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Pengaruh Terapi Kombinasi Ekstrak Etanol Mentimun (Cucumis sativus) dan Vildagliptin terhadap Penurunan Kadar Glukosa Darah Tikus Wistar yang Diinduksi Aloksan (The Effect of Combination Treatment of Cucumber (Cucumis sativus) Ethanolic Extract and Vilda
Get PDFDiabetes mellitus is a metabolic disease characterized by hyperglycemia. Effective management is needed. Cucumber is one of traditional medicine contains saponins with antihyperglycemic effects. This study aimed to determine the differences between combination therapy of cucumber ethanolic extract and vildagliptin and monotherapy of cucumber ethanolic extract or vildagliptin to decrease the blood glucose. The rats were injected with alloxan 125 mg/kgBW. There were 5 groups: K1 was normal group, K2 was a group of diabetic rats without treatment, K3 was a group of diabetic rats with cucumber ethanolic extract (200 mg/kgBW), K4 was a group of diabetic rats with vildagliptin treatment (1,8 mg/200 gBW), K5 was a group of diabetic rats with combination treatment of cucumber ethanolic extract (200 mg/kgBW) and vildagliptin (1,8mg/200 gBW). After 14 days, fasting blood glucose (FBG) was measured. The result showed that the mean FBG after treatment (FBG 2) of K1, K2, K3, K4, and K5 were (82,4; 277,2; 188,2; 199,2; 180,6) mg/dL, respectively. In conclusion, the potential of cucumber ethanolic extract and vildagliptin in combination treatment was more effective to decrease the blood glucose levels than both monotherapy of cucumber ethanolic extract or vildagliptin in Wistar rats. Â Keywords: Diabetes Mellitus, Cucumber, Vildagliptin, Blood Glucose Levels, Alloxa
Pengaruh Lama Pemberian Distres Kronis terhadap Aktivitas Sel Osteoklas pada Tulang Alveolar Tikus Sprague-Dawley (The Effect of Chronic Distress Duration to Osteoclast Cells Activity in Alveolar Bone of Sprague-Dawley Rats)
Get PDFExcessive and prolonged distress (chronic) can cause damage to periodontal tissues, specifically alveolar bone resorption. Alveolar bone resorption is caused by osteoclast cells activity. The purpose of the research is to determine effect of chronic distress duration to osteoclast cells activity in alveolar bone of male Sprague-Dawley rats attain the age of 3-4 months. The rats were given an electric shock stressor (Electrical Foot Shock) as distress chronic for 7, 14, and 28 days. Stressors were given for 30 minutes at 9 a.m every day during the treatment period. The amount of electrical current is 2-8 mA, 48 V voltages and 0.5 Hz frequency. Osteoclasts activity were observed histologically with 400x magnification using osteoclast Bone Interface (OBI) Index by dividing the length of howship's lacunae with osteoclasts. Result showed signifficant difference at 0.00 (p<0.05) beetwen the variable.Activity of osteoclasts in alveolar bone of Sprague-Dawley rats which were exposed to the stressor is increased when compared to the group that were not exposed to electrical shock stressor, but at day 14 decreased when compared to the other treatment groups. Keyword : chronic distress, osteoclast activity, alveolar bon
Pengaruh Pelatihan Perawatan Tali Pusat dengan Metode Simulasi terhadap Keterampilan Merawat Tali Pusat pada Ibu Primigravida Trimester II-III di Wilayah Kerja Puskesmas Ledokombo Kabupaten Jember (The Influence of Umbilical Cord Care Training (UCCT) by S
Get PDFUmbilical cord care is a treatment of newborn baby’s umbilical cord started when umbilical cord was cut off or dried up. A well took umbilical cord care allow baby to heal faster. Umbilical Cord Care Training (UCCT) by simulation method aims to provide skill in performing umbilical cord care of primigravida in preventing infections and tetanus neonatorum. This research was intended to analyze the influence of UCCT to umbilical cord caring skill of 2nd and 3rd trimester primigravida. This was a quasy experimental study with non-randomized control group and pretest-posttest design. The samples were 32 primigravide picked out by multistage random sampling and divided into two groups. Data were analyzed by Wilcoxon match pair test and Mann Whitney U test with 95% of CI. The result showed p value of Wilcoxon match pair test in experimental group was 0,000 and 1,000 in control group, while by Mann Whitney obtained p value of 0,000 (a=0,05). It can be concluded that there was an influence of UCCT to primigravida’s skill in performing umbilical cord care. Hereby, suggested to nurses to give UCCT by simulation method at maternal and child health center to prepare primigravida on caring newborn baby to prevent infections and tetanus  Keywords: umbilical cord care training, simulation method, skil
Hubungan Antara Profil Budaya Organisasi (Menggunakan Pendekatan Competing Values Framework) dengan Kinerja Organisasi Puskesmas di Kabupaten Jember Tahun 2012 (The Relationship between Organizational Culture Profile (using Competing Values Framework Appr
Get PDFCommunity Health Center (CHC) is a technical execution unit of District Health Office which isvery important in society. Organizational performance of CHC in Jember Regency 2012 wasvery low. One of the factors that affects the organizational performance is organizationalculture. The study aims to analyze the relationship between organizational culture profile(using Competing Values Framework approach) with organizational performance of CHC inJember Regency 2012. The study is an analytical research with cross sectional approach.The determination of sample using proportionate stratified random sampling technique, withthe amount of sample is 33 CHC (723 respondents). Analysis of data in this study useLambda correlation statistic test (α=0,05). The result of the study showed that the dominantorganizational culture type of CHC located in hierarchy culture 78,79%, clan 12,12%, market9,09%, and adhocracy 0%. The result of Lambda correlation statistic test showed that thereis a relationship between organizational culture with organizational performance of CHC inJember regency (0,045 < α) and the rate of lowering error is 62,50%.Keywords: organizational culture, organizational performance, Community Health Center,Competing Values Framework
Perbandingan Komplikasi Malunion pada Pasien Fraktur Humerus Pasca Terapi Operatif dan Non-Operatif di RS Bina Sehat
Get PDFHumerus fracture is a quite common fracture. Fracture of diaphyseal humerus is 1,2 % of all cases of fracture. The treatment of humeral shaft fracture can use 2 different approaches, operative treatment and conservative treatment. This research aimed to compare the complication of malunion in patients with operative and conservative treatment. This was an observational analytic study on patients at the Bina Sehat Hospital. Samples were divided into 2 groups, operative and non-operative. Both groups were examined by measuring the lenght of the humerus after fracture comparing with its contralateral, the ability of the internal rotation, the ability of the external rotation, and angulation inspection. Statistical test showed a difference humerus shortening between 2 groups reached 0.873 cm. The difference between 2 groups on the ability of internal rotation reached 11.4710. The difference between 2 groups on ability of external rotation reached 16.608o. And the result for angulation assessment also showed significant difference between 2 groups. In conclutson, there was a significant difference in complications of malunion between operative and non-operative groups. Â Keywords: humerus fracture, operative treatment, non operative treatment, comparative malunio
Analisis Maturasi Gigi pada Tikus yang Mengkonsumsi Minyak
Get PDFDental maturation is a process of anorganic mineral apotition and resorption ofprotein and water content in the matrix of teeth during the stage of growth and developoment.Disturbances in the stage will caused abnormalities of tooth e.i. hypoplasia andhypomineralisation that are known tooth hypomaturation. The disorder may be systemic orlocal, because of trauma, infection, hormonal, systemic diseases, nutritional deficiencies, etc.fish oil of lemuru containing Eicosanoid acid (EPA) and docohexanoic acid (DHA) are highenough. The EPA and DHA are antiinflammatory and play a role in the regulation ofsignaling molecules and imunomudulator. The purpose of this study was to analyze thematuration of teeth in rats consuming fish oil of lemuru after periodontal infection induced byLPS during amelogenesis. 30 male Wistar rats aged 5 days, divided into three groups. Thefirst group was rats induced by lypopolisacharide (LPS) in the molar region (it aims to makedental maturation disorder). The second group was rats inducted LPS and given fish oil, andthe third group was not LPS induction and not given fish oil (normal). After the rats is agesof 21 days, were done decaputation. Upper right molar teeth have been taken to doobservation in macroscopic (clinical) and microscopic (SEM). Microscopic andmacroscopic observations done scoring, and statistically analyzed using one-way ANOVAand LSD. The results of this study showed that significantly (p <0.005) rats fed fish oil oflemuru, maturation teeth better than LPS-induced rats. It was concluded that fish oil affectsthe maturation lemuru rat teeth, and prevent tooth maturation disorder is more severe.Key words : fish oil, tooth maturation, amelogenesis, SE
Pengaruh Ekstrak Metanol, Fraksi N-Heksana, dan Fraksi Metanol Biji Pepaya (Carica papaya L.) terhadap Kadar Testosteron dan Bobot Organ Reproduksi Tikus Jantan (Effect of Methanolic Extract, N-Hexanic Fraction, and Methanolic Fraction of Papaya Seed (Ca
Get PDFPapaya seeds (Carica papaya L.) was known have antifertility activity. Testosterone hormone and reproduction organs weight are influence antifertility activity. This study was conducted to compare the effect of the methanolic extract, fraction of n-hexane, and fraction of methanol papaya seeds ( dose 100 mg/kg BW ) with testosterone level and reproduction organs weight parameters of male rats. Measurement of testosterone level by ELISA method. The observation found that the three treatment didn’t decrease reproduction organs weight but decrease testosterone level compared to negative control group. Among the three treatments, metyhanolic extract and methanolic fraction decreased testosterone level. Extract and fraction of methanol alleged alkaloid content of which is known to inhibit development and count of spermatogenic cell.  Keywords: papaya seeds, testosterone, alkaloid, orga
(Kadar LDL dan HDL Dalam Darah Model Tikus Periodontitis (Blood Level of LDL and HDL in Periodontitis Rat Model )
Get PDFBackgroud. Increased levels of low density lipoprotein (LDL) and decreased levels of high density lipoprotein (HDL) in the blood is a risk factor for atherosclerosis leading to Coronary Heart Disease (CHD). Risk factor of atherosclerosis are multifactorial such as consuming high lipid diet, excessive eating, sedentary, and inflammatory response. According to the recent study indicated that inflammatory response could affect LDL and HDL blood levels that related to the risk of atherosclerosis lesion formation. Therefore, we suspected that periodontitis could affect LDL and HDL. Purpose. The purpose of this study was to show the effect of periodontitis in LDL and HDL. Methods. This experimental study used the post test only control group design. The object were 8 male wistar rats (Rattus norvegicus) with inclusion criterias were male rats, ±200 gr body weight, 3-4 months age, having a healthy condition, good appetite, and normal behavior. The rats were devided into two groups, i. e. control group and treatment group (periodontitis group) with 4 rats in each group. Periodontitis rat model was created by fitting cervical left low molar tooth with wire ligature and injected with 0,02 ml P. gingivalis ATCC 33277 (dosage 5µg/0,05 ml) in bucal sulcus, three times a week for 4 weeks (28 days), all of the rats were fed with standard diet. On day 29th all groups of rats were sacrificed and intracardial blood were taken 3 cc for examination of LDL and HDL blood levels by electrospectrophotometric method. Data were analyzed by T-test. Result. Result showed that periodontitis rat model had a significantly higher LDL levels compared to control group (P <0,05) and HDL levels were lower than controls, but the difference was not significant (P >0,05). Conclusion and suggestion. Based on this study periodontitis increase LDL blood levels. Further research related with duration of periodontitis are needed because periodontitis is usually a chronic disease and have a long lasting effect . In addition, the role of the severity of periodontitis are required to learn.  Keywords: HDL, LDL, Periodontitis
Perspektif Pasien dengan Perlindungan Sosial Kesehatan tentang Peran Advokasi Perawat di Ruang Rawat Inap Kelas III Rumah Sakit Paru Jember (Nurse's Advocation Role in Patients With Social Health Insurance in Class III Inpatient Wards Paru Hospital Jember
Get PDFVarious reports about service quality to social health insurance (Jamkesmas) participants pointed out that the given service to social health insurance was not compatible with the program’s purpose. As health professionals whom always keep patients company, nurses are required to be able to give primary care to all patients. Advocacy is one of nurse’s roles, in carrying out this role, nurses are helping patients making decision instead of making the decision for patients. This study is a qualitative study with phenomenological approach. Samples are acquired by purposive sampling method with the result 4 samples out of population. Data was obtained by interview using an interview guide as well as field notes. This data was analyzed with Colaizzi method. Results of study give rise to ten research themes which conclude a description of the particular goals. Those themes are the role of nurses in the inpatient admission procedure, provide information about the procedures of action, provide a suitable environment to the condition of the patient, assisting other health professionals, accompany the patient to undergo a medical examination, the type of actions taken, the role of nurses as patient managers, the nurse's role in planning after discharge, and JAMKESMAS service system. The nurses as care giver in Paru Hospital Jember should consider to the advocation role in all their actions. Keywords : patients’ perception, nurse advocation rol
Hubungan antara Aktivitas Fisik dan Kejadian Demensia pada Lansia di UPT Pelayanan Sosial Lanjut Usia Jember
Get PDFDemensia merupakan penyakit pada lansia yang bermanifestasi terhadap kemunduran kemampuan intelektual. Di Indonesia, prevalensi demensia pada lansia berusia 65 tahun adalah 5 persen dari populasi lansia. Prevalensi meningkat menjadi 20 persen dari lansia yang berusia 85 tahun ke atas. Kategori lansia berusia 65 tahun ke atas di Indonesia pada tahun 2003, sebanyak 11.280.000. Jumlah ini diperkirakan akan meningkat menjadi 29 juta pada tahun 2013 atau 10 persen dari populasi. Ada beberapa faktor yang mempengaruhi penurunan memori salah satunya adalah aktivitas fisik . Aktivitas fisik secara teratur telah terbukti dapat mengurangi risiko demensia, termasuk penyakit Alzheimer sebesar 50 %. Penelitian ini menggunakan jenis penelitian analitik observasional dengan desain cross sectional. Variabel yang diamati adalah tingkat demensia pada lansia dan aktivitas fisik yang dilakukannya. Responden kemudian diukur menggunakan instrumen kuisioner MMSE (Mini Mental State Examination). Populasi dalam penelitian ini adalah semua lansia yang tinggal di UPT Pelayanan Sosial Lanjut Usia Jember sebanyak 43 responden. Hasil penelitian dengan uji Spearman Rho menunjukkan bahwa nilai signifikansi = 0,00 (p 0,05 > 0,000). Terdapat hubungan yang bermakna antara aktivitas fisik dengan kejadian demensia pada lansia di UPT Pelayanan Sosial Lanjut Usia Jember. Kata kunci: aktivitas fisik, demensia