369 research outputs found

    Author's gift inscription, in The heather on fire; a tale of the Highland clearances

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    This edition includes an author's gift inscription, "To Mrs John Dillon with sincere esteem Mathilde Blind".Blind, Mathilde, 1841-189

    Gender and pedagogics - Mathilde Vaerting, professor of educational science (Jena, 1923-1933)

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    Der Aufsatz skizziert Leben und Karriere von Mathilde Vaerting (1884-1977), der ersten Professorin für Erziehungswissenschaft in Deutschland, Jena 1923-1933. Ihr Hauptwerk „Neubegründung der Psychologie von Mann und Weib", 1921ff., wird unter Aspekten der Forschungslogik analysiert und auf Konsequenzen für die Erziehungswissenschaft befragt. Ihre Forderung nach Gleichberechtigung und Abwehr jeglicher Herrschaft werden vor dem Hintergrund heutiger feministischer Forderungen diskutiert. Im Anschluß an die Betrachtung der zeitgenössischen Rezeption Mathilde Vaertings wird die Frage aufgeworfen, inwieweit ihr Leben und ihre Karriere die Stellung der Frau in der Wissenschaft während der zwanziger Jahre (und auch später?) spiegeln. (DIPF/Orig.)The author outlines the biography and career of Mathilde Vaerting (1884-1977), the first woman to hold a chair in educational science in Germany. Her major work - Neubegründung der Psychologie von Mannund Weib (1921 fol.) - is analyzed from a methodological point of view and with respect to its implications for educational research. Vaerting\u27s demands for equal rights for women and her rejection of any kind of domination are discussed within the framework of present feminist positions. After having studied how contemporaries reacted to Mathilde Vaerting\u27s writings, the author raises the question of whether Vaerting\u27s life and career reflect the Status of women in science during the 1920s (and later on?). (DIPF/Orig.

    Jouet, dessin animé: des produits dérivés

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    La prochaine séance du séminaire de l'Afreloce à l'ENS, "D'un support à l'autre", aura lieu le samedi 17 mai, de 10h à 13h, en salle Celan. Nous recevrons Myriam Bahuaud (Université Bordeaux 3), qui parlera des produits dérivés à destination des enfants (dessin animé, jouet). Cette séance clôturera le séminaire "D'un support à l'autre" pour l'année 2013-2014. Le séminaire reprendra en octobre 2014 à partir d'une nouvelle thématique et d'un nouveau programme, en cours d'élaboration. École Norm..

    Anti-pneumococcal vaccines in patients at risk of invasive pneumococcal disease and prevention of hyporesponsiveness

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    Deux vaccins sont actuellement disponibles pour la prévention des infections invasives à pneumocoques (IIP) : un vaccin polysaccharidique Pneumovax® (PPV23) et un vaccin conjugué Prevenar13® (PCV13), induisant respectivement une protection contre 23 et 13 sérotypes. Le PPV23 est considéré comme faiblement immunogène, en particulier chez les personnes âgées et les patients immunodéprimés. Le PCV13, en revanche, en raison de la conjugaison à une protéine porteuse, présente l'avantage d'induire une réponse immunitaire T-dépendante, non observée avec le vaccin PPV23. Dans notre travail nous avons donc évalué l'impact des stratégies vaccinales utilisant le PCV13 et le PPV23 sur différentes populations de patients à risque. Dans une première étude, nos résultats sur la vaccination anti-pneumococcique chez des patients atteints de myélome indolent (SMM) ont montré qu'une dose de PCV13 seul, induisait une réponse immune transitoire et de faible persistance. Ces résultats suggéraient l'utilisation d'un schéma vaccinal incluant plusieurs doses de PCV13 ou une association avec le PPV23. Depuis 2013, ce schéma combiné du PCV13 et du PPV23 est le schéma recommandé par la Haute Autorité de Santé en France chez les patients à risque, avec les délais suivants : une dose de PCV13 suivie d'une dose de PPV23, 8 semaines après. Nous avons par la suite étudié cette stratégie vaccinale combinée chez des patients à risque d'IIP : patients atteints de lupus érythémateux systémique (SLE) et patients atteints de polyarthrite rhumatoïde (PR). Nos résultats montrent une immunogénicité à court terme de la stratégie combinée, mais une protection qui ne persiste pas au-delà de deux ans. De façon surprenante, les taux d'anticorps 2 ans après la vaccination, sont inférieurs aux taux pré-vaccinaux pour les patients PR. Cet effet délétère du PPV23 sur la réponse vaccinale induite par le PCV13 est appelé hyporéponse. Ce phénomène, observé chez les patients PR, ne se retrouve pas chez les patients SLE dont la vaccination PPV23 a été effectuée plus à distance du PCV13. Ces résultats suggèrent que le schéma vaccinal plus tardif (c'est-à-dire une vaccination par le PPV23 six mois après le PCV13 au lieu de deux mois) inhiberait le phénomène d'hyporéponse. Dans une troisième partie, nous avons comparé différents schéma vaccinaux modulant les doses des vaccins et les délais d'injection chez des volontaires sains mais également dans un modèle murin d'hyporéponse développé au sein du laboratoire. Notre hypothèse était que la modulation du schéma vaccinal utilisant les 2 vaccins pouvait à la fois induire une protection à long terme et prévenir l'hyporéponse. Nos résultats ont montré que l'utilisation d'une dose diminuée de PPV23 ou l'injection concomitante des deux vaccins n'empêchaient pas l'hyporéponse. En revanche, en allongeant le délai entre le PCV13 et le PPV23, le phénomène d'hyporéponse est limité. Des études cliniques chez les patients à risque d'IIP sont nécessaires afin d'évaluer une stratégie combinée tardive, où le PPV23 serait reçu au moins 6 à 12 mois après le PCV13.Two vaccines are currently available for the prevention of invasive pneumococcal diseases (IPD): a polysaccharide vaccine, Pneumovax® (PPV23) and a conjugate vaccine, Prevenar13® (PCV13), inducing protection against 23 and 13 serotypes, respectively. PPV23 is considered to be weakly immunogenic, particularly in the elderly and immunocompromised patients. PCV13, however, due to the conjugation to a carrier protein, has the advantage of inducing a T-dependent immune response, not observed with PPV23 vaccine. In our work, we therefore evaluated the impact of vaccine strategies using PCV13 and PPV23 on different populations of patients at risk of IPD. In a first study, our results on anti-pneumococcal vaccination in patients with smoldering myeloma (SMM) showed that a single dose of PCV13 induces a transient immune response and long term persistence. These results suggested the use of a vaccination schedule including several doses of PCV13 or association with the PPV23. Since 2013, this combined strategy of PCV13 and PPV23 is recommended by la Haute Autorité de Santé (HAS) for patients at risk, with the following delays: a dose of PCV13 followed by a dose of PPV23, 8 weeks later. We then studied this combined vaccine strategy in patients at risk of IPD: patients with systemic lupus erythematosus (SLE) and patients with rheumatoid arthritis (RA). Our results show a short-term immunogenicity of the combined strategy, but a protection that does not persist beyond two years. Surprisingly, antibody levels 2 years after vaccination are lower than pre-vaccine levels for RA patients. This negative effect of PPV23 on PCV13-induced immune response is called hyporesponsiveness. This phenomenon, observed in RA patients, is not found in SLE patients who received PPV23 vaccination at distance from PCV13. These results suggest that the delayed vaccination schedule (ie, PPV23 vaccination six months after PCV13 instead of two months) could inhibit the hyporesponsiveness phenomenon. In a third study, we compared different vaccine strategies modulating vaccine doses and injection times in healthy volunteers but also in a mouse model of hyporesponsiveness developed in our laboratory. Our hypothesis was that modulation of the vaccine schedule using both vaccines could both induce long-term protection and prevent hyporesponsiveness. Our results showed that decreased doses of PPV23 or concomitant injection of both vaccines did not prevent hyporesponsiveness. However, by increasing the delay between PCV13 and PPV23, the phenomenon of hyporesponsiveness is limited. Clinical studies in patients at risk of IPD are needed to evaluate a delayed combined strategy, where PPV23 would be received at least 6 to 12 months after PCV13

    Vaccination anti-pneumococcique chez les sujets à risque d'infections invasives à pneumocoques et prévention de l'hyporéponse

    No full text
    Two vaccines are currently available for the prevention of invasive pneumococcal diseases (IPD): a polysaccharide vaccine, Pneumovax® (PPV23) and a conjugate vaccine, Prevenar13® (PCV13), inducing protection against 23 and 13 serotypes, respectively. PPV23 is considered to be weakly immunogenic, particularly in the elderly and immunocompromised patients. PCV13, however, due to the conjugation to a carrier protein, has the advantage of inducing a T-dependent immune response, not observed with PPV23 vaccine. In our work, we therefore evaluated the impact of vaccine strategies using PCV13 and PPV23 on different populations of patients at risk of IPD. In a first study, our results on anti-pneumococcal vaccination in patients with smoldering myeloma (SMM) showed that a single dose of PCV13 induces a transient immune response and long term persistence. These results suggested the use of a vaccination schedule including several doses of PCV13 or association with the PPV23. Since 2013, this combined strategy of PCV13 and PPV23 is recommended by la Haute Autorité de Santé (HAS) for patients at risk, with the following delays: a dose of PCV13 followed by a dose of PPV23, 8 weeks later. We then studied this combined vaccine strategy in patients at risk of IPD: patients with systemic lupus erythematosus (SLE) and patients with rheumatoid arthritis (RA). Our results show a short-term immunogenicity of the combined strategy, but a protection that does not persist beyond two years. Surprisingly, antibody levels 2 years after vaccination are lower than pre-vaccine levels for RA patients. This negative effect of PPV23 on PCV13-induced immune response is called hyporesponsiveness. This phenomenon, observed in RA patients, is not found in SLE patients who received PPV23 vaccination at distance from PCV13. These results suggest that the delayed vaccination schedule (ie, PPV23 vaccination six months after PCV13 instead of two months) could inhibit the hyporesponsiveness phenomenon. In a third study, we compared different vaccine strategies modulating vaccine doses and injection times in healthy volunteers but also in a mouse model of hyporesponsiveness developed in our laboratory. Our hypothesis was that modulation of the vaccine schedule using both vaccines could both induce long-term protection and prevent hyporesponsiveness. Our results showed that decreased doses of PPV23 or concomitant injection of both vaccines did not prevent hyporesponsiveness. However, by increasing the delay between PCV13 and PPV23, the phenomenon of hyporesponsiveness is limited. Clinical studies in patients at risk of IPD are needed to evaluate a delayed combined strategy, where PPV23 would be received at least 6 to 12 months after PCV13.Deux vaccins sont actuellement disponibles pour la prévention des infections invasives à pneumocoques (IIP) : un vaccin polysaccharidique Pneumovax® (PPV23) et un vaccin conjugué Prevenar13® (PCV13), induisant respectivement une protection contre 23 et 13 sérotypes. Le PPV23 est considéré comme faiblement immunogène, en particulier chez les personnes âgées et les patients immunodéprimés. Le PCV13, en revanche, en raison de la conjugaison à une protéine porteuse, présente l'avantage d'induire une réponse immunitaire T-dépendante, non observée avec le vaccin PPV23. Dans notre travail nous avons donc évalué l'impact des stratégies vaccinales utilisant le PCV13 et le PPV23 sur différentes populations de patients à risque. Dans une première étude, nos résultats sur la vaccination anti-pneumococcique chez des patients atteints de myélome indolent (SMM) ont montré qu'une dose de PCV13 seul, induisait une réponse immune transitoire et de faible persistance. Ces résultats suggéraient l'utilisation d'un schéma vaccinal incluant plusieurs doses de PCV13 ou une association avec le PPV23. Depuis 2013, ce schéma combiné du PCV13 et du PPV23 est le schéma recommandé par la Haute Autorité de Santé en France chez les patients à risque, avec les délais suivants : une dose de PCV13 suivie d'une dose de PPV23, 8 semaines après. Nous avons par la suite étudié cette stratégie vaccinale combinée chez des patients à risque d'IIP : patients atteints de lupus érythémateux systémique (SLE) et patients atteints de polyarthrite rhumatoïde (PR). Nos résultats montrent une immunogénicité à court terme de la stratégie combinée, mais une protection qui ne persiste pas au-delà de deux ans. De façon surprenante, les taux d'anticorps 2 ans après la vaccination, sont inférieurs aux taux pré-vaccinaux pour les patients PR. Cet effet délétère du PPV23 sur la réponse vaccinale induite par le PCV13 est appelé hyporéponse. Ce phénomène, observé chez les patients PR, ne se retrouve pas chez les patients SLE dont la vaccination PPV23 a été effectuée plus à distance du PCV13. Ces résultats suggèrent que le schéma vaccinal plus tardif (c'est-à-dire une vaccination par le PPV23 six mois après le PCV13 au lieu de deux mois) inhiberait le phénomène d'hyporéponse. Dans une troisième partie, nous avons comparé différents schéma vaccinaux modulant les doses des vaccins et les délais d'injection chez des volontaires sains mais également dans un modèle murin d'hyporéponse développé au sein du laboratoire. Notre hypothèse était que la modulation du schéma vaccinal utilisant les 2 vaccins pouvait à la fois induire une protection à long terme et prévenir l'hyporéponse. Nos résultats ont montré que l'utilisation d'une dose diminuée de PPV23 ou l'injection concomitante des deux vaccins n'empêchaient pas l'hyporéponse. En revanche, en allongeant le délai entre le PCV13 et le PPV23, le phénomène d'hyporéponse est limité. Des études cliniques chez les patients à risque d'IIP sont nécessaires afin d'évaluer une stratégie combinée tardive, où le PPV23 serait reçu au moins 6 à 12 mois après le PCV13

    Effi Briest, Mathilde Möhring. The Development of Theodor Fontane's Female Characters on the Background of Women Emancipation.

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    Theodore Fontane is best known as the author of numerous women's novels, which he wrote in the last ten years of his life. This diploma thesis deals with the topic of women's emancipation on the basis of textual analysis of two latter novels by Theodore Fontane - Effi Briest and Mathilde Möhring. In the first part, it characterizes the topic of the period women's emancipation and puts the author's biography into context. In the second part, it creates the picture of position of the main women characters. The last part describes the personal development of the women characters, on the basis of which I determine how much the women's emancipation reflects in the author's work and what is his attitude towards it. This thesis deals with the interpretation of the author's intent to illustrate the creation of an advanced character like Mathilde Möhring. Key words: Theodore Fontane, women's emancipation, Effi Briest, Mathilde Möhring, development of women's characters, women's novels, interpretation, author's intent, counterpoin

    Effi Briest, Mathilde Möhring. Vývoj postavy žen na pozadí dobové emancipace ve stejnojmenných románech Theodora Fontana.

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    Theodore Fontane is best known as the author of numerous women's novels, which he wrote in the last ten years of his life. This diploma thesis deals with the topic of women's emancipation on the basis of textual analysis of two latter novels by Theodore Fontane - Effi Briest and Mathilde Möhring. In the first part, it characterizes the topic of the period women's emancipation and puts the author's biography into context. In the second part, it creates the picture of position of the main women characters. The last part describes the personal development of the women characters, on the basis of which I determine how much the women's emancipation reflects in the author's work and what is his attitude towards it. This thesis deals with the interpretation of the author's intent to illustrate the creation of an advanced character like Mathilde Möhring. Key words: Theodore Fontane, women's emancipation, Effi Briest, Mathilde Möhring, development of women's characters, women's novels, interpretation, author's intent, counterpointTheodor Fontane je známý především jako autor četných ženských románů, které psal ve svém pokročilém věku. Tato práce zpracovává na základě analýzy textu téma ženské emancipace v jeho dvou pozdějších románech - Manželství Effi Briestové a Mathilda Möhringová. V první části charakterizuje téma dobové ženské emancipace a zasazuje autorovu biografii do kontextu. V druhé části utváří obraz pozice hlavních románových hrdinek. V poslední části je shrnut osobní vývoj ženských postav, na jejímž základě má být zodpovězena otázka, nakolik se ženská emancipace odráží v autorově díle a jaký je jeho postoj k ní. Práce se zároveň zabývá intepretací autorova záměru, který vytvořil postavu pokročilé Mathildy Möhringové, čímž dosáhl kontrapunktu k tomu, co doposud psal. Klíčová slova: Theodor Fontane, ženská emancipace, Effi Briest, Mathilde Möhring, vývoj ženských postav, interpretace, ženské romány, záměr autora, kontrapunktInstitute of Germanic StudiesÚstav germánských studiíFilozofická fakultaFaculty of Art

    Tunisian Politics in France: Long-Distance Activism since the 1980s

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    International audienceWhat does it mean to oppose or support an authoritarian regime from afar? During the years of Ben Ali's dictatorship in Tunisia between 1987 and 2011, diaspora activism played a key role in the developments of post-independence Tunisian politics. Centring this study on long-distance activism in France, where the majority of leftist and Islamist exile groups took refuge, Mathilde Zederman explores how this activism helps to shed new light on Tunisia's political history. Tunisian Politics in France closely explores the interactions and conflicts between different constellations of pro-regime and oppositional actors in France, examining the dynamics of what the author persuasively describes as a 'trans-state space of mobilisation'. In doing so, Zederman draws attention to the constraints and possibilities of long-distance activism. Utilising material gathered from extensive fieldwork in France and Tunisia, this study considers how the evolution of diaspora activism both challenges and reinforces the boundaries of Tunisian politics

    Book review: Photography of protest and community: the radical collectives of the 1970s by Noni Stacey

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    In Photography of Protest and Community: The Radical Collectives of the 1970s, Noni Stacey shows how a 1970s network of London-based photography collectives raised fundamental questions about the politics of photography, the role and responsibilities of photographers in relation to local communities and the uses of photography in the context of social activism. This book is a welcome addition to the expanding field of research on the photography of protest, writes Mathilde Bertrand, contributing to the ongoing documentation of this strong current in British photographic history. If you are interested in this book review, you can read an LSE RB interview with author Dr Noni Stacey. The archive of the Exit Photography Group is held at LSE Library; readers can find out more about the archive and the catalogue. Photography of Protest and Community: The Radical Collectives of the 1970s. Noni Stacey. Lund Humphries. 2020

    Piano music of Mathilde Kralik von Meyrswalden (1857-1944)

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    Thesis (D.M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.This dissertation examines the life and music of Mathilde Kralik von Meyrswalden (1857-1944), with a focus on her piano solo works. This project is intended to bring new light to the forgotten late-romantic Austrian composer. As a pupil of Anton Bruckner, and as a colleague of Gustav Mahler, Kralik's style belongs to the late Romantic period in Vienna. Her musical aesthetics are similar to the styles of Schubert, Liszt, Schumann, Wolf, Mahler, and StraufS; however she had her own unique voice from the beginning of her musical career. Though she was an active composer, performer, and musical figure of her time and was recognized and respected by the Viennese society, her life and work remain greatly understudied. Chapter 1 presents a detailed biographical background of Mathilde Kralik von Meyrswalden. Chapter 2 provides a complete list of work by Mathilde Kralik. Chapter 3 depicts the political background of her time, and then discusses the situation of women as artists in Vienna between 1850 and 19 50. Chapter 4 focuses on two people in her closest circle: her elder brother, Richard Kralik, who was a renowned writer and cultural commentator; and her friend, Alice Scarlates, who was a lecturer for Roman language at the University of Vienna and lived with Kralik in the same house in Wiener Cottage-Viertel for over 30 years. Chapter 5 analyzes her 5 Klavierstiicke- Festmarsh, Triiumerei, Liedchen, Intermezzo, and Gavotte. Chapter 6 continues the analysis with her other major piano solo work: Priiludium, Passacaglia, und Fugato. Lastly, Chapter 7 discusses the public and critical reception of her music, both during her time and in the modern era. The purpose of this project is first, to discover new sounds from a past style; second, to give credit to a serious, prolific, and independent female composer, who bravely chose a career with special challenges in her time and her surroundings; third, to encourage further research and performances of Kralik's works
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