1,734,695 research outputs found
Validação do clif-sofa e da definição de acute-on-chronic liver failure do consórcio easl-clif como preditores de mortalidade na cirrose
Full text linkDissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Cuidados Intensivos e Paliativos, Florianópolis, 2014.Introdução: O conceito de acute-on-chronic liver failure (ACLF) surgiu para identificar os pacientes com falência orgânica e com altas taxas de mortalidade. Entretanto, a ausência de uma definição precisa limita a aplicação clínica e a pesquisa relacionada a esta complicação.Objetivos: Validar a definição de ACLF e o escore CLIF-SOFA recentemente proposto pelo consórcio EASL-CLIF como preditores de mortalidade em pacientes admitidos por descompensação aguda da cirrose.Material e Métodos: Neste estudo de coorte prospectivo, os pacientes foram acompanhados durante sua internação hospitalar e, no caso de alta hospitalar, a avaliação da mortalidade foi realizada por contato telefônico no trigésimo e nonagésimo dias. Todos os pacientes realizaram avaliação laboratorial na admissão hospitalar.Resultados: Entre dezembro de 2010 e novembro de 2013, 192 pacientes cirróticos foram incluídos. Na admissão, 46 pacientes (24%) preencheram os critérios para ACLF ( Graus 1, 2 e 3 em 18%, 4% e 2%, respectivamente). A mortalidade em 30 dias foi de 65% no grupo ACLF e de 12% nos demais pacientes (P<0,001). Análise de regressão logística demonstrou que a mortalidade em 30 dias foi independentemente associada com a presença de ascite e ACLF na admissão. A estimativa da probabilidade de sobrevida de Kaplan-Meier no nonagésimo dia foi de 92% em pacientes sem ascite ou ACLF e de apenas 22% nos pacientes com ascite e ACLF. A AUROC do CLIF-SOFA em predizer a mortalidade em 30 dias foi de 0,847 ± 0.034, com sensibilidade de 64%, especificidade de 90% e razão de verossimilhança positiva de 6,61 para valores = 9.Conclusões: Nessa experiência de um único centro, o escore CLIF-SOFA e a definição do consórcio EASL-CLIF de ACLF provaram ser fortes preditores de mortalidade em curto prazo em pacientes admitidos por descompensação aguda da cirrose hepática
SOFA
No full textSOFA is an open-source framework for interactive physics simulation, with emphasis on biomechanical and robotic simulations. SOFA benefits from a large international community made up of research centers and companies. Being developed since 2006, the SOFA core has a LGPL license (permissive and non-contaminating) fostering the development of prototypes and products under any commercial license
Sequential Organ Failure Assessment (SOFA) over time for the group of patients treated by daily interruption of sedation and sedation algorithm
No full textThe individual scores are represented for each group (▪ for daily interruption of sedation and × for sedation algorithm); the lines represent the composite SOFA for each group (thick line for daily interruption of sedation; dashed line for sedation algorithm). The SOFA improved more rapidly for the sedation algorithm group (= 0.025). MV, mechanical ventilation.<p><b>Copyright information:</b></p><p>Taken from "Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients"</p><p>http://ccforum.com/content/12/3/R70</p><p>Critical Care 2008;12(3):R70-R70.</p><p>Published online 20 May 2008</p><p>PMCID:PMC2481461.</p><p></p
Kuasa yang Meminggirkan Perempuan dalam Sejarah
Full text linkTulisan ini bertujuan untuk mengidentifikasi kuasa yang meminggirkan peran perempuan dalam sejarah, terkait dengan dengan siapa yang memproduksi pengetahuan secara luas
Sofa
No full textA black leather or vinyl sofa. The sofa has a light colored accent stripe on each arm. The feet of the sofa are also light colored. There is a nail head design accent at the bottom of the sofa.https://mavmatrix.uta.edu/specialcollections_wdsmithphotography/9163/thumbnail.jp
Association of Sequential Organ Failure Assessment (SOFA) components with mortality
Full text linkBACKGROUND
Sequential Organ Failure Assessment (SOFA) is a practical method to describe and quantify the presence and severity of organ system dysfunctions and failures. Some proposals suggest that SOFA could be employed as an endpoint in trials. To justify this, all SOFA component scores should reflect organ dysfunctions of comparable severity. We aimed to investigate whether the associations of different SOFA components with in-hospital mortality are comparable.
METHODS
We performed a study based on nationwide register data on adult patients admitted to 26 Finnish intensive care units (ICUs) during 2012-2015. We determined the SOFA score as the maximum score in the first 24 hours after ICU admission. We defined organ failure as an organ-specific SOFA score of three or higher. We evaluated the association of different SOFA component scores with mortality.
RESULTS
Our study population comprised 63,756 ICU patients. Overall hospital mortality was 10.7%. In-hospital mortality was 22.5% for patients with respiratory failure, 34.8% for those with coagulation failure, 40.1% for those with hepatic failure, 14.9% for those with cardiovascular failure, 26.9% for those with neurologic failure and 34.6% for the patients with renal failure. Among patients with comparable total SOFA scores, the risk of death was lower in patients with cardiovascular organ failure compared to patients with other organ failures.
CONCLUSIONS
All SOFA components are associated with mortality, but their weights are not comparable. High scores of other organ systems mean a higher risk of death than high cardiovascular scores. The scoring of cardiovascular dysfunction needs to be updated
Sofa
No full textA sofa on display.https://mavmatrix.uta.edu/specialcollections_wdsmithphotography/8352/thumbnail.jp
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