11 research outputs found
"In Memoriam" Resolutions; Dr. Lincoln A. Timerman.
No full textEditors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony.Vols. 1-13 are called "new series."Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451
The Isolation of Invertase from Baker’s Yeast – An Introduction to Protein Purification Strategies
No full textNon
Proceedings of Societies. Dental Society of the State of New York. (Continued)
No full textEditors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony.Vols. 1-13 are called "new series."Merged in Jan. 1937 with: Journal of the American Dental Association, ISSN 1048-6364, to form: Journal of the American Dental Association and dental cosmos, ISSN 0375-8451
Characterization of an Exchange Reaction between Soluble FKBP-12 and the FKBP·Ryanodine Receptor Complex
No full textAplicaciones del modelo WAVE: simulación del crecimiento del cultivo y del movimiento del agua y los agroquímicos en la zona no saturada del suelo.
No full textExpansion of human activities has major impact on the environment, generating changes that must be countered, such as climate change and dispersion of pollutants from industry and agriculture, through strategies that enable the conservation of soil and water reserves. The implementation of strategies with systems approach, covering mathematical simulation models, enables better decision making and a better understanding of the complexity and interaction of the different processes that affect the fate of nutrients, pollutants and chemicals in the environment - soil – on cultures and dynamic water. The WAVE system is presented in this article as a mathematical tool that describes the transport and transformations of matter and energy in the soil, crops and unsaturated soil, however it is not support the processes of water groundwater, drains and rivers. La expansión de las actividades humanas tiene gran impacto en el medio ambiente, generando cambios que deben ser contrarrestados, como el cambio climático y la dispersión de contaminantes de la industria y la agricultura; a través de estrategias que permitan la conservación del suelo y de las reservas de agua. La implementación de estrategias con enfoque de sistemas, que abarque modelos de simulación matemáticos, permite una mejor toma de decisiones y una mejor comprensión de la complejidad y la interacción de los diferentes procesos que afectan el destino de los nutrientes, contaminantes y sustancias químicas en el medio ambiente - suelo- en los cultivos y en las zonas de movimiento de aguas. El sistema WAVE se presenta en el presente artículo como una herramienta matemática que describe el transporte y transformaciones de la materia y la energía en el suelo, los cultivos y el suelo no saturado, sin embargo no es compatible con los procesos de las aguas subterráneas, drenajes y ríos
A enfermagem promovendo a saúde no cuidado a pessoas que vivenciam cirurgia cardíaca
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Enfermagem.As Doenças Cardíacas vêm crescendo de forma assustadora nos últimos anos. Atualmente, apresentam-se entre as principais causas de mortalidade no Brasil. Entre as diversas formas de tratamento, sendo elas intervenções não-invasivas e invasivas, temos a realização da Cirurgia Cardíaca. A cirurgia é uma situação angustiante e única na vida do paciente e seus familiares. É evidente a forte relação existente entre a cirurgia cardíaca e o desgaste emocional do paciente e seus familiares, bem como a necessidade de envolvimento das pessoas que vivenciam este processo para que a recuperação e a reabilitação se dêem de forma efetiva. Entendo que cabe a nós, enfermeiros, auxiliar estas pessoas a compreenderem a situação pela qual estão passando e ajudá-las a entender que também são responsáveis pela sua saúde. Assim, a realização deste trabalho teve como objetivo principal refletir sobre os cuidados de enfermagem para a promoção da saúde das pessoas que se submeteram à cirurgia cardíaca e seus familiares, a partir do Modelo McGill de Enfermagem, cujo enfoque é a Promoção de Saúde, e do Modelo de Cuidado de Carraro. Para atingir os objetivos traçados, optei por desenvolver uma prática cuidativa - educativa com as pessoas que se submeteram à cirurgia cardíaca e seus familiares. Este trabalho foi desenvolvido durante o mês de novembro de 2004 em um hospital de referência da região central do Rio Grande do Sul. Ao final deste trabalho, compreendi que o processo de cuidar e educar gerou frutos gratificantes. Entre eles posso citar o despertar do interesse das pessoas com as quais trabalhei, na busca da promoção de sua saúde. Acredito, também, que a presença de uma pessoa disposta a conversar, trocar experiências e conhecimento ajudou estas pessoas a vivenciar o momento de cirurgia cardíaca com mais serenidade e de forma mais participativa e consciente. Cardiac Diseases have increased in drastic form in recent years. Currently, they present themselves among the chief causes of death in Brazil. Among the diverse methods for treatment, whether they are non-invasive or invasive interventions, there is the challenge of Cardiac Surgery. Surgery presents a uniquely anguishing situation for within the life of the patient and his/her family. The strong evidence between cardiac surgery and emotional stress on the part of the patients their families; as well as the need for involvement from the people who face this process, in order that the recovery and rehabilitation are carried out effectively. It is the belief of this author that nurses have the capacity to assist these people in comprehending the situation they are facing and help them understand they are also responsible for their health. Thus, the completion of this study signifies an attempt to reflect upon nursing care towards the promotion of health of those who are submitted to cardiac surgery, as well as their family members, according to the McGill Model of Nursing and Carraro's Care Model. In order to achieve this established objective, the author opted to develop an educational-care practice for those people who were submitted for cardiac surgery, as well as for their families. This study was developed during November of 2004 in a well-known hospital in the central region of Rio Grande do Sul, Brazil. Upon completion of this study, it was clear that that the care and educative process offers gratifying results. Among such results were the awakening within the people involved in the study of an increased interest towards the specific issues of the study, the search for health promotion, the importance of having someone to talk with, exchange experiences, and share knowledge as they go through the challenge of cardiac surgery in a calmer and more participatory fashion
Selective binding of FKBP12.6 by the cardiac ryanodine receptor
No full textThe calcium release channels (CRC)/ryanodine receptors of skeletal (Sk) and cardiac (C) muscle sarcoplasmic reticulum (SR) are hetero-oligomeric complexes with the structural formulas (ryanodine recepter (RyR)1 protomer)4(FKBP12)4 and (RyR2 protomer)4(FKBP12.6)4, respectively, where FKBP12 and FKBP12.6 are isoforms of the 12-kDa receptor for the immunosuppressant drug FK506. The sequence similarity between the RyR protomers and FKBP12 isoforms is 63 and 85%, respectively. Using 35S-labeled FKBP12 and 35S-labeled FKBP12.6 as probes to study the interaction with CRC, we find that: 1) analogous to its action in skeletal muscle sarcoplasmic reticulum (SkMSR), FK506 (or analog FK590) dissociates FKBP12.6 from CSR; 2) both FKBP isoforms bind to FKBP-stripped SkMSR and exchange with endogenously bound FKBP12 of SkMSR; and 3) by contrast, only FKBP12. 6 exchanges with endogenously bound FKBP12.6 or rebinds to FKBP-stripped CSR. This selective binding appears to explain why the cardiac CRC is isolated as a complex with FKBP12.6, whereas the skeletal muscle CRC is isolated as a complex with FKBP12, although only FKBP12 is detectable in the myoplasm of both muscle types. Also, in contrast to the activation of the channel by removal of FKBP from skeletal muscle, no activation is detected in CRC activity in FKBP-stripped CSR. This differential action of FKBP may reflect a fundamental difference in the modulation of excitation-contraction coupling in heart versus skeletal muscle
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
No full textGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
Hypothermia as an adjunctive therapy to percutaneous intervention after ST-elevation myocardial infarction—Effects on regional myocardial contractility
No full textABSTRACT: Background: The effects of endovascular therapeutic hypothermia (ETH) in ST-elevation myocardial infarction (STEMI) regional contractility are unknown, and its impact on segmental contractility has still not been evaluated. We sought to evaluate segmental myocardial strain after ETH adjuvant to percutaneous coronary intervention (PCI) in STEMI. Methods: We included patients who underwent 1.5T cardiovascular magnetic resonance exams 5 and 30 days after acute anterior or inferior STEMI in a previous randomized trial. Left ventricle (LV) strain was evaluated on infarcted, adjacent, and remote myocardium. Segmental circumferential (CS) and radial strains (RS) were measured using feature-tracking imaging. Repeated measures of analysis of variance were used for comparisons within time and treatment. Results: Forty patients were divided into hypothermia (ETH, n = 29) and control (n = 11) groups, with 5210 LV segments. In ETH infarcted areas, RS (11.2 ± 16 vs 14.8 ± 15.2, p = 0.001) and CS (−5.4 ± 11.1 vs −8 ± 11.1, p = 0.001) showed recovery from 5–30 days compared to controls (11.4 ± 14 vs 13.1 ± 1 6.8, p = 0.09; −6.5 ± 10.6 vs −6.4 ± 12.5, p = 0.94). In control remote areas, RS (28 ± 18 vs 31.7 ± 18.5, p = 0.001) and CS (−15.5 ± 10.7 vs −17.1 ± 9, p = 0.001) improved from 5–30 days compared to ETH (28.6 ± 18.6 vs 29 ± 20, p = 0.44; −15.2 ± 10.4 vs −15.3 ± 10.6, p = 0.82). Transmural infarcted areas in ETH improved RS (11.8 ± 13.2 vs 8.17 ± 14.7, p = 0.001) and CS (−6.1 ± 10.9 vs.−3.1 ± 11.3, p = 0.001) compared to controls, with better contractility at 30 days. Conclusion: In anterior or inferior STEMI patients, ETH adjuvant to PCI is associated with significant improvement in RS and CS of infarcted areas, including transmural segments, but not in remote area. This might further increase our pathophysiological knowledge on early LV remodeling and ultimately suggest potential clinical value. Availability of data and materials: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request
Efficacy and safety of rilpivirine in treatment-naive, HIV-1-infected patients with hepatitis B virus/hepatitis C virus coinfection enrolled in the phase III randomized, double-blind ECHO and THRIVE trials
No full textObjectives: The efficacy and hepatic safety of the non-nucleoside reverse transcriptase inhibitors rilpivirine (TMC278) and efavirenz were compared in treatment-naive, HIV-infected adults with concurrent hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection in the pooled week 48 analysis of the Phase III, double-blind, randomized ECHO (NCT00540449) and THRIVE (NCT00543725) trials. Methods: Patients received 25 mg of rilpivirine once daily or 600 mg of efavirenz once daily, plus two nucleoside/nucleotide reverse transcriptase inhibitors. At screening, patients had alanine aminotransferase/aspartate aminotransferase levels ≤5× the upper limit of normal. HBV and HCV status was determined at baseline by HBV surface antigen, HCV antibody and HCV RNA testing. Results: HBV/HCV coinfection status was known for 670 patients in the rilpivirine group and 665 in the efavirenz group. At baseline, 49 rilpivirine and 63 efavirenz patients [112/1335 (8.4%)] were coinfected with either HBV [55/1357 (4.1%)] or HCV [57/1333 (4.3%)]. The safety analysis included all available data, including beyond week 48. Eight patients seroconverted during the study (rilpivirine: five; efavirenz: three). A higher proportion of patients achieved viral load <50 copies/mL (intent to treat, time to loss of virological response) in the subgroup without HBV/HCV coinfection (rilpivirine: 85.0%; efavirenz: 82.6%) than in the coinfected subgroup (rilpivirine: 73.5%; efavirenz: 79.4%) (rilpivirine, P = 0.04 and efavirenz, P = 0.49, Fisher's exact test). The incidence of hepatic adverse events (AEs) was low in both groups in the overall population (rilpivirine: 5.5% versus efavirenz: 6.6%) and was higher in HBV/HCV-coinfected patients than in those not coinfected (26.7% versus 4.1%, respectively). Conclusions: Hepatic AEs were more common and response rates lower in HBV/HCV-coinfected patients treated with rilpivirine or efavirenz than in those who were not coinfected. © The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
