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    THE DAILY PALO ALTO TIMES "Sail** palo Blto tlimee [-urai-tl eeerr sf'rrmx'ii «-**-** Sund.jr ■ tU-rtioii ^tanite ami High Slr-nr* H W. Slmklns. Publisher. Kntircd as *rc<rn<t clss* tnailsr februsr** 14. taod. at tb* post atket al Pslo Alta, Csli tat mil. atxder tie sd of Co*s*-at at Mir-h S- «•**•• FlUDAY. AIGI'ST t. 1807. HOMELV rilll .*■-*( it'll \ . An employes duty doe* not eSd -with giving his time tot*- s certain number of honra. An employer In- -vests a given sum in wages, and he must make a profit on the money thus expended or he would hsve no Inducement to continue In business. The faithful employe will uae his Drains sa well ss his hands to mske hi- work profitable to his employer. Those who sr* thus faithful ar* car- tain of advancement to the best position-.. Xocal Jots Mlsa Phoebe Shsttuck, of Berkeley, is s guest in tbe home of William Dunsmore. Mlsa Oleta Little, of San Joae. Is the guest this week of Marian and Margaret McLachlan. Mr. and Mra. 0. W. Mosber. with their dsughter Alteen. will spend the next few weeks at Mount Hermon. Mrs. A. Jenson and son Antolne will go to Alma and Los Gatos tomorrow for a few weeks' stay In the mountains. Mrs. J. P. Mills snd children and Mrs. C. J. Moore and children went to Padflc Grove thla morning for ,i few dsys' outing. t D. A. Curry ls down from Yosemlte on .a business trip. He reports everything aa very sctlve In the valley. Miss Lulu Plun*- returned from A prevailing mark of til-breeding; among girl* Is tbo practice of "cut-. ting" or "snubbing" acquaintance*. s»n Mateo Tuesday, accompanied h: without cause, and there never la j mtle Mlaa Dorothy Brown, with a raltd reaaoa for being Ill-man* j whom ah* spent two weeks. wired. To snub others ia to adrer-' D|1 c w -^^ M#J fim|)y hw Um one's self a snob, the most de- j returnad frnm lh(. roa.. ntlA „*. (lt,„ testable of human beings. CQpji(Mr tha,_ ,.eIBnt nora. on t*B,. ! versity svenue and Waverley street Mra. I. M. Calderwood, who bss Mr and Mrs. p. C. Hughes will come trom the city tomorrow to spend a coupl* of days ■ with tbe family of J. A. Dunker. ThU will b* Mr. Hughes' first trip to Palo Alio since his accident last winter. George Mitchell and Mr. Weyler went to Plesssnton this morning to atteiJ the race* tbere. Mr. Eastman, of Palo Alto, has a horse eo- tered in some of the events. Hla horse won second plsce yesterday, making three bests In 2:15, 2:1« snd 2:17. Dr. Hall waa called to the Faber ranch above the Porto]* valley today to attend one of the Sullivan children. The hoy had fallen fi-om a tree and waa unconscious for sn hour or so, but ws* not aerlou* In* Jured. For Rent—-Modern 9-room country home one mile from Palo Alto station. Electric tlgbta and telephone. Address A. L. MeKendry. Box 6», Palo Alto. 1-lw WANTSIr CLASSIFIED. Wsnted—Woman to ssalst with housework. Apply SSO Addison svenue. Il-lw* Wsnted—Young man stenographer and assistant bookkeeper. Address P. O Box Q_9, Palo Alto. jo--t-c Wanted —6 or 7 room furnished cottage—Palo Alto. .Menlo Park or Bed- wood City. Adret*. Box K. Time*, office, jl-iw-* The self-confidence of young men ; 1* admirable—It la n groundwork upon which to build a successful .career. Tat there la a good bit of -ridlciilotjsnea*. in the assumption of ■untried and untrained youth Ihst 'they know more, aod know It better, than men of years snd experi- 9*339, been In Santa (Mara for th* past year, bs* returned snd now occu- Iletter P*y for Soldlen- Waahlogton, August 2.—President Roosevelt has the report of tbe bosrd appointed to recommend changes In the Dick-Cspron bill for au Incresse In pay for the army, navy, marine corps and revenue --litter service. These changes are un- oVi-mimmI to hav* been modeled on the recommendations made last year by Secretary Taft That hit) provided for a 20 per Wanted—Competent woman for general housework In fsmlly of three adults. Inquire 1348 Waverley. B-l.wkly-S-2-c Wanted—By responsible party. from August -2d or September 1st to September 22d. furnished house with three or four bedrooms. Apply 1028 Bryant street. J-lw* *■*■>-- fUDtT FOR RENT FURNISHED--A house of tf rooms, suitable for s Urge fsmlly. club or boarding house. Ssa J. J. Morris. 7-3-_m* pies her residence st S81 Cowper cent fist Incresse In salaries. Sec- street, retary Taft urg->d 20 per cent for Karl Wolff and Harry Dunamorff lieutenants and captains, IB per cant were considerably bruised at tbe Are -n* ronton, lieu tenant-colonels and yesterday and Clarence Jordan ran a* silver through the fleshy part of Children ar* almost Invariably n,« ****• possessed of common sense and William Beatty snd wtl* hsve re- right vlewa. Most grown people turned from a two months' stay at are deficient la these qualities. The Seabrlght and are again located nt wducatlon gained in th* schoola snd tbe home of Mrs. Diamond on Births training of business life tend to ant street cause people to think In grooves Ramsey Moaner and Thomas Mo- and make them narrow-minded and .)>■-- ar* home from an outing at tbe edgoted. characteristics that pre- seaside Mrs. R. H. Mosber and her elude common sens* and charity of son Whlddeo will remain a while thought. Tbe remedy Is for one to longer at Santa Crus. •teach himself to take Interest In dl- Mra 0. Alexander Wright and Teraffled anbjects. The broad- MI-_ -aUf( Wright return*** Tues- astnded psrson 1* like aa oasis tn dar from a m0othg vlalt la Yoeem- th* desert of mankind. Tbe moat common form of the Injustice of parent* to their children ta In not teaching them the value of time and money. The hard-working father who cripple* his finances to keep hla chUdrell la Idle comfort and the fond mother who ruins her health In waiting upon them may be heroic In a way, but tbelr heroism • ta a positive Injury to tbelr children <**'I»P«1 and s discomfort to themaelves. r*t*on Orove. colonela, and 10 per cent for general officers. These figure* are now recommended, and now it Is also proposed to give privates aad noncommissioned officers a 25 per c*nt increase. This would probably n*ce*sttate an Increase of something like IIS,- 000.000 In the appropriations for next year, half of which would b* for the army . The noard making the recommends!tone consisted of Assistant Secretaries Wlnthrop, tressury: N'ewberrj. navy; Alne- worth. wsr. The President will probably approve their report with few changes, snd Adln B. Cspron, representative from Rhode Island, wilt probably amend his bill to conform to thes* recommendations and reintroduce It tn the next congress. For Rent—One 10-room house, one 11-room house, one S-room bungalow aad two housskeeplag rooma; are well located and modern. Apply 63fi Emerson. 2*-lw-c For Rent—Sice furnished rooms for housekeeping. It*. Hamilton avenue. _7-lw* For Rent—Four furnished rooms for housekeeping;. lower, floor: choice; fresh painted, sunny snd clean. Suit to let upstairs. IH Homer avenue. JO-tf For Rant—32.10—Six-room cot- tags and barn on High street, be- j tween University svenue snd Hsmll-1 ton avenue- Apply to 8. W. Charles, Slmklns building, opposite post- j offlce. 10-lw-e For Rent—Two south rooma, furnished; modern conveniences. -172 Channing avenue. 30*lw-* Itu, They report s roost enjoyable trip and are deltghtod with the great wonder lend. Mrs. H. H. Harrington esme over from Llvermoro to vlalt the fsmlly of C. H. Chrlaisosen snd sttend the No ''round tor Pessimism, wedding of h*r nelce, Mis* Helen! The statement of Dun's Review of Chrlstensen She left for her home Trad* that. "There Is none of the this mdrniog. coeto-nary complaint of dullness ln 3. X. McDonnell, with Frsxer A (commercial or Industrial channels, r. has returned froa bis va- i tbst in tbe leading Industries ther* it Santa Crut and Pacific Is tittle idle machinery, steel and Tonng people must b* taught ..if- * **** **** *-**A <*h»° **» were | cotton mill, reporting ******* *^ reliance, else they will make « fstl- **** ****• **** **** ** °****** *** \\*** 'nto..th* **" ***** °th*T ore ot Ufa. ■ ihort ***** ' '*» C. L Bryant has leased the resl- FVtr Every Woman. "Jdence at ■>*.& High surest. Mr. Bry- The special summer number of "*}.*ii ta a teacher In the San Joaquin Style and American Dressmaker Is valley. Mrs. Bryant aad daughters will conduct the residence as *-| rooming house. Mr*. I»uls Benolt and Mrs. Mat-] tie Fenton will leave tomorrow for ] ^.^p*, tho letter's home In YoIoj Mrs. ,T ** Benolt will remsln two or three j weeks In tha Sacramento valley via- '•***• Ring old friends, this Mrs. F. J. Smallpage and her ann I-afayette I. Smallpage will go south tomorrow for a three weeka' trip. 2 new mod. house*, t and 7 rooms: gas. electricity. Ressonabls. See owner. A. W. Bell, ill Homer sve. 2t>-w-tt ronMli For Sale—At a bargain, or will rent to responsible party, new six- room modern house, partly furnished: pantry, bath, basement, coal | and gas rang**. Inquire 808 Fulton street 2-lm-c ready. There are still more improvements to be found In thia Issue. The article On "Canning and Pre- aervlng," hy Lily Haxworth Wallace, In both timely and Instructive, ai well as Interesting. A new aerie* of article* on Irology" has been begun tn beautiful number. There Is also s most valuable ar UcJa on "Th* Care of Children." There 1. the usual stunning array Mr ****"•****. ***'** * *** *** rot design, for dress*, snd coetumes ,U*nt ** 5tanford' **" ****** lB tlm* lor women and children. for *** op*nln« of *** ********* A copy of the July issue will be Tbe many friends of C. H. Qard matted free to any address. ner. one of the former owners of Subscription prlre, |1 a year. Send the Fair store, will be pleased to your name aad address for sample learn that be has found a favorable branches." should be reassuring ss to the future of commerce and trade. As a matter of fact, the money scar- clly In this country is not due [n g [depression, but to tbe expansion of trade. So long as consumption continues on sn extensive scale snd there ts no failure of crops, the prosperity of the country ts -•■■»*»- assured. -Oakland Rnqulr- For Sale—Fine •array. Rvnepe's barn. Call Dr. It-tf copy to Style and American Dm maker, 31-28 East Twenty-flr*t New Tork. location at Santa Barbara and hss gone into the mercantile buslneaa tbere. • ■" ' The funeral of Augustus Fischer Ml- Marker*. School _,„ j^ ,*.,,, fcftaj,re0OB |n th* mOT- Iteopena Monday. August l**th. at • tuary chapel at Alta Meu cemetery. tba new building, Center avenu* snd The services wer* conducted by Katharine street,-four blocks north Rer. Walter Hays and the remains Interred tn a beautiful lot selected by his friends. Charles Duncan, a former well- known student, arrived yesterday to i visit his sister. Mis* Duncan He avenue snd Waverley street. * After, Wi,nt *o pacific Grove today. Ra August 1st Mia* Marker may bs cob- will return to New Tork la a short salted dally at ber offlc* In th* new! ****** ****** >♦ ts i**nnanenlly en- buUdlag. ! ***** ln ********* .. ■■.--. — j X. F. Dyer and family will leave tomorrow for Snlann, Mr. Dyer having been made principal of the Ar- mijo Htgh School there. The family has been nere two years. Mr. Dyer secured his master's degree from Stanford Isst spring Robert Haitett, formerly associated with Eraser A Company, came up from Santa Crus thts week on a buatnesa trip and spent a night wtth friends. The coast air evidently agree* with Mr. Haxlett. aa he Is looking the picture of health. Trom ths "ad of the Wsvsrley csr line, l-f .tl th* sidewalks are finished, a bus will convey pupils to aad from the school, from Untverslt) -*•*-%-. 9t*0t*aem9m amem >>***»•*>♦'**•*» I M. H. Bille ' y Landscape Gardener Phon* Bio* 131 Tr-ssa. Shrubs. Plants aad Hh-nrt Welch! Sharks. A crusade has been commenced In New York against grocers and others in Ihe habit of ualng fraudulent weights and measure*. The state sealer of weight* and measures visited twenty grocer)' ator** In Albany and lQ nearly every place found th* measure* deficient It la Charged that ther* are butcher shop* In New V.-ik In which the comp*naatIon of employes is based on their ability to defraud the customer by giving short weight. New York ts not the only place where such Iniquities ar* practiced. We have our share of the abuse* here and tt ought to be pat an end to by the authorities — Chronicle. For Sale—Horse, buggy and harness, tnqulre 076 Hamilton avenue, tt-tt* Lsrgs lots, low price, high ground, northwest of university. Inducements to home builders. For S. F. commuters, bargains near Fair Osks and Menlo. In Palo Alto, down-town house, fine Investment. 1-S cash; sl- so srasll houses, eaay payments like rant, snd low-prlc* lots. A. W. Bell. .'.32 Homer sve. 3r"-w-tf For Sale—House t> rooms, bath, barn 42x33 ft: bouse 3 rooms, store soom, waxon shed, windmill and tank water piped over ranch, under good fence: 14 bogs, 3 horses. 1 milch cow, 300 chickens, 50 pigeons, 3 wagons, spring wagon, breaker cart; 6 acre, land cheap for cash if taken In <0 days- Addrsss Box ST. Palo Atto. Cal. J»-3w-c For Sale.—Jersey snd Durham hull (natural born Mute-I I t-_ year Call at -even, mornings or evenings. 558 Forest avenue. Jt-tf A Desirable Country Home Four |4| acres land, a new shingled house, six rooms, , floored attic, cement cellar, all modern improvements; * good barn; within three miles of Palo Alto; fine views, best of soil and climate. An ideal place. Price 6,500. Palo Alto Realty Co. JOHN F. BTXBEE AND B. F. HALL. Managers. Pslo Alto, Santa Clsrs Connty, Cnllforais. : Sing a song of gladness, When all is rest and ease, With not a trace of sadness, A chance which only one can seize By using a Gas Range! Palo Alto Gas Company 5.7 HK1M ST. PHONE MAIN 62 A. D. WILLIAMS FIKHT-rU-flS SHOE HHIMNO Stand at -I •>•! - CIGAK STORK. 1-rl Uaim.lt, A„. ♦ * \ If youhavetried | the Rest * * j Now get the Best \ sB*rmc MACHINE. aou-m auaiNO, uiouojuh. S a.vc Money STRONGEST CUARAlCrEX. Nation*! Sewing Machine Co, SAM FRANCISCO. CAU Pac rvuy at LOOT. Witty J onrn*l(*.m, .i.--i-i.ii A. Rlis. ths author and journalist. w« talktn*; about-witty newspaper hesdlln-,*. "As witty a headline as I know." Mid he. "was written by a youth of is m i. Ssn Frsnclsei- n«wspsp*r -*r- fle*. There was ■ bill to prohibit th* sale of alcoholic drlnjks within fonr miles of the l*nlv«rsity of California, and this bill the youth headed: '* 'An Act to Promote Ped-wtrfan- Um Anionic Onr Students.* "—Ex For Sale—At s bargain, a sood home. See owner, tit Chsnnlns tvenue. 8-ltf t-nw WsjEe- the Casse. There appear* to be a dearth of female help In canneries this season, so report eoines from several ennnerie* In this county, tneludtn-c th* one here. Why u thla* It is surely quite unusual.—Lo* Oatos Mail. ••ads Rip*rl*n-*sd man for £ sll hmnehsa of work Contract f f Or day work. Rsaldsnos, 170 Wsvsrlsy 8t. ** PALO ALTt>. CAIa. SM'*-t-t4*V<«--i*i,l«V4«i4,-l<l*J lleware of l*lr.*» aad Si-rVne*.**. Get wis*, have your chimney* .ember* of the I. O. P. Club, j rlesned before you burn your house nn --r-tanliRtlOQ of boys, will be en- down: have your water tank cleaned tertstned this evenlb*- r*v W**srtt*f: to prevent fevers and sickness at Ol«sley at his home. 45** Homer1 home. Chimney sweep will only re- nwnue. The younit people nre an-j main a few days more next week. Udpatln* a pleasant tlm*. with: Address W. Huey. Hor 909. Palo ■tames snd refreshments. 'Alto. 1-lt" , I, For Sale—A No. 1 shop-made business wa*to«, al*o a rosd wss-on with two seats. 616 Chsnnlng ave- n«e 1-tf For Sal*—Oood red ost bay. Ad- dre** A. l_ MeKendry. Box <t. Palo Alto. 1-lw For Sale—Very chsap If taken al once: house of seven rooms; lot SOx I ISO. Call or addrees tbe owner, SSO Cowper street. Palo Alto. Cal. twf-.-lt* For Sole-—Two extension dfnins; tsbles. used short time: one and a half doaen dining room chair*. Inquire 133 Melville. Rod Sf. 17*8-1. wjkly. t-t-c l'. * ■!. - * for Ssle. Nice Crawford peaches. Prop card ot call on J. F. Clark, four mile* south of Ssn Frsnclsco rosd. Will deliver. Address Mountain View. tl-tw* The D*ily Times—10c a w****k. Last—Wallet ronUIntns railroad ticket and addi-*****. Return to tbts other Reward 1-lt* MiM*fct,r. *. *!«-•: 11 Furnltur* bought snd sold by W. F Peon*bak*r. 538 Emerson str**t Pbone Whits 487. is-tf The Fundamental Principles in the building of the vose Piano 1. The scientific production of each separate part: 2. The skilful combination of all the parts. The result is Vox Quality. BENJ. CURTAZ S SON, MU Taa Has Ansasc Saa r-aadaco, CaL ,,,.,...«,. Root Beer *> st oar Hod* FowntaJn. None * I "Just sa p*od" X X Stanford Pharmacy 1 H F. * 11 \M't.i:k. t J 117 VnlTershy Av*., cor. CTreie ♦ aaa earn ea-a a 44444444*444 . mmm II Tb* only branch in Palo Alto of, ths F. Thomas Parisian Dy* Works, j 37 Tenth street. San Francisco. U st "**•» Cal*-*ralty av*nu*. at th* Thrss Llttl* Tailor*. I. J. Dloom manager Phons mark lu. • *-ett*rw*i*a a-__*> ! whotsT-asrt-ne iw-i PtvoM* Fsli-r -ft rv... atmtm or Ssllowtj * ith.*-).*-. Mmlm 73. Dental Office Removed. On and after August i. Dr. C. S. McCowen will occupy a suite of rooms in the new First National Bank Ruilding 31-jt-c.. Hires* I*.».>• Beer. That's what's la that llttl* barr*] at Slade's clgmr store—S cents a stein. 17-tf -■*■•>• eeemaaee-eeemaeme t ma MISS FUNSTON I Fine Tsiksr-M-Kl* s«,-. ■ Spxwtt- 1 Tw»-.t..'> Hos-aja- -^wn, SutioM. 4 menlo rawc. i i-oaaaaaaaaa 1 | eaaaaaaaaaaaa tammmmmmammmaaamemeaaaee- LMBOm It jr-ni nre mi. r. -(.-.] in Chll- dren'-i *nd t*SSstssj" We*r. l"-m- cy ti<*«l-. tasces, N'odons, Ete_ rail st .1 Th* Dsily Times—lOe a wsak. THK STKltLING ♦ S17 l nli. r-Hy Avenne. ♦ 1 n-tsern £*-yaBt *nd Fto***r>ure. J ♦ ♦ *>»♦•• 44a mat » 4am m meeaeeemee Tho Dall

    The value of open-source clinical science in pandemic response: lessons from ISARIC

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    International audienc

    ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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    The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use

    At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

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    By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital risk prioritisation of at-risk patients

    Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry

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    Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings
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