2,434 research outputs found
The effect of rhGM-CSF on the proliferation of osteogenic sarcoma cells
No full textRecombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) promotes the growth of a variety of hematopoietic and nonhematopoietic cells, both benign and malignant. There is now evidence that osteoblast-like cells produce GM-CSF and their growth is stimulated by this cytokine in vitro. We have studied the effect of rhGM-CSF on DNA synthesis and cell proliferation in the human osteogenic sarcoma cell lines U-20S, G-292, MG-63, and HOS. RhGM-CSF stimulated a dose-dependent increase in radioactive thymidine incorporation in each of the four cell lines in the presence of serum-free media, and in two cell lines (HOS and U-20S) in the presence of fetal bovine serum (FBS). In addition, rhGM-CSF produced significant increases in cell proliferation in two cell lines (MG-63 and U-20S) in the presence of 2% FBS. These results suggest that GM-CSF may have an important role in the biology of human osteogenic sarcoma cells. The clinical implications of these findings merit further investigation
The worldwide status of phasmids (Insecta: Phasmida) as pests of agriculture and forestry, with a generalised theory of phasmid outbreaks
No full text© 2015 Baker. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://
creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided
you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate
if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/
zero/1.0/) applies to the data made available in this article, unless otherwise stated. The file attached is the published version of the article.NHM Repositor
Ashburn Anstalt v WJ Arnold & Co. Ltd [1989] Ch 1, Court of Appeal
No full textEssential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Ashburn Anstalt v WJ Arnold & Co. Ltd [1989] Ch 1, Court of Appeal. The document also includes supporting commentary from author Aruna Nair.</p
Treść i dynamika objawienia imienia Bożego w Księdze Wyjścia Część I: Analiza narracji Wj 3,16–24,18
No full textThe article addresses the significance of the formulas of the Divine Name: יְהוָה, אֶהְיֶה אֲשֶׁר אֶהְיֶה, and אֶהְיֶה (Exod 3:14–15). Referring to the narrative character of the Book of Exodus and assuming that the ambiguous formulas of the Divine Name in the initial part of the story are elements of a deliberate literary strategy, the author proposes interpreting these formulas using a narrative method. An analysis of two narrative sections of the Book of Exodus (3:16–18:27; 19:1–24:18) reveals that God, whose presence is initially depicted as concealed, is later portrayed, through the presentation of the Name formulas, as manifesting His presence through active intervention. The narrated events, in which YHWH acts on behalf of the Israelites against their enemies (Exod 3:16–18:27) and subsequently leads them to covenantal commitment (Exod 19:1–24:18), present God-YHWH as being. This notion clearly aligns with the declaration embedded in the Name formulas.Artykuł podejmuje zagadnienie znaczenia formuł imienia Bożego: יְהוָה, אֶהְיֶה אֲשֶׁר אֶהְיֶה oraz אֶהְיֶה (Wj 3,14-15). Odwołując się do narracyjnego charakteru Księgi Wyjścia oraz przyjmując założenie, że niejednoznaczne formuły imienia Bożego w początkowej części opowieści stanowią element przemyślanej strategii literackiej, autor proponuje tłumaczenie tych formuł za pomocą metody narratywnej. Przeprowadzona analiza dwóch fragmentów narracji Księgi Wyjścia (3,16–18,27; 19,1–24,18) pozwala zauważyć, iż Bóg, którego obecność na początkowym etapie opowieści zaprezentowana zostaje jako niejawna, wraz z przedstawieniem formuł imienia, ukazany zostaje jako manifestujący swoją obecność w aktywnym działaniu. Opowiedziane wydarzenia, w których JHWH jest podmiotem działającym na rzecz Izraelitów przeciw ich wrogom (Wj 3,16–18,27), a następnie doprowadzającym ich do zawarcia przymierza (Wj 19,1–24,18), ukazują Boga-JHWH jako będącego, co w czytelny sposób koresponduje z deklaracją zawartą w formułach imienia
Generalizations of theq-Morris Constant Term Identity
No full textAbstractTheq-Morris constant term identity gives the constant term in the Laurent polynomial expansion ofΦ≔∏Nl=1(wl;q)a(q/wl;q)b∏1⩽j<k⩽N(wj/wk;q)λ(qwk/wj;q)λ. A conjecture is given for the constant term ofΦwhen multiplied by ∏N0+1⩽j<k⩽N(1−qλ(wj/wk))(1−qλ+1(wk/wj)). This conjecture is proved in the casesa=λ(generalN0,N1,b,λ),a=b=0 (generalN0,N1,λ), andN1=2 (generala,b,λ,N0), whereN0+N1=N. Also, a general identity relatingq-Morris-type constant terms andq-Selberg-type integrals is derived and is used to rewrite the conjecture as aq-Selberg-type integral evaluation
Maternal smoking during pregnancy and appetite control in offspring
No full textAims: Intrauterine exposure to tobacco smoke products has been associated with long-term neurobehavioral effects. Modified appetite control might explain the recently observed association between maternal smoking during pregnancy and obesity in offspring. Methods: Some 10,557 British adults aged 42 years born between 3-9 March 1958 were followed up in a birth cohort study (NCDS). The main outcome measure was self-reported poor appetite at age 42 years and main exposure was maternal smoking during pregnancy. Results: The proportion of offspring with poor appetite increased with maternal smoking during pregnancy: nonsmoking 4.5%; (4.0% - 5.0%), medium smoking 5.6%; (4.5 % - 6.8 %), variable smoking 6.8 %; (4.9 % - 9.1 %) and heavy smoking 7.7 %; (6.3 % - 9.4 %). The unadjusted odds ratios for maternal smoking during pregnancy (ever/never) and poor appetite is 1.49 (1.25 - 1.77) and after adjustment for BMI at 42 years and other potential confounding factors it is 1.22 (1.07 - 1.48). Conclusions: Offspring of mothers who smoked during pregnancy were more likely to report a poor appetite independent of a number of potential confounding factors. Although not in the expected direction, the results suggest maternal smoking during pregnancy may influence appetite perception through a developmental influence or through confounding by social factors
Peace or war with the Transvaal
No full textleyds-70-7659.pdf created from original pamphlet in the WJ Leyds Collection held in the Africana Section of the Stellenbosch University Library and Information Service
Treść i dynamika objawienia imienia Bożego w księdze Wyjścia Część II: Analiza narracji Wj 25,1-40,38
No full textThe article constitutes a continuation of the study addressing the significance of the formulas of the Divine Name: יְהוָה, אֶהְיֶה אֲשֶׁר אֶהְיֶה, and אֶהְיֶה (Exod 3:14–15). The analysis focuses on the subsequent textual material of the Book of Exodus (Exod 25:1–40:38), where YHWH is primarily portrayed as manifesting His presence in the Tabernacle, which He commands to be built as His dwelling place. Applying the method of narrative analysis to the entirety of the narrative material, the author concludes that the primary communicative aim of the book is to present God as being. This concept is signaled in the formulas of the Divine Name and confirmed throughout the narrative representation of the events. The depiction of YHWH’s presence intensifies progressively as the narrative unfolds, with God transitioning from an unknown name and imperceptible presence to being known by the name YHWH and permanently present among the Israelites.Artykuł stanowi kontynuację studium podejmującego temat znaczenia formuł imienia Bożego: יְהוָה, אֶהְיֶה אֲשֶׁר אֶהְיֶה oraz אֶהְיֶה (Wj 3,14-15). Analizie poddana zostaje dalsza partia materiału tekstualnego Księgi Wyjścia (Wj 25,1–40,38), gdzie JHWH zaprezentowany jest przede wszystkim jako manifestujący swoją obecność w przybytku, który nakazuje zbudować na mieszkanie dla siebie. Stosując metodę analizy narratywnej do całości materiału narracyjnego, autor dochodzi do wniosku, że głównym celem komunikacyjnym księgi jest ukazanie Boga jako będącego, co jest sygnalizowane w formułach imienia Bożego i potwierdzone w całej narracyjnej reprezentacji wydarzeń. Prezentacja obecności JHWH staje się coraz bardziej intensywna wraz z postępem narracji, a Bóg przechodzi od nieznanego imienia i niedostrzegalnej obecności do bycia znanym w imieniu JHWH i trwale obecnym pośród Izraelitów
Depth Control for Blind Water Jet Drilling in Bone
No full textAbstract - When surgically drilling blind holes in bone using a Water Jet (WJ), control over the resulting depth is a challenging issue of paramount concern. This thesis was part of a project aimed at replacing the awl and mallet technique used in traditional microfracture procedures with an arthroscopic high-pressure WJ instrument is capable of accurately drilling 2–4 mm deep holes in subchondral bone. The focus of this paper was to develop, analyze and evaluate concepts for ensuring the depthwise accuracy of a microfracturing WJ. Research was performed on both WJ systems and the microfracture procedure, and a thorough problem analysis detailing all concerning requirements and parameters was set up. It was determined that due to the strong non-uniformity of human bone, both spatially and between subjects, a WJ capable of monitoring the depth and implementing a closed-loop control system was needed to ensure safe and accurate drilling. To measure the depth of the hole and allow for feedback control, a flexible Nickel Titanium probe concept was devised and tested. The concept featured a 3D printed nozzle with built-in WJ orifice and depth probe, which could be extended down the hole made by the WJ by an ex-vivo actuator featurimg load and displacement sensors. When the load sensor detected a sudden rise in extension resistance, bottom contact was assumed and the hole depth was calculated based on the displacement of the probe. A proof-of-concept experiment showed the viability of using a flexible probe to measure the depth. Additionally, the algorithm produced for calculating the depth was shown to be robust against the hysteresis and backlash exhibited by the setup. When probing holes with depths of 0, 1, 2, 3, 4 and 5 mm and bore diameters of 1, 1.5, and 2 mm drilled in solid PMMA, the prototype managed an error mean of 0.00 mm with a SD of 0.19 mm. To test the probe in holes shaped as expected during microfracture surgery, a virtual interference experiment was carried out using mCT scans of WJ-drilled bones and simulated probes of varying diameters. Seven scans were probed from 4 different angles each; the results suggested that a probe with a 0.2–0.3 mm diameter was optimal in terms of traversing the hole without blockages and without risking over-penetration. Moreover, this thesis produced recommendations on carrying the project further, towards a fully integrated system capable of drilling accurate blind holes in human bone, in a closed-loop depth-controlled manner.BMEBioMechanical EngineeringMechanical, Maritime and Materials Engineerin
Mojżesz wysłannik Jahwe (Wj 1,1–14,31)
No full textThe Exodus of the Israelites from Egypt was the most important event in the history of the Chosen People. The historical and theological context of the biblical events contained in Exodus 1:1–14:31 was described.The aim of the research became the analysis and interpretation of the theological message contained in the first part of the Exodus recounting the liberation of the Israelites from Egyptian slavery (Exodus 1:1–14:31).In the analysis and exegesis of biblical texts, the intertextual method was used, as well as the historical-critical method over the issue of Moses’ mission.As a result of the study, it can be concluded that: 1) the knowledge of the God of Israel and His intentions is the key theme of the first fifteen chapters of the Exodus. Yahweh is the main protagonist of the events described in the Book of Exodus. He is their author and perpetrator; 2) the theme of the first part of the Exodus is the conflict over whom Israel is to serve; 3) the historical sources do not reflect in their entirety the facts known from the biblical account, for the reason that the Bible is not a historical chronicle, but a record of God’s revelation. Its main task is to convey theological content.The conclusions to be drawn are: 1) the revelation that was to Moses also applies to the Israelites, as well as to the Egyptians. However, the times and the manner of revelation change. God’s words are addressed to everyone, including modern people.The study conducted does not exhaust the subject of Moses’ mission to Israel. It is not a complete characterization of Moses. At the same time, it is necessary to keep in mind the further impact of the message of the Exodus on subsequent generations of Israel, as well as on modern times. The study can become a contribution to further theological reflection on the message of the Exodus.Wyjście Izraelitów z Egiptu było najważniejszym wydarzeniem w historii narodu wybranego. Został opisany kontekst historyczno-teologiczny wydarzeń biblijnych zawartych w Wj 1,1–14,31.Celem badań stała się analiza i interpretacja przesłania teologicznego zawartego w pierwszej części Księgi Wyjścia opowiadającej o wyzwoleniu Izraelitów z niewoli egipskiej (Wj 1,1–14,31).Przy analizie i egzegezie tekstów biblijnych wykorzystano metodę intertekstualną, a także historyczno-krytyczną nad zagadnieniem misji Mojżesza.W wyniku przeprowadzonych badań można stwierdzić, że: 1) poznanie Boga Izraela i Jego zamiarów jest kluczowym tematem pierwszych piętnastu rozdziałów Księgi Wyjścia. Jahwe jest głównym bohaterem wydarzeń opisanych w Księdze Wyjścia. On jest ich sprawcą i autorem; 2) tematem pierwszej części Księgi Wyjścia jest konflikt o to, komu służyć ma Izrael; 3) źródła historyczne nie odzwierciedlają w całości faktów znanych z relacji biblijnej, dlatego że Biblia nie jest kroniką historyczną, lecz zapisem objawienia Bożego. Jej głównym zadaniem jest przekaz treści teologicznej.Wnioski, jakie należy wyciągnąć to: 1) objawienie, które było do Mojżesza, dotyczą także Izraelitów, jak i do Egipcjan. Zmieniają się jednak czasy i sposób objawienia. Słowa Boga skierowane są do wszystkich, również do ludzi współczesnych.Przeprowadzone badania nie wyczerpują tematu misji Mojżesza względem Izraela. Nie jest pełną charakterystyką Mojżesza. Należy przy tym pamiętać o dalszym oddziaływaniu przesłania Księgi Wyjścia na kolejne pokolenia Izraela, a także na czasy współczesne. Badanie mogą stać się przyczynkiem do dalszej refleksji teologicznej nad przesłaniem Księgi Wyjścia
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