325,791 research outputs found

    S. Bruti, La cortesia. Aspetti culturali e problemi traduttivi, Pisa University Press, Pisa, 2013, 131 pp.

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    Il libro, organizzato su quattro capitoli, presenta un’analisi della (s)cortesia da un duplice punto di vista, culturale e traduttivo. Nel primo capitolo Bruti si focalizza su studi preesistenti relativi alla cortesia. Se a partire dagli anni Settanta circa, gli studi sulla stessa avevano una prospettiva soprattutto pragmatica ed erano fortemente anglocentrici, oggi si cerca di ampliare l’analisi prendendo in considerazione più lingue e utilizzando un approccio multidisciplinare. Come Bruti ribadisce più volte, per analizzare la cortesia, che spesso parlanti di culture diverse creano e percepiscono in modi differenti, non si può prescindere dal contesto situazionale in cui questa viene prodotta e ciò risulta tanto più vero nel momento in cui bisogna tradurre la stessa nel testo audiovisivo, dove coesistono più forme espressive e sussistono vincoli di varia natura. Nei successivi tre capitoli Bruti prende in considerazioni esempi tratti dal Pavia Corpus of Film Dialogue e si concentra sulla creazione e la traduzione rispettivamente di complimenti, insulti e forme allocutive, quest’ultime particolarmente insidiose nella traduzione dall’inglese all’italiano. Se studi sulla creazione dei complimenti nella lingua inglese rilevano dei tratti discorsivi ricorrenti, non è sempre possibile fare delle generalizzazioni di questo tipo sulla creazione degli insulti, per i quali emerge una certa creatività. Per quanto riguarda il testo tradotto (doppiato e/o sottotitolato) in italiano spesso si interviene semplificando, attenuando o addirittura eliminando l’insulto o il complimento

    Modulation of generalized spike-and-wave discharges during sleep by cyclic alternating pattern.

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    Because arousal plays a critical role in activation of epileptic phenomena, we analyzed the behavior of interictal generalized spike-and-waves (S-W) during the two recently identified modalities of arousal control during NREM sleep: (a) the cyclic alternating pattern (CAP), expressed by successive biphasic (phase A and phase B) fluctuations of arousal; and (b) non-CAP (NCAP), characterized by prolonged stable periods of EEG and arousal level. Within the single NREM stages, phase A consists of clusters of phasic events associated with transient arousal activation, whereas phase B is represented by the periodic reappearance of the EEG background and reflects a rebound inhibitory condition. The polysomnograms of 10 subjects with a wide age range and affected by primary generalized epilepsy displayed significant differences (all at p less than 0.01) between the spike indexes (S-W/min) of CAP (2.9) and NCAP (1.3), of phase A (7.4) and phase B (0.3), and of NCAP and phase B. For distribution of S-W, a significant prevalence of EEG paroxysms was detected during CAP as compared with NCAP (68 vs. 32\%, p less than 0.001), and 93\% of all the interictal bursts that occurred in CAP occurred in phase A (p less than 0.001). Our data stress the arousal-dependent influence of CAP and NCAP on modulation of generalized epileptic mechanisms during sleep

    Proteostasis and "redoxtasis" in the secretory pathway: Tales of tails from ERp44 and immunoglobulins.

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    In multicellular organisms, some cells are given the task of secreting huge quantities of proteins. To comply with their duty, they generally equip themselves with a highly developed endoplasmic reticulum (ER) and downstream organelles in the secretory pathway. These professional secretors face paramount proteostatic challenges in that they need to couple efficiency and fidelity in their secretory processes. On one hand, stringent quality control (QC) mechanisms operate from the ER onward to check the integrity of the secretome. On the other, the pressure to secrete can be overwhelming, as for instance on antibody-producing cells during infection. Maintaining homeostasis is particularly hard when the products to be released contain disulfide bonds, because oxidative folding entails production of reactive oxygen species. How are redox homeostasis ("redoxtasis") and proteostasis maintained despite the massive fluxes of cargo proteins traversing the pathway? Here we describe recent findings on how ERp44, a multifunctional chaperone of the secretory pathway, can modulate these processes integrating protein QC, redoxtasis, and calcium signaling

    Anelli vascolari congeniti: diagnosi, clinica e trattamento.

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    Gli anelli vascolari congeniti completi o incompleti rappresentano un’anomalia dell’arco aortico e dei vasi epiaortici che circondano completamente o parzialmente la trachea e l’esofago, determinando un variabile grado di compressione con un’ampia e aspecifica espressione clinica. L’aspecificità e la rarità di queste condizioni rendono difficoltosa la diagnosi da parte del clinico. Il ritardo diagnostico può determinare una cattiva prognosi e portare a sequele non più correggibili con chirurgia. Per tali motivi, davanti a fallimenti terapeutici usuali nel trattamento di condizioni cliniche frequenti come distress respiratorio o disfagia, è importante prendere in considerazione una diagnosi differenziale anche con patologie più rare, come gli anelli vascolari. La diagnosi prenatale, introdotta dalla messa in pratica routinaria di una scansione ecocardiografica fetale nello screening morfologico, ha semplificato il riconoscimento di queste condizioni e permesso un'adeguata diagnosi e conseguentemente una migliore prognosi. Presso la UOC di Cardiologia e Cardiochirurgia Pediatrica dell’Ospedale del Cuore di Massa sono stati selezionati 75 pazienti sottoposti a intervento chirurgico per anello vascolare dal 2005 al 2020: 42 per anelli vascolari completi e 33 incompleti. È stata riscontrata un’associazione significativa con malformazioni di altri apparati, in particolare con atresia esofagea e stenosi tracheale congenita e con altre anomalie intracardiache, soprattutto in alcuni sottogruppi di queste condizioni. Tra le sindromi genetiche associate si ritrova la S. di Di George, in accordo con i dati di letteratura. La diagnosi prenatale di anello vascolare rappresenta, quindi, una indicazione ad effettuare ulteriori indagini prenatali. Inoltre, consente un migliore outcome ponendo indicazioni sulla sede migliore dove nascere, sul follow up con attenta monitorizzazione della clinica e scelta del corretto timing chirurgico. La chirurgia effettuata al momento opportuno, abbatte i tempi di intubazione, di degenza e di reinterventi e riduce la necessità di posizionamento di stent tracheali nel post-operatorio per minore incidenza di tracheomalacia e minor numero di tracheostomie

    Diffusive author(s), cohesive author: Analysis of S/N (1994)

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    This study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)

    Mosaic of submerged habitats in the Venice lagoon shows signs of marinization

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    The relationships between habitat patterns and ecosystem functioning have been widely explored in terrestrial ecosystems, but less in marine and coastal ecosystems, calling for further research in this direction. This work focuses on the mosaic of submerged habitats in the Venice lagoon, Italy. It aims to describe the habitats’ spatial patterns at multiple spatial scales, and to explore their linkages with the ecological status defined according to the EU Water Framework Directive (WFD, 2000/60/EC). The submerged habitats’ mosaic has been analysed by calculating a set of seascape metrics at different spatial scales. These metrics have been linked with the biological quality elements (BQEs) that are monitored in the lagoon in compliance to the WFD. The results show that the habitats’ spatial patterns differ between the areas of the lagoon with marine-like features and the areas which still retain more lagoon characteristics. The similarity between the pattern found in the whole lagoon and those found in marine-like areas suggests a general loss of lagoon characteristics at the lagoon scale. Regarding the ecological status, every BQE seems to be associated with a different habitat configuration at the water body scale. This does not facilitate the joint improvement of the BQEs, as required by the Directive. If we cannot achieve that, at some point we will probably have to choose what to prioritize. On a broader perspective, this calls for a reflection on what lagoon we want for the future, a vision that should be shared and account for the lagoon’s complexity, current trends and challenges

    Divide-and-conquer potentials enable scalable and accurate predictions of forces and energies in atomistic systems

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    In committee of experts strategies, small datasets are extracted from a larger one and utilised for the training of multiple models. These models' predictions are then carefully weighted so as to obtain estimates which are dominated by the model(s) that are most informed in each domain of the data manifold. Here, we show how this divide-and-conquer philosophy provides an avenue in the making of machine learning potentials for atomistic systems, which is general across systems of different natures and efficiently scalable by construction. We benchmark this approach on various datasets and demonstrate that divide-and-conquer linear potentials are more accurate than their single model counterparts, while incurring little to no extra computational cost.Team Marcel Sluite

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Silica-supported TEMPO catalysts : synthesis and application in the Anelli oxidation of alcohols

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    The application of silica-supported TEMPO as a recyclable catalyst in the Anelli oxidation of alcohols is reported. The catalyst is easily obtained in a one-step reductive amination procedure starting from a commercially available aminopropyl-functionalized silica. Details of the synthesis of the supported catalyst and its analysis by MAS NMR are presented. Various alcohol oxidations according to the Anelli protocol have been carried out and the stability of the applied silica-supported TEMPO has been studied
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