1,723,298 research outputs found
Análise luminotécnica em ambientes do IFCE – Campus Tabuleiro do Norte conforme NBR ISO/CIE 8995-1
Full text linkO estudo luminotécnico de ambientes permite a realização de projetos de sistemas de iluminação, bem como a verificação do atendimento das instalações aos requisitos mínimos estabelecidos na NBR ISO/CIE 8995-1. Para isso, é necessário que a iluminação esteja compatível com as destinações do ambiente e com as atividades nele desenvolvidas. Para a realização de estudos luminotécnicos, softwares computacionais, dentre eles o DIALux®, são amplamente utilizados. O objetivo deste trabalho consiste, portanto, em verificar o atendimento das instalações de iluminação de ambientes do IFCE campus Tabuleiro do Norte às especificações da NBR ISO/CIE 8995-1 e, em caso(s) de discordância, propor adequações a partir da realização de simulações no software DIALux®. Inicialmente será realizada a caracterização dos cinco ambientes analisados, são eles: Laboratórios de Comandos e Instalações Elétricas Industriais, de Eletroeletrônica e de Química, Sala de Aula 07 e Sala dos Professores; seguida do ensaio fotométrico (por meio de medições de iluminância, utilizando luxímetro) para a verificação do atendimento à NBR ISO/CIE 8995-1. Diante do ensaio fotométrico realizado, dois dos cinco ambientes analisados não atenderam à NBR ISO/CIE 8995-1. Dessa forma, a estes dois foram propostas adequações nos sistemas de iluminação, através de simulações no software DIALux®, para garantir que os usuários desempenhem suas atividades de forma eficiente, com conforto e segurançaTrabalho não financiado por agência de fomento, ou autofinanciad
Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses
No full textTA-8995 is a potent inhibitor of cholesteryl ester transfer protein (CETP) with beneficial effects on lipids and lipoproteins. The effect of TA-8995 on cholesterol efflux capacity (CEC), a measure of high-density lipoprotein (HDL) function, and HDL subparticle distribution is largely unknown. To assess the effect of the CETP inhibitor TA-8995 on ABCA1- and non-ABCA1-driven CEC and on HDL particle distribution. Total, non-ABCA1-, and ABCA1-specific CEC from J774 cells and HDL subclass distribution assessed by two-dimensional gel electrophoresis were measured at baseline and after 12-week treatment in 187 mild-dyslipidemic patients randomized to placebo, 1 mg, 5 mg, 10 mg TA-8995, or 10 mg TA-8995 combined with 10 mg rosuvastatin (NCT01970215). Compared with placebo, total, non-ABCA1-, and ABCA1-specific CEC were increased dose dependently by up to 38%, 72%, and 28%, respectively, in patients randomized to 10 mg of TA-8995. PreBeta-1 HDL, the primary acceptor for ABCA1-driven cholesterol efflux, was increased by 36%. This increase in preBeta-1 HDL correlated significantly with the total and the ABCA1-driven CEC increase, whereas the high-density lipoprotein cholesterol (HDL-C) increase did not. TA-8995 dose dependently increased not only total and non-ABCA1-specific CEC but also ABCA1-specific CEC and preBeta-1 HDL particle levels. These findings suggest that TA-8995 not only increases HDL-C levels but also promotes functional properties of HDL particles. This CETP inhibitor-driven preBeta-1 HDL increase is an important predictor of both ABCA1 and total CEC increase, independent of HDL-C increase. Whether these changes in HDL particle composition and functionality have a beneficial effect on cardiovascular outcome requires formal testing in a cardiovascular outcome tria
Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects
Full text linkTwo double-blind, randomized studies were conducted to assess the tolerability, pharmacokinetics and pharmacodynamics of oral TA-8995, a new cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Study 1: Subjects received single doses of TA-8995 or placebo (fasted). Doses were 5, 10, 25, 50 (fed/fasted), 100 and 150 mg (Caucasian males, 18-55 years), 25 mg (Caucasian males, > 65 years and Caucasian females, 18-55 years), 25, 50, 100 and 150 mg (Japanese males, 18-55 years). Study 2: Caucasian males (18-55 years) received 1, 2.5, 10 or 25 mg once daily TA-8995 or placebo for 21-28 days. Blood and urine for pharmacokinetics and/or pharmacodynamics were collected. Tolerability was assessed by adverse events, vital signs, electrocardiograms and laboratory safety tests. Peak TA-8995 concentrations occurred approximately 4 h post-dose. Mean half-lives ranged from 81 to 166 h, without an obvious dose relationship. Exposure increased less than proportionally to dose. TA-8995 was not excreted in urine. Following 2.5 to 25 mg once daily dosing, TA-8995 demonstrated nearly complete inhibition of CETP activity (92-99%), increased high density lipoprotein-cholesterol (HDL-C) by 96 to 140% and decreased low density liporotein-cholesterol (LDL-C) by 40% to 53%. There were dose-related increases in apolipoproteins A-1 and E, HDL2-C and HDL3-C, and decreases in apolipoprotein B and lipoprotein A. There was no evidence of significant effects of age, gender, ethnicity or food on pharmacokinetics or pharmacodynamics. All doses were well tolerated. TA-8995 is a potent CETP inhibitor and warrants further investigatio
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial
Full text linkDyslipidaemia remains a significant risk factor for cardiovascular disease and additional lipid-modifying treatments are warranted to further decrease the cardiovascular disease burden. We assessed the safety, tolerability and efficacy of a novel cholesterol esterase transfer protein (CETP) inhibitor TA-8995 in patients with mild dyslipidaemia. In this randomised, double-blind, placebo-controlled, parallel-group phase 2 trial, we recruited patients (aged 18-75 years) from 17 sites (hospitals and independent clinical research organisations) in the Netherlands and Denmark with fasting LDL cholesterol levels between 2·5 mmol/L and 4·5 mmol/L, HDL cholesterol levels between 0·8 and 1·8 mmol/L and triglyceride levels below 4·5 mmol/L after washout of lipid-lowering treatments. Patients were randomly allocated (1:1) by a computer-generated randomisation schedule to receive one of the following nine treatments: a once a day dose of 1 mg, 2·5 mg, 5 mg, or 10 mg TA-8995 or matching placebo; 10 mg TA-8995 plus 20 mg atorvastatin; 10 mg TA-8995 plus 10 mg rosuvastatin or 20 mg atorvastatin or 10 mg rosuvastatin alone. We overencapsulated statins to achieve masking. The primary outcome was percentage change in LDL cholesterol and HDL cholesterol from baseline at week 12, analysed by intention to treat. This study is registered with ClinicalTrials.gov, number NCT01970215. Between Aug 15, 2013, and Jan 10, 2014, 364 patients were enrolled. At week 12, LDL cholesterol levels were reduced by 27·4% in patients assigned to the 1 mg dose, 32·7% in patients given the 2·5 mg dose, 45·3% in those given the 5 mg dose, and 45·3% in those given the 10 mg dose (p <0·0001). LDL cholesterol levels were reduced by 68·2% in patients given 10 mg TA-8995 plus atorvastatin, and by 63·3% in patients given rosuvastatin plus 10 mg TA-8995 (p <0·0001). A daily dose of 1 mg TA-8995 increased HDL cholesterol levels by 75·8%, 2·5 mg by 124·3%, 5 mg by 157·1%, and 10 mg dose by 179·0% (p <0·0001). In patients receiving 10 mg TA-8995 and 20 mg atorvastatin HDL cholesterol levels increased by 152·1% and in patients receiving 10 mg TA-8995 and 10 mg rosuvastatin by 157·5%. We recorded no serious adverse events or signs of liver or muscle toxic effects. TA-8995, a novel CETP inhibitor, is well tolerated and has beneficial effects on lipids and apolipoproteins in patients with mild dyslipidaemia. A cardiovascular disease outcome trial is needed to translate these effects into a reduction of cardiovascular disease events. Dezim
Estudos de caso comparativos entre normas de iluminação : NBR 5413 e NBR ISO 8995-1
Full text linkEste trabalho apresenta um estudo comparativo entre as normas de iluminação brasileiras: a NBR 5413, que foi revogada em abril de 2013 e a NBR ISO 8995-1, que passou a vigorar desde então. Serão apresentados projetos para uma sala de aula, uma sala bancária e uma metalurgia para usinagem de peças para com cálculos manuais e através do DIALUX para comparação. O nível adequado de iluminação evita fadiga dos usuários e melhora o desempenho para realização das tarefas. O planejamento adequado da iluminação interna alia economia e conforto. Apesar da importância da iluminação de interiores, que nos afeta diretamente em locais de trabalho e lazer, a norma brasileira ficou mais de 20 anos sem atualizações até ser substituída em 2013. A ISO 8995-1 segue padrões internacionais de níveis de iluminação e aborda aspectos quantitativos e qualitativos da iluminação. O estudo técnico mostrou que os custos envolvidos no projeto são semelhantes, o valor das luminárias com controle de ofuscamento é levemente superior ao valor das luminárias comuns, entretanto, o valor exigido para iluminância é determinante para o custo total do projeto.This paper presents a comparative study between Brazilian lighting standards: NBR 5413, which was repealed in April 2013 and ISO 8995-1, which became effective since then. Designs for a classroom, a bank and a metallurgy was showed with manual calculations and through DIALUX for comparison. Appropriate level of lighting prevents fatigue and improves performance users to accomplish tasks. Proper planning of indoor lighting, combines economy and comfort. Despite the importance of indoor lighting that affects us directly at workplaces and leisure, the Brazilian standard was more than 20 years without updates until replaced in 2013. ISO 8995-1 follows international standards for lighting levels and addresses issues quantitative and qualitative lighting. The technical study showed that costs involved in the project are similar, the value of fixtures with glare control is slightly higher than the common lamps, however, the required value for illuminance is crucial to the overall project cost
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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