1,473 research outputs found
Measurement of the CP-violating phase phi(s) in (B)over-bar(s)(0) -> J / psi pi(+)pi(-) decays
No full textThe mixing-induced CP -violating phase ϕs in View the MathML source and View the MathML source decays is measured using the J/ψπ+π− final state in data, taken from 3 fb−1 of integrated luminosity, collected with the LHCb detector in 7 and 8 TeV centre-of-mass pp collisions at the LHC. A time-dependent flavour-tagged amplitude analysis, allowing for direct CP violation, yields a value for the phase ϕs=70±68±8 mrad. This result is consistent with the Standard Model expectation and previous measurements
Effective lifetime measurements in the B-s(0) -> K+K-, B-0 -> K+pi(-) and B-s(0) -> pi K-+(-) decays
No full textMeasurements of the effective lifetimes in the View the MathML source, B0→K+π− and View the MathML source decays are presented using 1.0 fb−1 of pp collision data collected at a centre-of-mass energy of 7 TeV by the LHCb experiment. The analysis uses a data-driven approach to correct for the decay time acceptance.
This is the most precise determination to date of the effective lifetime in the View the MathML source decay and provides constraints on contributions from physics beyond the Standard Model to the View the MathML source mixing phase and the width difference ΔΓs
Commentaria ad articulos gabellarum ac regimen incapitationum regni Portugalliae : in quibus fere omnia circa gabellae, non modo à nostratibus, verùm etiam ab exteris doctoribus scripta, pro enucleandis hisce legibus, suis locis acommoda, diligente traduntur ... / author Antonius Telles Leitam de Lima
No full textSign.: []4,9, A-Z4, Aa-Zz4, Aaa-Iii4, Kkk2PortadellaPort a dos tintesÍnde
Novos compostos baseados em cortiça para aplicações biomédicas: de antibacterianos a modeladores de neurodegeneração
No full textTese de Doutoramento em Engenharia de Tecidos, Medicina Regenerativa e Células EstaminaisPolyphenols are extensively studied due to their wide range of bioactivities. In this thesis we used this
knowledge to evaluate a series of cork-based polyphenols/extracts to act: as anti-bacterial agents (Chapter
3); in the reduction of UV-mediated toxicity (Chapter 4); and as modulators of amyloid-b (Ab)
aggregation/cytotoxicity (hallmark of Alzheimer’s disease, AD, Chapter 5). We found that
vescalagin/castalagin (extracted/purified from cork powder) are the main responsibles for the bioactivities
of cork extracts due to their galloyl (Ga) units. Cork extracts rich in vescalagin/castalagin protected cells
from UV-mediated cell death (Chapter 4). They also inhibited the folding of amyloid-like peptides/proteins
from the extracellular matrix of bacteria, blocking the formation of biofilms (Chapter 3); as well as to
remodel the Ab aggregation into non-toxic forms (Chapter 5). We then synthesized (Chapter 6) three Gapresenting
dendrimers that recapitulate the vescalagin/castalagin bioactivities, and showed that
dendrimers with 6 Ga units present a compromise between bioactivity and hydrophilicity enabling their
use in the cellular environment while drastically reducing the presence of toxic Ab oligomers. We also
showed (Chapter 7) that glycosaminoglycans’ (GAGs) building blocks and their analogues, e.g.
glucosamine-6-sulfate (GlcN6S) and glucosamine-6-phosphate (GlcN6P), complement the bioactivities of
vescalagin/castalagin in the context of AD by: modulating the Ab-mediated toxicity; reducing membrane
dysfunction; re-establishing healthy insulin signaling; lowering the acetylcholinesterase activity to basal
levels; and reducing inflammation markers. We further developed a self-assemble monolayer (SAM)
platform (Chapter 8) able to recapitulate the influence of the GAGs sulfation degree on the presentation
of fibronectin (Fn) and its impact in the adhesion/morphology of stem cells. Overall, we show that corkbased
compounds, e.g. vescalagin/castalagin, present a wide range of bioactivities (e.g. anti-UV, antibacterial,
anti-amyloidogenic) that are recapitulated by Ga-presenting dendrimers.
Vescalagin/castalagin/Ga-terminated dendrimers can be used alone or in combination with GlcN6S or
GlcN6P to reduce AD hallmarks. We also show that the sulfation degree presented on SAM-coated
surfaces is critical for their bioactive character.Os polifenóis são muito estudados dado a sua ampla bioatividade. Nesta tese, usámos este conhecimento
para avaliar vários compostos/extratos da cortiça para atuarem como: anti-bacterianos (Capítulo 3); anti-
UV (Capítulo 4); e moduladores da agregação/toxicidade da b-amilóide (Ab) (associado à doença de
Alzheimer, AD, Capítulo 5). Demonstrámos que a vescalagina/castalagina presentes nos extratos de
cortiça são essenciais para a sua bioatividade, dada a presença do grupo galoíl (Ga). Extratos ricos em
vescalagina/castalagina reduziram a morte celular mediada pela radiação UV (Capítulo 4) e inibiram a
organização dos péptidos/proteínas da matriz extracelular de bactérias, bloqueando a formação de
biofilme (Capítulo 3). A vescalagina/castalagina foram ainda capazes de remodelar o Ab em formas não
tóxicas (Capítulo 5). Também sintetizámos dendrímeros apresentando a unidade Ga (Capítulo 6)
mimetizando a bioatividade da vescalagina/castalagina. O dendrímero com 6 Gas apresentou um
compromisso entre bioatividade/hidrofilicidade, permitindo a sua utilização no ambiente celular e
reduzindo a toxicidade dos oligómeros de Ab. Provámos ainda (Capítulo 7) que a glucosamina-6-sulfato
(GlcN6S) e a glucosamina-6-fosfato (GlcN6P) apresentam bioatividade complementar à da
vescalagina/castalagina no contexto da AD, reduzindo a toxicidade do Ab, protegendo a membrana
celular, normalizando a sinalização da insulina, reduzindo a atividade da acetilcolinesterase e a expressão
dos marcadores de inflamação. Também desenvolvemos uma plataforma de “self-assemble monolayers”
(SAMs, Capítulo 8) capaz de mimetizar a influência do grau de sulfatação dos glicosaminoglicanos (GAGs)
na apresentação de fibronectina e o seu impacto na adesão/morfologia de células estaminais. Em
resumo, identificámos uma vasta bioatividade da vescalagina/castalagina (ex. anti-UV, anti-bacteriana,
anti-amiloidogénica) que pode ser mimetizada por dendrímeros apresentando unidades de Ga. A
vescalagina/castalagina/dendrímeros de Ga são capazes de reduzir as várias características da AD, de
uma forma individual ou em combinação com GlcN6S/GlcN6P. Também demonstrámos que o grau
sulfatação apresentado em superfícies cobertas por SAMs é critico para o seu carácter bioativo.I would like to acknowledge the funding, specifically the Programa Operacional Regional do Norte (Norte 2020): NORTE-08-5369-FSE-000037 (PhD scholarship) and NORTE-01-0246-FEDER-000022
(Northern Discoveries: The Discoveries CTR – Setting Sails). This work was also supported by the European Commission: FP7-REGPOT-CT2012-316331-POLARIS, H2020-TWINN-2015-692333–CHEM2NATURE, 739572-THE DISCOVERIES CTR and the Portuguese Foundation for Science and Technology (FCT): AL ICVS/3Bs #50026
Awake bruxism frequency and psychosocial factors in college preparatory students
No full textObjective: To assess the frequency of reported masticatory muscles activity during wakefulness (i.e., awake bruxism [AB]), levels of anxiety, depression, stress, and the oral health-related quality of life (OHRQoL) in college preparatory students. Methods: Sixty-nine college preparatory students participated in the study. AB was evaluated by the Oral Behaviors Checklist (OBC) and a smartphone-based ecological momentary assessment (EMA; [Bruxapp®]). Anxiety and depression were measured by the Hospital Anxiety and Depression Scale, stress was evaluated by the Perceived Stress Scale, and OHRQoL was obtained by The Oral Health Impact Profile-14. Data were analyzed by Pearson’s correlation coefficient (α = 0.05). Results: The average EMA-reported frequency of AB behaviors was 38.4%. Significant correlations were found between AB and the OBC, anxiety, depression, stress, and OHRQoL (p < 0.001). Conclusion: College preparatory students demonstrated moderate frequency of AB, which was significantly correlated with psychosocial factors. © 2020 Taylor & Francis Group, LLC
Frequency of blood types A, B and AB of Santa Catarina felines
No full textThe AB system identifying blood types of felines, consisting of three types of blood: A, B and AB. By means of the blood typing technique, a practical and efficient practice, it is possible to perform a previous task of the animal blood type, minimizing the occurrence of transfusion infections and neonatal isoerythrolysis. The objective of this study was to characterize the type of feline prevalence in Santa Catarina, in addition to showing a predominance among the different groups of felines of the breed and mixed races. This study was performed in the hemagglutination test of 500 felines, from August 2017 to May 2018. The results showed that blood type was the most prevalent, totaling 479 (95.8%) of the total felines. The blood type B blood, obtained a total of 13 (2.6%) felines. The blood type AB presents with less prevalence, adding 8 (1.6%) felines. Of the 479 type A cats, 391 (81.2%) were undefined, 37 were Per-sians (7.7%), 35 were Siamese (7.3%), 4 were Exotic (0.83%), 3 (0,62%), 2 Himalaios (0,41%), 2 were Bengal (0,41%), 1 British Shorthair (0,20%), 1 American Shorthair (0, 20%) and 1 was of the Savana breed (0.20%). Among the 13 cats type B, 10 were non-defined (76.9%), 1 was Persian (7.7%), 1 was Siamese (7.7%), and 1 was Exotic (7.7%). Of the 8 fe-lines of the AB type, 7 years without a defined breed (87.5%) and 1 were of the Siamese breed (12.5%). The population of the state of Santa Catarina has a higher frequency of type A cats, followed by the blood type and the AB type of the rarer type, demonstrating that they are more favorable to all blood types positive for the blood type, are not able to correlate with each other and the specific blood levels. In view of the fact that there may be differences, it is important to know the frequency of blood types according to the geographical region, which will give greater confidence to feline transfusion medicine.O sistema AB de identificação dos tipos sanguíneos de felinos é constituído por três tipos de sangue: A, B e AB. Por meio da técnica de tipagem sanguínea, uma ferramenta prática e eficiente, é possível realizar a identificação prévia do tipo sanguíneo do animal e minimizar a ocorrência de reações transfusionais e isoeritrólise neonatal. O objetivo deste estudo foi caracterizar o tipo sanguíneo de maior prevalência de felinos de Santa Catarina, e ainda realizar uma comparação dos tipos sanguíneos de felinos de raça e mestiços, verificando a predominância entre eles. Para este fim, foi realizado teste de hemaglutinação de 500 felinos, no período de agosto de 2017 a maio de 2018. Os resultados demonstraram que o tipo sanguíneo A foi o mais prevalente, totalizando 479 (95,8%) do total dos felinos. O tipo sanguíneo B, obteve um total de 13 (2,6%) animais. E o tipo sanguíneo AB se mostrou o menos prevalente, somando 8 (1,6%) felinos. Dos 479 gatos tipo A, 391 (81,2%) eram sem raça definida, 37 eram Persas (7,7%), 35 eram Siameses (7,3%), 4 eram da raça Exótico (0,83%), 3 eram Angorás (0,62%), 2 Himalaios (0,41%), 2 eram da raça Bengal (0,41%), 1 British Shorthair (0,20%), 1 American Shorthair (0,20%) e 1 era da raça Savannah (0,20%). Dentre os 13 gatos tipo B, 10 eram sem raça definida (76,9%), 1 era Persa (7,7%), 1 era Siamês (7,7%), e 1 era Exótico (7,7%). Dos 8 felinos do tipo AB, 7 era sem raça definida (87,5%) e 1 era da raça Siamês (12,5%). A análise dos dados demonstrou que na população de felinos do estado de Santa Catarina há uma maior frequência de gatos do tipo A, seguido do tipo sanguíneo B e o tipo AB é o tipo mais raro. Os resultados demonstram também que a maioria dos felinos, tanto de raça quanto mestiços, são positivos para o tipo sanguíneo A, não sendo possível fazer correlação entre raças e tipos sanguíneos específicos. Por haver divergências, é importante que se conheça a frequência dos tipos sanguíneos de acordo com a região geográfica, o que refletirá em maior segurança à medicina transfusional felina
Utility of Smartphone-based real-time report (Ecological Momentary Assessment) in the assessment and monitoring of awake bruxism: A multiple-week interval study in a Portuguese population of university students
No full textPurpose: The Ecological Momentary Assessment (EMA) concept was the basis for developing a smartphone application for the on-time report of awake bruxism (AB) activities. This study aims to monitor AB report over time in a population of healthy young adults. Methods: A population of young adults recruited among dental students in good general health was recruited. All answered to a questionnaire, including the Oral Behavior Checklist (OBC-1). They were then monitored with a smartphone application for AB report during seven consecutive days and completed three further observation periods (EMA-1, 2 and 3) at one-month intervals. After the third period (EMA-3), participants answered again the OBC questionnaire (OBC-2). Changes over time were described, and Pearson Correlation test was performed to assess the correlation between EMA and OBC items reports. A significance level of p =.01 was set. Results: Thirty-one University students completed the study protocol. Answers to the OBC showed an increase in the prevalence of self-reported bracing and teeth clenching from the first to second report (38.7%–54.8% and 77.4%–90.3%, respectively). A slight increase in the ‘relaxed’ condition (62.5%–69.0%) was observed with EMA-based smartphone application over time. No correlation between OBC items and EMA was detected between OBC-1 and EMA-1. A moderate positive correlation in bracing report (+0.509, p =.01) and weak positive correlation in teeth contact report (+0.380, p =.05) were found between OBC-2 and EMA-3. Conclusion: Using a smartphone-based approach to AB report may be helpful to monitor AB over time and increase an individual's awareness to recognise actions such as bracing and teeth contact concerning the single-time report
Ecological Momentary Assessment of Awake Bruxism Frequency in Patients with Different Temporomandibular Disorders
No full textSelf-reported awake bruxism (AB) has been associated with temporomandibular disorders (TMD). However, the daily amount of AB behavior has not been quantified in pain patients. Therefore, this study aimed to assess AB frequency in patients with myofascial pain and temporomandibular joint (TMJ) pain and compare it to a group of pain-free individuals. Eighty-four individuals belonging to either a TMD group (n = 54) or a healthy control group (n = 30) were selected. AB frequency was obtained by ecological momentary assessment with a dedicated smartphone application that sent sound alerts at random intervals during the day for one week. Upon receiving the alert, the volunteer reported the current muscular condition and/or the teeth position, i.e., relaxed jaw muscle, jaw bracing, teeth contact, teeth clenching, or teeth grinding. Data were evaluated by independent t-test (α = 0.05). During the seven days, AB frequency was 62.1% ± 26.8% for TMD patients and 36.2% ± 27.3% for pain-free subjects (p < 0.001). Mandible bracing was most common in the TMD group (p < 0.001), while teeth contact, clenching, and grinding did not differ between groups. Moreover, no differences were found in AB frequency between myofascial pain and TMJ pain patients. Therefore, TMD patients have higher AB frequency characterized by jaw bracing, irrespective of pain location
A mediação na prevençao e solução de conflitos locatícios
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas, Programa de Pós-Graduação em Direito.A presente dissertação de mestrado tem por objetivo verificar o alcance, no Brasil contemporâneo, do exercício da mediação na prevenção e solução de conflitos locatícios. A pesquisa está estruturada em quatro capítulos, desenvolvidos da seguinte forma: O primeiro, denominado conflito e conflito advindo das relações locatícias, procura verificar os aspectos gerais dos conflitos de um modo mais amplo, e mais especificamente dos conflitos locatícios. O segundo capítulo apresenta algumas formas de solução de conflitos (autotutela, autocomposição e heterocomposição) e, em especial, a mediação. No terceiro capítulo, é analisada a teoria geral da mediação, abordando seus elementos, as características gerais, os campos de atuação, seu processo, a ética no processo de mediação, a educação para mediadores e os tipos de mediação. O quarto capítulo analisa a mediação como forma de prevenção e solução dos conflitos locatícios, versando sobre os mediadores, as partes, a assistência profissional na prevenção e solução dos conflitos locatícios, as hipóteses em que a utilização da mediação é adequada, bem como as que caracterizam sua inadequação, e finalmente, o papel da mediação na prevenção e solução de conflitos locatícios. Conclui-se que a mediação pode ser usada na prevenção e solução de conflitos locatícios, desde que, no caso em questão, essa via esteja efetivamente solucionando o conflito de forma adequada. Também é um fato que faltam estudos sobre mediação desmitificados, críticos e que não omitam as relações sociais na análise do conflit
Adsorption of zwitterionic assemblies on Si(111)-7 × 7: A joint tunneling spectroscopy and ab initio study
No full textInternational audienceThe adsorption of zwitterionic molecules on Si(111)-7 × 7 substrates has been probed by scanning tunneling microscopy and spectroscopy and studied via density-functional-theory calculations. Experimental results obtained at room and low temperatures revealed the reconstruction of Si(111)-7 × 7 half-cells with molecular constructs accommodating three zwitterions. A structural model for the inscription of the Si(111)-7 × 7 half-cell with zwitterionic edifices is proposed and the nature of the interactions between the molecular assemblies and the surface is established thanks to joint experimental data and simulations
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