864 research outputs found
Revealing the history of sheep domestication using retrovirus integrations
No full textThe domestication of livestock represented a crucial step in human history. By using endogenous retroviruses as genetic markers, we found that sheep differentiated on the basis of their "retrotype" and morphological traits dispersed across Eurasia and Africa via separate migratory episodes. Relicts of the first migrations include the Mouflon, as well as breeds previously recognized as "primitive" on the basis of their morphology, such as the Orkney, Soay, and the Nordic short-tailed sheep now confined to the periphery of northwest Europe. A later migratory episode, involving sheep with improved production traits, shaped the great majority of present-day breeds. The ability to differentiate genetically primitive sheep from more modern breeds provides valuable insights into the history of sheep domestication
The Sailor\u27s Hymn
No full textA song asking sailors to let God be their captain.https://egrove.olemiss.edu/kgbsides_uk/2211/thumbnail.jp
Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC
No full textOverexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple‐negative subtype (triple‐negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 silencing or overexpression on several aspects of BCa cell growth in vitro. FTH1 silencing promoted cell growth and mammosphere formation, increased c‐MYC expression, and reduced cell sensitivity to chemotherapy. In contrast, FTH1 overexpression inhibited cell growth, decreased c‐MYC expression, and sensitized cancer cells to chemotherapy; silencing of c‐MYC recapitulated the effects of FTH1 overexpression. These findings show for the first time that FTH1 suppresses tumor growth by inhibiting the expression of key oncogenes, such as c‐MYC
THE CHARACTER OR THE AUTHOR? THE BATTLE OF DON QUIXOTE, SCHWEIK AND…, SHAKESPEARE TO THE READER
No full textThe character or the author is a debate that sometimes leans on the power of the reader and sometimes on the power of the author to describe the power of a work. But what distinguishes a work represented by the character, and what can distinguish another work represented by the author? When we say that the work is represented by the character, it is not about the idea thrown by Roland Barthes in his essay ‘the death of the author’, nor from Foucault’s question ‘who cares who speaks’, but about the case when the character manages to ‘walk on its own’, thus transforming him into an explanatory dictionary for phenomena. And, in the case of Don Quixote and Schweik, it all has to do with their ‘ability’ to be judged by the reader without the ‘presence’ of the author. Meanwhile Shakespeare’s characters, often extremely significant to some of the most disturbing phenomena in human life, such as betrayal, the desire for power or the desire for wealth, cannot be separated from the author by the reader. Why? According to the author of this work, this difference between Don Quixote, Schweik and Shakespeare is not due to the small number of characters of Cervantes and Hashek and the large number of those of Shakespeare. But Don Quixote and Schweik’s naive portrayal causes readers to dare to judge these characters by themselves. That is why the biggest misunderstandings happen with Schweik and Don Quixote, whereas Shakespeare is the painter of ‘betrayal’, ‘power’ and ‘wealth’ - three things we owe to the ability of thinking. Therefore, Shakespeare's ‘wisdom of the characters’ needs someone to introduce them. And the reader needs the author in order to believe this ‘character wisdom’.Keywords: Don Quixote, Schweik, Shakespeare, Cervantes, Hashek, characters, readers, the author, etc
Determination of atmospheric parameters of δ Scuti stars
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYAsteroseismology offers an opportunity for examination and detailed understanding of the internal structure of stars by probing their pulsating modes. To obtain reliable results by asteroseismology, accurate atmospheric parameters and metallicities of pulsating stars are required. Hence, in this study we carried out a spectroscopic survey of 8 single delta Scuti stars in detail. The accurate atmospheric parameters (effective temperature, surface gravity), projected rotational velocities and the metallicities of these stars were derived.Turkish Phys SocScientific and Technological Research Council of Turkey (TUBITAK) [2214-A, 2211-C]; Canakkale Onsekiz Mart University Research Foundation [FDK-2016-861]; GACR agency [14-02385S]This work has been partly supported by the Scientific and Technological Research Council of Turkey (TUBITAK) grant numbers 2214-A and 2211-C. FKA thanks to Canakkale Onsekiz Mart University Research Foundation (Project No. FDK-2016-861) for supporting this study. JK thank to the grant 14-02385S of GACR agency. This study is a part of the Ph.D. thesis of FKA. We thank to Dr. G. Catanzaro for putting the code for Balmer lines analysis at our disposal
Editorial
No full textGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Policy Analysi
Upper and Lower Solutions for Second-Order with M-Point Impulsive Boundary Value Problems
No full textIn this paper, we consider a second-order m-point impulsive boundary value problem. By applying the upper and lower solutions method and the Schauder's fixed point theorem, we obtain the existence of at least one positive solution. We also give an example to illustrate our main result.Scientific and Technological Research Council of Turkey [TUBITAK-2211-A]The second author was granted a fellowship by the Scientific and Technological Research Council of Turkey (TUBITAK-2211-A)
Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer
No full textSummary: Estrogen drives breast cancer (BCa) progression by directly activating estrogen receptor α (ERα). However, because of the stochastic nature of gene transcription, it is important to study the estrogen signaling pathway at the single-cell level to fully understand how ERα regulates transcription. Here, we performed single-cell transcriptome analysis on ERα-positive BCa cells following 17β-estradiol stimulation and reconstructed the dynamic estrogen-responsive transcriptional network from discrete time points into a pseudotemporal continuum. Notably, differentially expressed genes show an estrogen-stimulated metabolic switch that favors biosynthesis but reduces estrogen degradation. Moreover, folate-mediated one-carbon metabolism is reprogrammed through the mitochondrial folate pathway and polyamine and purine synthesis are upregulated coordinately. Finally, we show AZIN1 and PPAT are direct ERα targets that are essential for BCa cell survival and growth. In summary, our study highlights the dynamic transcriptional heterogeneity in ERα-positive BCa cells upon estrogen stimulation and uncovers a mechanism of estrogen-mediated metabolic switch. : Zhu et al. perform single-cell RNA-seq to reveal a dynamic transcriptional network in ERα+ breast cancer cells following estrogen stimulation and show that estrogen signaling promotes breast cancer cell survival and growth by mediating a metabolic switch in which folate-mediated one-carbon metabolism is reprogrammed via the mitochondrial folate pathway. Keywords: breast cancer, single-cell RNA sequencing, estrogen receptor α, metabolic switc
Stephen S. Gardner and Cass Anthony Collins Jr.
No full textInscribed on back: Camp Lee, VA. Oct -- Commissioned as the youngest second lieutenants at the recent graduation at the Quartermaster School, Camp Lee, Va. were Stephen S. Gardner of 168 Main Street, Wakefield Mass., and Cass Anthony Collins Jr. of 2211 Wabash Street, Detroit, Michigan. Lauded for outstanding work by Brig. General H.L. Whittaker, Q.M. School Commandant, the two officers are among eight men who were commissioned under 21 years of age, in a record graduating class of 1199 officer candidates.https://egrove.olemiss.edu/gartin_photo/1014/thumbnail.jp
Reviving the rock-salt phases in Ni-rich layered cathodes by mechano-electrochemistry in all-solid-state batteries
No full textThe rock-salt phase (RSP) formed on the surface of Ni-rich layered cathodes in liquid-electrolyte lithium-ion batteries is conceived to be electrochemically "dead". Here we show massive RSP forms in the interior of LiNixMnyCo(1−x-y)O2 (NMC) crystals in sulfide based all solid state batteries (ASSBs), but the RSP remains electrochemically active even after long cycles. The RSP and the layered structure constitute a two-phase mixture, a material architecture that is distinctly different from the RSP in liquid electrolytes. The tensioned layered phase affords an effective percolation channel into which lithium is squeezed out of the RSPs by compressive stress, rendering the RSPs electrochemically active. Consequently, the ASSBs with predominant RSP in the NMC cathode deliver remarkable long cycle life of 4000 cycles at high areal capacity of 4.3 mAh/cm2. Our study unveils distinct mechano-electrochemistry of RSPs in ASSBs that can be harnessed to enable high energy density and durable ASSBs.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.RST/Storage of Electrochemical Energ
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