130 research outputs found
KRAS Therapeutics: Identification of novel scaffolds for Dynamic Drugging Pockets of Oncogenic G12D Mutant Kirsten Rat Sarcoma protein
No full textAs a proto-oncogene, Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutations can cause prolonged activation, leading to abnormal cell proliferation and subsequently development of a variety of human cancers. Therefore, the continuous efforts dedicated to fight against cancer through the discovery of anticancer leads is very significant. We report the identification of 2 novel scaffolds and their derivatives against KRAS G12D mutant protein. We used an integrated pharmacophore-based scaffold screening approach to select the optimum feature quintessential for scaffold stability. The scaffold nucleus was computationally grown using in-house tools. The library is screened, simulated, and analyzed. Intensive PCA analysis was performed, and conformational abundance was analyzed against the full-scale pharmacophore and molecular free states. We report five novel molecules with scores at par with the known FDA approved molecule. These molecules show preferential binding to the GDP-bound state of K-Ras and block the carboxylic group of the aspartatesp at 12th position. Compared to the retrospective analysis of the proposed molecules with the 12G variant, the leads show a considerable conformational density and Gibbs free energy difference. Overall, the reported novel molecules performed significantly ascompared to the known drug reference molecule of KRAS-G12D
Eksperimentasi Permasalahan Teknik-teknik pada Cello Concerto No.1 Bagian Pertama “Allegretto” Karya Dmitri Shostakovich
No full textABSTRAK Penguasaan teknik bagi seorang resitalis merupakan suatu keharusan, sesuai dengan tingkat kesulitan teknis yang ingin dicapai. Penulis mengacu pada penandaan teknis oleh pemain cello Mstislav Rostropovich untuk fingering dan bowing dalam repertoar pertama Cello Concerto No. 1 karya Dmitri Shostakovich yang kemudian ditemukan ketidakcocokan dalam preferensi pertimbangan teknis dan membuat penulis ingin mencoba bereksperimen untuk memecahkan masalah kesulitan teknis dalam repertoar tersebut. Technical Problems Experimentation in The Cello Concerto No.1, First Movement "Allegretto" by Dmitri Shostakovich ABSTRACT A recitalist's mastery of technique is a must, according to the level of desired achievements of technical difficulties. The author refers to the technical markings by cellist Mstislav Rostropovich for fingerings and bowings in the first cello concerto No.1 by Dmitri Shostakovich, which later was found discrepancies in the preferences of technical considerations, thus have made the author want to try to solve technical problems in the repertoire in a more personal way.
Tinjauan Yuridis Hak Cipta Sebagai Jaminan Fidusia Menurut UU No.28 Tahun 2014
No full textA. Nama : Ayub Rombe Datu
B. NIM : 1440050109
C. Judul : Tinjauan Yuridis Hak Cipta Sebagai Jaminan
Menurut Undang Undang No. 28 Tahun 2014
D. Jumlah Halaman : i + 126Halaman
E. Kanta kunci : Hak Cipta, Jaminan Fidusia
F. Ringkasan Ini :
Hasil penulisan ini melalui penilitian yang dilakukan bertujuan untuk
mengetahui fungsi, tujuan, dan aturan baru yang ditetapkan pada Undang
Undang Hak Cipta No. 28 Tahun 2014 dimana Hak Cipta menurut Undang
Undang tersebut bisa dijadikan jaminan serta proses jaminan terhadap Hak
Cipta menurut aturan hukum yang berlaku di Indonesia.Penelitian ini
merupakan penelitian normatif yaitu penelitian dengan cara mengkaji
ketentuan yang mengatur mengenai Hak Cipta sebagai Objek Jaminan Fidusia
dilakukan dengan metode “literature research” atau melalui studi kepustakaan,
penulis mengumpulkan bahan dari literaturliteratur baik yang bersifat
hardcopy maupun softcopy yang berhubungan dengan menggunakan analisis
normatif, tetapi tetap didukung oleh pendapat-pendapat hukum dari pihakpihak
yang terkait.Hasil dapat disimpulkan: (1) Pada UU No. 28 Tahun 2014
pasal 16 ayat 1 ayat satu sampai dengan ayat 3 menyatakan bahwa hak cipta
sebaga benda bergerak tidak berwujud dapat dijadikan jaminan fidusia. (2)
Hak Cipta dapat dijadikan obyek jaminan fidusia di dalam Pasal 16 ayat (4)
dilaksanakan sesuai ketentuan perundang- undangan yang berlaku dalam hal
ini adalah undang-undang jaminan fidusia. (3) Memilik hubungan aturan pada
konteks jaminan dengan undang – undang jaminan fidusia sehingga proses
jaminannya dilaksanakan sesuai ketentuan yang berlaku pada undang undang
jaminan fidusia.
G. Daftar Acuan : 31 Buku, 7 Perundang – undangan, 6 Website,
1 Tesis
Dosen Pembimbing : 1. Hulman Panjaitan SH., MH
2. Anton Nainggolan SH., MH./
A. Name : Ayub Rombe Datu
B. NIM : 1440050109
C. Title : Juridical Review of Copyright as Guarantee
According to Law no. 28 Year 2014
D. Number of Pages : i + 126Pages
E. Keyword : Copyright, Fiduciary Guarantee
F. This Summary:
The results of this writing through research carried out aimed at
know the functions, objectives, and new rules stipulated in the Act
Copyright Law No. 28 of 2014 where Copyright according to Law
The law can be used as a guarantee as well as a guarantee process for rights
Copyright according to the laws that apply in Indonesia. This research
is a normative research, namely research by examining
provisions governing Copyright as an Object of Fiduciary Guarantee
carried out using the "literature research" method or through library research,
the author collects material from the good literature that is
hardcopy and softcopy related to using analysis
normative, but still supported by legal opinions from the parties
related. The results can be concluded: (1) In Law no. 28 Year 2014
Article 16 paragraph 1 paragraph one to paragraph 3 states that copyright
as an intangible movable object can be used as a fiduciary guarantee. (2)
Copyright can be used as an object of fiduciary guarantee in Article 16 paragraph (4)
carried out in accordance with the provisions of the legislation in force in the case of
this is the fiduciary guarantee law. (3) Having a rule relationship on
the context of the guarantee with the fiduciary guarantee law so that the process
The guarantee is carried out in accordance with the provisions in force in the law
fiduciary guarantee.
G. Reference List : 31 Books, 7 Legislations, 6 Websites,
1 Thesis
Supervisor : 1. Hulman Panjaitan SH., MH
2. Anton Nainggolan SH., M
A single journal study : Malaysian Journal of Computer Science
No full textSingle journal studies are reviewed and measures used in the studies are highlighted. The following quantitative measures are used to study 272 articles published in Malaysian Journal of Computer Science, (1) the article productivity of the journal from 1985 to 2007, (2) the observed and expected authorship productivity tested using Lotka's Law of author productivity, identification and listing of core authors; (3) the authorship, co-authorship pattern by authors' country of origin and institutional affiliations; (4) the subject areas of research; (5) the citation analysis of resources referenced as well as the age and half-life of citations; the journals referenced and tested for zonal distribution using Bradford's law of journal scattering; the extent of web citations; and (6) the citations received by articles published in MJCS and impact factor of the journal based on information obtained from Google Scholar, the level of author and journal self-citation
Finite element modelling of FRC beams containing PVA and Basalt fibres: A comparative study
No full textIntegrating Lean and Green Supply Chain Management Systems in Manufacturing
No full textThe attached document may provide the author's accepted version of a published work. See Citation for details of the published work
Obeidollah Khishagi Ghosouri: Unknown expert on Hafez
No full textStill to this day Hafez is a widely researched topic of interest and discussion by his many devotees. Not many publications on this area have gotten away from scrutiny and criticism. The book ofBahrolferasah written by the Afghan scholar, Obeidollah Khishagi Ghosouri, is a noteworthy explanatory work on Haf-z. However the book has not received the attention it deserved from researchers, due to the anonymity of its author. This article will try to briefly introduce the book and its author to the readers
فیلڈ مارشل محمدایوب خاں کی خود نوشت ’’جس رزق سے آتی ہو پرواز میں کوتاہی‘‘ :ایک مطالعہ
No full textThis article is a review of autobiography of Field Marshal Muhammad Ayub Khan, Ex. President of Pakistan. The book entitled "Friends not masters" which was translated into Urdu by a famous writer Ghulam Abbas. Ayub Khan was born in a village "Rehana" near Rawalpindi. After compilation of educatin he got commissin in Royal Army and proceeded to England for professional training. When Pakistan came into existence, he joined Pakistand Army and gradually became Field Marshal of Pakistan Army. According to the author, the book may be called a verbal creation regarding his autobiography which is anthology of conversations among some close friends of the author. Basically book is based on the ideology that the citizens of developing countries are desirous for the friendship and help of the advanced / developed countries especially America, but it would be equal level like friends not masters. The book also discussed the political ups and downs in Pakistan because the author remained the President of Pakistan for more than 10 years
Computational Modeling of Gas Liquid Interfaces Using Different Multiphase Models
No full textA time dependent Computational Fluid Dynamics analysis of gas jets impinging onto liquid pools has been conducted. The aim of the study is to obtain a better understanding of highly complex, and industrially relevant flows in jetting system. Three different multiphase models, i.e., The Eulerian model, the volume of fluid model and the mixture model are used to analyze the surface deformations namely dimpling, splashing and penetration. The Standard k-? model is used to incorporate the Turbulence in the continuous phase. Two-dimensional axisymmetric geometries with different dimensions have been used in the study. Simulations are performed using commercial CFD code Fluent 6.1. PISO (pressure- implicit with splitting of operators) algorithm was employed to compute the pressure velocity coupling. The computed results are compared with experimental and theoretical data reported in the literature. Also the results of the study highlight and compare the discrepancies between the three multiphase models in capturing the flow structure and cavities formed at gas-liquid interfaces
Beyond the 3 R’s ‘Reduce, Reuse, Recycle’: a matterphorical eco-pedagogy project with a picturebook author, illustrator, teacher educator and a London primary school
No full textThis article describes a picturebook arts-based happening that came about spontaneously through an academic meeting the author of the picturebook Ammu’s Bottle Boat and the classteacher eco-lead of a Primary school linked with her university, and finding both to be inspiring champions of eco-pedagogy. Classteacher Andromachi, picturebook author Niveditha, illustrator Aindri and teacher educator Victoria then all met on zoom and planned sessions with the group of children who represent environmental matters for their class as school eco-ambassadors, reading and discussing the book, then making artwork in response to it. Bringing these perspectives together is not only highly unusual but significant in terms of a shared happening where a picturebook enacts this ecocritical nature, or nature-culture. Following Donna Haraway’s inseparability of nature-culture into ‘Natureculture’ (where collective eco-relationships are recognised as both biophysically and socially formed and thus closely associated) the author, illustrator, teacher, teacher-educator and children co-create in response to a picturebook’s ecocritical value. For Haraway, language and matter are also intertwined in ‘matterphorical’ ways, connecting physical, material and language elements together. For Gandorfer and Ayub, matterphorical practice is ‘an aesth-ethics of thought’ which ‘calls for an ethics of both sense-making and sensing in the making’. In this context, the art of the picturebook ‘shapes’ the associated practices of authorship, illustration, environmental education and teaching with ecopedagogies; combining sense-making and sensory learning as they interplay. The article will first set the context for eco-conscious education and various ways in which environmental research and ‘zero carbon’ schools have come together, introduce and explore the picturebook that features here by both its author and illustrator, and conclude with a teacher’s perspective of Green school practice using this picturebook in her primary school
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