25 research outputs found
Some fixed point results in complete generalized metric spaces
No full textThe Banach contraction principle is the most important result. This principle has many applications and some authors was interested in this principle in various metric spaces as Brianciari.
The author initiated the notion of the generalized metric space as a generalization of a metric space by replacing the triangle inequality by a more general inequality, for all pairwise distinct points of . As such, any metric space is a generalized metric space but the converse is not true. He proved the Banach fixed point theorem in such a space. Some authors proved different types of fixed point theorems by extending the Banach's result. Wardowski introduced a new contraction, which generalizes the Banach contraction. He using a mapping introduced a new type of contraction called -contraction and proved a new fixed point theorem concerning -contraction. In this paper, we have dealt with -contraction and -weak contraction in complete generalized metric spaces. We prove some results for -contraction and -weak contraction and we show that the existence and uniqueness of fixed point for satisfying -contraction and -weak contraction in complete generalized metric spaces. Some examples are supplied in order to support the useability of our results. The obtained result is an extension and a generalization of many existing results in the literature
Age and total and free prostate-specific antigen levels for predicting prostate volume in patients with benign prostatic hyperplasia
No full textObjectives: To investigate the predictive values of free prostate-specific antigen (fPSA), total PSA (tPSA) and age on the prostate volume. Methods: The data of 2148 patients with lower urinary tract symptoms were analyzed retrospectively. The patients who had transrectal ultrasonography guided 10 core biopsies owing to the findings obtained on digital rectal examination and presence of high PSA levels (PSA = 2.5-10 ng/dl), and proven to have BPH histopathologically were included in the study. Age, tPSA, fPSA and the prostate volumes (PV) of the patients were noted. Results: One thousand patients that fulfilled the inclusion criteria were included in the study. The PV of the patients were significantly correlated with age, tPSA and fPSA (p < 0.001 and r = 0.307, p < 0.001 and r = 0.382, p < 0.001 and r = 0.296, respectively). On linear regression model, fPSA was found as a stronger predictive for PV (AUC = 0.75, p < 0.001) when compared to age (AUC = 0.64, p < 0.001), and tPSA (AUC = 0.69, p = 0.013). Conclusions: Although tPSA is an important prognostic factor for predicting PV, the predictive value of fPSA is higher. PV can easily be predicted by using age, and serum tPSA and fPSA levels
Comparison of three questionnaire forms used in the diagnosis of lower urinary tract symptoms: A prospective study
No full textPurpose: Questionnaire forms (QFs) are used in the evaluation of all patients presenting with lower urinary tract symptoms (LUTSs). Our study aims to investigate the compatibility of the three QFs with each other and to investigate the relationship between education level and complete completion of these forms. Materials and methods: A total of 224 patients between February 2018 and February 2019 were included. The patients were divided into 3 groups as primary, intermediate, and advanced according to their education level and the patients who gave incomplete answers to the questions were determined. Results: The mean age of the patients was 61.0 ± 7.57(45-85), International Prostate Symptom Score (IPSS) value was 16.2 ± 8.3(1-35), the international incontinence form–male lower urinary tract symptoms (ICIQ-MLUTS) value was 16.5 ± 7.9(0-38), the visual prostate symptom score (VPSS) value was 9.9 ± 3.0(3-16). There was a significant correlation between the three QFs (P < 0.05). The correlation between IPSS and ICIQ-MLUTS was strong (r = 0.745). The incomplete response rate was 32.1% (n = 72) in ICIQ-MLUTS, 16.5% (n = 37) in VPSS, and 10.7% (n = 24) in IPSS (P < 0.05). The incomplete response rate was not affected by education. The rate of patients who could be questioned with ICIQ-MLUTS but not with the other two QFs varied between 12.9% and 85.2%, depending on the symptoms. Conclusions: Each QF has its advantages and disadvantages. The strong correlation between IPSS and ICIQ-MLUTS found in our study indicates that these tools can be used interchangeably in daily clinical practice. ICIQ-MLUTS can evaluate symptoms that are not present in other QFs. In the evaluation of illiterate patients, VPSS should be used without any alternative
Planting Geometry May Be Used to Optimize Plant Density and Yields without Changing Yield Potential per Plant in Sweet Corn
No full textPlanting geometry is one of the most important management practices that determine plant growth and yield of corn. The effects of eight planting geometries (35 × 23 cm, 40 × 21 cm, 45 × 19 cm, 50 × 18 cm, 55 × 17 cm, 60 × 16 cm, 65 × 15 cm, 70 × 15 cm) on plant growth and yields of three sweet corn hybrids (Argos F1, Challenger F1, Khan F1) were investigated under Erzurum, Türkiye conditions in 2022 and 2023 years. Variance analysis of the main factors shows a highly significant effect on whole traits but in two-way interactions some of the traits were significant and in the three-way interactions, it was insignificant. As an average of years, the number of plants per hectare at the harvest varied between 92,307 (35 × 23 cm) and 120,444 (70 × 15 cm) according to the planting geometries. The highest marketable ear number per hectare (107,456), marketable ear yield (24,887 kg ha−1), and fresh kernel yield (19,493 kg ha−1) were obtained from the 40 × 21 cm planting geometry. The results showed that the variety Khan F1 grown at 40 × 21 cm planting geometry obtained the highest marketable ear number (112,472), marketable ear yield (29,788 kg ha−1), and fresh kernel yield (22,432 kg ha−1). The plant density was positively correlated with marketable ear number (r = 0.904 **), marketable ear yield (r = 0.853 **), and fresh kernel yield (r = 0.801 **). The differences among the varieties were significant for the studied traits, except for plant density and kernel number per ear. In conclusion, the variety Khan F1 should be grown at the 40 × 21 cm planting geometry to maximize yields under study area conditions without water and nutrient limitations
Early clinical markers of aggressive multiple sclerosis
No full textPatients with the 'aggressive' form of multiple sclerosis accrue disability at an accelerated rate, typically reaching Expanded Disability Status Score (EDSS) ≥ 6 within 10 years of symptom onset. Several clinicodemographic factors have been associated with aggressive multiple sclerosis, but less research has focused on clinical markers that are present in the first year of disease. The development of early predictive models of aggressive multiple sclerosis is essential to optimize treatment in this multiple sclerosis subtype. We evaluated whether patients who will develop aggressive multiple sclerosis can be identified based on early clinical markers. We then replicated this analysis in an independent cohort. Patient data were obtained from the MSBase observational study. Inclusion criteria were (i) first recorded disability score (EDSS) within 12 months of symptom onset; (ii) at least two recorded EDSS scores; and (iii) at least 10 years of observation time, based on time of last recorded EDSS score. Patients were classified as having 'aggressive multiple sclerosis' if all of the following criteria were met: (i) EDSS ≥ 6 reached within 10 years of symptom onset; (ii) EDSS ≥ 6 confirmed and sustained over ≥6 months; and (iii) EDSS ≥ 6 sustained until the end of follow-up. Clinical predictors included patient variables (sex, age at onset, baseline EDSS, disease duration at first visit) and recorded relapses in the first 12 months since disease onset (count, pyramidal signs, bowel-bladder symptoms, cerebellar signs, incomplete relapse recovery, steroid administration, hospitalization). Predictors were evaluated using Bayesian model averaging. Independent validation was performed using data from the Swedish Multiple Sclerosis Registry. Of the 2403 patients identified, 145 were classified as having aggressive multiple sclerosis (6%). Bayesian model averaging identified three statistical predictors: age > 35 at symptom onset, EDSS ≥ 3 in the first year, and the presence of pyramidal signs in the first year. This model significantly predicted aggressive multiple sclerosis [area under the curve (AUC) = 0.80, 95% confidence intervals (CIs): 0.75, 0.84, positive predictive value = 0.15, negative predictive value = 0.98]. The presence of all three signs was strongly predictive, with 32% of such patients meeting aggressive disease criteria. The absence of all three signs was associated with a 1.4% risk. Of the 556 eligible patients in the Swedish Multiple Sclerosis Registry cohort, 34 (6%) met criteria for aggressive multiple sclerosis. The combination of all three signs was also predictive in this cohort (AUC = 0.75, 95% CIs: 0.66, 0.84, positive predictive value = 0.15, negative predictive value = 0.97). Taken together, these findings suggest that older age at symptom onset, greater disability during the first year, and pyramidal signs in the first year are early indicators of aggressive multiple sclerosis
Estimated glomerular filtration rate is associated with both arterial stiffness and N-terminal pro-brain natriuretic peptide in newly diagnosed hypertensive patients
No full textEven a slight decrease in the glomerular filtration rate (GFR) is an independent risk factor for cardiovascular disease. Arterial stiffness, left ventricular hypertrophy and N-terminal pro-brain natriuretic peptide (NT-proBNP) are independent risk factors for cardiovascular disease, which are particularly common in end-stage renal disease. We aimed to evaluate the association between GFR with arterial stiffness, left ventricle mass (LVM) and NT-proBNP in hypertensive subjects with normal to mildly impaired renal function. The study population consisted of 285 newly diagnosed hypertensive patients (mean age; 49.9 +/- 11.8 years). GFR was estimated (eGFR) by the Modification of Diet in Renal Disease formula. Pulse wave velocity (PWV) and augmentation index (AIx), which reflects arterial stiffness, were calculated using the single-point method via the Mobil-O-Graph (R) ARCsolver algorithm. LVM was obtained by echocardiography. Plasma NT-proBNP was measured by electrochemiluminescence. The patients were divided into two groups according to the median eGFR value (eGFR(low) group = 101 ml/min/1.73 m(2)). LVM and NT-proBNP values were higher in eGFR(low) group compared with eGFR(high) group (p50.05). Pulse wave velocity and augmentation index values were higher in eGFR(low) group compared with eGFR(high) group (p50.05, for all). Multiple linear regression analysis showed that eGFR was independently associated with PWV (beta = -0.422, p < 0.001) and NT-proBNP (beta = -0.404, p < 0.001). Present study showed that eGFR was independently associated with PWV and NT-proBNP values. Importantly, these findings may explain, in part, the increase in cardiovascular risk in with slightly impaired renal function
The evidence and the rationale for the use of honey as wound dressing
No full textAlthough there are now several brands and types of honey wound-care products available as registered medical devices, there is little promotional advertising of honey products for wound care. The misconception that there is no evidence to support the use of honey, which seems to be quite common, may be due to this lack of advertising, and to the systematic reviews that have been published on honey concluding that the evidence is of low quality and/or there is a need for more evidence. However, the same lack of high-quality evidence exists with all the other options that clinicians have for dressing wounds. This places practitioners in a quandary. When clinical evidence of the highest level is not available, then decisions on modes of treatment need to be based on whatever evidence there is available. This review outlines the 16 randomised controlled trials (RCTs) of honey in wound care published since Molan reviewed the previous 17 in 2006, which bring the total of participants in the trials up from 1,965 to 3,556 and broadens the range of types of wounds on which trials with honey have been conducted. Another important factor influencing the choice by clinicians of which product to use on a wound is scientific rationale. This review covers the evidence and explanation of mode of action for various bioactivities in honey which aid wound healing: a very broad-spectrum antimicrobial activity that is effective on antibiotic-resistant strains; activation of autolytic debridement; anti-inflammatory activity; antioxidant activity; stimulation of growth of cells for tissue repair; and an osmotic action. The need for standardisation of these bioactivities is discussed
Exposure of Vicia faba to sulcotrione pesticide induced genotoxicity
No full textISI Document Delivery No.: 949IKTimes Cited: 0Cited Reference Count: 45Cited References: ARNON DI, 1949, PLANT PHYSIOL, V24, P1, DOI 10.1104/pp.24.1.1 Bombail V, 2001, CHEMOSPHERE, V44, P383, DOI 10.1016/S0045-6535(00)00300-3 Bonnet JL, 2008, ARCH ENVIRON CON TOX, V55, P576, DOI 10.1007/s00244-008-9145-2 Cavas T, 2003, MUTAT RES-GEN TOX EN, V538, P81, DOI 10.1016/S1383-5718(03)00091-3 Cavas T, 2005, ENVIRON TOXICOL PHAR, V19, P107, DOI 10.1016/j.etap.2004.05.007 Chaabane H, 2005, J AGR FOOD CHEM, V53, P4091, DOI 10.1021/jf040443c Chaabane H, 2007, WATER RES, V41, P1781, DOI 10.1016/j.watres.2007.01.009 Chabaane H., 2008, PEST MANAG SCI, V64, P86 Cherrier R, 2004, AGRONOMIE, V24, P29, DOI 10.1051/agro:2003057 Cherrier R, 2005, PEST MANAG SCI, V61, P899, DOI 10.1002/ps.1105 de Lima Patricia Danielle Lima, 2005, Genet Mol Res, V4, P822 DEKERGOMMEAUX DJ, 1983, MUTAT RES, V124, P69, DOI 10.1016/0165-1218(83)90186-6 Dyson JS, 2002, J ENVIRON QUAL, V31, P613 Eyheraguibel B, 2011, J AGR FOOD CHEM, V59, P4868, DOI 10.1021/jf1047282 Eyheraguibel B, 2010, J AGR FOOD CHEM, V58, P9692, DOI 10.1021/jf101792h Foltete AS, 2011, CHEMOSPHERE, V85, P1624, DOI 10.1016/j.chemosphere.2011.08.026 Gadeva P, 2008, MUTAT RES-GEN TOX EN, V652, P191, DOI 10.1016/j.mrgentox.2008.02.007 Goupil P., 2011, ECOTOXICOLOGY, V20, P329 Grant WF, 1998, MUTAT RES-REV MUTAT, V410, P291, DOI 10.1016/S1383-5742(98)00004-0 Hartmann A, 2001, FOOD CHEM TOXICOL, V39, P843, DOI 10.1016/S0278-6915(01)00031-X Iarmarcovai G, 2006, TOXICOL LETT, V166, P1, DOI 10.1016/j.toxlet.2006.05.015 Kim JS, 2002, PHOTOSYNTHETICA, V40, P541, DOI 10.1023/A:1024395801360 Klobucar GIV, 2003, AQUAT TOXICOL, V64, P15, DOI 10.1016/S0166-445X(03)00009-2 Kontek R, 2007, J APPL GENET, V48, P359, DOI 10.1007/BF03195232 Krishna G, 2000, MUTAT RES-FUND MOL M, V455, P155, DOI 10.1016/S0027-5107(00)00117-2 Llorente MT, 2002, ECOTOXICOLOGY, V11, P27, DOI 10.1023/A:1013741012993 MA TH, 1995, MUTAT RES-ENVIR MUTA, V334, P185, DOI 10.1016/0165-1161(95)90010-1 MacKinney G, 1941, J BIOL CHEM, V140, P315 Marcano L, 2004, ENVIRON RES, V94, P221, DOI 10.1016/S0013-9351(03)00121-X Mattiuzzo M, 2006, CARCINOGENESIS, V27, P2511, DOI 10.1093/carcin/bgl102 MAYONADO DJ, 1989, PESTIC BIOCHEM PHYS, V35, P138, DOI 10.1016/0048-3575(89)90111-9 Rouchaux J., 2001, TOXICOL ENVIRON CHEM, V79, P211, DOI DOI 10.1080/02772240109358989 Russo C, 2004, ECOTOX ENVIRON SAFE, V57, P168, DOI 10.1016/S0147-6513(03)00027-7 SCHULZ A, 1993, FEBS LETT, V318, P162, DOI 10.1016/0014-5793(93)80013-K SECOR J, 1994, PLANT PHYSIOL, V106, P1429 Seoane AI, 2001, MUTAT RES-GEN TOX EN, V490, P99, DOI 10.1016/S1383-5718(00)00145-5 Siu WHL, 2004, AQUAT TOXICOL, V66, P381, DOI 10.1016/j.aquatox.2003.10.006 SOEDA T, 1987, PESTIC BIOCHEM PHYS, V29, P35, DOI 10.1016/0048-3575(87)90082-4 Sokal R.R., 1981, BIOL RES Souguir D, 2008, PROTOPLASMA, V233, P203, DOI 10.1007/s00709-008-0004-9 Ter Halle A, 2006, ENVIRON SCI TECHNOL, V40, P2989, DOI 10.1021/es052266h Turkoglu S, 2007, MUTAT RES-GEN TOX EN, V626, P4, DOI 10.1016/j.mrgentox.2006.07.006 Voutsinas G, 1997, CELL BIOL INT, V21, P411, DOI 10.1006/cbir.1997.0171 Wichert R.A., 1999, P BCPC C WEEDS, V1-3, P105 WILSON JS, 1992, WEED TECHNOL, V6, P583Sta, Chaima Ledoigt, Gerard Ferjani, Ezzeddine Goupil, PascaleAcademic press inc elsevier scienceSan diegoLedoigt, G (reprint author), Univ Clermont Ferrand, Univ Blaise Pascal, UMR PIAF 547, BP 10448, F-63000 Clermont Ferrand, [email protected] genotoxicity of sulcotrione 2-(2-chloro-4-(methylsulfonyl)benzoyl)-1,3-cyclohexanedione, a selective triketonic herbicide was evaluated on Vicia faba seedlings in hydroponic culture conditions. Sulcotrione (10(-5), 10(-4) and 2 x 10(-4) M) treatments for 45 h, caused a dose dependent increase in micronuclei frequencies in root meristematic cells. Cytological analysis of root tips cells showed aneugenic effects of the sulcotrione on the plant root meristems. Sulcotrione induced chromosomal alterations at the lowest concentration used (10(-5) M) when incubated for 42 h, indicating the potent mutagenic effect of this element. This is the first report for the genotoxicity of such a sulcotrione herbicide. (C) 2012 Elsevier Inc. All rights reserved
Integrated Proteomic and Metabolomic prediction of Term Preeclampsia
No full textAbstractTerm preeclampsia (tPE), ≥37 weeks, is the most common form of PE and the most difficult to predict. Little is known about its pathogenesis. This study aims to elucidate the pathogenesis and assess early prediction of tPE using serial integrated metabolomic and proteomic systems biology approaches. Serial first- (11–14 weeks) and third-trimester (30–34 weeks) serum samples were analyzed using targeted metabolomic (1H NMR and DI-LC-MS/MS) and proteomic (MALDI-TOF/TOF-MS) platforms. We analyzed 35 tPE cases and 63 controls. Serial first- (sphingomyelin C18:1 and urea) and third-trimester (hexose and citrate) metabolite screening predicted tPE with an area under the receiver operating characteristic curve (AUC) (95% CI) = 0.817 (0.732–0.902) and a sensitivity of 81.6% and specificity of 71.0%. Serial first [TATA box binding protein-associated factor (TBP)] and third-trimester [Testis-expressed sequence 15 protein (TEX15)] protein biomarkers highly accurately predicted tPE with an AUC (95% CI) of 0.987 (0.961–1.000), sensitivity 100% and specificity 98.4%. Integrated pathway over-representation analysis combining metabolomic and proteomic data revealed significant alterations in signal transduction, G protein coupled receptors, serotonin and glycosaminoglycan metabolisms among others. This is the first report of serial integrated and combined metabolomic and proteomic analysis of tPE. High predictive accuracy and potentially important pathogenic information were achieved.</jats:p
Thermo-Mechanical Modeling and Experimental Validation of an Uncooled Microbolometer
No full textThis paper presents mechanical and thermal modeling of a microbolometer using finite element modeling in ANSYS. The considered design of microbolometer is modeled, fabricated and measured. The deformations on the arm structure of the microbolometer are measured and compared with the developed model. Additionally, the measurements for mechanical deformations over 8-inch wafer are used to identify the effect of the process variations on the final device. The measured deformation distribution is correlated with the varied thickness of the bottom Si3N4 layer of the arm structure. Finally, the ANSYS models are utilized in order to extract thermal characterization properties of the microbolometer design, namely thermal conductance and the time constant
