17,483 research outputs found
Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2) : a cluster-randomised controlled trial
No full textFunding Information: R M Pearse reports grants from Edwards Lifesciences and Intersurgical; and personal fees from Edwards Lifesciences and GlaxoSmithKline, outside of the submitted work. R M Pearse also reports being a member of the editorial boards of the British Journal of Anaesthesia and the British Journal of Surgery. A B A Prempah was the recipient of the World Federation of Societies of Anaesthesiologists–International Anesthesia Research Society Clinical Research Fellow in Global Surgery and Anaesthesia in Africa. All other authors declare no competing interests. Funding Information: The ASOS-2 pilot and trial were partially supported by a grant (OPP#1161108) from the Bill & Melinda Gates Foundation, as a subaward from Praekelt. Researchers for the process evaluation were supported by a grant from the World Federation of Societies of Anaesthesiologists. Publisher Copyright: © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licensePeer reviewe
Lidar Rayleigh-fit criteria
No full textThe talk explains how aerosol-free regions in a lidar signal can be determined by means of the so-called Rayleigh-fit. Criteria based on statistical analyses of the residuals are proposed and explained in detail, which allow to assess the quality of the Rayleigh-fit. Some of the methods can be used to develop quantitative criteria for the uncertainty in the retrieved reference value for the lidar signal inversion
ASOS data
No full textASOS data along with model output data for the cyclones: Bulbul, Fani, Titli and Than
Equity valuation Asos PLC
No full textThis thesis aims to study the value of Asos PLC. The valuation was based in four methodologies, the Discounted Cash Flow (DCF), the Economic Value Added (EVA), the Trading Multiples and the Transaction Multiples.
Using the DCF method, a price of 3.054p was obtained and the EVA yielded a comparable lower value of 2.528p. Regarding the Relative Valuation, this was the method which delivered the lowest values of 1.573p for the Trading Multiples and 1.253p for the Transaction Multiples.
It was concluded that the four methodologies yielded different prices per share, though the DCF being the most accurate and complete model to demonstrate Asos’ intrinsic value. Given this and comparing the DCF output to the market valuation, Asos’ stock was rated as being Overweight.
Nonetheless, a sensitivity analysis was conducted in order to test how the valuation could change, along with the variation of some of the model’s sources of uncertainty. The conclusion of this analysis was that, changes in both WACC and perpetual growth rate variables, would significantly affect the outcome of the valuation, although the WACC being responsible for greater impacts.
Additionally, a more in-depth analysis to Asos’ stock price performance from 2001 to 2014 was conducted. When applying the Value at Risk statistical technique, it was concluded that, with 99% confidence level, an investor is exposed to the risk of losing 8,90% of the total amount invested in Asos.
Finally, this thesis’ valuation was compared to the most recent J. P. Morgan report about this equity. Both final recommendations were DCF-based and some fundamental inputs were estimated very closely, such as the WACC and the perpetual growth rate. The report presented a final recommendation of Overweight, with a price target of 3.100p, being very approximate to the result of this study of 3.054p
Comparison of ceiling and visibility observations for NWS manned observation sites and ASOS sites
No full textMay 1993.Also issued as Jon C. Cornick's thesis (M.S.) -- Colorado State University, 1993.The National Weather Service modernization program involves, among other things, a shift from manned weather observation to automated, unmanned instrument sensing. The Automated Surface Observing System (ASOS) is the device that will replace the conventional manned weather observation in use today. ASOS observations of ceiling and visibility were compared to the standard manual observations at 16 sites having at least four months of overlap data. The 16 sites were located in the central plains states of Colorado, Nebraska, Missouri, Kansas, Oklahoma, and Texas. The period of study was confined to the precommissioning period of the sites when both conventional data and ASOS data were available. The study spans from mid-September of 1991 to late July 1992, with the greatest amount of data collected between February and June 1992. The overall results show that ASOS ceiling reports were within 1000 ft of conventional ceiling reports 92.7% of the time. Similarly, ASOS derived visibility was within one reportable category of conventionally derived visibility 93.7% of the time. These percentages were determined from a data base composed of approximately 64,000 observations. During periods of active weather that would require a weather type entry into the coded observation, the high level of equality is decreased. The percentage of visibility reports within one reportable category is 60.8% and the percentage of ceilings within 1000 ft of conventional reports is 76%. These percentages were determined from a data base of approximately 9,300 observations containing a current weather entry. There were 5,263 cases of conventionally observed weather that would be categorized as requiring IFR (Instrument Flight Rules) by the FAA (Federal Aviation Administration) for safe air travel. ASOS observations correctly identified 4,499 of these events for an 85.5% equivalency rate. ASOS observations indicated 5,129 IFR occurrences, or nearly the same amount as conventional observations. Fog is the most frequently reported weather phenomena when large discrepancies occur between conventional and ASOS ceiling or visibility reports. This investigation shows that ASOS reported visibilities in foggy conditions are generally higher than those reported by conventional means. Ceilings in foggy conditions as reported by ASOS are generally much lower than those reported conventionally
Sequences of ASOs used in the study.
No full text<p>All RNase H-dependent ASOs used for target mRNA reduction were 20 bases in length, all linkages were phosphorothioate and 2′-<i>O</i>-methoxyethyl residues were incorporated at the positions 1–5 and 16–20. An analog of each ASO was also synthesized with 2′-<i>O</i>-methoxyethyl at each position.</p><p>*Asterisks indicate ASOs targeting SOD/TO-AB mutant sites and base changes relative to parent ASO are indicated by lower case letters.</p><p>Sequences of ASOs used in the study.</p
Estrategia de comunicación de Asos.
No full textASOS es una marca de ropa y belleza líder en Reino Unido, lugar donde se encuentra su sede
principal, y con una gran presencia en países de la Unión Europea, llegando a recibir pedidos de más de 237 países alrededor del mundo.
Esta investigación tendrá como fin averiguar los factores principales que hacen que ASOS sea
una marca con tanto éxito en el mundo del ecommerce, intentando establecer unas normas o pautas generales que cualquier empresa deba seguir para alcanzar un mínimo de eficiencia en cuanto a marketing online se refiere
ASOS data
No full textASOS data along with model output data for the cyclones: Bulbul, Fani, Titli and ThaneTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
ASOs targeting a repeat sequence in <i>GCCR</i> are more active than ASOs targeting other regions of the gene.
No full text<p>A) Sequence of part of <i>GCGR</i> intron 1. The first row shows the sequence of the intron 5′ of the repeats. Regions containing repeats (shown in red) are aligned in subsequent rows. A ninth repeat is homologous at 19/20 bases. Sequence of the intron 3′ of the repeats is shown in the bottom row. B) ASOs complementary to the repeat regions and other sequences in intron 1 were tested for ability to reduce levels of <i>GCGR</i> mRNA. Reduction was assessed by qRT/PCR 24 hours after electroporation of HepG2 cells in the presence of 1 µM ASO. Data were normalized to total RNA as measured by Ribogreen assay and are presented as expression in target mRNA relative to mock transfected control (UTC) for duplicate treatments with error bars representing range of activity. ASOs C1 and C2 do not have any perfect antisense alignment to human genes. C) Concentration response of multiple-site (398457) and single-site (395459) ASOs. HepG2 cells were treated with ASOs at concentrations between 0.5 nM and 150 nM in the presence of cationic lipid. <i>GCGR</i> mRNA reduction was assessed by qRT/PCR the following day. D) Concentration response curves of 17-nucleotide gapmer ASOs. <i>GCGR</i> mRNA reduction was assessed following treatment with ASO as detailed above. Red lines correspond to ASOs targeting multiply repeated sites; black lines to ASOs targeting single sites. E) Activity is increased when sites are repeated compared to activity on a transcript with the same single site. HepG2 cells were treated with 17-nucleotide ASOs at concentrations between 0.5 nM and 150 nM. <i>GCGR</i> (red lines) and <i>nucleoporin</i> (black lines) mRNA reduction was assessed by qRT/PCR the following day. Significance of the difference in IC<sub>50</sub> values between ASOs targeting the GCGR multiple site <i>nucleoporin</i> single site as evaluated by Mann-Whitney U Test is shown below the figure.</p
The case of Inditex and ASOS : mergers and acquisitions
No full textThe apparel and fashion retailing business is currently in transition from brick and mortar to
online. The fast fashion giants Inditex and H&M face competition from fashion e-commerce,
while struggling themselves with their online rollout. Simultaneously, the stars of online-only
fast fashion retailing, like ASOS and Zalando, experience aggressive competition that causes
pricing pressure and shrinking margins. In contrast to ASOS’s market capitalizations over one
year ago, with price-earnings ratios above 100, the stand-alone valuation indicates that ASOS
is currently trading close to fair value, which makes it an attractive takeover target. Acquiring
ASOS would enable Inditex to efficiently enter e-commerce with a famous online-only brand.
ASOS shareholders could exit their investment, leaving the company with a strategic investor
to enable further expansion. The strategic fit allows for synergies to increase the valuation of
the combined firm. Selling Inditex products on the ASOS marketplace and extending ASOS’s
deliver-to store option with the Inditex store network would increase sales. Cost synergies are
expected from the consolidation of sourcing and manufacturing as well as the rationalization
of administrative and organizational redundancies. Overall, synergies of approximately €12bn
would add shareholder value of approximately 11,47% to Inditex’s current market cap. ASOS
shareholders will be offered €66,75 or 2,25 Inditex shares per ASOS share, respectively 30%
premium on fair value. The mix of cash and stock enables Inditex to utilize its cash pile, avoid
leverage and align interests
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