1,721,061 research outputs found
Is bariatric surgery safer before, during, or after liver transplantation? A systematic review and meta-analysis
No full textBackground: The incidence of morbid obesity is increasing constantly. One of the most common complica tions related to obesity is represented by non-alcoholic fatty liver disease that can range from fatty liver to
non-alcoholic steatohepatitis, which is progressively becoming the first cause of end-stage liver disease and
need for liver transplantation with alcohol hepatitis. Moreover, many factors contribute to an elevated inci dence of morbid obesity in the post-transplant setting and individuals with obesity undergoing liver trans plantation rarely succeed in losing weight postoperatively. Individuals with obesity in the pre- and post transplant setting benefit from weight loss with reduced morbidity and mortality. Bariatric surgery is effec tive in inducing weight loss and obesity-related medical problems resolution but its application in the liver
transplant setting is limited.
The aim of this systematic review and meta-analysis is to explore postoperative morbidity and mortality of
bariatric surgery performed before, during, or after liver transplantation.
Method: This is a systematic review and proportion meta-analysis of 24 studies based on the PRISMA (Pre ferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline.
Results: Bariatric surgery performed in patients with obesity and end-stage liver disease waiting for liver
transplantation is associated with a 5% major post-bariatric surgery complications rate and a 7% 1-year post liver transplantation mortality. Patients who had bariatric surgery for morbid obesity after liver transplanta tion had a 16% post-bariatric surgery major complication rate. For patients undergoing simultaneous bariatric
surgery and liver transplantation, meta-analysis was not applicable but the review of the literature found 1/
10 patients experiencing major postoperative bariatric-related complications and 31/32 patients were alive
1 year after operation.
Conclusion: Bariatric surgery must be performed in selected cases in the setting of liver transplantation.
Simultaneous bariatric surgery and liver transplantation are associated with low morbidity and mortality
while bariatric surgery after liver transplantation showed increased morbidity. Bariatric surgery before LT is
feasible and can improve liver function for patients in transplant waiting list
Accurate assessment of nonalcoholic fatty liver disease lesions in liver allograft biopsies by a smartphone platform: A proof of concept
No full textMacrovesicular steatosis (MS) is a major risk factor for liver graft failure after transplantation and pathological microscopic examination of a frozen tissue section remains the gold standard for its assessment. However, the latter requires an experienced in-house pathologist for correct and rapid diagnosis as well as specific equipment that is not always available. Smartphones, which are must-have tools for everyone, are very suitable for incorporation into promising technology to generate moveable diagnostic tools as for telepathology. The study aims to compare the microscopic assessment of nonalcoholic fatty liver disease (NAFLD) spectrum in liver allograft biopsies by a smartphone microscopy platform (DIPLE device) to standard light microscopy. Forty-two liver graft biopsies were evaluated in transmitted light, using an iPhone X and the microscopy platform. A significant correlation was reported between the two different approaches for graft MS assessment (Spearman's correlation coefficient:r= .93;p < .001) and for steatohepatitis feature (r= .56;p < .001;r= .45;p < .001). Based on these findings, a smartphone integrated with a cheap microscopy platform can achieve adequate accuracy in the assessment of NAFLD in liver graft and could be used as an alternative to standard light microscopy when the latter is unavailable
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Relations entre le niveau d'adiponectine circulante, la steatose et la fibrose hépatique chez les patients atteints d'une hépatite chronique virale C
No full textNICE-BU Médecine Odontologie (060882102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
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