76 research outputs found
Improvise interface design of UTHM academic online resources e-learning system (author) / Azizul Zamri Muhamed Amin
Get PDFEducation is very important especially in these challenging times. Various technologies day by day are growing, also the current educational technology. If in the past the traditional delivery of education there should be a lecturer in front and students listened to what the lecturer presented orally. Now keeping pace with technology education where knowledge is delivered not only in accordance with the timetable in the classroom, but can also be delivered on-line and accessible regardless of time and place restrictions call as blended learning techniques. Blended learning is used to deliver knowledge among technology websites, videos, interactive cd, multimedia equipment and many more. The availability of this technology has triggered a variety of learning techniques such as blended learning. There are so many systems that can can support learning techniques process such as Online Academic Online Resources (AUTHOR), an e-learning system used by UTHM. A learning management system must be developed with creativity and innovative features in terms of interface design and system capability to ensure the effectiveness of the system for lecturers and students. Therefore the purpose of this study is to find out why lecturers and students at the Faculty Of Computer Science and Information Technology, UTHM are not fully utilized this e-learning system (AUTHOR). The findings shows that through the development of a workable prototype with improvise interface design using blended learning concept can be applied in this e-learning system (AUTHOR). Hopefully with this improvised interface design will attract the lecturers and students more to fully utilized this system in the future
Dataset of curcumin derivatives for QSAR modeling of anti cancer against P388 cell line
No full textAbstractThe dataset of curcumin derivatives consists of 45 compounds (Table 1) with their anti cancer biological activity (IC50) against P388 cell line. 45 curcumin derivatives were used in the model development where 30 of these compounds were in the training set and the remaining 15 compounds were in the test set. The development of the QSAR model involved the use of the multiple linear regression analysis (MLRA) method. Based on the method, r2 value, r2 (CV) value of 0.81, 0.67 were obtained. The QSAR model was also employed to predict the biological activity of compounds in the test set. Predictive correlation coefficient r2 values of 0.88 were obtained for the test set
TOKSISITAS SENYAWA ANALOG KALKON 3’-METOKSIASETOFENON MENGGUNAKAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)
Get PDFSenyawa kalkon merupakan prekursor dari flavonoid yang penting sebagai antioksidan. Kalkon memiliki berbagai bioaktivitas seperti antikanker, antimikroba, antijamur, antitumor dan anti-inflmasi. Pada penelitian ini dilakukan sintesis senyawa (E)-1-(3’-metoksifenil)-3-(3-nitrofenil)prop-2en-1-on dengan metode iradiasi gelombang mikro dan menggunakan katalis basa KOH. Senyawa yang dihasilkan diuji kemurniannya dengan KLT, uji titik leleh dan analisis HPLC serta telah dikarakterisasi dengan spektroskopi UV, FTIR, 1H-NMR dan MS serta diuji toksisitasnya dengan metode Brine Shrimp Lethality Test (BSLT). Senyawa ini menunjukkan aktivitas toksisitas yang kurang baik dengan nilai LC50 >200 μg/mL
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON DARI 4’- HIDROKSIASETOFENON DENGAN DIMETOKSIBENZALDEHID
Get PDFSenyawa kalkon terdiri dari dua cincin aromatik yang dihubungkan oleh tiga atom karbon dengan sistem karbonil α, β tak jenuh. Senyawa kalkon dilaporkan memiliki bioaktivitas yang beragam dan menarik, diantaranya sebagai antioksidan, antikanker, anti-inflamasi, antialzheimer dan antimikroba. Senyawa (E)-3-(2,3-dimetoksifenil)-1-(4’-hidroksifenil)prop-2-en-1-on disintesis melalui iradiasi gelombang mikro dengan katalis KOH dan pelarut etanol absolut. Analisis struktur senyawa ini dilakukan menggunakan spektroskopi UV, FTIR, HRMS dan 1H-NMR. Rendemen yang diperoleh yaitu 74,6%. Berdasarkan uji toksisitasnya, senyawa ini tidak berpotensi sebagai antikanker karena memiliki nilai LC50 = 291,789 μg/mL
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON TERSUBSTITUSI METOKSI
Get PDFtumbuhan dalam jumlah yang relatif sedikit. Senyawa ini merupakan prekursor untuk biosintesis flavonoid dan isoflavonoid. Senyawa kalkon telah dilaporkan memiliki berbagai aktivitas biologis yang menarik seperti antimikrob, antitumor, antioksidan, antiinflamasi, antimalaria, dan antikanker. Aktivitas senyawa kalkon dipengaruhi oleh gugus α,β-tak jenuh dan substituen yang terdapat pada cincin aromatiknya. Pada penelitian ini, tiga analog kalkon tersubstitusi mono-metoksi pada cincin A aromatik dan cincin B aromatiknya telah disintesis menggunakan metode iradiasi microwave dengan katalis KOH dan pelarut etanol. Struktur setiap produk dikarakterisasi dengan spektroskopi UV-Vis, FTIR, 1H NMR, 13C NMR, dan HRMS. Uji toksisitas dilakukan menggunakan metode Brine Shrimp Lethality Test (BSLT). Berdasarkan hasil uji BSLT, ketiga senyawa tersebut berpotensi sebagai senyawa antikanker dengan nilai LC50<200 μg/mL
Daya antibakteri senyawa non Alkaloid kulit kayu pulai gading (Alstonia scholoris, R. Brown) terhadap Staphyloccus aurus secara in vitro
Get PDFPulai gading (Alstonia scholaris, R. Brown) sudah sejak lama digunakan sebagai obat kulit dan sakit perut seperti diare, antara lain disebabkan oleh Staphylococcus aureus. Alkaloid yang dipercaya mempunyai khasiat sebagai obat, ternyata tidak dapat menghambat pertumbuhan S. aureus.
Penelitian ini bertujuan mengisolasi senyawa non alkaloid fraksi kloroform than etanol kulit kayu A. scholaris dan menguji aktivitas antibakterinya terhadap S. aureus secara in vitro. Pemisahan senyawa alkaloid dan non alkaloid ekstrak fraksi kloroform dan etanol kulit kayu A. scholaris dilakukan dengan ekstraksi jalur khusus alkaloid menurut cara Adel Zamri (1989), sedangkan uji antibakteri dilakukan dengan metode paper disk pada konsentrasi 5%, 10% dan 20% (b/v) untuk masing¬masing fraksi.
Hasil penelitian menunjukkan bahwa pada konseniraii 5% dan 10% (b/v) kedua fraksi tidak menyebabkan hambatan terhadap pertumbuhan S. aureus. Pada konsentrasi 20% (b/v), senyawa non alkaloid fraksi kioroform menyebabkan hambatan yang lebih besar dan berbeda nyata dibandingkan dengan senyawa non alkaloid fraksi etanol. Senyawa non alkaloid fraksi kloroform dan etanol bersifat bakteriostatik terhadap S. aureus.
Pulai gading (Alstonia scholaris, R. Brown) has been used as a skin and diarrhoea medicine since many years, Staphylococcus aureus was a bacteria which has known as one of diarrhoea causing agents. The alkaloid compounds has a medicinal activity, but it can't inhibit S. aureus growth.
The aims of this research were to isolate ethanolic and chloroform fraction of non alkaloid compounds from A. scholaris bark and examined the antibacterial activities to S. aureus in vitro. The compounds separation was done by Adel Zamri extraction method (1989), while the antibacterial activities determined by paper disk method in the concentrations of 5%, 10% and 20% (w/v) for each fraction.
The results showed that the non alkaloid compounds of ethanolic and chloroform fraction were caused no inhibition on the S. aureus growth in the concentrations of 5% and 10% (w/v). On the concentration 20°(o (w/v), non alkaloid compounds of chloroform fraction give the larger inhibition activity than ethanolic non alkaloid compounds and significantly different. Ethanolic and chloroform fraction of non alkaloid compounds showed a bacteriostatic activity on S. aureus.
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Reflective Learning Journal Using Blog
No full textAbstractGetting students to write reflective journal is a good way for them to learn new concepts. This approach is also useful in order for the lecturer to gain feedback on the concepts that the students learned. The question that the author wishes to pursue is “How best the journal is going to be managed?” To manage the reflective learning journal assignment, the author has been experimenting with the use of special blog called Jurnal Pengurusan Emosi. All registered students in Managing Emotion, an elective course in the Centre for General Studies, Universiti Kebangsaan Malaysia were required to submit their journal on weekly basis using email and their journal entries are automatically published in the blog. The feedback of the students were very good, among the reasons quoted in relation to the use of the blog were in terms of facilitating their expression of thoughts, learning and sharing of each other's knowledge, and enhancing their understanding of concepts that they learned in class. This paper aims to share author's experience in managing Jurnal Pengurusan Emosi
Sintesis Dan Uji Aktivitas Antioksidan Senyawa Flavonol 2-(3,4,5-Dimetoksifenil)-3-Hidroksi-4h-Kromen-4-On
Get PDFFlavonols derivatives of 2'-hydroxycalone have been synthesized under basic condition (KOH). The structures of all compounds were characterized based on the interpretation of spectroscopic data including HPLC, UV, FTIR, NMR and HRMS. Antioxidant activity was evaluated using the DPPH assay which showed that the flavonol 2'-hydroxycalone derivative was potentially active as antioxidants with IC50 values <1000 µg / mL
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG PARA METIL KALKON
Get PDFSenyawa kalkon (E)-1,3-di-p-tolilprop-2-en-1-on telah berhasil disintesis dari 4’-metilasetofenon dan 4-metilbenzaldehid melalui kondensasi Claisen-Schmidth menggunakan NaOH (3N) sebagai katalis dibawah iradiasi microwave menghasilkan rendemen sebesa 62,64 %. Senyawa yang dihasilkan diuji kemuniannya dengan KLT, uji titik leleh dan analisis HPLC serta dikarakteisasi strukturnya berdasarkan interpretasi data spektroskopi UV, FTIR, 1H-NMR dan MS. Uji toksisitas senyawa kalkon ini menggunakan metode Brine Shrimp Lethality Test (BSLT) terhadap larva Artemia salina Leach. Nilai LC50 untuk senyawa(E)-1,3-di-p-tolilprop-2-en-1-on adalah 7,656 μg/mL. Senyawa analog kalkon tersebut positif berpotensi sebagai antikanker
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