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Efek Angiogenesis Lumbrokinase terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi Angiogenesis Effect of Lumbrokinase on the Cardiac Histopathology of Hypertensive Wistar Rat
Get PDFHypertension remains a serious health problem it is dubbed as “the silent killerâ€. Pathophysiology of hypertension involve alteration of vascular structure. The use of anti hypertension leads to many side effects, and many people tend to choose natural therapy. The study aimed to investigate the effect of lumbrokinase on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Lumbrokinase 0.5 gr/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with lumbrokinase from 187 mmHg to 159 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of lumbrokinase. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 10.55± 1.44 compared to 7.45± 1.21 in control group. It can be concluded that lumbrokinase had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, lumbrokinase, vascular structure, angiogenesis
Perbandingan Kekuatan Tarik Bahan Adhesif Resin Komposit Hibrid pada Braket Ortodontik terhadap Perbedaan Intensitas Sinar Tampak (Comparation of Tensile Strength Hybrid Composite Adhesive Material Resin at Orthodontic Brachet to Different Light Cure
Get PDFHybrid composite resin it’s brachet adhesive agents of little and big particle bond. Light cure intensity influence hybrid composite resin polymmerisation. In orthodontic most research is about brachet bonding strength by using tensile strength test. The aim of this study was to determine the difference of tensile strength of hybrid resin composite on orthodontic brachet with different light cure intensity. Samples for this study ware upper maxilary jaw premolar tooth. Samples ware divided into two groups. Each groups was etched, bonded, and applied by hybride composite resin on base of brachet. Group 1 was exposed by light cure intensity at 650-850 mW/cm2, and group two with 2700 mW/cm2 intensity. Tensile strength test was done to know bracke bonding strength with teeth. The result of this study showed there was significant difference between tensile strength of light cure at 650-850 mW/cm2, and 2700 mW/cm2intensity with signifficant value 0.002 (p<0,005). Conclusion of this study that high light cure intensity had better brachet bonding strength than low light cure intensity.  Keywords: hybrid composite resin, light cure intensity, tensile strength
Hubungan Motivasi Perawat dengan Pelaksanaan Prinsip 12 Benar dalam Pemberian Obat di Ruang Rawat Inap RSU dr. H. Koesnadi Bondowoso (The Correlation between Nurses’ Motivation with the Implementation of 12 Principles of Right in Medicine Giving in Inpat
Get PDFNurse is the most appropriate medical staff to give medicine and vacate their time for the patients. In giving medicine, nurse also must concern on the given prescription must be appropriate, the exact qualification of dosis that is given and always applying 12 principles right away. This condition might cause the occurrence of interaction between the characteristic of a nurse that is her motivation and his work. The purpose of the research is to analyze the relation of nurse’s motivation and applied of 12 principles of right in giving medicine in inpatient wards of dr. H. Koesnadi hospital in Bondowoso. The design of this research that is used is observational analysis with cross sectional and sample approach used 51 correspondences. Data collection technique is sample probability with simply random sampling. The result of the data analysis used chi square test. The result show that P value 0.005 (0.005< α=0.05) means that there is relation between nurse’s motivation and the applies 12 principles of right in giving medicines having this research, hopefully for the institution of the hospital for increase even more the nurse’s motivation in working by giving reward and punishment to the nurses and give them special seminar related to 12 principles of right in giving medicines.  Keywords: nurse’s motivation, 12 principles of right in giving medicines, inpatient ward
Uji Aktivitas Antibakteri dan Antibiofilm Minyak Atsiri Rimpang Bengle (Zingiber purpureum Roscoe) terhadap Bakteri Staphylococcus epidermidis (Antibacterial and Antibiofilm Activity Test of Bengle Rhizome Essential Oil (Zingiber purpureum Roscoe) agains
Get PDFStaphylococcus epidermidis has become one of the most important pathogenic bacteria that lead to nosocomial infection. This is caused by its ability to form a biofilm on the surface. Essential oils are one of the natural product that could be used as antiinfection agents. Bengle rhizome essential oil has been known to have activity against non-pathogenic bacteria S. epidermidis. This study was proposed to know the antibacterial and antibiofilm activity of bengle rhizome essential oil against clinical isolate of S. epidermidis at concentrations of 45, 60, 75, and 90%. Antibacterial activity was determined by the diffusion method with hole plate technique, while antibiofilm activity was determined by the microtiter assay method with crystal violet staining and quantified by measuring the optical density (OD) at λ 595 nm. This study showed that bengle rhizome essential oil has antibacterial and antibiofilm activity. The largest antibacterial and antibiofilm activity was shown from 90% concentration of bengle rhizome essential oil.
Keywords: nosocomial infections, antibacterial, antibiofilm, bengle essential oil, Staphylococcus epidermidis
Potensi Rebusan Kulit Buah Manggis Alami (Garcinia mangostana Linn) untuk Meningkatkan Aktivitas Mikrobisida Sel Neutrofil terhadap Streptococcus mutans (The Potency of Mangosteen Peel Infution (Garcinia mangostana L.) to Increase Neutrophil Microbicidal
Get PDFNeutrophils were part of leucocyte cells which dominate in blood circulation. When the microorganism entered the body, neutrophils kill it immediately. The steps that were migration, ingestion, swallowing, and microbicidal activity or intercellular killing. The contents of mangosteen peel is presumed to help neutrophils beat bacteria. Samples numbered 28 consist of 7 treatment groups, namely K 1 (negative control), K II (positive control), K III 100% MPI (Mangosteen Peel Infution), K IV 75% MPI, K V 50% MPI, K VI 25% MPI, and K VII 100% MPIwithout neutrophils. Isolated neutrophils exposed to MPI appropriate treatments groups above and then incubated for 3 hours. Subsequently exposed to S. mutans and incubated again for 3 hours. After that, the sample werecultured in BHI-A media and incubated for 1x24 hours. Furthermore, bacterial colonies were counted with a colony counter method. The result showed a significant difference between MPI treatment groups with control groups. The conclusion of this research is thenatural mangosteen peel infution hasthe potential to increase microbicidal activity of neutrophils and can act as an antibacterial. Â Keywords: mangosteen (Garcinia mangostana L.),microbicidal,neutrophils, S. mutans
Efek Ekstrak Air Kulit Buah Delima (Punica granatum L) terhadap Salmonella typhimurium secara In Vivo (The Effect of Pomegranate (Punica granatum L) Peel Aqueous Extract on Salmonella typhimurium In Vivo)
Get PDFSalmonella typhi infection is commonly treated by an antimicrobial agent such as levofloxacin. At the moment, herbal usage has risen as an alternative therapy. Pomegranate (Punica granatum L) is a commonly used herb which contains flavonoid as its major active compound. Aqueous extract of pomegranate peel had been known for its antimicrobial effect to S. typhi on in vitro study. The aim of this research was to investigate the activity of aqueous extract of pomegranate peel to S. typhimurium in vivo and find the antimicrobial effect of different concentrations. The study was conducted by using typhoid fever model in mice infected by S. typhimurium. Each mice was treated with aqueous pomegranate peel extract in three consentrations: 0,65 mg/ml, 1,3 mg/ml and 2,6 mg/ml for treatment groups and levofloxacin 1,3 mg/ml for positive control group. Ileum of each mice was isolated and cultured. The result of post hoc LSD test showed that negative control group significantly different with treatment group and the result of Pearson test showed p=0,000 and r = -0,865. In conclusion, aqueous extract of pomegranate peel had an antimicrobial activity on S. typhimurium in vivo where the higher extract concentration the lesser number of S. typhimurium colony. Â Keywords: Antimicrobial, Pomegranate, Salmonella typhimuriu
Perbedaan Metode Buzz Group Discussion dengan Ceramah Audiovisual terhadap Tingkat Pendidikan Warga Binaan tentang HIV/AIDS di Lembaga Pemasyarakatan Klas IIA Kabupaten Jember (The Differences between Using Buzz Group Discussion Method and Audiovisual Lec
Get PDFHIV/AIDS increased not only occurred in general population, but also in prison population. Knowledge about HIV/AIDS is urgently needed to prevent the transmission of the disease. This research aimed to determine the differences about Buzz group discussion method and Audiovisual lectures to the knowledge level of inmates about HIV/AIDS in prison class IIA Jember Regency. The research used quasi-experimental with non-equivalent control group pretest-posttest design. Sampling technique used purposive sampling involving 44 respondents divided into intervention group and control group. Data were collected using pretest and postest questionnaires.Data were analyzed by using Wilcoxon test and Mann Whitney test. The result of Wilcoxon test showed that there were differences of knowledge level of inmates about HIV/AIDS before and after health education using buzz group discussion method (p value=0,000) and audiovisual lectures (p value = 0,004). However, there was no difference between intervention group and control group against the knowledge level of inmates about HIV/AIDS (p value=0,337, α=0.05). Buzz group discussion and audiovisual lectures methode can be used as alternative health education method because can help participants more active during the procces of health education, health officer in prison Class IIA Jember regency can choose both as health education methods.
Keywords: Buzz group discussion, audiovisual lecture, knowledge level, HIV/AID
Hubungan Antara Karakteristik Individu, Paparan Debu Asap Las (Welding Fume) dan Gas Karbon Monoksida (CO) Dengan Gangguan Faal Paru Pada Pekerja Bengkel Las (Studi di Kelurahan Ngagel Kecamatan Wonokromo Surabaya) The Correlation Between Individual Characteristic, Exposure of Welding Fumes and Carbon Monoxide With Pulmonary Function Disorder of Welding Workers (Study in Ngagel Village, Wonokromo Sub district, Surabaya)
Get PDFWelding industries are prone to hazards. Welding fumes and carbon monoxide resultedfrom the welding process can cause pulmonary function disorder. Based on the surveyof welding station in Ngagel, there were 7 workers exposed to pulmonary functiondisorder. This study aimed to analyze the relationship between individual characteristic,welding fumes and carbon monoxide (CO) with pulmonary function disorder of weldingworkers in Ngagel Village, Wonokromo, Surabaya. This study is observational analyticwith cross sectional approach and sample of 36 workers from 5 welding station. Theresult of this studied that there were relationship between pulmonary function disorderand welding fumes, individual characteristics in terms of age, duration of exposure,working periode, cigarette smoke, and the amount of cigarette and not correlatedbetween nutrional status, temperature, humadity with pulmonary function disorder.Keywords: welding fume, carbon monoxide, individual characteristic, work climate,pulmonary function disorder
Hubungan Pemakaian Alat Pelindung Diri dengan Tingkat Kecacatan Klien Kusta di Wilayah Kerja Puskesmas Jenggawah dan Tempurejo Kabupaten Jember Tahun 2014 (The Correlation of Application Universal Precaution for Prevent Degree of Disability Clients Lepro
Get PDFLeprosy is chronic disease that caused by germs Mycobacterium leprae and could be caused problems relating to physical health that associated with a disability. Clients leprosy with disability can prevent with wearing universal precaution. The research done by observational analytic design. Design of collecting data was the level of disability and questionnare of users universal precaution. The respondent was only undergo treatment of MDT in the workplace of Jenggawah Health Centers and Tempurejo Health Centers who are 17 client leprosy. Based on research conducted that clients leprosy (35.3%) wear universal precaution and the clients leprosy (64.7%) not wear of universal precaution.Data analyzed with the technique of chi square correction. The result of a correction Fisher’s Exact test p value 0.010 show there was the relation of universal precaution with the level of disability clients leprosy. The results of research is expected to be the basis of promotion programs, prevention, and the aggrandizement of leprosy in Indonesia by integrating model intervention nursing of community and involving the related agencies.
Keywords: Universal precaution, degree of disability, lepros
Pengaruh Minuman Kopi terhadap VO2max dan Pemulihan Denyut Nadi pasca Melakukan Treadmill (The Influence of a Coffee Drinks to VO2max and Pulse Recovery after Doing Treadmill)
Get PDFCoffee can be classified as a psicostimulant which cause person stay awake. Coffee contains any ingredients such as caffeine.Caffeine could improve the performance of athletes. VO2max is a highest ratio of oxygen consumed during intense physical activity. The purpose of this study was to determine the effect of caffeine consumption on VO2max and exercise recovery pulse. The study used experimental research with Randomized Clinical Trial (RCT) methods. There were 20 volunteers, who were divided into two groups. The control group was given a drink that contains no caffeine while the treatment group was given a drink containing caffeine. Then all volunteers were asked to perform Modified Bruce Treadmill Test procedure until exhaustion occurred then VO2max.The next 4 days were washing out period where the control and treatment groups swap the roles. The results showed the average value of VO2max in the treatment group was 30.69 ml/ kg/min higher than in the control group 25.98 ml/ kg/min, but the duration of pulse recovery in the treatment group was 127 minutes slower than the control group, 121 minutes, indicating to its effects as a stimulant. In conclusion, administration of caffeine increased VO2max, but delayed time of pulse recovery. Â Keywords: Modified Bruce Treadmill Test, pulse recovery, caffeine,VO2ma