1,746,438 research outputs found
miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome
No full textIn primary Sjögren's syndrome (pSS) the exocrine glands become infiltrated with lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry eyes and dry mouth. Previous investigations have suggested that dysregulated localized and systemic inflammation contributes to the development and pathogenesis of pSS. A miR microarray performed in primary human conjunctival epithelial cells (PECs) demonstrated significant differences in miR expression at the ocular surface between pSS patients and healthy controls. MicroRNA-744-5p (miR-744-5p) was identified as being of particular interest, as its top predicted target is Pellino3 (PELI3), a known negative regulator of inflammation. Validation studies confirmed that miR-744-5p expression is significantly increased in PECs from pSS patients, whilst PELI3 was significantly reduced. We validated the miR-744 binding site in the 3' untranslated region (UTR) of PELI3 and demonstrated that increasing PELI3 levels with a miR-744-5p antagomir in an inflammatory environment resulted in reduced levels of IFN dependent chemokines Rantes (CCL5) and CXCL10. These results reveal a novel role for miR-744-5p in mediating ocular inflammation via Pellino3 expression in pSS patients and suggest that miR-744-5p may be a potential therapeutic target for the management of severe dry eye disease and ocular inflammation in pSS patients
Resolución UNRN N° 744/2009. Aprobar la contratación de personal temporario
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 744/2009. Aprobar la contratación de personal temporariofals
MIR744 (microRNA 744)
Full text linkMiR-744 is a short, single-stranded non-coding RNA molecule. Gene encoding miR-744 locates at chromosome 17. Two mature forms (miR-744-5p and miR-744-3p) have been reported to be implicated in cellular process leading to the development of human diseases. The function of miR-744 is dependent on cell type and contexts. MiR-744 could function as tumor suppressor or tumor promoter and the role varies in different cancer types
Overview of the development and status of carbon dioxide (R-744) refrigeration systems onboard fishing vessels
Full text linkGlobally, most fishing vessels still use the ozone-depleting and climate-harmful R-22 in their freezing and refrigerated seawater (RSW) systems. However, in some regions, the natural refrigerant ammonia is the preferred refrigerant. Another natural refrigerant, carbon dioxide (R-744), is becoming a viable option and is increasingly used onboard. This option will not exclude ammonia, but rather will be a good alternative to it to meet the demand for different cooling/freezing needs in post-R-22 systems. There are currently major developments in R-744 refrigeration technology that are widening the potential applications of R-744. These include compressors with larger capacities, more energy-efficient components, system designs with lower freezing temperatures and integration of heat recovery and thermal storage. This paper provides a review of the development of refrigeration systems with R-744 onboard fishing vessels. It includes a description of the commonly used cooling and freezing methods and of the development in R-744 refrigeration technology, especially within the system and component design, capacity and performance. It also includes the current status of R-744 refrigeration technologies in fishing vessels. Although there are limited publications on R-744 systems for fishing vessel applications, the review shows positive prospects of utilizing R-744 and further research and innovation within this topic is recommended. © 2022 The Author(s) Author keywords Energy-efficient; Fishing vessel; Natural refrigerants; R-744/CO2; Refrigeration; Transcritica
Paleogene and early Neogene planktonic foraminifera of ODP sites 119-738 and 119-744
No full textA virtually complete composite history of Cenozoic pelagic sedimentation was recovered from ODP Sites 738 (62°43' S) and 744 (61°35' S), drilled during Leg 119 on the Kerguelen Plateau. An excellent magnetobiochronologic record was obtained from upper Eocene through Holocene sediments at Site 744, and an expanded lower Paleocene through lower Oligocene sequence was cored at Hole 738. Analysis of the stratigraphic distribution of over 125 planktonic foraminifer taxa from these sites reveals changes in species composition that were strongly influenced by the climatic evolution of Antarctic water masses.
Early Paleocene planktonic foraminifer assemblages are nearly identical in species composition to coeval assemblages from low and middle latitude sites, showing the same patterns of post-extinction recovery and taxonomic radiation. Biogeographic isolation, revealed by the absence of tropical keeled species, became apparent by late early Paleocene time. Diversity increased near the Paleocene/Eocene boundary when keeled morozovellids immigrated to the Kerguelen Plateau. Greatest diversity (23 species) was achieved by early Eocene time, corresponding to a Cenozoic warming maximum that has been recognized in lower Eocene deep sea and terrestrial sediments worldwide. A gradual decline in diversity from the late early through middle Eocene, primarily due to the disappearance of acarininids, parallels the record of cooling paleotemperatures in Southern Ocean surface waters. Chiloguembelina-dominated assemblages appeared in the late middle Eocene and persisted through the early Oligocene as Antarctic surface waters became thermally isolated.
Late Eocene and early Oligocene assemblages exhibit considerably lower diversity than the older Eocene faunas, and were dominated by chiloguembelinids, subbotinids, and catapsydracids during a time of pronounced climatic cooling and development of continental glaciation on East Antarctica. The small foraminifer Globigerinit? juvenilis replaced chiloguembelinids as the dominant taxon during the late Oligocene. Diversity increased slightly toward the end of the late Oligocene with new appearances of several tenuitellid, globoturborotalitid, and globigerinid species. The trend toward diminishing planktonic foraminifer diversity was renewed during the late early Miocene as siliceous productivity increased in the Antarctic surface waters, culminating with the reduction to nearly monospecific assemblages of Neogloboqu?drin? p?chyderm? that occur in Pliocene-Holocene biosiliceous sediments.
An Antarctic Paleogene zonal scheme previously devised for ODP Sites 689 and 690 in the Weddell Sea is used to biostratigraphically subdivide the Kerguelen Plateau sequence. The definition of one Antarctic Paleogene biozone is modified in the present study to facilitate correlation within the southern high latitudes. The ages of 13 late Eoceneearly Miocene datum events are calibrated based on a magnetobiochronologic age model developed for Site 744
Specialty farming in Idaho: Selecting a site
No full textBulletin no. 744 Moscow, Idaho :University of Idaho, College of Agriculture, Cooperative Extension System, 1992-10-01. Author(s): Barney, D.L.; Finnerty, T.L.; Mancuso, C.J
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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