163,098 research outputs found
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
A Tripartite Post-Recession Rebalancing
No full textIn this latest Advance & Rutgers Report, entitled “A Tripartite Post-Recession Rebalancing,” Dean James W. Hughes and Professor Joseph J. Seneca deliver an incisive assessment of the current market conditions and obstacles in the path of our economic recovery. They offer a statistical cautionary tale that the private and public sector need to hear and acknowledge in order for the economy to make continued progress.This report was published as Issue Paper Number 7, November 2011, in Advance & Rutgers Report
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
The More, the Better? Combining Interventions to Prevent Preterm Birth in Women at Risk: a Systematic Review and Meta-Analysis
No full textAbstract not availableAlexander Jarde, Anne-Mary Lewis-Mikhael, Jodie M. Dodd, Jon Barrett, Shigeru Saito, Joseph Beyene, Sarah D. McDonal
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Studies of hepatitis C virus envelope proteins : interaction with host cells and as targets for the humoral response
No full textHepatitis C virus (HCV) is a major cause of chronic hepatitis infection worldwide. It leads to chronic infection in over 80% in infected patients and may result in liver cirrhosis, hepatocellular carcinoma and autoimmune disorders.The aim of this thesis was to study the functional role of human antibodies to different HCV envelope protein E2 (E2) epitopes, to characterize the interaction of die E2 protein with cell surface molecules, and to study the role of glycosylation of El, the other envelope protein of HCV, in pseudotype virus infectivity. The antibody response to hyper variable region 1 (HVR1) of the E2 protein was studied in five patients infected with the same HCV strain. The patients had different clinical outcomes: three developed chronic infection and two resolved the infection. In this study, an early antibody response to HVR1 correlated with the resolution of the infection but not the E2 antibody response. This suggests that early anti-HVR1 antibodies may play an important role in the clearance of the HCV infection.To further study the nature of protective antibodies to HCV, human monoclonal antibodies against E2 were isolated from a combinatorial Fab library displayed on phages. The library was established from the bone marrow of a chronically HCV infected patient. This patient was infected by HCV of genotype 2b and the recombinant E2 used to select the monoclonal antibodies was of genotype la. Seven distinct antibody clones were further studied. Three clones had high affinity for E2 of genotype lb. All seven clones recognized conformation dependent epitopes, which seem conserved between different genotypes. Four clones expressed as IgG that bound to two or three different E2 epitopes, were NOB-positive for blocking the CD81-E2 interaction in vitro. This suggests the existence of at least two conserved epitopes in E2 that mediate inhibition of the E2-CD81 interaction. An assay for determination of serum antibodies to two of these epitopes was established. No correlation was found between levels of such serum antibodies and the clinical outcome of acute HCV infection.Since there is not an efficient in vitro system for the propagation of HCV, a pseudotype virus using Vesicular Stomatitis Virus (VSV) bearing HCV glycoproteins was developed. The HCV glycoproteins, El and E2, contain ER retention signals in their transmembrane (TM) domain. We generated chimeric El and E2 glycoprotein constructs (E1-G and E2-G, respectively) by replacing their native TM with sequences encoding TM of the G protein of VSV and its cytoplasmic tail, allowing translocation of E1-G or E2-G to the cell surface.Subsequently, a deletion of the HVR1 sequence from E2-G was performed, creating the recombinant protein E2(delta)HVR1-G. Pseudotype virus generated using E2(delta)HVR1-G had a reduced plaquing efficiency (50%) as compared to the E2-G pseudotype virus (with intact HVR1). Cells treated with pronase were not permissive for infection with E2(delta)HVR1-G or E2-G pseudotypes. However, heparinase I treatment of cells reduced only E2-G infectivity (by 40%). but not the infectivity of E2(delta)HVR1. Similarly, plaquing efficiency of E2-G pseudotype viruses could be greatly reduced by addition of heparin, while E2(delta)HVR1 could not.. Our results suggest that the HVR1 of E2 glycoprotein binds to cell surface proteoglycans, and may facilitate virushost interaction. The role of glycosylation of chimeric E1-G for intracellular transport, and infectivity of pseudotype virus was investigated. Surface expressed E1-G exhibited sensitivity to Endo-H treatment similar to full length El, suggesting that additional complex oligosaccarides were not added while E1-G was in transit from ER to cell surface. E1-G's four N-glycosylation sites were mutated separately (aspargine ---- glutamine), or in certain combinations. FACS analysis and confocal microscopy revealed a gradual decrease in cell surface expression of E1-G protein with an increasing number of mutations to the glycosylation sites. VSV pseudotype virus generated from E1-G mutants with only two of the four-glycosylation sites still intact displayed infectivity. Nglycosidase F treatment of pseudotype viruses generated from E1-G or its mutants decreased virus titer by - 35%, and the neutralization activity of patient sera did not significantly alter with N-glycosidase F treated pseudotype virus. Our results suggest that glycosylation may not play a key role for interaction of E1-G ectodomain with the host cell surface for pseudotype entry.In conclusion, several aspects studied in this thesis may provide critical insights into HCV vaccine design and new therapeutic strategies, if any.List of scientific papersI. Allander T, Beyene A, Jacobson SH, Grillner L, Persson MA (1997). "Patients infected with the same hepatitis C virus strain display different kinetics of the isolate-specific antibody response." J Infect Dis 175(1): 26-31 https://pubmed.ncbi.nlm.nih.gov/8985192II. Allander T, Drakenberg K, Beyene A, Rosa D, Abrignani S, Houghton M, Widell A, Grillner L, Persson MA (2000). "Recombinant human monoclonal antibodies against different conformational epitopes of the E2 envelope glycoprotein of hepatitis C virus that inhibit its interaction with CD81. " J Gen Virol 81(Pt 10): 2451-9 https://pubmed.ncbi.nlm.nih.gov/10993933III. Beyene A, Drakenberg K, Grillner L, Allander T, Persson MAA (2004). "The occurence of antibodies against two conserved E2-epitopes in hepatitis C infections with different clinical outcome." (Manuscript)IV. Basu A, Beyene A, Meyer K, Ray R (2004). "The hypervariable region 1 of the E2 glycoprotein of hepatitis C virus binds to glycosaminoglycans, but this binding does not lead to infection in a pseudotype system. " J Virol 78(9): 4478-86 https://pubmed.ncbi.nlm.nih.gov/15078928V. Beyene A, Basu A, Meyer K, Ray R (2004). "Influence of N-linked glycans on intracellular transport of hepatitis C virus E1 chimeric glycoprotein and its role in pseudotype virus infectivity." Virology 324(2): 273-85 https://pubmed.ncbi.nlm.nih.gov/15207615</p
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