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Pengaruh Ekstrak Bawang Putih Terhadap Kadar Serum Kreatinin Tikus Hipertensi Two Kidney One Clipp (Effect of Allium sativum Extract to Serum Creatinine of Two Kidney One Clipp Hypertension Rat)
Get PDFBackground: Garlic (Allium sativum) has long been used both as a food and traditional medicine. Several studies have shown potential of garlic (Allium sativum) as an antihypertensive. In previous in vitro study found that dipeptide on garlic extract after hydrolyzed by the enzyme papain have ACE inhibitory activity. Induction of hypertension with 2 Kidney One Clip (2K1C) methodcauses the kidneys lose their physiological functions. A.sativum is expected to ameliorate kidney function. This study aimed to analyze creatinine levels in rat induced by 2K1C. Method: These study was an in vivo study with Pre-Post Test Only Control group Design. Before treatment, 30 subjects induced hypertension by 2K1C method. Treatment was conducted for four weeks. The recent study was conducted on 36 Rattus norvegicus, Wistar strain were divided into 6 groups. Measurement of creatinine was conducted by spectrophotometry method. Result: The results showed that there were significant differences in creatinine levels between groups (p 0.05). A.sativum 75m/kgBB gave the best decrease in creatinine levels up to 1.75 mg/dL compared to the A.sativum 25mg/kgBB and A.sativum group 50 mg/kgBB. There were significant differences in creatinine levels A.sativum 75 mg/kgBB and captopril (p 0.05). Kelompok A. sativum 75m/kgBB menunjukkan penurunan kadar kreatinin yang sangat signifikan hingga 1.75 mg/dL dibanding kelompok A. sativum 25mg/kgBB and A. sativum group 50 mg/kgBB. Terdapat perbedaan kadar kreatinin yang signifikan antara kelompok A. sativum 75 mg/kgBB dan captopril (p <0.05). Simpulan: Terdapat perbedaan kadar kreatinin yang signifikan antar kelompok dan penurunan kadar kreatinin terbaik yaitu pada dosis 75 mg / kg. Kata Kunci: A.sativum, hipertensi, kreatinin, 2K1
Hubungan antara Kadar Low Density Lipoprotein dengan Tekanan Darah Sistolik saat Puncak Exercise pada Personil Kepolisian Daerah Sulawesi Tenggara (The Relationship between Low Density Lipoprotein Levels and Systolic Blood Pressure during Peak Exercise of Police Personnel in Southeast Sulawesi)
Get PDFBackground: Systolic blood pressure during exercise is the blood pressure as measured by aneroid sphygmomanometer at the peak exercise (treadmill), namely when the subject has experienced fatigue or heart rate has reached > 85% of Maximum Heart Rate. Purpose:This research purpose is to determine the relationship between LDL level and systolic blood pressure at the exercise peak of police personnel in Southeast Sulawesi. Methods: This research used analytical-observasional study with cross sectional aproach. The independent variables used in this research are LDL level while the dependent variables was systolic blood pressure during the peak exercise. Research location is in Maxima Laboratory Kendari.The subjects of this study were 95 people based on the inclusion and exclusion criteria that selected by Purposive Sampling method. Data collection was gained by taking the secondary data and was processed by using statistical test data of Independent T-test with a significance p-value <0.05. Result: The result of bivariate analysis showed that there was a relationship between LDL level and systolic blood pressure at the exercise peak on the police personnel in Southeast Sulawesi with a p-value = 0,000 (<0.05). Conclusion: This study can be conlcuded that there was a relationship between LDL level and systolic blood pressure at the peak exercise of police personnel in Southeast Sulawesi.Keywords: low density lipoprotein, systolic blood pressure, peak exercise. ABSTRAKLatar belakang : Puncak tekanan darah sistolik pada saat exercise adalah tekanan darah sistolik yang diukur dengan menggunakan sfignomanometer air raksa pada saat puncak exercise, dimana subyek sudah mengalami kelelahan atau denyut jantung telah mencapai 85% dari denyut jantung maximal. Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil Kepolisian Daerah Sulawesi Tenggara. Metode: penelitian ini merupakan penelitian analitik-observasional dengan metode cross sectional. variabel independen adalah kadar LDL plasma dan dependen variabel adalah tekanan darah sistol pada puncak exercise. penelitian dilakukan di Laboratorium Klinik Maxima Kendari. sebanyak 95 sampel penelitian yang memenuhi kriteria inklusi dan eksklusi diambil dengan metode purposive sampling. Data tekanan darah saat puncak exercise dan kadar LDL plasma diambil dari data sekunder rekam medik pasien. Data kemudian dianalisa dengan uji statistik Independent T-test dan bermakna bila nilai p <0,05. Hasil: Analisa statistik menunjukkan adanya hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil POLDA Sulawesi Tenggara, dengan nilai p=0,000. Simpulan : Pada penelitian ini dapat disimpulkan bahwa terdapat hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil POLDA Sulawesi Tenggara.Kata Kunci: low density lipoprotein, tekanan darah sistolik, puncak exercis
Uji Aktivitas Antibakteri Ekstrak Kasar Bawang Putih (Allium sativum ) terhadap Bakteri Shigella dysenteriae yang Resisten terhadap Ampisilin
Get PDFABSTRACT Background : Gastrointestinal infections, especially caused by Shigella dysenteriae bacteria is still a health issue in Indonesia. The number of ampicillin resistance to S. dysenteriae has been widely reported. Garlic (Allium sativum) is a traditional medicine that efficacy as an antibacterial. Garlic contains an organosulfur compound Allicin. Research Purpose: This study aimed to determine the antibacterial activity of garlic rule extract on the growth of S. dysenteriae bacteria that are resistant to ampicillin. Research Methods: This study used the experimental with post test only control group design. The antibacterial activity test was determined based on the diameter of clear zone formed. Test were performed on garlic filtrate, ciprofloxacin as a positive control and aquades as a negative control. Each treatment was performed three times. Research Result: This research showed that rule extract of garlic (A. sativum) had a clear zone against S. dysenteriae that was resistant to ampicillin. Conclusion: The conclusion of this research was that rule extract of garlic (A. sativum) had an antibacterial activity against S. dysenteriae which resistant to ampicillin. Keywords : Antibacterial activity, Garlic (A. sativum), S. dysenteria
Antibacterial Activity Test on Ethanol Extract of Gedi Leaf (Abelmoschus manihot L.) on the Growth of Escherichia coli and Staphylococcus aureus
Get PDFABSTRACTBackground: Infectious diseases are one of the major causes of death worldwide, mostly caused by bacteria. The use of less targeted antibiotics leads to resistance cases, thus encouraging the discovery of alternative medicine.In general, gedy leaves are known as animal feed but gedy leaves contain antibacterials such as flavonoids, saponins, tannins and terpenoids. Research Purpose:This study aims to determine the antibacterial activity of ethanol extract of gedy leaves on the growth of E. coli and S. aureus. Research Method: This research uses post test only control design, free variable is ethanol extract of gedi leaves and dependent variable is bacterial growth inhibition zone. Ginger leaf ethanol extract was obtained by maceration method for 3 x 24 hours. The test of antibacterial activity using the well diffusion method. Research result: The results of ethanol extract of gedi leaf with concentration of 2.5 mg/ml, 1.25 mg/ml and 0.625 mg/ml resulted in inhibition zone to E. coli growth successively; they were 11.33 mm, 8 mm and 6.3 mm. Extracts of the same concentration also showed inhibition of S. aureus growth with inhibit zone of 8 mm, 3.6 mm and 2 mm. Conclution:The conclusion of this research is the extract ethanol of gedi leaf has antibacterial activity against E. coli and S. aureus.Keywords: Antibacterial,E. coli and S. aureus , Gedi leaf (Abelmoschus manihot L.), Infection
Aktivitas Antibakteri Ekstrak Etanol Daun Cayratia trifolia L. Domin. Terhadap Bakteri Escherichia coli
Get PDFABSTRACTPlant Cayratia trifolia L. Domin is one of the plants that can be used as a traditional medicine. One of them is the treatment of infectious diseases. Infectious diseases are the most disease suffered by the population in developing countries, including Indonesia. Some infectious diseases that can be caused by the bacterium Escherichia coli is a urinary tract infection or urinary tractus infection, diarrhea, prevalence of diarrheal diseases in Southeast Sulawesi Province was 7,3% higher than the national prevalence of diarrhea is 3,5 % this study aims to determine the antibacterial activity of ethanol extract of leaves C. trifolia L. Domin against the bacteria E. coli. This type of research is experimental research design using cylinder cup consisting of 5 treatments. Each treatment consists of three repetitions. C. trifolia L. Domin leaves then C. trifolia L. Domin as test materials made concentration of 10%, 20% and 30%. The results showed that ethanol extracts of leaves C. trifolia L. Domin with a concentration of 10% has an average value of 7,67 mm zone of inhibition concentration of 20% has an average value of 10,33 mm zone of inhibition and concentration of 30% has an average value 14,00 mm zone of inhibition. Results of ANOVA showed ethanol extract of leaves C. trifolia L. Domin had a zone of inhibition against Escherichia coli with different concentrations. And on the LSD (Least Significant Difference) concentration that was 30% effective in inhibiting the growth of bacteria E. coli. Keywords: zone inhibition, leaves Cayratia trifolia L. Domin, Escherichia coli, Cylinder cup
Antibacterial Activities of Kacapiring Leaf Ethanol Extract (Gardenia jasminoides Ellis) on the Bacteria of Staphylococcus aureus and Propionibacterium acnes
Get PDFABSTRACTBackground and Objective(s): Infection is the process of entering pathogenic bacteria or microorganisms into the body capable of causing disease. Bacterial infections can cause skin infections such as acne. Acne is inflammation that is accompanied by blockage of the oil glands of the skin and hair (pilosebasea duct). Gardenia jasminoides Ellis is a plant that empirically can be used to treat infectious diseases caused by bacteria. This study was conducted to determine the antibacterial activity of the extracts of kacapiring leaves (Gardenia jasminoides Ellis) against Staphylococcus aureus and Propionibacterium acnes bacteria. Methods: Making extracts was done by maceration method using 96% ethanol. The concentrations of extracts used were 5%, 10% and 15%, with chloramphenicol and clindamycin as positive controls and distilled water as negative controls. Antibacterial activity was tested by the Cup-plate technique. Results: The antibacterial activity of kacapiring leaves ethanol extract to S. aureus showed that at concentrations of 5%, 10% and 15% the inhibitory power diameters values were respectively 5.58 mm, 9.3 mm and 11.41 mm while the antibacterial activity of extracts kacapiring leaves ethanol to P. acnes bacteria at concentrations of 5%, 10% and 15% had inhibitory power diameters of 6.33 mm, 9.25 mm and 11 mm respectively. Conclusion: Ethanol extract of kacapiring leaves has antibacterial activity against Staphylococcus aureus and Propionibacterium acnes bacteria. At a concentration of 5% and 10%, it shows the moderate category and at a concentration of 15% shows a strong category.Keywords: antibacterial, cup-plate technique , gardenia jasminoide
Konsumsi Makanan Ibu Hamil Berhubungan dengan Berat Badan Lahir Bayi di Daerah Pesisir
Get PDFABSTRACTBackground: Low nutritional intake during pregnancy and nutritional status of pregnant women cause various effects for mother and babies. One of the effects is low birth weight. The prevalence of LBW in coastal areas is still high. This study aims to determine the relationship between eating habits of pregnant women with birth weight in coastal areas.Method: This study was an observational analytic study using a cross-sectional method. The sample were 50 respondents obtained using the consecutive sampling method. Data collection on eating habits used a food frequency questionnaire (FFQ). Data analysis used Fisher's Exact test with a significance value of p <0.05.Results: The results showed that infant birth weight in coastal areas was associated with the habits of pregnant women eating carbohydrate sources (p=0.45), protein sources (p=0.17) and vegetables (p=0.006). Infant birth weight in coastal areas was not related to the habits of pregnant women eating fruit (p=1.00). Conclusion: There was a relationship between infant birth weight in coastal areas and the habit of pregnant women eating carbohydrates sources, protein sources and vegetables. There was no relationship between infant birth weight in coastal areas and the habit of pregnant women eating fruits. Keywords :Birth weight, eating habits, pregnant wome
Hiperglikemia dan Status Inflamasi pada Pasien Sindroma Koroner Akut
Get PDFABSTRACTBackground: Hyperglycaemia in patients with acute coronary syndromes (ACS) is associated with increased cardiovascular (CV) risk. Hyperglycaemia in patients with ACS may be associated with increased systemic inflammation. Leukocytes are the major cellular mediators of inflammation and their elevated count is associated with higher CV event rate in ACS patients. Thus, it is possible that there is a relationship between hyperglycaemia and high leukocyte count among patients with ACS. Research Purpose: Aim of study is to investigate the relationship between hyperglycaemia and leukocyte count in ACS patients. Research Methods: This is a cross sectional study, which was held on January to April 2014 among 60 ACS patients in CVCU Wahidin Sudorohusodo Hospital. Glucose level and leukocyte count on admission were measured in 60 ACS patients. Patients was grouped into two groups, hyperglycemic ACS group (glycaemia on admission ≥ 140 mg/dL) and normoglycemic one (glycaemia on admission < 140mg/dL). Leukocyte count was compared to hyperglycemia and normoglycemia patients. Reseaerch Result: Mean of leucocytes count was significantly different between normoglycaemia and hyperglycaemia ACS patients, both in all patients (9.34 ± 2.58 x 103 vs 13.63 ± 3.10 x 103 , P<0.0001) and in non DM patients (9.34 ± 2.58 x 103 vs 14.08 ± 3.20 x 103 , P<0.0001). There was no significant difference of mean leucocytes count between DM and non DM ACS patients admitted with hyperglicaemia (12.38 ± 2.54 x 103 vs 14.08 ± 3.20 x 103 , P=0.121). Conclusion: The conclusion of this study was hyperglycaemia is assocciated with inflammatory status in ACS patients. Keywords :Acute coronary syndrome, hyperglycemia, and inflammation statu
Pengaruh Pola Makan terhadap Status Gizi Narapidana Lapas Kelas II A Baubau
Get PDFABSTRACT Background: Fulfillment of food is a human need to maintain its life and carry out daily activities, the law Number 12 of 1995 Article 14 mandates that prisoners are entitled to health services and adequate food. Research Purpose: This study aims to determine the effect of diet on nutritional status of prisoners in prison Class II A Baubau. Research Method: The study was conducted in February of 2018 at the Class II A Baubau Prison Center on 132 prisoners. The research method used was observational analytics with cross sectional approach by measuring body weight and height also interview using questionnaire. The data of the research were analyzed using chi square test. Research Result: The results showed that 23.5% of respondents were nutritional status of thin, 65.9% normal nutritional status and 10.6% of respondents had more nutritional status. Prisoner diet was found that 82.6% of respondents get food according to the prison regulations and 17.4% of respondents get food not in accordance with prisons. Chi square test showed that there is influence of diet to nutritional status of prisoner shown with value P = 0.000. Conclusion: The conclusion of this research, that there was a dietary influence on the nutritional status of prisoners of Class II A Baubau. It was expected that the government and the prisons can pay attention to the intake of nutrients received by prisoners to achieve optimal prison health and coaching processes.Keywords: Prison, Inmates, Dietary Habit, Nutritional Statu
Studi Kualitatif Fenomenologi Pengalaman Hidup Pasien Pasca Kolostomi di Wilayah Jawa Barat
Get PDFABSTRACTPatient with colostomy followed colorectal has been cancer increasing significantly in Indonesia. Colostomy caused not only physical problems but also psychological and social problems. Health care profesional, especially nurses need to provided hollistic care services to the patients after colostomy. Study with Qualitative method to describe the live experience of the colostomy patient was important. This study was a phenomenological qualitative approach . Data obtained with in-depth interviews to 8 informants consisting of 5 men and 3 women, aged between 30-73 years. The length of time living with a colostomy between 4 months to 6 years. Data were analyzed by using Colaizzi method. Themes emerged from this study: ;sources of support;live with a colostomy; live adaptation; the burdens living with a colostomy. Living with a colostomy faced problems including the limitation to fulfill their needs, psychosocial changes, spiritual distress, and economic problems. Based on those problems, nurses can give support and attention for post colostomy patients. Keywords : Lived Experiences, Colostomy, Bandun