71 research outputs found
VISIBLE/ULTRAVIOLET SPECTROSCOPY OF VIBRATION-VIBRATION (V-V) PUMPED CARBON MONOXIDE EXCITED BY A Q-SWITCHED CO LASER
No full text W. Urban, J.-X. Lin, V.V. Subramaniam, M. Havenith, and J.W. Rich, Chem. Phys. 130. 389 (1989).Author Institution: Department of Mechanical Engineering, The Ohio State University; Laboratoirc E.M2.C., UPR 288 C.R.N.S. at Ecole Centrals Paris; Department of Mechanical Engineering, The Ohio State UniversityAn electric discharge CO laser, wall-cooled by liquid nitrogen, is Q-switched by an intracavity chopper. Pulsed output on the fundamental band of 3 watts average power is obtained, with on the component forced by laser-induced cascade. This technique is an extension of the method previously reported by Urban et al(1). The laser is used to excite pure CO, as well as CO/Ar and mixtures, in a flowing-gas absorption cell. Molecular vibrational modes are thereby maintained in a state of extreme V-V pumped disequilibrium. Electronic state emission from CO and various reaction products is being used to infer V-V and V-E energy transfer channels, as well as chemical reaction mechanisms. Further developments of a kinetic model previously used for experiments of this type(1) will also be discussed
INDIA'S MANY NATIONS: EXAMINING THE VARYING DURABILITY OF SUBNATIONAL PROTESTS AND RIOTS IN POST-INDEPENDENCE INDIA
No full textBachelor'sBACHELOR OF SOCIAL SCIENCES (HONOURS) IN POLITICAL SCIENC
Fluid-mediated sources of granular temperature at finite Reynolds numbers
No full textWe derive analytical solutions for hydrodynamic sources and sinks to granular temperature in moderately dense suspensions of elastic particles at finite Reynolds numbers. Modelling the neighbour-induced drag disturbances with a Langevin equation allows an exact solution for the joint fluctuating acceleration–velocity distribution function P(v′,a′;t). Quadrant-conditioned covariance integrals of P(v′,a′;t) yield the hydrodynamic source and sink that dictate the evolution of granular temperature that can be used in Eulerian two-fluid models. Analytical predictions agree with benchmark data from particle-resolved direct numerical simulations and show promise as a general theory from gas–solid to bubbly flows.This article that has been published by Cambridge University Press as Lattanzi, Aaron M., Vahid Tavanashad, Shankar Subramaniam, and Jesse Capecelatro. "Fluid-mediated sources of granular temperature at finite Reynolds numbers." Journal of Fluid Mechanics 942 (2022): A7. DOI: 10.1017/jfm.2022.351. Copyright 2022 The Author(s). Attribution 4.0 International (CC BY 4.0). Posted with permission
Structure and dynamics of antibody hapten complexes
No full textAntibody molecules are highly antigen-specific receptors of the immune system. In this thesis, structural and functional relationship in antibody molecules are studied.The nature of the \rm V\sb{L}-\rm V\sb{H} interface and the role of specific residues that are involved in the conserved packing interactions across the domains are analyzed. Specific residues in the framework and hypervariable regions are identified as key residues that contribute to the stability of the interface. Using the residues involved in conserved contacts across the domain, a list of constraints on C-C distances are obtained which can be used as additional constraints in computer modeling of antibody Fv structures.The high degree of sequence and structural homology among the antibodies make them good targets for homology modeling. Using computer-aided modeling, the structure of the variable domain fragment of two antibodies, NC6.8 and NC10.14, raised against sweet taste ligand NC174, are predicted and the key residues in the combining site of the antibodies identified. Experimental methods, like spectroscopy and competitive ligand binding have also supported these modeling studies. Molecular dynamics simulations of the uncomplexed antibody NC6.8 are performed to understand the nature of the correlated motions of the antibody, prior to hapten binding. The dynamics simulations show that the CDR loops adopt a variety of conformations and the dynamic structure could play a role in antigen binding. The effect of the mutation of in the antibody NC6.8, is evaluated in terms of free energy. The 'slow growth' method is used to determine the stability of the mutation in the native and the complexed antibody, as compared to the unfolded state of the protein. The net difference in the free energy for the change is 1.26 kcal/mol for the native antibody and 1.42 kcal/mol for the complexed antibody, with the Phe residue being more stable in the folded antibody as compared to its unfolded state.Made available in DSpace on 2011-05-07T13:53:03Z (GMT). No. of bitstreams: 2
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Beyond the 3 R’s ‘Reduce, Reuse, Recycle’: a matterphorical eco-pedagogy project with a picturebook author, illustrator, teacher educator and a London primary school
No full textThis article describes a picturebook arts-based happening that came about spontaneously through an academic meeting the author of the picturebook Ammu’s Bottle Boat and the classteacher eco-lead of a Primary school linked with her university, and finding both to be inspiring champions of eco-pedagogy. Classteacher Andromachi, picturebook author Niveditha, illustrator Aindri and teacher educator Victoria then all met on zoom and planned sessions with the group of children who represent environmental matters for their class as school eco-ambassadors, reading and discussing the book, then making artwork in response to it. Bringing these perspectives together is not only highly unusual but significant in terms of a shared happening where a picturebook enacts this ecocritical nature, or nature-culture. Following Donna Haraway’s inseparability of nature-culture into ‘Natureculture’ (where collective eco-relationships are recognised as both biophysically and socially formed and thus closely associated) the author, illustrator, teacher, teacher-educator and children co-create in response to a picturebook’s ecocritical value. For Haraway, language and matter are also intertwined in ‘matterphorical’ ways, connecting physical, material and language elements together. For Gandorfer and Ayub, matterphorical practice is ‘an aesth-ethics of thought’ which ‘calls for an ethics of both sense-making and sensing in the making’. In this context, the art of the picturebook ‘shapes’ the associated practices of authorship, illustration, environmental education and teaching with ecopedagogies; combining sense-making and sensory learning as they interplay. The article will first set the context for eco-conscious education and various ways in which environmental research and ‘zero carbon’ schools have come together, introduce and explore the picturebook that features here by both its author and illustrator, and conclude with a teacher’s perspective of Green school practice using this picturebook in her primary school
Estimation of three-dimensional water column sound speed profiles and sediment compressional wave speed and density profiles using a distributed network of buoys
No full textAuthor Posting. © Acoustical Society of America, 2020. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 147(3), (2020): 1392-1403, doi:10.1121/10.0000794.Broadband data acquired during the Modal Mapping Experiment (MOMAX) V experiment are used to invert simultaneously for the three-dimensional (3D) water column sound speed profiles and the compressional wave speed and density profiles of the seabed in shallow waters off the coast of New Jersey. Linear Frequency Modulation sweep signals in the band 50–300 Hz are transmitted from a nearly stationary source at several discrete positions to a set of freely drifting receivers. Mode travel times are estimated from the signals acquired by the drifting buoys, and these are then used as input data in an inversion algorithm that estimates the acoustic properties of the water column and sediments. The resulting 3D compressional wave speed profiles in the seabed are generally consistent with the one-dimensional profile obtained during the narrowband component of MOMAX V, as well as the results from other experiments in the same area. The validity of the inversion results has also been assessed by the ability of the inverted model to predict the fields measured during the narrowband experiments.The authors gratefully recognize the support of the entire team that was responsible for the execution of MOMAX V. The work reported in this paper was done with the support of the Office of Naval Research under Grant Nos. N00014-09-1-0505 and N00014-12-1-0083 and the Space and Naval Warfare Systems Command through Naval Sea Systems Command Contract No. N00024-02-D-6604.2020-09-0
Case Study on the Dynamic Response of Long Bridges Subject to Spatially Varying Ground Motions
No full textabstract: This report analyzed the dynamic response of a long, linear elastic concrete bridge subject to spatially varying ground displacements as well as consistent ground displacements. Specifically, the study investigated the bridge’s response to consistent ground displacements at all supports (U-NW), ground displacements with wave passage effects and no soil profile variability (U-WP), and ground displacements with both wave passage effects and soil profile variability (V-WP). Time-history ground displacements were taken from recordings of the Loma Prieta, Duzce, and Chuetsu earthquakes. The two horizontal components of each earthquake time-history displacement record were applied to the bridge supports in the transverse and longitudinal directions. It was found that considering wave passage effects without soil profile variability, as compared with consistent ground displacements, significantly reduced the peak total energy of the system, as well as decreasing the maximum relative longitudinal displacements. The maximum relative transverse displacements were not significantly changed in the same case. It was also found that including both wave passage effects and soil profile variability (V-WP) generally resulted in larger maximum transverse relative displacements, across all earthquake time-histories tested. Similarly, it was found that using consistent ground displacements (U-NW) generally resulted in larger maximum longitudinal relative displacements, as well as larger peak total energy values.Dissertation/ThesisMasters Thesis Civil, Environmental and Sustainable Engineering 201
Web-based instruction for adult learners : an asynchronous delivery model for formal lifelong learning
No full textWeb-based Instruction (WBI) is becoming a favored teaching and
learning option in higher education. Unfortunately, the effects of WBI
on success, perception and gender have not been clearly
demonstrated or sufficiently addressed, especially for adult learners
who are engaged in the formal lifelong learning via the popular
asynchronous WBI (A-WBI). This paper attempts to address the
following objectives: (i) to propose a framework for A-WBI to deliver
lessons to adult learners who are enrolled in formal lifelong learning;
(ii) to implement the proposed framework; (iii) to explore adult
learner perceptions of A-WBI and of how gender influences their
perception; (iv) to explore the influence of A-WBI on the adult learner
summative assessment (final examination component); and (v) o
analyze the relationship between adult learner interaction with A-WBI
and their final examination marks. Objectives (i) and (ii) are achieved
by using the design and implementation approach while objectives
(iii), (iv) and (v) are achieved by an interpretive case study
methodology approach. The findings indicate: (i) moderate learner
responses for the use of A-WBI when studying have led to poor
performance in the summative assessment among adult learners; (ii)
female learners are the high-risk group in A-WBI; and (iii) quality
interaction in the A-WBI discussion forum has a strong relationship
with learner final examination scores. The paper concludes with
discussions on the findings and recommendations. (Abstract by author
Multiphysics Design Optimization Model for Structural Walls Incorporating Phase Change Materials
No full textabstract: Buildings consume a large portion of the world's energy, but with the integration of phase change materials (PCMs) in building elements this energy cost can be greatly reduced. The addition of PCMs into building elements, however, becomes a challenge to model and analyze how the material actually affects the energy flow and temperatures in the system. This research work presents a comprehensive computer program used to model and analyze PCM embedded wall systems. The use of the finite element method (FEM) provides the tool to analyze the energy flow of these systems. Finite element analysis (FEA) can model the transient analysis of a typical climate cycle along with nonlinear problems, which the addition of PCM causes. The use of phase change materials is also a costly material expense. The initial expense of using PCMs can be compensated by the reduction in energy costs it can provide. Optimization is the tool used to determine the optimal point between adding PCM into a wall and the amount of energy savings that layer will provide. The integration of these two tools into a computer program allows for models to be efficiently created, analyzed and optimized. The program was then used to understand the benefits between two different wall models, a wall with a single layer of PCM or a wall with two different PCM layers. The effect of the PCMs on the inside wall temperature along with the energy flow across the wall are computed. The numerical results show that a multi-layer PCM wall was more energy efficient and cost effective than the single PCM layer wall. A structural analysis was then performed on the optimized designs using ABAQUS v. 6.10 to ensure the structural integrity of the wall was not affected by adding PCM layer(s).Dissertation/ThesisM.S. Civil and Environmental Engineering 201
Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development
No full textThe post-transcriptional control of gene expression is becoming increasingly important in the understanding of regulated events in eukaryotic cells. The parasitic kinetoplastids have a unique reliance on such processes, because their genome is organized into polycistronic transcription units in which adjacent genes are not coordinately regulated. Indeed, the number of RNA-binding proteins predicted to be encoded in the genome of kinetoplastids is unusually large, invoking the presence of unique RNA regulators dedicated to gene expression in these evolutionarily ancient organisms. Here, we report that a small CCCH zinc finger protein, TbZFP3, enhances development between life-cycle stages in Trypanosoma brucei. Moreover, we demonstrate that this protein interacts both with the translational machinery and with other small CCCH proteins previously implicated in trypanosome developmental control. Antibodies to this protein also co-immunoprecipitate EP procyclin mRNA and encode the major surface antigen of insect forms of T. brucei. Strikingly, although TbZFP3 is constitutively expressed, it exhibits developmentally regulated association with polyribosomes, and mutational analysis demonstrates that this association is essential for the expression of phenotype. TbZFP3 is therefore a novel regulator of developmental events in kinetoplastids that acts at the level of the post-transcriptional control of gene expression
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