8 research outputs found
Differential cytopathology and kinetics of measles oncolysis in T=two primary B-cell malignancies provides mechanistic insights
No full textClinical trials using vaccine measles virus (MV) as anticancer therapy are already underway. We compared the oncolytic potential of MV in two B-cell malignancies; adult acute lymphoblastic leukemia (ALL, an aggressive leukemia) and chronic lymphocytic leukemia (CLL, an indolent leukemia overexpressing Bcl-2) using patient-derived material. In vitro, distinct cytopathological effects were observed between MV-infected primary ALL and CLL cells, with large multinucleated syncytia forming in ALL cultures compared to minimal cell-to-cell fusion in infected CLL cells. Cell viability and immunoblotting studies confirmed rapid cell death in MV-infected ALL cultures and slower MV oncolysis of CLL cells. In cell lines, overexpression of Bcl-2 diminished MV-induced cell death providing a possible mechanism for the slower kinetic of MV oncolysis in CLL. In vivo, intratumoral MV treatment of established subcutaneous ALL xenografts had striking antitumor activity leading to complete resolution of all tumors. The antitumor activity of MV was also evident in disseminated ALL xenograft models. In summary, both ALL and CLL are targets for MV-mediated lysis albeit with different kinetics. The marked sensitivity of both primary ALL cells and ALL xenografts to MV oncolysis highlights the tremendous potential of MV as a novel replicating-virus therapy for adult AL
Genome gains at chromosome 21q21/22 segment leads to co-amplification of Down Syndrome Critical Regions and known oncogenes in a case of donor cell-derived acute myeloid leukaemia following allogeneic sex mismatched umbilical cord blood transplantation fo
No full textType 1 interferon responses underlie tumor-selective replication of oncolytic measles virus
No full textThe mechanism of tumor-selective replication of oncolytic measles virus (MV) is poorly understood. Using a stepwise model of cellular transformation, in which oncogenic hits were additively expressed in human bone marrow-derived mesenchymal stromal cells, we show that MV-induced oncolysis increased progressively with transformation. The type 1 interferon (IFN) response to MV infection was significantly reduced and delayed, in accordance with the level of transformation. Consistently, we observed delayed and reduced signal transducer and activator of transcription (STAT1) phosphorylation in the fully transformed cells. Pre-treatment with IFNb restored resistance to MV-mediated oncolysis. Gene expression profiling to identify the genetic correlates of susceptibility to MV oncolysis revealed a dampened basal level of immune-related genes in the fully transformed cells compared to their normal counterparts. IFN-induced trans-membrane protein 1 (IFITM1) was the foremost basally downregulated immune gene. Stable IFITM1 overexpression in MV-susceptible cells resulted in a 50% increase in cell viability and a significant reduction in viral replication at 24 h after MV infection. Overall, our data indicate that the basal reduction in functions of the type 1 IFN pathway is a major contributor to the oncolytic selectivity of MV. In particular, we have identified IFITM1 as a restriction factor for oncolytic MV, acting at early stages of infection
Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial
No full textBACKGROUND: Treatment for adults with acute lymphoblastic leukaemia requires improvement. UKALL14 was a UK National Cancer Research Institute Adult ALL group study that aimed to determine the benefit of adding the anti-CD20 monoclonal antibody, rituximab, to the therapy of adults with de novo B-precursor acute lymphoblastic leukaemia.METHODS: This was an investigator-initiated, phase 3, randomised controlled trial done in all UK National Health Service Centres treating patients with acute lymphoblastic leukaemia (65 centres). Patients were aged 25-65 years with de-novo BCR-ABL1-negative acute lymphoblastic leukaemia. Patients with de-novo BCR-ABL1-positive acute lymphoblastic leukaemia were eligible if they were aged 19-65 years. Participants were randomly assigned (1:1) to standard-of-care induction therapy or standard-of-care induction therapy plus four doses of intravenous rituximab (375 mg/m2 on days 3, 10, 17, and 24). Randomisation used minimisation and was stratified by sex, age, and white blood cell count. No masking was used for patients, clinicians, or staff (including the trial statistician), although the central laboratory analysing minimal residual disease and CD20 was masked to treatment allocation. The primary endpoint was event-free survival in the intention-to-treat population. Safety was assessed in all participants who started trial treatment. This study is registered with ClincialTrials.gov, NCT01085617.FINDINGS: Between April 19, 2012, and July 10, 2017, 586 patients were randomly assigned to standard of care (n=292) or standard of care plus rituximab (n=294). Nine patients were excluded from the final analysis due to misdiagnosis (standard of care n=4, standard of care plus rituximab n=5). In the standard-of-care group, median age was 45 years (IQR 22-65), 159 (55%) of 292 participants were male, 128 (44%) were female, one (<1%) was intersex, and 143 (59%) of 244 participants had high-risk cytogenetics. In the standard-of-care plus rituximab group, median age was 46 years (IQR 23-65), 159 (55%) of 294 participants were male, 130 (45%) were female, and 140 (60%) of 235 participants had high-risk cytogenetics. After a median follow-up of 53·7 months (IQR 40·3-70·4), 3-year event-free survival was 43·7% (95% CI 37·8-49·5) for standard of care versus 51·4% (45·4-57·1) for standard of care plus rituximab (hazard ratio [HR] 0·85 [95% CI 0·69-1·06]; p=0·14). The most common adverse events were infections and cytopenias, with no difference between the groups in the rates of adverse events. There were 11 (4%) fatal (grade 5) events in induction phases 1 and 2 in the standard-of-care group and 13 (5%) events in the standard-of-care plus rituximab group). 3-year non-relapse mortality was 23·7% (95% CI 19·0-29·4) in the standard-of-care group versus 20·6% (16·2-25·9) in the standard-of-care plus rituximab group (HR 0·88 [95% CI 0·62-1·26]; p=0·49).INTERPRETATION: Standard of care plus four doses of rituximab did not significantly improve event-free survival over standard of care. Rituximab is beneficial in acute lymphoblastic leukaemia but four doses during induction is likely to be insufficient.</p
Gilbert Patterson Community School Yearbook 1987
No full textThe annual publication of the students of Gilbert Patterson Community School, Lethbridge, Alberta (Volume 1986-87)pdfVEVJCM10K
"Ive've Only Juit Begun" li
dedicated to the. memory of,
Clinton Hall. Clinton'i active
Involvement and enthuilaim to
leaan li Indeed an example vie
all ihould neipect and model.
Clinton - uie ihall think o{ you of,ten,
and nemembesi you almiayi.
GILBERT PATKUSCK
F SCHOOL II - ai 3~ bn
Yearbook Staff
YEARBOOK STAFF '86 - '87
Yei, we've only ju.it begun to hope, that
thti yean’i yeanbook pnovtdei you with the many
excellent memonlei we've expenteneed hene at
Gtlbent Patenion. 0/tth tnenedtble ita££ ehangei and
new fionmat we have had iome iet baeki. Yet,
with gneat aiiiitanee ^nom oun new £ound photognaphen,
Mn. Sehueant and a lot of, teamwonk we ane pleaied
to pneient "lue've Only Juit Begun".
^Jlll II III IIIII Hill II III II III l[^
ft/e'ue. Only Juit Begun
(jue’ve only ju.it begun.......... to live
Vuhite lace and pwmliei
A kLii tuck and we'ne on out way.
bie've only juit begun
Bejofitthe iLiLng iun - we (,ly
So many wadi to chooie
hue itait ohh walking and leann to wn
\nd yei we've we juit begun.
Slwnlng Honlzoni that aw new to ui
(Matching the ilgni atong the way
Tatktng it oven juit the two oh ui
(Mocking together day to day
Together. Together.
hnd when the evening comei, we imile
So much oh Uhe ahead
(Me'll hind a place whew thew Li worn to gww.
\nd yei we've juit begun!!
GPCS 87
President PRESIDENT'S MESSAGE
Looking back over this year, our school
has changed a lot with our new bandroom,
renovated shop, the new six-day rotation
system and our new teachers. I think this all
helped in making our school the best it has been
since I've been here. I really had a great time
being president and believe me, it's not easy!
I had fun planning and organizing events over the
year and I hope you all enjoyed it as much as I
did.
As we, the grade nine's go on to grade ten,
I don't think we'll ever forget this super school!
For those of you who are staying for another one
or two years good luck and keep our school the
best ever!
Sincerely,
Leah Schipper
VICE PRESIDENT'S MESSAGE
Another great year has gone by, but this year was exceptional. The
participation and school spirit really made Paterson shine.
Many people in our community realized that our school is a place that
welcomes them. We, as a student body and staff, worked to ensure we
emphasized the community theme.
Being vice president has meant a lot of hard work but the position
was very rewarding. I've had a lot of new, enjoyable experiences. I
would encourage others to support Student Council activities.
I would like to express my appreciation to all the people who helped
out in the many school events. To the teachers for their support and
the students for their awesome participation. These people make Paterson
great.
In future years I'm sure this 86/87 school year will be looked back
on as one to remember. Our achievements were many and will be even greater
as "We've only just begun".
Good luck to all in your quest for success.
Sincerely,
Meg Thompson
IM NCT R£ACY
FOR THIS'
Student Council
Emily Campbell, Brenda Wong, Allison Townsend, Katrina
Tanne, Joanne Paterson, Krista Beny, Jenny Murphy.
Nathan Baines, Graham Maryancik, Patrick Cheng, Christie
Beswick, Jody Neufeld.
Joel Nowlin, Brett Walters, Mike Fletcher, Mr. Stevenson.
ivncL ^errrtiMi ...
Principal’s Message
"You've only just begun. .
to this line of the song from which y
Although you are completing your
years at Gilbert Paterson Community
School, you hold the key to all of
the future which stretches ahead of
you. What you achieve and the
level of satisfaction and
happiness which you obtain in the
years to come will be significantly
affected by the decisions that you
make today.
There are some keys to
personal success that have proven
themselves over the years. Look
to the future with optimism and cultivate a positive mental attitude.
Success is much more elusive for the individual with a sour
disposition. You will have successes and you will have failures to
be sure. Remember to view each as a learning experience.
Strive to be the best that you can be. On the track, races
are won and lost by mere split seconds - this is the difference between
glory and tears. It is the same in life. Striving to be a "little bit
better" can make the difference.
People tend to get what they expect from themselves and
others. Therefore, expect the best from yourself and from those
around you.
And most importantly - be a friend to yourself. You are
special - act that way.
Even though "you've only just begun" you can look forward
with great anticipation to a very bright future indeed. In the words
of the great Scottish bard:
'May the roads rise to meet you
May the wind be always at your back. . .
and may God hold you in the hollow of His
Administration
I 1
Mr. P. Stevenson
Mr. D. Groft
Mr. R. Lewis (Principal)
Mr. M. Schuchardt
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8E
Christie Beswick
Lesa Carmichael
Paul Carter
Mike Castleton
Debbie Chow
Adrian Crow
Ronald Denhoed
Raquel Fudra
Raymond Giese
PameI a Green
Shannon Ha I I
Adam Henderson
Dagan King
David Krueger
David Kunst
Anna Kuru luik
Shawn Leitch
Scott Mills
Broadie Murphy
Kerry Nagata
Kurt Otto
MitcheI I Pierson
Lyndi Pollock
Richard Revesz
Barbi Rice
Lisa Snee
Donna Stevenson
Sheyna Stickel
Destiny Svennes
Fred Tam
I A
I
Michelle Ward
Leana Webber
8F
Margot Allison
Shawna Bai ley
Chris Bankonin
Susan Cameron
Freeman Choi
Cameron Court
Claire Crooks
Brain Fletcher
Karen Harrington
Tanya Jackson
Dam lo Jurisich
Grant Krywolt
Jud Lewis
Bryan Liska
Becky Little
Anne-Marie Mediwake
Dale Nielsen
Keith Norton
Shauna Oler
Nova Pierson
Jared Pierson
Chris Pratt
Todd Simpson
Sandra Spackman
Scott Stevens
Glenda Stirling
Sanjeev Visvanatha
Kelli Wolsey
Doug Yoshida
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teak away {torn ieliiihneii
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Challenge. youn woald -
a. wonld which. is you.
9A
Launa Barfuss
Barb Cooper
Spencer Court
Jason Crowchief
Steven De Groot
Joe I Dyck
Don F letcher
Tanya Fortin
Jason Gough
Mark How
Jason Kirkman
Darren Kramble
Kelly Kyle
Jenny Leavitt
David Manser
Dionne Maple
Deana McFadden
Brent Newman
Duncan Purvis
Cary Rice
EIka SchoIdra
Scott Taylor
Jason Turner
Jason Wiebe
Brenda Wong
Cheryl Wong
Peter Wright
91
Krista Beny
Debb Carpenter
Lesley Coutts
Natasha Evdodimoff
John Gordon
Vera Gracey
Stacey Gupton
Danny Hermon
Trevor HeggedaI
Naomi Huxley
Bengt Jericho
Chris Johnstone
Lisa Jones
Glen Kaszuba
Shannon Lemire
Chris Liska
Penkye Parchang
Bonnie Regier
Doug Schow
Juanita Shouting
Jennifer Stengl
Maegan Thompson
Craig Vanroon
Lisa Wiebe
M CflVIRm?
9C
Chad Be 1 I
Shane Bowkett
Cheri Brown
Brad Carrier
Barry Christopherson
Scott Dunn
Kris French
Debra Groothuis
Christine Gurr
Lianne Harris
Evelyn Hunt
Stuart Huxley
Kurt Kenny
Kristina Koenig
Robin McHugh
Jennifer Mi Her
Stephanie MuendeI
Joel Nowlin
Joanne Paterson
Jennifer Schroeder
justwe
/OW5!
W . Jl
9D
-I 2/2
Josh Ah lert
CarmeI I Bokvist
Emi ly CampbeI I
Cam David
Garth Davidson
Wi 11iam Gardiner
Joyce Gi I lespie
Kent Gurski
Brad Harsch
Tim Hosken
Sandra Howe
Ji I I Kaszuba
Troy Kreutz
Danny Krueger
Mike Layton
Carrie-Lynn Neuteld
Troy Nixey
Si las Potter
Wende I I Rusnack
Leah Schipper
•2
Scott Ti llotson
Shawn Wasi lenko
Stacy Willi ams
Wj
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9E
Dionne Aspeslet
Jamie Bagu
Derek Boucher
Cory Carson
Bart Chudleigh
Kyle Cook
Renata Frank
Cory Ha 11
KorneIi a Harms
Sheryl-Rae Harrison
Steven Isele
Leroy Jones
Nicole Kleinmark
Shannon McDonald
Theresa Mickey
Jennifer Murphy
Tracy Perrotta
Byron Pierson
Susan Schmidt
Renae Schweigert
David Trockstad
Richard Walker
Lori Yantz
"I'll never forget the time you strapped me for
talking in class."
9F
Patricia Appleton
Kari Berent
Jane Cho
Vicki Cormack
Dawna De Maere
Dorothy Dick
Shawna Duda
Michael Evans
Elizabeth Fitzner
Eric Herget
Scott Hironaka
Jay Jordan
Massie Kitagawa
Michelie KorneIsen
Danny Laycock
Robert Luciani
Erick Mah
Cindy Munro
Jason Murray
Tracey Nie Isen
KeIly Penner
Miche l le Rothe
Leslie Sheppart
Dianne Spooner
Barbara Stewart
Tracy Takahashi
Katrina Tanne
Pamela Thompson
Allison Townsend
Sarah Townsend
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Cross-Country
Cheerleaders
Junior
Senior
Seniors
Junior Senior
Girls’
Junior Senior
Badminton
Grade 9
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Options 7,8,&9
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WUMtWS
OUTDOOR
education
FRENCH
BAND
COMPUTERS
Clubs
Clubs
Clubs
Clubs
BOTTOM: Craig Van Roon, Spencer Court, Danny Harmon,
Garth Davidson
Kelly Penner, Marianne Ward, Joyce Dong, Mr. Iwassa,
Michelle Ward, Rhonda Neufeld, Pam Green
Serge Gowans, Graham Maryancik, Darren Ferby, Murray
MacLennan, Colin Wiebe
MIDDLE:
TOP:
MOVIE CLUB
BOTTOM: Karen Sinclair, Mr. Snee, Lisa Snee, Jodi Gordon
MIDDLE: Max McCuaig, Scott Dunn, Maurice Lizee, Geoff Lacny,
Bill Dunn
2ND FR. TOP: Mark Rausch, Nathan Baines, Rob Wood, Chris
Donaldson, Scott Mills, Kent Nagata
TTOOPP:: Brian Liska
TQtjEViEfc...
BADMINTON CLUB
DANCE COMMITTEE
BOTTOM: Eric Herget, Duncan Purvis,
Doug Schow, Debb Carpenter
TOP: Katrina Tanne, Don Fletcher,
Mr, Stevenson, Joanne Paterson
BOTTOM: Tamara Hamilton, Staci Matkin, Jolaine White,
Tanya Jackson, Karen Karl
TOP: Brandi Smith, Renee Ketcheson, Jodi Vanderzee,
Mrs. Arthur, Elaine Yung, Krista Dorchak
CHESS CLUB
BOTTOM: Jason Murray, Kris Whitehead, Travis
Dorchak, Mike Miller, - , - , Danilo Jurisich
Connie Harms
MIDDLE: Blaire McMurren, Bob Beaton, Jerry
Stewart, -, -, Mrs. Jurisich
TOP: Richard Walker, Rodney Kornelson, Jud
Lewis, Shannon Lemire, -, Glen Kaszuba
STAGE BAND
BOTTOM: Jay Jordan, Trevor Groves, Mr. Scales, Brian
Fletcher, Lianne Harris
MIDDLE: Jane Cho, Michelle Kornelson, Chris Pratt,
Jamie Bagu, Colin Wiebe
TOP: Tim Hosken, Sanjeev Visvanatha, Jud Lewis,
Jason Lisowich, Scott Stevens, Doug Yoshida,
Clayton Hironaka, Massie Kitagawa
DANCE DECORATIONS
BOTTOM: Sonja Sage, Cheryl Harsch, Jenny Chapman
Tammy Crundwell, Kendra Beny, Allison Conley,
Donna Phillips
MIDDLE: Vanessa Chang, Tamara Hamilton, Susanne
Liska, -, Heather Hahn, Paul Carter, Christi
Beswick, Kathryn McLaine, Lisa Struble, Joyce
Dong
TOP: Chris Burgis, -, Jory Kohn, Michelle
Schultz, Tammy Friesen, Susan Cameron
GRAD COMMITTEE
BOTTOM: Dionne Aspeslet, Scott Tamblyn,
Jill Kaszuba, Chris Liska, Jenny
Levitt
TOP: Mr. Stevenson, Barb Stewart,
Joanne Paterson, Lori Yantz,
Katrina Tanne, Joel Nowlin,
Emily Campbell, Krista Beny,
Scott Kironaka, Duncan Purvis,
Kerri-Lynn Neufeld
Mr. Groft, Tracy Neilson, Claire Crooks, Allison Townsend,
Sarah Townsend, Massie Kitagawa, Candace Hebert.
CLASS OF 87 - VALEDICTION
Ladlei, Gentlemen, Parenti, Teachen, and fellow Graduates.
You know, the. brain is a wonderful thing. Ft itarti to work the.
moment we ate born and never itopi until we have to ipeak In public!
Hopefully, I can live up to the honor that you have given to me
tonight.
The theme &or this grade nine graduation is "Never Say Goodbye",
dihen I began to think about thoie wordi and what I would iay tonight
I remembered the 'Beetlei' iong 'Hello-Goodbye". 1^ we Never Say
Goodbye, then let'i Alwayi Say Hello.
Aeron Canada thli June, there will be many grade nine itudenti
graduating, die itudenti at Gilbert Patenon are like theie other
itudenti. Flrit, we are teenagen and parenti you know what that
meani! Secondly, teenagen have many concern about the world
iltuatlon and our future. Afiter all we are the future, die hear
about Nuclear diar^are, Crime, High Unemployment Ratei, Vrugi and
Aldi and It worrlei ui. die know that we tface many challenges and
that the road ahead will not be eaiy becauie THE ROAD TO SUCCESS IS
OFTEN UNDER CONSTRUCTION! Much like the roadi around here!
Gilbert Patenon hai prepared ui to iay 'HELLO' and greet
new Mlleitonei ai we reach them, die will Never Say Goodbuye to our
Junior High yean, but we know we muit move on. Next tfall many
o& ui will be attending L.C.l. die will iay "Hello L.C.l. ' die had
a iuperlor education at Gilbert Patenon. Our teachen taught ui
well. I(J we didn't alwayi iay 'HELLO' to their teachlngi and Ideai,
we can only blame ounelvei. Thank you teachen &or your guidance
and patience over the yean, die will 'Never Say Goodbye' to the
cualitlei and valuei which you have given to ui .
In iome wayi we are like Christopher Columbui. Can you Imagine
how he ^elf? He didn't know where he wai going, he didn't know
where he wai when he got there and he didn't know where he had been
when he got back! die alio don't know what llei ahead, but we are
prepared (,or the journey becauie our teachen and parenti have 'Never
Sold Goodbye'. They have alwayi encouraged ui to keep trying. Along
the way we will be iaylng 'HELLO' to new teachen, new rfrlendihlpi, ano
new ioclal activities. die will be ipreadlng our wlngi a little more.
Parenti, we will need your love and guidance 'and the car keyi'!
Ai with all teenagen there will be timei when we wilt not alwayi iee
'Eye to Eye' but ij, we can keepthe tlnei of, communication open and
alwayi iay 'HELLO' we’ll (,lnd the pot oj, gold at the ralnbow'i end.
And now fellow graduates. In the iprlngtlme gardnen plant
their ieedi. Here are a £ew tipi to achieve the garden ofi iucceii.
Flrit, plant three rowi o{, Peai ! PERSEVERANCE, PREPERAT1ON,
PROMPTNESS and PUNCTUALITY. The tail one is eipeclatty (,or my
twin iister.
Next plant three rowi o£ Squaih: SQUASH GOSSIP, SQUASH CRITICISM
and SQUASH INDIFFERENCE.
Then plant ^our rowi of, Lettuce: LET US BE FAITHFUL TO diHAT diE
HAVE LEARNED AT GILBERT PATERSON, LET US BE UNSELFISH AND LOYAL, LET
US BE TRUE TO OUR FRIENDS and LET US LOVE ONE ANOTHER.
And o{, counie a garden would not be complete without a row o< we 'Never Say Goodbye' to theie qualities we will harveit
a very happy tlfie.
STUART HUXLEY
THANK YOU TEACHERS AWP GILBERT PATERSON SCHOOL.
THANK YOU PARENTS.
ANV FELLOQ/ GRADUATES REMEMBER........ NEVER SAM GOODWE, ALQ/AVS SAM
HELLO!
hsucL jyuiMiind. crnntb...
MfJb sMltJ ...
'^ojipajr w»y wwp
nprM/Q^y
speJO
Awards
QacL -
INTER-COLLEGIATE PRES
LongITools:dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases
No full textAbstract
The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our ”modern” postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases
LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases
No full textThe current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our “modern” postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases.</p
