commitment and culturally adapted management, thereby contributing to broader discussions on the interplay between faith and culture in complicated historical contexts
Classical Judaic position re: the phenomenon of the national and individual (klal-prat) when understanding freedom
No full textУ статті розглядається проблема свободи як умови реалізації "космічного морального
призначення". Виокремлюються індивідуальний та общинний аспекти цього призначення.
Здійснюється аналіз традиційних для іудаїзму підходів до розуміння взаємної зумовленості діади "клаль-прат".The article examines the problem of freedom as the condition for realizing "the cosmic moral destiny". The work identifies
the individual from the communal aspects of this setting. In this analysis, the author achieves understanding the mutual conditionality
of the "klal-prat" dyad
Classical Judaic position re: the phenomenon of the national and individual (klal-prat) when understanding freedom
No full textУ статті розглядається проблема свободи як умови реалізації "космічного морального
призначення". Виокремлюються індивідуальний та общинний аспекти цього призначення.
Здійснюється аналіз традиційних для іудаїзму підходів до розуміння взаємної зумовленості діади "клаль-прат".The article examines the problem of freedom as the condition for realizing "the cosmic moral destiny". The work identifies
the individual from the communal aspects of this setting. In this analysis, the author achieves understanding the mutual conditionality
of the "klal-prat" dyad
Efficiency improvement for multi depot vehicle routing: A case study in cash distribution
No full textThis research is aimed at increasing efficiency of cash distribution from three distribution centers delivered to 377 branches, and 3,699 automatic teller machines by using Cluster First Route Second technique. New concept of assignment problem with time window is presented in this paper for clustering. A Group Sweep Algorithm which is modified from a traditional Sweep Algorithm combined with a nearest neighbor search is also presented as the routing methodology. Application software has developedusing PHP and MySQL. AMPL with CPLEX 10.0 is used to solve the assignment problem and is perfectly embraced underneath the developed application software to allow the user friendly experience. The software allow the flexibility in changing various parameters such as, capacity proportion of each cash distribution center, speed of vehicle, service time at each branch or ATM,time window of each branch or ATM or distribution center, etc. The result shows that 11 vehicle can be reduced resulting in cost reduction in a total amount of US$195,097 annually
Multi Depot Clustering and Vehicle Routing: Case Study in Cash Distribution
No full textThis research propose to decrease the transportation cost of cash distribution from three distributioncenters delivered to 4076 service points by using Cluster First – Route Second technique. Newconcept of assignment problem with time window is presented in this paper for clustering. A GroupSweep Algorithm which is modified from a traditional Sweep Algorithm combined with a nearestneighbor search is also presented as the routing methodology. Application software has developedusing PHP to interface with MySQL and AMPL with CPLEX (10.0) to friendly to used and can flexble tochange various parameters. The result shows that 11 vehicle can be reduced resulting in costreduction in a total amount of 5,852,910 Bath per year
Efficiency improvement for multi depot vehicle routing: A case study in cash distribution
No full textThis research is aimed at increasing efficiency of cash distribution from three distribution centers delivered to 377 branches, and 3,699 automatic teller machines by using Cluster First Route Second technique. New concept of assignment problem with time window is presented in this paper for clustering. A Group Sweep Algorithm which is modified from a traditional Sweep Algorithm combined with a nearest neighbor search is also presented as the routing methodology. Application software has developedusing PHP and MySQL. AMPL with CPLEX 10.0 is used to solve the assignment problem and is perfectly embraced underneath the developed application software to allow the user friendly experience. The software allow the flexibility in changing various parameters such as, capacity proportion of each cash distribution center, speed of vehicle, service time at each branch or ATM,time window of each branch or ATM or distribution center, etc. The result shows that 11 vehicle can be reduced resulting in cost reduction in a total amount of US$195,097 annually
Efficiency Improvement for Multi Depot Vehicle Routing: A Case Study in CashDistribution
No full textThis research is aimed at increasing efficiency of cash distribution from three distributioncenters delivered to 377 branches, and 3,699 automatic teller machines by using Cluster First –Route Second technique. New concept of assignment problem with time window is presented inthis paper for clustering. A Group Sweep Algorithm, which is modified from a traditional SweepAlgorithm combined with a nearest neighbor search, is also presented as the routingmethodology. Application software has developed using PHP and MySQL. AMPL with CPLEX10.0 is used to solve the assignment problem and is perfectly embraced underneath thedeveloped application software to allow the user-friendly experience. The software allow theflexibility in changing various parameters such as, capacity proportion of each cash distributioncenter, speed of vehicle, service time at each branch or ATM, time window of each branch orATM or distribution center, etc. The result shows that 11 vehicle can be reduced resulting incost reduction in a total amount of US$195,097 annually
Multi Depot Clustering and Vehicle Routing: Case Study in Cash Distribution
No full textThis research propose to decrease the transportation cost of cash distribution from three distributioncenters delivered to 4076 service points by using Cluster First – Route Second technique. Newconcept of assignment problem with time window is presented in this paper for clustering. A GroupSweep Algorithm which is modified from a traditional Sweep Algorithm combined with a nearestneighbor search is also presented as the routing methodology. Application software has developedusing PHP to interface with MySQL and AMPL with CPLEX (10.0) to friendly to used and can flexble tochange various parameters. The result shows that 11 vehicle can be reduced resulting in costreduction in a total amount of 5,852,910 Bath per year
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