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Uji Antidiabetik Ekstrak Buah Pare (Momordica charantia L.) terhadap Penurunan Kadar Glukosa Darah pada Mencit yang Diinduksi Streptozotocin
Get PDFABSTRACT Diabetes mellitus is a chronic disease in which the patient has excess glucose levels in the blood. Pare (Momordica charantia L.) is one of the plants that have efficacy in treating various diseases one of them is antidiabetes. Activity of active substances from the pare may play a role in lowering blood sugar levels. This research is done to know the effect of increasing concentration of pare extract to decrease blood glucose level in mice induced by streptozotocin.This study was experimental laboratory, the study was done by measured the initial blood sugar level in mice, sugar content after induction of steptozotosin, and after administration of 100 mg / kgBW extract test, 250 mg / kgBW and 400 mg / kgBW with observation time for 7 days , as well as gave metformin suspension as a positive control.The results showed that the optimum value of antidiabetic activity of ethanol extract of pare fruit at a concentration of 400 mg / kgBW and had an average decrease of 122 mg / dl.Keywords: Antidiabetes, Momordica charantia L., Streptozotoci
Pengaruh Kadar Gula Darah terhadap Kejadian Reinfark dan Kematian pada Penderita Sindroma Koroner Akut
Get PDFRecent decades data relates between admission hyperglycemia and mortality that increase among acute coronary syndrome(ACS) patients. Aim of study is to assess relationship between hyperglycemia and Cardiac Event, i.e. death, reinfarction among ACS patients. This is a prospective cohort study, which was held on March to April 2014 among 83 ACS patients in CVCU Wahodin Sudorohusodo Hospital. Patients was grouped into two groups, hyperglycemic ACS group and normoglycemic one. Reinfarction and death events at each group was observed within first 30 days after infarction. In this study, it found death and reinfarction events were higher in hyperglycemic group than in normoglycemic group (22 vs 4, RR = 3.7, p=0.026 for death event, and 14 vs 1, RR =8.7, p=0.03 for reinfarction). Conclusion of this study was hyperglycemia is related to reinfartion and death events among ACS patients.Keywords: Acute Coronary Syndrome, Hyperglycemia, Reinfarction, Deat
Analisis Faktor Risiko yang Berhubungan dengan Kejadian Katarak Senilis Di RSU Bahteramas Tahun 2016
Get PDFCataract is a condition where the lens of eyes that normally clear and transparent becomes cloudy. Cataract can cause blindness. Some risk factors related to cataract likes age, sex, diabetes mellitus, UV radiation, smoking and jobs. Some researches argue that these risk factors influence the number of cataracts incidence. This study aims to know the risk factors associated with the incidence of cataracts in Ophtalmology Department in RSU Bahteramas.This study was an analytic observational that used case-control study design. The sample size of this study was 140 respondents consisted of 70 cases and 70 controls were taken by purposive sampling. The data collection was obtained from medical records of patients to determine the age, sex, and history of diabetes mellitus. The instrument of this study was questionnaire to determine their job, education, income and smoking history. Data was declared significant if OR>1.The result of this study has shown that age ≥45 years (OR = 14,397), gender (OR=4.354), history of diabetes mellitus (OR = 10.688), the location of worker (OR = 2.935), education level (OR = 3.842), income (OR = 2.252), and smoking history (OR = 2.771) are risk factors that influence the incidence of senile cataracts.It can be concluded that age, gender, history of diabetes mellitus, outside location worker, low education level, low income, and history of smoking are risk factors for the incidence of senile cataract in RSU Bahteramas Kendari. Keywords :cataract, risk factors, age, gender, history of diabetes mellitus, location of worker, education, income, smoking history
Aktivitas Antibakteri Ekstrak Etanol Porifera (Spongia Officinalis ) terhadap Staphylococcus Aureus ATCC 25923
Get PDFStaphylococcus aureus is the most dangerous of all of the many comman staphylococcal bacteria. It stains gram positive and is non moving small round shaped or non motile cocci..Porifera (Spongia officinalis) are lowly organised less evelved animals and can be used as the medication resources. The aim of this study was to inveftigate antibacterial extract etanol of Porifera (Spongia officinalis)against the growth of Staphylococcus aureus ATCC 25923.Present study was an experimental in vitro test. Antibacterial activity assays were carried out by the disc diffusion method. Antibacterial activity was determined by the clear zone formed around the papaer disc and minimum inhibitor concentration which could inhibit the growth of Staphylococcus aureus ATCC 25923.The results are supported by the presence of secondary metabolite by phytochemical test such as alkaloid, terpenoid, steroid, saponin and tanin.Extract ethanolof Spongia officinalis. Extract etanol Spongia officinalishas antibacterial activity againts Staphylococcus aureus ATCC 25923. Minimum inhibitory concentration from the ekstrak etanol Spongia officinalis was 10 ppm.Conclution ; Extract etanol Spongia officinalishas antibacterial activity againts Staphylococcus aureus ATCC 25923Keywords: Spongia officinalis, Staphylococcus aureus, Antibacterial activities, MIC (Minimal Inhibitory Consentration
Uji Efek Antipiretik dan Antiinflamasi Ekstrak Etanol Buah Pare (Momordica charantia L.) terhadap Mencit Jantan
Get PDFThis research was carried out to determine the content of secondary metabolites contained in the ethanol extract of bitter melon (Momordica charantia L.) and antipyretic and antiinflammatory effects on mice. Bitter melon extract obtained by maceration method using ethanol 96%. Bitter melo ethanol extract was made in three variations of dose 50 mg / KgBW, 150 mg / KgBW, and 250 mg / KgBW. The content of secondary metabolites determined phytochemical Skrining by TLC (thin layer chromatography) with specific reagent. Antipyretic effect performed by vaccine DPT (Diphtheria Pertussis Tetanus) as inducers of fever and Parasetamol 500 mg as a positive control and antiinflammatory effect using the method of edema artificial on the soles of the mice foot with carrageenan 2% as an aphrodisiac edema and Diclofenac Sodium 50 mg as a positive control. Subjects used is a white male mice were given intraperitoneally (i.p). Analysis of the data using ANOVA statistical analysis and continued with LSD Post Hoc test. Phytochemical screening results showed that ethanol extract of bitter melon contains alkaloids, tannins, flavonoids, saponins, and triterpenoids. The results indicated that ethanol extract of bitter melon at dose of 150 mg/KgBW has antipyretic effect with total temperature decrease 1,1oC and anti-inflammatory effects with the largest of inflammation inhibition percent by 68.57%. One way ANOVA analysis signify a probability value (p) < 0.05 with 95 % of confidence level that indicate a significant influence of ethanol extract of bitter melon to its antipyretic and antiinflammatory effects on male mice.Keywords : Antipyretic, Anti-inflammatory, Momordica charantia, Bitter melo
Analisis Faktor Determinan Proksi Kejadian Hipertensi di Poliklinik Interna BLUD RSU Provinsi Sulawesi Tenggara
Get PDFHypertension represent the serious and big problem in all the world. From other side because prevalensi which high enough that is 19,7 % and tend to increase a period of/to to come, also because high ferocity storey;level in the form of permanent handicap and sudden death. Hypertension disease of Regency. hypertension in BLUD General Hospital South East Sulawesi Province that in 2008 the number of new visits to the outpatient hypertension as many as 1672 case, as many as 1758 case in 2009 and in 2010 as many as 1789 case. This study aims to analyze the determinants proxy of occurence hypertension in BLUD general hospitals South East Sulawesi Province. This research have the character of the observasional with the device [of] case study manage the (Case Control Study), where case is hypertension patient, is control the non patient hipertensi.Uji used by Odds Ratio and regresi logistics with the value ά= 0,05. Result of study show there are relation which signifikan to hypertension by family history OR = 6.84 95% CI (3.92 to 11.94), obesity OR = 6.32 95% CI (3.64 to 10.96), consumption of salted fish OR = 9.52 95% CI (5.35 to 16.95), physical activity OR = 8.07 95% CI (4.60 to 14.14), smoking OR = 8.19 95% CI (4.60 to 14.59), stress OR = 5.18 95% CI (3.38 to 9.96), diet OR = 5.44 95% CI (3.12 to 9.50), area of residence OR = 1.53 CI 95% (0.92 to 2.55), on multivariate analysis, consumption of salted fish is a proxy determinant of the incidence of hypertension. Advice need for society to control the risk factors for hypertension by controlling salt consumption, smoking, obesity, regular physical activity, leading a healthy lifestyle, diet.Keywords : hypertension occurence, family history, obesity, consumption of salted fish, physical activity, smoking, stress, diet, area of residence
Pengaruh Latihan Progressive Muscle Relaxation Terhadap Status Fungsional Dalam Konteks Asuhan Keperawatan Pasien Kanker dengan Kemoterapi di RS Dr.Wahidin Sudirohusodo Makassar
Get PDFChemotherapy is one of the cancer treatment that could provide many side effects and decrease the functional status and quality of life cancer patients. Progressive muscle relaxation (PMR) training is one of the nursing intervention that leads to decreased physical and phsycological effect from chemotherapy. The purpose of this study was to identify the effect of progressive muscle relaxation training on functional status in the context of the nursing care for cancer patients with chemotherapy. This study was a quasi experimental using a nonequivalent control group with pretest and posttest design. The sample was cancer patients who received chemotherapy and inpatient in RS Dr. Wahidin Sudirohusodo Makassar. A concecutive sampling was used as the sample collection method and 48 subjects were obtained this study, divided into two groups, each group consisted of twenty four subjects as intervention group who were given PMR training twice a day for seven days, and twenty four subjects as control group who were not given PMR training. The instrument that used in this study were demography form and Functional Living Index-Cancer to measure functional status which consisted 22 questions with 7-point Likert-Type linear analog scale. A T test was used to examine the differences of the mean of functional status scores and each dimension. The finding showed that there was a significant increased of the mean of functional status after PMR training in intervention group (p=0,000). It means that PMR training has an effect in increasing level of functional status in cancer patients with chemotherapy. It is recommended to apply PMR training as a nursing intervention to cancer patients with chemotherapy and suggested to conduct futher research using more samples.Key Word: cancer, chemotherapy, functional status, progressive muscle relaxatio
Uji Aktivitas Antibakteri Ekstrak Metanol Rumput Laut (Kappaphycus alvarezii) pada Berbagai Tingkat Konsentrasi terhadap Pertumbuhan Bakteri Streptococcus mutans
Get PDFRed algae Kappaphycus alvarezii contain flavonoids compound which has activity as an anti bacterial. This study aims to determine the difference of inhibition zone of the growth of Streptococcus mutans bacteria by seaweed methanol extract (K. alvarezii) at each concentrations. This research was conducted by post–test only design (one-shot case study) with a variable treatment of the seaweed methanol extract (K. alvarezii) against S. mutans. Extracts were then divided into 7 concentration of 5%, 25%, 50%, 65%, 75%, 85%, and 95%. Data were analyzed to determine the difference of inhibition zone seen from the ANOVA test (analysis of varience) followed by a post hoc test. The results of the bivariate analysis showed there were no difference of inhibition zone of the growth of S. mutans bacteria by seaweed methanol extract of K. alvarezii at the concentration of 65%, 75%, 85%, and 95% (p = 0,143). This research concluded that there were no defference of inhibition zone of the growth of S. mutans bacteria by seaweed methanol extract of K. alvarezii.Keywords : Kappaphycus alvarezii, Streptococcus mutan
Analisis Kadar Kolesterol Low Density Lipoproteinsebagai Faktor Risiko Komplikasi pada Pasien Diabetes Melitus Tipe 2
Get PDFDyslipidemia in type 2 diabetes mellitus (T2DM) can be increased the cardiovascular risk and this condition was equivalent with the elevated of LDL-cholesterol. In type 2 diabetes, LDL was small, dense and more aterogenic. This research was an observational study used cross sectional approach. The samples were 50 samples consist of twenty five of T2DM with non-CHD patient (50%) and twenty five of T2DM with CHD patient (50%) with age 45 years old or more. The level of serum LDL was measured by photometry used ABX Pentra 400. The data was analyzed by statistical method. The result study was conducted that normal LDL level was 9 (18%) patients and abnormal LDL level was 16 (32%) in T2DM with non-CHD patient. While in patient with T2DM with CHD had abnormal LDL level overall (50%). The high level of LDL in T2DM was accelerated complication occurrence, mainly coronary heart disease (CHD).Keywords: Type 2 diabetes mellitus (T2DM), dyslipidemia, LDL level, CHD complicatio
Uji Efek Antidiabetik Ekstrak Daun Andong (Cordyline fruticosa L. A. Cheval) Mus musculus yang Diinduksi Streptozotosin
Get PDFThe plant andong leaf is a medicinal plant that has not been widely used and contains phenolic, flavonoids,tanins and saponins has many benefits, one of which lower blood glucose levels. This study aim to look at the effects of decrease in blood glucose levels in mice that induced by STZs. The method used was experimental research design is RAL with treatment variations leaf extracts 15%, 30% and 45%, glibenclamid as positive control and Na. CMC negative control. The results were analyzed by ANOVA and continued with Duncan. The results showed that there is a very real difference in the treatment given, andong leaf extracts concentrations is themost effective extracts 15% with the average is 17,67 mg/dL on the hour to three.Key words : Leaf andong, antidiabetic, Mus musculus, streptozotocin