181 research outputs found
Abouchements ectopiques rares de l'uretère (à propos de 2 cas et discussion embryologique)
No full textDeux cas rares d'abouchement ectopique de l'uretère sont rapportés ici : un cas d'abouchement dans l'utérus, le second dans le rectum. Nous constaterons que ces ectopies ne sont pas explicables par les concepts embryologiques classiques. Ceux-ci stipulent que les ectopies urétérales proviennent d'une ectopie du bourgeon urétéral sur le canal de Wolff, le bourgeon urétéral s'incorporant ensuite en dehors du trigone vésical, dans un dérivé du sinus urogénital, ou bien restant solidaire du canal de Wolff. Or ni le rectum, ni l'utérus ne dérivent du sinus urogénital ou du canal de Wolff. Nous tenterons de fournir une explication plausible de la survenue de telles ectopies, à l'aide de travaux embryologiques moins connus, sur les étroits rapports du canal de Wolff et du canal de Müller lors de l'embryogénèse, sur le cloisonnement du cloaque.ROUEN-BU Médecine-Pharmacie (765402102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Pathways for accessing legacy materials in Tohono O'odham
No full textThis paper reports work on two sets of legacy materials for Tohono O'odham, a Uto-Aztecan language spoken in Arizona and Sonora Mexico. Tohono O'odham speakers have declined in their numbers, with just above 8,000 speakers in 2000, suggesting a 20% decline since 1990. However, O'odham speakers and revitalization programs could benefit from linguistic resources. Author (2005) discusses a century's worth of archival holdings, covering numerous genres, most of which is unpublished. Here we look at efforts to increase access to the texts from a dialect survey in the 1980s and at efforts to create an online version the out-of-print dictionary compiled by Madeleine Mathiot in 1973. Both projects would increase accessibility of O'odham language materials. The projects bear on several issues of relevance: archiving, collaboration, representing manuscript formats in a community-friendly format, technology, and mobilization of data. The Tohono O'odham dictionary project has gone through several incarnations, mostly at the University of Arizona. Unfortunately, the Mathiot dictionary is still not online, stymied by funding shortages, software and font challenges, changes in grad student personnel, and lack of clarity regarding copyrights. We are more than halfway done with editing the text files of this dictionary, with Mathiot herself editing for presentation and to include errors not addressed in the published version. Once this version is done and online, it will be straightforward to address orthographic differences from the tribal orthography, as well as create options for self-publishing so that community members can print it. Ofelia Zepeda and Jane Hill worked with 92 elders in the 1980s collecting word-lists and texts as part of a dialect survey. These materials have been transcribed in Tohono O'odham, but are untranslated and unpublished. We are scanning the manuscripts into PDF format for preservation and creating text files, and a community member is working on translations. Preliminary versions of accessible texts have the potential to be changed in global ways, given word-processing tools. Preserving the transcripts for accuracy is the first step, which creates a foundation for community-driven revisions. This project involves community members, original researchers, and graduate and post-graduate assistants. The resulting files offer a number of ways to increase access for the tribal community, and established collaborations with the tribal college offer an avenue for successful explorations to mobilize these materials for speakers and revitalization programs
Author Correction:A 41,500 year-old decorated ivory pendant from Stajnia Cave (Poland)
No full textCorrection to: Scientific Reports https://doi.org/10.1038/s41598-021-01221-6, published online 25 November 2021The original version of this Article contained errors in the author list where Marjolein D. Bosch was omitted from the author list, and Mikołaj Urbanowski was incorrectly listed as an author of the original Article, and has subsequently been removed.The Author contributions section now reads:“S.T. W.N. and A.N. conceived the project; S.T., W.N., A.P., M.B., S.C., M.D., H.F., A.M., M.D. B., D.P., M.P.R., C.M.R., V.S-M., G.M.S., P.S., M.S., K.S., A.V., F.W., H.W., A.W., M.Z., S.B., A.N., J-J. H., performed research; S.T., A.P., W.N., M.B., M.D.B., S.C., M.D., H.F., A.M., D.P., M.P.R., C.M.R., V.S-M., G.M.S., P.S., M.S., K.S., A.V., F.W., H.W., A.W., M.Z., S.B., A.N., J-J. H. analysed all archaeological data; S.T. and A.P. wrote the paper with the collaboration of all the co-authors.”The original Article and its accompanying Supplementary Information file have been corrected
Mathematical modeling reveals the biological program regulating lymphopenia-induced proliferation
No full textRecognition of peptide-MHC by the TCR induces T lymphocytes to undergo cell division. Although recognition of foreign peptide induces a program of cellular division and differentiation by responding T cells, stimulation by self-peptide MHC complexes in lymphopenic conditions induces a slower burst of divisions that may or may not be accompanied by effector differentiation. Although both responses are triggered by signals from the TCR, it is not known whether they represent distinct programs of cell cycle control. In this study, we use a mathematical modeling approach to analyze the proliferative response of TCR transgenic F5 T cells to lymphopenia. We tested two fundamentally different models of cell division: one in which T cells are triggered into an “autopilot” deterministic burst of divisions, a model successfully used elsewhere to describe T cell responses to cognate Ag, and a second contrasting model in which cells undergo independent single stochastic divisions. Whereas the autopilot model provided a very poor description of the F5 T cell responses to lymphopenia, the model of single stochastic divisions fitted the experimental data remarkably closely. Furthermore, this model proved robust because specific predictions of cellular behavior made by this model concerning the onset, rate, and nature of division were successfully validated experimentally. Our results suggest cell division induced by lymphopenia involves a process of single stochastic divisions, which is best suited to a homeostatic rather than differentiation role
Unexpected Requirement for ZAP-70 in Pre-B Cell Development and Allelic Exclusion
No full textAbstractZAP-70, a member of the Syk family of tyrosine kinases, has been reported to be expressed exclusively in T and NK cells. We show here that it is expressed throughout B cell development and that it plays a role in the transition of pro-B to pre-B cells in the bone marrow, a checkpoint controlled by signals from the pre-B cell receptor (pre-BCR), which monitors for successful rearrangement of immunoglobulin heavy chain genes. Whereas mice deficient in Syk show a partial block at this step, mice mutant in both Syk and ZAP-70 show a complete block at the pro-B cell stage and a failure of heavy chain allelic exclusion, hallmarks of defective pre-BCR signaling
"Submersion": A board game for coastal risk exploration and adaptation planning
No full textInternational audienceIn the face of climate change and rising sea levels, "Submersion" is a strategic collaborative board game designed by H2020-PROTECT to deepen understanding and foster proactive decision-making regarding the risk of coastal submersion. Tailored for a high-school audience and above, the game prompts players to manage a coastal city, grappling with the challenges posed by the risk of marine submersion. The objective is clear: safeguard the city's future by minimizing the impact of this risk.The game unfolds in Mer-Ville, a picturesque coastal town threatened by climate-induced changes. Players, acting as members of the City Council, navigate the delicate balance between preserving the city's historical treasures, sustaining its economic activities, and implementing effective adaptation measures. As climate scenarios unfold, players must grapple with varying degrees of sea-level rise, emphasizing the importance of strategic planning and resource allocation.Key Objectives:Understanding Risk: Explore the concept of risk and its reduction strategies. Adaptation Responses: Learn about diverse responses to the risk of marine submersion Climate Scenarios: Grasp the impact of different climate scenarios on sea level rise and adaptation difficulty. Limits of Adaptation: Understand the constraints and limitations associated with adaptation measures. Temporal Aspect: Recognize that adaptation requires time and advance planning
Heat balance in the Nordic Seas in a global 1/12° coupled model
No full textThe Nordic Seas are a gateway to the Arctic Ocean, where Atlantic water undergoes a strong cooling during its transit. Here we investigate the heat balance of these regions in the high resolution Met Office Global Coupled Model GC3 with a 1/12_ grid. The GC3 model reproduces resolution Met Office Global Coupled Model GC3 with a 1/12_ grid. The GC3 model reproduces the contrasted ice conditions and ocean heat loss between the eastern and western regions of the Nordic Seas. In the west (Greenland and Iceland seas), the heat loss experienced by the ocean is stronger than the atmospheric heat gain, because of the cooling by ice melt. The latter is a major contribution to the heat loss over the path of the East Greenland Current and west of Svalbard. In the model, surface fluxes balance the convergence of heat in each of the eastern and western regions. The net east-west heat exchange, integrated from Fram Strait to Iceland, is relatively small: the westward heat transport of the Return Atlantic Current over Knipovich Ridge balances the eastward heat transport by the East Icelandic Current. Time fluctuations, including eddies, are a significant contribution to the net heat transports. The eddy flux represents about 20% of the total heat transport in Denmark Strait and across Knipovich Ridge. The coupled ocean-atmosphere-ice model may overestimate the heat imported from the Atlantic and exported to the Arctic by 10 or 15%. This confirms the tendency toward higher northward heat transports as model resolution is refined, which will impact scenarios of future climate
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