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Deteksi Lesi Aterosklerosis Koroner pada Model Tikus Periodontitis (Detection of Coronary Atherosclerotic Lesions in Periodontitis Rat Model)
Get PDFBackground: Recent concept istated that periodontitis can induce the formation of coronary atherosclerotic lesions but there is less experimental study about that. Purpose: Analyze the effect of periodontitis on the formation of coronary atherosclerotic lesions.The parameters are coronary artery wall thickness, collagen intimal disintegration, atheroma, stenosis, endothelial disintegration, lipid deposition and fatty emboly. Methods: This experimental laboratoris (in vivo) study used male wistar rats with a total sample of 12 animals, were divided into 2 groups: control and periodontitis treatment that were prepared by mounting wire ligature and Porphyromonas gingivalis injection (0,5 McFarland/1,5x108 CFU/ml) in the gingival sulcus left mandibular first molar teeth 3 times a week for 4 weeks. On 5th week, mice were secrificed and heart that contain the coronary arteries was taken. Heart were fixed , histological preparations were made and colored by Picrosirius Red and Oil Red O. Results: The Arterial walls of periodontitis group are significantly (p <0.05) thicker than the control group. the presence of collagen intimal disintegration, atheroma, stenosis, endothelial disintegration, lipid deposition and fatty emboly are also significantly (p<0,05) more in periodontitis group than in the control group. Conclusion: Periodontitis increase the risk of coronary atherosclerotic. Keywords: Atherosclerosis Lesion, Periodontiti
Pengaruh Kitosan Cangkang Udang Putih (Penaeus merguiensis) terhadap Jumlah Sel Osteoblas Tulang Femur Tikus Wistar Betina Pasca Ovariektomi (The Effect of White Shrimp (Penaeus merguiensis) Shells Chitosan on the Total Osteoblast of Femoral Female Wista
Get PDFOne of imbalance disorders of bone formation is osteoporosis. This frequently occurs in postmenopause women because of estrogen deficiency that leads to an increase in osteoclast cell differentiation exceeds osteoblast cell differentiation. Shrimp shell is an export waste that can be used to produce chitosan. Chitosan can increase osteoblast cell differentiation and inhibit the differentiation of osteoclast cell in the bone formation process. The study aimed to determine the effect of chitosan white shrimp shell on the total osteoblasts of femur female wistar rats after ovariectomy. This research was the quasi experimental laboratories research by using female wistar rats that divided into three groups; a non-ovariectomy control, a negative ovariectomy, and an ovariectomy treatment group that was given chitosan 0,05 g/day. After 14 days, the experimental mice were euthanized and osteoblast was calculated. There were 43 osteoblast cells in the control group, 21 osteoblast cells in the negative control group, and 38 osteoblast cells in the treatment group. The data was analysed using one way ANOVA and showed a significant differences between all groups (0,000). It can be concluded that the chitosan of white shrimp shell can increase the osteoblasts femur female wistar rats after ovariectomy. Â Keywords: osteoporosis, chitosan, osteoblast cel
Efektivitas Seduhan Daun Yakon (Smallanthus sonchifolius) terhadap Kadar Low Density Lipoprotein (LDL) dan High Density Lipoprotein (HDL) pada Tikus Diabetik yang Diinduksi Streptozotocin (The Efectivity of  Yacon Leaves (Smallanthus sonchifolius) Infusion to Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) Level in Diabetic Rats Induced by Streptozotocin)
Get PDFDiabetes mellitus (DM) is a metabolic disorder characterized by elevated level of blood glucose abnormalities associated with the metabolism of carbohydrates,lipids and proteins. Lipids metabolism disorder can increase LDL and lower HDL level. One of plants in Indonesia, that has potential as antihyperglycemic and hypolipidemic agent is yakon (Smallanthus sonchifolius) containing chlorogenic acid (CGA). This study aimed to determine the effect of yacon leaves infusion to LDL and HDL level in diabetic rats induced by streptozotocin (STZ). This study was an experimental research laboratories with the post test only control group design. Rats checked the blood glucose early then induced by STZ with dose 65 mg / kg BW. At 3 days post injection, they were checked the blood glucose. Then the rats were divided into 2 groups the control and treatment group. The treatment group was given yacon leaves infusion ( 3.6 ml/200 g BB rats ) for 14 days. Then they were checked LDL and HDL level by using electrospectrofotometer. Statistical analysis showed that there were significant differences in LDL level and no significant difference in HDL level. It could be concluded that the yacon leaves infusion could lower LDL level in diabetic rats induced by STZ, while HDL level had not change. Keywords: Diabetic, HDL, LDL, yaco
Pengaruh Progressive Muscle Relaxation terhadap Aliran Puncak Ekspirasi Klien dengan Asma Bronkial di Poli Spesialis Paru B Rumah Sakit Paru Kabupaten Jember (The Effect of Progressive Muscle Relaxation on Peak Expiratory Flow of Clients with Bronchial As
Get PDFAirway obstruction is an important physiological disease in asthma clients that will inhibits the flow of air during inspiration and expiration, so that lung ventilation is not optimal. This situation makes clients lose base ability to reach normal airflow during breathing, especially when expiratory, which leads to reduction in peak expiratory flow. Non-pharmacological therapies can be used as a supplementary or complementary pharmacological therapy, one of which is progressive muscle relaxation. The objective of this research was to analyze the effect of progressive muscle relaxation on peak expiratory flow of clients with bronchial asthma. Respondents in this research were 11 people. Data analysis used dependent t-test with CI 95% (α=0,05). The results of data analysis showed the results of p value = 0,000 (p<0,05). The conclusion of this research is that there is a significant effect of progressive muscle relaxation on peak expiratory flow of clients with bronchial asthma. This research is expected to be applied and administered in health care, especially in the rehabilitation of clients with asthma to improve respiratory function optimally.  Keywords: progressive muscle relaxation, asthma, peak expiratory flo
Pengaruh Ekstrak Metanol, Fraksi N-Heksana dan Fraksi Metanol Biji Pepaya (Carica papaya L.) terhadap Motilitas Spermatozoa Tikus (Effect of the Methanol Extract, Hexane Fraction and Methanol Fraction of Papaya Seeds (Carica papaya L.) on Rat Spermato
Get PDFLack of contraceptive choices which meet the requirements is one of the contributing factors to less participation of man in contraceptive use. This research aimed to study the effectiveness of papaya seeds on rat spermatozoa motility. The rats were separated into 4 groups: negative control group (CMC-Na 1%), methanol extract of papaya seeds (100 mg/kg BW) treatment group, n-hexane fraction of papaya seeds (100 mg/kg BW) treatment group, and methanol fraction of papaya seeds (100 mg/kg BW) treatment group. Each treatment group consisted of 5 rats. Each group was administrated orally for 20 days. On 21st day, the rats were sacrified, the spermaatozoa were and were observed on their motility. The data then was anallyzed using Anova followed with LSD. The sperms which moved progressively in negative control, methanol extract, n-hexane fraction and methanol fraction were 67.6%, 29.8%, 38% and 10.6% respectively the methanol fraction of papaya seeds is more potent in reducing sperm motility.
Keywords: antifertility, papaya seeds, spermatozoa motilit
Hubungan Bonding Attachment dengan Resiko Terjadinya Postpartum Blues pada Ibu Postpartum dengan Sectio Caesaria di Rumah Sakit Ibu dan Anak (RSIA) Srikandi IBI Kabupaten Jember (The Correlation between Bonding Attachmentand The Risk of Happen of Postpar
Get PDFMother with postpartum blues could love and care to her baby, but sometimes can react negatively and do not respond at all. Interaction between mother and baby will form a bond and attachment, it can be made by rooming in. The purpose of this research was to analyze the correlation between bonding attachment and the risk of happen of postpartum blues on postpartum mothers with sectio caesaria in the Srikandi IBI Mother and Child Hospital, Jember Regency. This research used analytical observation design with cross sectional approach. Sample was 47 respondents, sampling technique used non probability sampling with purposive sampling. Data was collected by questionnaires. The result shown that 17 respondents (68,0%) have lack of bonding attachment and happen of postpartum blues. The Spearman rank test shown p value=0,000; r=-0,736, which mean there was correlations between bonding attachment and the risk of happen of postpartum blues on postpartum mothers with sectio caesaria. r = -0,736, it means that there is strong correlations between bonding attachment and the risk of happen of postpartum blues on postpartum mothers with sectio caesaria. Negative (-) means that becomes less bonding attachment, the more high risk experiencing postpartum blues.. Â Keywords : Bonding Attachment, Postpartum Blue
Peran Dukun dalam Implementasi Kemitraan Bidan dan Dukun di Wilayah Kerja Puskesmas Bangsalsari Kabupaten Jember (The Role of Traditional Birth Attendance in the Implementation of Partnership between Midwife and Traditional Birth Attendance at Bangsalsari
Get PDFOne of factors that affected maternal death are skill and ability of delivery. According tothe data of Health Department of Jember District , the numbers of childbirth helped bytraditional birth attendance at the subdistrict area of Bangsalsari Community HealthCenter were 165 in 2012 and 102 childbirth in 2013. The goal of study was to describethe role of traditional birth attendance in the implementation of Midwife and TraditionalBirth Attendance Partnership in pregnancy and delivery period in BangsalsariCommunity Health Center, Jember District. The study was a qualitative study with haveinvolving 11 informants by Purposive technique. The result showed that traditional birthattendance have did some of their roles in pregnancy and delivery period. Pregnantmother have motivate traditional birth attendance to do check pregnancy and deliveryprocess to midwife but some of them did not have go to midwife to check pregnancy andpreferred to choose traditional birth attendance as their delivery. Unfortunately traditionalbirth attendances still help delivery process because there were some of people ask andforce them to assist delivery process.Keyword: Traditional birth attendance role, Partnership, Pregnancy, Delivery
Upaya Promosi Kesehatan Pendewasaan Usia Perkawinan Oleh Pusat Informasi Konseling Remaja (PIK-R) Ditinjau Dari Teori Precede-Proceed (The Effort of Health Promotion on Maturation of the Marriage Age by Information and Concelling Center for Adolescent (PI
Get PDFThe result of UNICEF report showed that Indonesia has high percentage on early marriage inthe world, Indonesia was in 37th rank from 63 country. One of district in Jember regency whichhas the highest mark in early marriage is Sukowono district. There were 411 mate whomarriage in early age. The effort to reduce the amount of early marriage was by maturation ofthe age marriage which hold by information and conselling center for adolescent (PIK-R). Theactivity of PIK-R in effort on Maturation of marriage age by giving information, but this activityonly give to the members of PIK-R. It caused most of adolescent didn't know more aboutmaturation of marriage age. The purpose of this research was to know effort of healthpromotion on maturation of the marriage age by PIK-R based precede proceed theory. Thisresearch design used Qualitative research based on the result showed that most of society inSukowono district did early marriage because their parents were match them, so their familygave support to do early marriage. The effort of maturationof the marriage age which washold by PIK-R consist of planning, implementation and evaluation. Planning of PIK-R consistof target determined, content, media, advocacy and regulacy. The implementation of PIK-Rwas hold by giving information to the society about maturation of the marriage age, butevaluation from implementation was not suitable with planning.Keywords : Health promotion on maturation of the age marriage, PIK-R, Precedeproceedtheory
Hubungan Kendali Glukosa Darah dengan Osteoartritis Lutut pada Pasien DM di RSD Dr. Soebandi
Get PDFDiabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia. Incidence of this disease increases in Indonesia, causing an increase chronic complications of DM including ostearthritis. Incidence of knee ostearthritis in DM patient often associated with blood glucose control. The aim of study was to know the relationship between blood glucose control and knee osteoarthritis in DM patients at Dr. Soebandi hospital. This is an observasional study with Cross Sectional design. The research was conducted at Poly Internal Medicine Dr. Soebandi hospital, the population was all patients who come at DM Poly Internal Medicine Dr Soebandi hospital period of September-October 2013, as much as 54 objects. To analyse the relationship between variabels, Chi Squre test (d = 0.05, significant if p˂0.05) was performed. The result showed that the relationship between blood glucose control and knee osteoarthritis was less significat with the value p=0.90 and odd's ratio (OR) of 0.131. It was concluded that there was no corrrelation between blood glucose control and knee osteoarthritis in DM patients at Dr. Soebandi hospital.  Keywords: Diabetes Mellitus, blood glucose control, knee osteoartriti
Efek Angiogenesis Beraprost terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi (Angiogenesis Effect of Beraprost on the Cardiac Histopathology of Hypertensive Wistar Rat)
Get PDFHypertension is a state where there is an increase of blood pressure above normal threshold,120/80 mmHg. The phatophysiology of hypertension involves the changes of vascular structure. Therefore, the beraprost drug was created. It is a vasodilator and antitrombolytic which is able to induce angiogenesis. The study aimed to investigate the effect of Beraprost on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Beraprost 100mcg/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with Beraprost from 180 mmHg to 143 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of Beraprost. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 16.637.29 compared to 7.45 1.21 in control group. It can be concluded that Beraprost had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, Beraprost, vascular structure, angiogenesis