24 research outputs found
Angiotensin II and Prostaglandin Interactions on Systemic andRenal Effects of L-NAME in Humans
No full textFor investigation of whether interactions between
prostaglandins and angiotensin II modulate renal response to
acute nitric oxide synthesis inhibition in humans, seven young
volunteers who were kept on a 240-mM Na diet underwent
four experiments with 90 min of infusion of 3.0 mg/kg.min21
NG-nitro-L-arginine methyl ester (L-NAME), each preceded by
a 3-d treatment with placebo (PL), 50 mg of losartan (LOS), 75
to 125 mg of indomethacin (IND), or both drugs. Mean arterial
pressure (MAP), GFR, effective renal plasma flow (ERPF),
and Na excretion rate (UNaV) were measured at baseline and
from 0 to 45 min and 45 to 90 min of L-NAME infusion. After
PL, L-NAME reduced GFR by 5% at 45 min (P , 0.05) and by
9% at 90 min (P , 0.001), ERPF by 11 to 17% (P , 0.001),
and UNaV by 28 to 45% (P , 0.001). MAP, unchanged at 45min, rose by 5% (P , 0.001) at 90 min. LOS prevented pressor
but not renal effects of L-NAME. With L-NAME1IND, MAP
rose even at 45 min (15%; P , 0.001 versus baseline) with a
10% rise at 90 min (P , 0.001). Changes in GFR (213 to
220%), ERPF (219 to226%), and UNaV (251 to270%) were
greater than those with L-NAME1PL or L-NAME1LOS (P ,
0.05 to 0.001). With L-NAME1IND1LOS, MAP did not increase,
and GFR, ERPF, and UNaV fell much less than with
L-NAME1IND alone (P , 0.02 to 0.001) with no differences
versus PL or LOS alone. Angiotensin II blockade does not affect
renal changes caused by L-NAME but prevents their potentiation
by prostaglandin inhibition. Thus, endogenous prostaglandins
counteract renal actions of endogenous angiotensin II in Na repleted humans even when nitric oxide synthesis is inhibite
A novel CISD2 intragenic deletion, optic neuropathy and platelet aggregation defect in Wolfram syndrome type 2
No full textBackground: Wolfram Syndrome type 2 (WFS2) is considered a phenotypic and genotypic variant of WFS, whose minimal criteria for diagnosis are diabetes mellitus and optic atrophy. The disease gene for WFS2 is . The clinical phenotype of WFS2 differs from WFS1 for the absence of diabetes insipidus and psychiatric disorders, and for the presence of bleeding upper intestinal ulcers and defective platelet aggregation. After the first report of consanguineous Jordanian patients, no further cases of WFS2 have been reported worldwide. We describe the first Caucasian patient affected by WFS2. Case presentation: The proband was a 17 year-old girl. She presented diabetes mellitus, optic neuropathy, intestinal ulcers, sensorineural hearing loss, and defective platelet aggregation to ADP. Genetic testing showed a novel homozygous intragenic deletion of in the proband. Her brother and parents carried the heterozygous mutation and were apparently healthy, although they showed subclinical defective platelet aggregation. Long runs of homozygosity analysis from SNP-array data did not show any degree of parental relationship, but the microsatellite analysis confirmed the hypothesis of a common ancestor. Conclusion: Our patient does not show optic atrophy, one of the main diagnostic criteria for WFS, but optic neuropathy. Since the "asymptomatic" optic atrophy described in Jordanian patients is not completely supported, we could suppose that the ocular pathology in Jordanian patients was probably optic neuropathy and not optic atrophy. Therefore, as optic atrophy is required as main diagnostic criteria of WFS, it might be that the so-called WFS2 could not be a subtype of WFS. In addition, we found an impaired aggregation to ADP and not to collagen as previously reported, thus it is possible that different experimental conditions or inter-patient variability can explain different results in platelet aggregation. Further clinical reports are necessary to better define the clinical spectrum of this syndrome and to re-evaluate its classification.Background: Wolfram Syndrome type 2 (WFS2) is considered a phenotypic and genotypic variant of WFS, whose minimal criteria for diagnosis are diabetes mellitus and optic atrophy. The disease gene for WFS2 is . The clinical phenotype of WFS2 differs from WFS1 for the absence of diabetes insipidus and psychiatric disorders, and for the presence of bleeding upper intestinal ulcers and defective platelet aggregation. After the first report of consanguineous Jordanian patients, no further cases of WFS2 have been reported worldwide. We describe the first Caucasian patient affected by WFS2. Case presentation: The proband was a 17 year-old girl. She presented diabetes mellitus, optic neuropathy, intestinal ulcers, sensorineural hearing loss, and defective platelet aggregation to ADP. Genetic testing showed a novel homozygous intragenic deletion of in the proband. Her brother and parents carried the heterozygous mutation and were apparently healthy, although they showed subclinical defective platelet aggregation. Long runs of homozygosity analysis from SNP-array data did not show any degree of parental relationship, but the microsatellite analysis confirmed the hypothesis of a common ancestor. Conclusion: Our patient does not show optic atrophy, one of the main diagnostic criteria for WFS, but optic neuropathy. Since the "asymptomatic" optic atrophy described in Jordanian patients is not completely supported, we could suppose that the ocular pathology in Jordanian patients was probably optic neuropathy and not optic atrophy. Therefore, as optic atrophy is required as main diagnostic criteria of WFS, it might be that the so-called WFS2 could not be a subtype of WFS. In addition, we found an impaired aggregation to ADP and not to collagen as previously reported, thus it is possible that different experimental conditions or inter-patient variability can explain different results in platelet aggregation. Further clinical reports are necessary to better define the clinical spectrum of this syndrome and to re-evaluate its classification
Alegoría y Trauerspiel
No full textThe author analyzes the characteristics of the allegory that Baltasar Gracián unfolds widely in the
work The Criticón establishing interesting comparisons with the allegory notion that Walter Benjamin
develops in his book Ursprung des deutschen Trauerspiels. The open defense that Benjamin makes of the
calderonian theater front to german Trauerspiel allows to extend this defense not only to the baroque
development of the allegory like expression but to other aspects like the immanent moral, the dialectic one of
the theatricality, the temporality or the mystification in the opus magna of Gracián
Riceventi, lettori e pubblico. Una proposta transdisciplinare
No full text[Italiano]: La dignità comunicativa di un messaggio, sia esso il nucleo di un testo letterario, di un atto linguistico o di un episodio storiografico, dipende in buona parte dal ruolo giocato dal destinatario. Esso rappresenta un nodo cruciale per l’ermeneutica e la teoria della letteratura, oltre che per la ricerca filologica, che hanno nel lettore un interlocutore vivo, reale o simulato, dell’autore e del suo testo. In linguistica al ricevente non spetta solo il compito di accogliere passivamente il messaggio, ma anche quello di guidare il mittente nelle scelte linguistiche e testuali: a lui sono dunque riservate le sorti di ogni atto della comunicazione. Allo stesso modo il destinatario diventa la ragion d’essere della storiografia, che al pubblico offre schemi e strumenti interpretativi per leggere la storia alla luce delle vicende e degli interrogativi del presente.
Questi i temi e le prospettive d’indagine da cui muovono i saggi qui raccolti: una proposta transdisciplinare che ha origine da un lavoro di ricerca pluriennale e dagli incontri seminariali tenuti nell’ambito del Programma di Dottorato di Studi Letterari, Linguistici e Storici presso il Dipartimento di Studi Umanistici dell’Università degli Studi di Salerno./ [English]: The communicative dignity of a message, be it the core of a literary text, a linguistic act or a historiographic episode, depends largely on the role played by the receiver. It represents a critical node for hermeneutics and theory of literature, as well as for philological research, which have in the reader an active interlocutor, real or simulated, of the author and his text. In linguistics, the receiver is not only responsible for passively accepting the message, but also for guiding the sender in his linguistic and textual choices: the fate of every act of communication is therefore reserved for him. At the same time, the receiver becomes the raison d'être of historiography, which offers the public interpretative schemes and tools to read history in the light of the events and questions of the present.
These are the themes and the perspectives of investigation from which the essays collected here move: a transdisciplinary proposal that originates from a multi-year research work and from the seminar meetings held within the Doctoral Program in Literary, Linguistic and Historical Studies at the Department of Humanities of the University of Salerno
Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain.
No full textA. O.-S. is the guarantor of the paper,
taking responsibility for the integrity of the work as a whole,
from inception to published article. M. L.-L. contributed to
data acquisition, cleaning, analysis, and interpretation; drafting
the article and revising it critically for important intellectual content;
and final approval of the version to be published. M. A. contributed
to data interpretation; drafting the article and revising it critically for
important intellectual content; and final approval of the version to
be published. J. D.-D. contributed to study conception and design;
data acquisition, analysis, and interpretation; drafting the article;
and final approval of the version to be published. H.-D. E., J. N.,
and P. V.-B. contributed to data acquisition, cleaning, analysis,
and interpretation; revising the article critically for important intel-
lectual content; and final approval of the version to be published.
S.A.D. contributed to study conception and design, and interpreta-
tion; and final approval. All authors have read and approved the
manuscript.Determining pneumococcal pneumonia (PP) burden in the elderly population is challenging due to limited data on invasive PP (IPP) and, in particular, noninvasive PP (NIPP) incidence. Using retrospective cohorts of adults aged ≥50 years in Denmark (2 782 303) and the Valencia region, Spain (2 283 344), we found higher IPP hospitalization rates in Denmark than Valencia (18.3 vs 9/100 000 person-years [PY], respectively). Conversely, NIPP hospitalization rates were higher in Valencia (48.2 vs 7.2/100 000 PY). IPP and NIPP rates increased with age and comorbidities in both regions, with variations by sex and case characteristics (eg, complications, mortality). The burden of PP in adults is substantial, yet its true magnitude remains elusive. Discrepancies in clinical practices impede international comparisons; for instance, Valencia employed a higher frequency of urinary antigen tests compared to Denmark. Additionally, coding practices and prehospital antibiotic utilization may further influence these variations. These findings could guide policymakers and enhance the understanding of international disparities in disease burden assessments.The VITAL project has received funding
from the Innovative Medicines Initiatives 2 Joint Undertaking
(grant agreement number 806776) and the Dutch Ministry of
Health, Welfare and Sport. The Joint Undertaking receives sup-
port from the European Union’s Horizon 2020 research inno-
vation program and EFPIA members.Medicin
European data sources for computing burden of (potential) vaccine-preventable diseases in ageing adults
No full textFunded by the European Union, the private members, and those contributing partners of the IHI JU.
Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the aforementioned parties. Neither of the parties can be held responsible for them
Lampião da Esquina: produção informacional, memória e identidade
No full textEste trabalho tem como objetivo compreender como o jornal “Lampião da Esquina” pode ser considerado uma fonte de informação pioneira sobre o movimento LGBTQIAP+ no Brasil no contexto do final da Ditadura Militar (1964-1985). Para isto, busca conceituar, dissertar e refletir tal período no histórico brasileiro a fim de entender de que forma o jornal foi instaurado. Apresenta como o “Lampião” surgiu, de que forma ele se enquadra como fonte de informação, que tipo de jornal ele é e quais as dificuldades enfrentadas diante da censura e outras de repressão impostas pelo governo brasileiro, sofridas não só por ele, mas como por todos os jornais que surgiram no mesmo período. Utilizando respaldos teóricos de Arns Cardeal, Baez, Carneiro, Fausto, entre outros, para discorrer sobre a ditadura brasileira. Quanto a classificação do tipo de jornal que o “Lampião” se enquadra, Medrado, Oliveira e Orrico, Brasil e Kunciski são exemplos de autores utilizados. Para situar o jornal como fonte de informação, seu surgimento e sua importância destaca-se o autor Tevissan. A partir desta delimitação, averígua-se qual impacto que ele causou na sociedade brasileira dos fins dos anos de 70, de que maneira as matérias do jornal influenciaram e ainda influenciam na construção da identidade da comunidade LGBTQIAP+ e na preservação de sua memória, sendoo está reflexão baseada em autores como Dubar, Hall, Pollak e Le Goff.This work aims to understand how the newspaper “Lampião da Esquina” can be considered a pioneering source of information about the LGBTQIAP+ movement in Brazil in the context of its political reopening. For this, it seeks to conceptualize, discuss and reflect on the Brazilian historical period to understand how the newspaper was created. How “Lampião” came about, what form it fits as an of information, what type of newspaper is it and what are the faced in the face of censorship and other pressure source imposed by the Brazilian government, suffered not only by it but difficulties everyone the newspapers that were defined in the same period. Using the theorists of Arns Cardeal, Baez, Carneiro, Fausto, among others, to discuss the Brazilian dictatorship. Regarding the classification of the type of newspaper that “Lampião” fits, Medrado, Oliveira, and Orrico, Brasil and Kunciski are examples of authors used. To situate the newspaper as a source of information, its author and its importance stand out. Based on this delimitation, to see what impact it had on Brazilian society in the 1970s, how the influence of journalism on the LGBTQ community is in the construction of the identity of its memory, based on authors such as Dubar Hall, Pollak, and Le Goff.73 p
Phalangodus anacosmetus Gervais 1842
No full textPhalangodus anacosmetus Gervais, 1842 Phalangodus anacosmetus Gervais, 1842: 3, pl. 4 (dorsal habitus, chelicerae and pedipalpi anterior view); Orrico & Kury 2009: 472, 489–491, 493 (citation; systematics) (see the rest of citations in Kury 2003: 96). Allocranaus giganteus Mello-Leitão, 1940: 307, fig 8 (dorsal habitus); (see the rest of citations in Kury 2003: 96) (Synonymy established by Kury 1996). Material examined. COLOMBIA. Without further information, 1 ma (MNHN 1734); Bogotá: 1 fe (MNHN 20- 162) (specimens examined in MNHN and they also were viewed thanks to detailed pictures provided by the second author, RPR); Cundinamarca, Finca Bella Vista near Sasalma (collected at night on low foliage), 13.v. 1965, P.R. & D.L. Craig leg., 1 ma (CAS). Diagnosis. Phalangodus anacosmetus differs from P. palpiconus by the narrow (in dorsal view), low ocularium, a slightly enlarged pair of paramedian tubercles on scutal area III and sinuous femur IV (in dorsal view). Redescription. See Kury (1996).Published as part of Hara, Marcos Ryotaro, Pinto-Da-Rocha, Ricardo & Villarreal, Osvaldo, 2014, Revision of the cranaid genera Phalangodus, Iquitosa and Aguaytiella (Opiliones: Laniatores: Gonyleptoidea), pp. 567-580 in Zootaxa 3814 (4) on page 569, DOI: 10.11646/zootaxa.3814.4.8, http://zenodo.org/record/22461
Subretinal Fibrosis in Stargardt’s Disease with Fundus Flavimaculatus and ABCA4 Gene Mutation
No full textPurpose: To report on 4 patients affected by Stargardt’s disease (STGD) with fundus flavimaculatus (FFM) and ABCA4 gene mutation associated with subretinal fibrosis. Methods: Four patients with a diagnosis of STGD were clinically examined. All 4 cases underwent a full ophthalmologic evaluation, including best-corrected visual acuity measured by the Snellen visual chart, biomicroscopic examination, fundus examination, fundus photography, electroretinogram, microperimetry, optical coherence tomography and fundus autofluorescence. All patients were subsequently screened for ABCA4 gene mutations, identified by microarray genotyping and confirmed by conventional DNA sequencing of the relevant exons. Results: In all 4 patients, ophthalmologic exam showed areas of subretinal fibrosis in different retinal sectors. In only 1 case, these lesions were correlated to an ocular trauma as confirmed by biomicroscopic examination of the anterior segment that showed a nuclear cataract dislocated to the superior site and vitreous opacities along the lens capsule. The other patients reported a lifestyle characterized by competitive sport activities. The performed instrumental diagnostic investigations confirmed the diagnosis of STGD with FFM in all patients. Moreover, in all 4 affected individuals, mutations in the ABCA4 gene were found. Conclusions: Patients with the diagnosis of STGD associated with FFM can show atypical fundus findings. We report on 4 patients affected by STGD with ABCA4 gene mutation associated with subretinal fibrosis. Our findings suggest that this phenomenon can be accelerated by ocular trauma and also by ocular microtrauma caused by sport activities, highlighting that lifestyle can play a role in the onset of these lesions
Angiotensin II and Prostaglandin Interactions on Systemic and Renal Effects of L-NAME in Humans
No full text
