30,156 research outputs found
HPLC determination of adenosine in human synovial fluid
No full textA high-performance liquid chromatographic method has been developed for the quantitative determination of
adenosine in human synovial fluid. The method is simple, rapid and, overall, selective. No interference with the
components of the biological matrix was observed in these chromatographic conditions. An ODS (250 4.6 mm) 5
mm column was used with an isocratic elution of a phosphate buffer–acetonitrile mobile phase. Detection was carried
out on a UV detector at 260 nm. Calibration curve was found to be linear in the 0.7–70 mg ml 1 range. Linear
regression analysis of the data demonstrates the efficacy of the method in terms of precision and accuracy. The
precision of this method, calculated as the relative standard deviation (RSD) of the recoveries (1.57–2.21%), was
excellent. The limits of quantitation (LOQ) and detection (LOD) were respectively 0.7 and 0.2 mg ml 1. The method
was applied to some samples of synovial effusion from patients affected by rheumatoid arthritis. The concentrations
of adenosine which were found were included in the range of the calibration curve
Synthesis of new heterocyclic derivatives of retinoids
No full textReaction of α- and β-ionones I and II with dialkylformamide/phosphorus oxychloride affords enamines III (R = Me2N, Et2N) and IV (R = Me2N) along with the expected chloro derivs. III and IV (R = Cl). Reaction of III (R = Me2N) with hydrazines, hydroxylamine and guanidine furnished pyrazole, isoxazole, pyrimidine derivs., e.g. V, showing the potential of these enaminones as key intermediates in the synthesis of synthetic retinoids
High-performance liquid chromatographic study of formation of n-nitrosopropranolol in simulated gastric juice
No full textMaria Bersani
No full textLa voce illustra la biografia e l'apporto letterario dato da Maria Bersani alla letteratura per l'infanziaThe headword explains the biography and the contribution of the author Maria Bersani to the children's literatur
Amine Exchange and Unexpected Ring Opening Reaction on Pyranone Derivatives : Synthesis of 3-Amino-Substituted Oxonaphthopyrancarbaldehydes and Tetrahydropyrimidinethanones as New Potential Oligonucleotide Stabilization Agents
No full textSimultaneous HPLC determination of multiple components in a commercial cosmetic cream.
No full textA high-performance liquid chromatographic method for the simultaneous determination of magnesium ascorbyl phosphate (I), imidazolidinylurea (II), a mixture of methyl-(III), ethyl-(IV), propyl-(V), butyl-(VI) parabens dissolved in phenoxyethanol, and ascorbyl palmitate (VII), was studied by using a cyano-propyl column and a methanol gradient at 220 and 240 nm. Calibration curves were found to be linear in the 0.05-5 mg ml(-1) range (compounds I, II, VII) and 0.9-160 mg ml(-1) (compounds III-VI). Linear regression analysis of the data demonstrates the efficacy of the method in terms of precision and accuracy. An extraction method is developed and validated in order to apply this chromatographic method to a commercial cosmetic cream. The precision of this method, calculated as the relative standard deviation (RSD) of the recoveries (1.57-2.21%) was excellent for all compounds I-VII
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
O curso de licenciatura em educação física da Universidade Federal de Santa Catarina: suas concepções de ensino e de educação física
No full textDissertação (mestrado) - Universidade Federal de Santa Maria. Centro de Educação Fisica e Desporto
Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents
No full textFive- and six-membered heterocyclic ionone-like derivatives 4-6 have been synthesised in one step and with good yield from the key intermediate 3a and appropriate bifunctional reagents. Four were active as inhibitors of the respiratory burst of human neutrophils without affecting cell viability. The two most active compounds (5a,d) tested in neutrophil migration assays, were also found to be potent inhibitors of neutrophil chemotactic responsiveness. These two molecules could be considered as lead compounds of new drugs which can be an effective tool to treat psoriasis and related neutrophilic dermatoses
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