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Gambaran Histopatologi Organ Jantung Tikus Putih Jantan Galur Wistar (Rattus norvegicus) dalam Uji Toksisitas Akut Kombinasi Ekstrak Daun Jati Belanda (Guazuma ulmifolia Lmk.) dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.)
Get PDFJati belanda leaves (Guazuma ulmifolia Lmk.) and Roselle petals (Hibiscus sabdariffa L.) have been known for their activity as antihyperlipidemia with different mechanisms. Combination of these plants was expected to has a synergy effect in reducing cholesterol. However, the toxicity of jati belanda leaves and roselle petals extract combination must be investigated for knowing its safety. Based on the acute toxicity test, the LD50 value of jati belanda leaves and roselle petals extract combination was >5,000 mg/kg bw. It was classified as category 5 or unclassified. This research aimed to study about its effect in cardiac by cardiac histopathology examinations of the rats. The result showed that there was no cardiac histopathology changes of the rats at doses 5,000 mg/kg bw.
Keywords: jati belanda leaves, roselle petals, acute toxicity, cardiac histopathology
 
Pengaruh Diabetes Self-Management Education and Support (DSME/S) Terhadap Kualitas Hidup pada Pasien Diabetes Melitus Tipe 2
Get PDFType 2 DM is a chronic disease requiring long-term care, so it needs self-management education toprevent the complication. The patient's inability to perform self-care can reduce the quality of life. DSME/Sis one of education which facilitates knowledge, skills, patient abilities, and family support in self-care.DSME/S is given in the form of discharge planning to improve knowledge and skills in self-care. Thisresearch aimed to analyze the effect of Diabetes Self-Management Education and Support (DSME/S) onquality of life of patients with type 2 diabetes mellitus in RSD dr. Soebandi. The research design wasquasi experimental with pre-test post-test with control group design. A number of samples were 30 peopledivided into two groups: 15 people in the treatment group and 15 people in the control group. DSME/Swas conducted in 6 sessions. Sessions 1-4 were performed in the hospital and sessions 5-6 wereperformed at the patient’s home. The data were analyzed by using dependent t test and independent ttest which significance level of 0.05. The result of t-dependent test indicated that there was significantdifferent quality of life between pre-test and post-test in the treatment group (p = 0.001) and control group(p = 0.002). The result of Independent t test showed a significant difference between treatment group andcontrol group (p = 0.001). The enhancement of quality of life on the treatment group was greater than thecontrol group. The conclusion showed that there was significant effect of DSME/S on the quality of life oftype 2 DM patients. DSME/S could improve patient self-care knowledge and abilities in controlling bloodsugar and prevent complications may effect of quality of life. Nurses can apply DSME/S in healthpromotion programs to type 2 DM patients in hospital.
Keywords: Type 2 diabetes mellitus, quality of life, DSME/
Pengaruh Propilen Glikol dalam Patch Dispersi Padat Ketoprofen terhadap Karakteristik Fisika Kimia dan Laju Penetrasinya
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Ketoprofen is a non steroid anti-inflammatory drug (NSAID) used as analgesic and anti-inflammation. This research had been done by ketoprofen patch preparation and evaluations aiming to enhance its penetration through the skin using propylene glycol as penetration enhancer. Evaluations included homogenity testing and FTIR for ketoprofen solid dispersion and organoleptic, weight uniformity, thickness, folding endurance, surface pH, moisture content, and penetration rate assay of ketoprofen patch. Penetration rate was determined by paddle type dissolution and the sample was analyzed by spectrophotometry UV-Vis. The value of moisture content and penetration rate were analyzed by One Way ANOVA with confidence level of 95 %. The value of moisture contents were F0 1.17 ± 0.0551 %; F1 1.27 ± 0.0208 %; F2 1.33 ± 0.08 %; and F3 1.43 ± 0.0208 %. The penetration rates of ketoprofen were F0 0.5258 ± 0.0191 µg/cm2.minute; F1 0.6935 ± 0.0613 µg/cm2.minute; F1 0.6935 ± 0.0613 µg/cm2.minute; and F3 1.1260 ± 0.0850 µg/cm2.minute. It can be concluded that the formula with propylene glycol 150 mg/patch can deliver the best penetration rate and moisture content that were fullfill the requirements.
Keywords: ketoprofen, patch, propilen glikol, penetratio enhancer, solid dispersion
 
Optimasi Konsentrasi Span 80 dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida-kitosan (Optimization of Span 80 Concentration and Stiring Time on The Preparation of Metformin Hydrochloride-Chitosan Microspheres )
Get PDFMetformin hydrochloride (MH) has been used as first line for type 2 diabetes mellitus treatment. However, it has relatively low bioavailability, short half-life and could cause gastrointestinal side effects, therefore it is appropriately prepared as microspheres. Microspheres is micro particle which is between 1-1,000 µm in size. Many factors affected the result of microspheres preparation, such as surfactant concentration and stirring time. This research was aimed to find the best composition of span 80 concentration and stirring time to produce MH-chitosan (CH) microspheres with the highest entrapment efficiency (EE) using factorial design optimization. MH was used as active substance, CH as polymer, span 80 as surfactant and non-aqueous solvent evaporation method was chosen for microspheres preparation technique. The optimized formula 2 % span 80 and 2 hours stirring time gained 86.803 ± 0.544 % EE, 24.571 ± 0.157 % drug loading, and 88.220 ± 0.137 % yield. The microspheres had a relatively smooth, bright surface, and spherical structure. The average particle’s size was 161.2 ± 1.743 μm. FTIR analysis indicated that there were no changes in the spesific functional clusters of MH as an active substance.
Keywords: metfomin-hydrocloride-chitosan microspheres, non-aquoeous solvent evaporation, factorial design, span 80 concentration, stirring time.
 
Perbedaan Kepuasan Perawat dalam Pendokumentasian Asuhan Keperawatan Berbasis Komputerisasi dan Manual (Studi di RS Paru dan RS Baladhika Husada Kabupaten Jember) (The Different of Nursing Satisfaction by Computerized Nursing Documentation and Manual Nurs
Get PDFNursing documentation is the important thing that must be done by a nurse. There are two kind ofnursing documentation, computerized nursing documentation and manual nursing documentation.This research purposes to find out the different of nursing satisfaction by computerized nursingdocumentation and manual nursing documentation. Crosssectional design was used in thisresearch. Sampling technique used simple random sampling. Total of sample was 30 respondentsand devided by 2 groups who used computerized nursing documentation and who used manualnursing documentation. Data was analyzed by Mann Whitney. The result showed nurse who usedcomputerized nursing documentation have very satisfactied category (100%). Nurse who usedmanual nursing documentation have very satisfactied category (100%). The result of statisticanalyze showed that p Value (1.000)>alpha (0.05), that means there wasn’t differences of nursingsatisfaction by computerized nursing documentation and manual nursing documentation (study inParu Hospital and Baladhika Husada Hospital Subdistrict at Jember). The reason why nursingsatisfaction by manual nursing documentation have very satisfactied category, because it couldease in used of than computerized nursing documentation.Keywords: computerized nursing documentation, manual nursing documentation, satisfactio
Titer Widal pada Populasi Sehat di Universitas Jember
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Enteric fever is endemic in developing countries including Indonesia. Widal test in a single serum sample is commonly used as laboratory diagnosis especially where culture facilities are not available. Examination of the single Widal test in endemic countries such as Indonesia, will give less accurate results with the large number of false-positive or false-negative. One of false-positive results is single Widal interpretation of test in endemic areas where the majority of the healthy population had contact or infected previously, and showed a positive result of Widal test. Widal titre examination in healthy population both men and women have not been investigated in Jember. So the aim of this study was to determine Widal titres among apparently healthy population in Jember University. In this cross-sectional study, blood samples were collected as much as 3 mL from healthy men (n=47) and women (n=47) and were analyzed for the presence of Salmonella antibodies by carrying out the Widal slide agglutination test. The data was analyzed using SPSS version 23 descriptively. The result showed that the most frequent antibody titres of O, H, AO, AH, BO, and BH antigens were 1/320 (37,2%), 1/320 (38,2%), 1/320 (86,1%), 1/320 (67,0%), 1/320 (77,7%) and 1/40 (27,7%) respectively in healthy population. In conclusion, antibody titre of AO dominated the most positive results in healthy population.
Keywords: Widal test, healthy population, Indonesia
 
Gambaran Kondisi Ibu Hamil dengan Diabetes Mellitus di RSD dr. Soebandi Jember Tahun 2013-2017 (Description of Pregnant Women Condition with Diabetes Mellitus in RSD dr. Soebandi Jember on 2013-2017)
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Diabetes Mellitus or diabetes is a chronic metabolic disease disorder caused by pancreas does not produce enough insulin or the body can’t effectively use produced insulin. In pregnant women with a family history of diabetes mellitus, the prevalence of pregnancy with diabetes mellitus is 5.1%. This research aim to determine description of pregnant women condition with diabetes mellitus in RSD dr. Soebandi Jember. This research used descriptive method with case series design. The sample size of 19 pregnant women with diabetes mellitus was selected by total sampling technique. The results showed that the high maternal age (52.6%), low education (89.5%), unemployment or housewife (89.2%), had a genetic 78.9%), BMI overweight (57.9%), glucosuria (89.5%), history of pre-eclampsia (57.9%), low parity (79%), never miscarried (84.2%). Based on the result of the research, it was concluded that maternal education, maternal job, genetic, overweight BMI, glucosuria, and history of pre-eclampsia had an effect towards the occurrence of pregnant women with diabetes mellitus, also maternal age, parity and history of miscarriage had no effect on the occurrence of pregnant women with diabetes mellitus. To raise awareness of the risks of pregnancy with diabetes mellitus can be done with screening for diabetes mellitus.
Keywords: diabetes mellitus, pregnant women, RSD dr. Soebandi.
 
Efek Ekstrak Kulit Mangga Arumanis terhadap Penurunan Edema Kaki Mencit Putih Jantan yang Diinduksi Karagenin
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Mango is a plant contains many active compounds with health benefits. Total phenolic content of mango peel is higher than mango flesh, with its major component are mangiferin and quercetin. Quercetin has anti-inflammatory effects through the inhibition of inflammatory mediators are serotonin, bradykinin, histamine and prostaglandin, possibly could reduce oedema as a sign of inflammation. This study used carrageenin to induce inflammation by making paw oedema in mice. The aim of this research was to know the effect of arumanis mango peel extract to reduce paw oedema in white male mice. The was quasi experimental study with 7 study groups. Spearman analyses showed a correlation with significance of (p= 0.003) that mean it has a significant correlation (p <0.01) at the 330th min. Spearman correlation coefficients was 0,632, indicated that the dose of extract and paw oedema have strong correlation. It can be concluded that mango peel extract has effect for reducing paw oedema in white male mice, with the smallest dose was 1,002mg / gBW.
Keywords: mango, quercetin, paw oedema
 
Pengaruh Pijat Bayi Terhadap Bounding Attachment di Ruang Dahlia RSD dr. Soebandi Jember
Get PDFBounding attachment is very important for newborn to be adapted to the new environment. Mother’stouch can help babies adapt to environmental differences between inside the womb and outside thewomb. How to improve the bounding attachment is early breastfeeding initiation, rooming in,kangaroo mother care for premature, and baby massage. The purpose of this research is todetermine the impact of baby massage to bounding attachment. The method of research was quasiexperimental with design of research pretest-post test with control group. This research is in Dahliaroom in dr. Soebandi general Hospital, with samples as 40 respondent with 20 people forexperimental group and 20 people for control group. The research use standard operationalprocedure of baby massage and quality of bounding attachment questionnaire. Take the sample bypurposive sampling. The results of research is give difference in average pretest-post test on theexperimental group of -7,35 whereas on the control group of -2,55. Statistic test result obtained the pvalue 0.001, this mean on the alpha 5% can be expressed there is influence of baby massage forbounding attachment. There are several factors that influence to the bounding attachment that isemotional health of parent, family support, the proximity and match of the parents and baby. Theresult of this research are recommended as the nursing treatment and to the public especiallymother postpartum.Keywords : baby massage, bounding attachmen
Hubungan Jenjang Pendidikan terhadap Perilaku Menjaga Kesehatan Gigi dan Mulut Anak Tunagrahita di SLB Kota Sidoarjo
Get PDFIntellectual disability is a child who suffers from intellectual ability below average and tends to have retardation in intelligence, physical, emotional, and social. They are not independent enough in keeping their own health especially oral hygiene, it can affect their oral health behavior. Education that is one of external factors influences health behavior. Education and knowledge influence each other so that people are expected to have high education in order to be knowledgeable especially in terms of maintaining health. The purpose of this study was to analyze the correlation between education level and oral health behavior of children suffering from intellectual disability. This research was an observational analytic research with cross sectional approach. The subjects of this study were a number of children of SDLB, SMPLB and SMALB in SLB Sidoarjo, with total sampling as many as 115 students. The subjects were asked to fill out a questionnaire of knowledge and attitude how to brush teeth and performed the action as well. The collected data were analyzed by using spearman correlation test. The result of this research showed that correlation coefficient for education level with knowledge, attitude and behavior was > 0,05, so there was no relation between those variables. Meanwhile, the result of correlation coefficient of education with action was < 0.05, so there was correlation between those two. The conclusion of this research is there is no correlation between the level of education and oral health behavior of intellectual disability children in SLB Sidoarjo.
Keywords: Mental retarded, dental health behavior, education level