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Hiperurisemia Pada Remaja di Wilayah Kerja Puskesmas Arjasa Kabupaten Situbondo Hyperuricemia in Adolescents (16-24 Years Old) in Arjasa Primary Health Center, Situbondo Regency
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Hyperuricemia is a condition which there is an elevated of uric acid serum level above normal, whereas gout is a group of diseases caused by deposition of monosodium urate crystals in the tissues, due to metabolism disorders in the form of hyperuricemia. Most commonly experienced by the elderly, but this disease also can be experienced by elderly and young adolescents. The purpose of this study is to describe of hyperuricemia patients in adolescents (16-24 years) in Arjasa Primary Health Center (PHC) area of ​​Situbondo Regency, as many 11 people. The cross-sectional method is used in this study. We measure body mass index (BMI) and consumption pattern using food frequency questions (FFQ) method. Most of hyperurisemia patient in young adolescent are male, have good enough education level ie Senior High School, unemployement, have enough knowledge, have family income > 1,374,000, -, have a history of hyperuricemia in their family, obesity, consumption of high purine food ie offal, food and drink containing alcohol ie tapé, and do not consume of deuretic medicines.
Keywords: Hyperuricemia, Adolescent
Kadar Puncak (Cmax), Waktu Puncak (Tmax), Waktu Paruh (T½) dan Bersihan Teobromin pada Sukarelawan Sehat setelah Pemberian Dark Chocolate Bar Per Oral
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Dark chocolate contains two derivates of metilxantin, I.e. caffeine (1,3,7-trimetilxantin) and theobromine (3,7 dimetilxantin). Theobromine can be found in plasma. Theobromine concentration in plasma determined not only by drug dosage but also by pharmacokinetic parameters. This research aimed to determine pharmacokinetic parameters by using HPLC (High Performace Liquid Chromatography) method. This study used Quasi Experimental Design by using 16 plasma samples collected at the 0, 1.5, 3, 6, 10, 24 hours. The pharmacokinetic parameter calculations were obtained from the polynomial curve and linear curve of drug concentration in plasma by time. The maximum concentration (Cmax) theobromine on plasma after consumption of dark chocolate bar per oral was 4.173 mg/L. The maximum time (Tmax) was at the 2.501 hours. The half time (t½) theobromine was 4.880 hours. Theobromine clearance in plasma was 14.2 ml/kg/hour. The study has reported pharmacokinetic parameters of theobromine in plasma after eating dark chocolate bars orally.
Keywords: Chocolate, half-time, maximum concentration, maximum time, theobromine
 
Hubungan Gaya Pengasuhan dan Struktur Kekuatan Keluarga dengan Risiko Penyalahgunaan NAPZA: Alkohol pada Remaja di SMA Kecamatan Kalisat Kabupaten Jember (Relationship between Parenting Style, Family Power Structure and Risk of Drug Abuse: Alcohol in Adol
No full textAdolescence is one of population at risk of drug abuse. One kind of drug is alcohol. A family has avery important role in the risk of alcohol abuse in adolescents. A family simultaneously has structureand function which very important for adolescent development. This study aimed to analyze therelationship between parenting style, family power structure and risk of drug abuse: alcohol inadolescents in the high school of Kalisat Sub-district of Jember Regency. The research method wasanalytical observation with cross sectional approach. Respondents were 249 adolescents withmultistage random sampling. Independent variable is parenting style, family power structure; andrisk of drug abuse: alcohol is dependent variable. The data were analyzed by chi square (α = 0,05).The result showed that significant relationship between parenting style and risk of drug abuse:alcohol (p value 0,000); significant relationship between family power structure and risk of drugabuse: alcohol (p value 0,004). Family power can protect adolescents from the risk of alcoholabuse. There are rules must be believed and performed by adolescents. Furthermore, family canperform parenting with balance of freedom and responsibility of adolescents. However, parents shallconsider the personality of their adolescents.Keywords: risk of alcohol abuse, parenting style, family power structur
Prevalensi dan Distribusi Penderita Geographic Tongue pada Mahasiswa Fakultas Kedokteran Gigi Universitas Jember Angkatan 2014 – 2016 (Prevalence and Distribution of Geographic Tongue in Faculty Of Dentistry University of Jember Class of 2014-2016)
Get PDFBackground: Geographic tongue is a tongue disorder. The lesion is a asymptomatic and rarely lesion. These disorder is influenced by genetic and other predisposing factors. Previous studies had shown geographic tongue occured more frequently in female than male, in these study will be disscused how the prevalence and distribution by age and gender. Objective: To determine the prevalence and distribution of geographic tongue of University Students in Faculty of Dentistry University of Jember class of 2014-2016. Method: Was used descriptive epidemiology and the results presented in table and would be described. Result and Conclusion: Results showed the prevalence was 14 patients from 324 subjects or 4,3%. The results showed higher in female than male and higher in 18 years old.
Keywords: Distribution, geographic tongue, prevalence.
 
Perbandingan Komplikasi dan Keluaran antara Persalinan Pervaginam dan Seksio Sesaria pada Ibu dengan Riwayat Seksio Sesaria di RSD dr. Soebandi Jember
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The number of cesarean section in Indonesia is 9,8% and approaching cesarean limit suggested by WHO which is 10%. The most common reason for cesarean section is prior cesarean. Cesarean section has higher maternal mortality risk compared to vaginal delivery. Vaginal delivery with prior cesarean has higher complication risk compared to cesarean section. Maternal complications and neonatal outcomes are important to decide delivery methods. Maternal complications that can be compared are postpartum infection, postpartum hemorrhage, and uterine rupture. Neonatal outcomes that can be compared are APGAR score and neonatal birth injury. This study aimed to compare maternal complications and neonatal outcomes between vaginal delivery and cesarean section in women with prior cesarean section. There was a significant difference in the incidence of postpartum infection (p=0.01) and neonatal birth injury (p=0.05). There was no significant difference in APGAR score and the incidence of postpartum hemorrhage. There was no uterine rupture observed. In conclusion, vaginal delivery is a viable option for pregnant woman with prior cesarean.
 
Efektivitas Kombinasi Vankomisin dan Vitamin C terhadap Pertumbuhan MRSA (Methicillin Resistant Staphylococcus aureus) (Effectiveness of Vancomycin and Vitamin C Combination on MRSA (Methicillin Resistant Staphylococcus aureus) Growth)
Get PDFNephrotoxicity due to prolonged use of vancomycin becomes a big issue in patients with MRSA infections and the use of vitamin C has been proved to decrease this side effect. Vitamin C with its combination with antibiotic will halt MRSA growth by forming Reactive Oxygen Species (ROS). This study aimed to determine the effect of vancomycin and vitamin C combination in order to halt the MRSA growth and the minimum concentration of vitamin C which can decrease the Minimum Inhibitory Concentration (MIC) of vancomycin. This study used a quasi experimental design with 7 groups, 1 as negative control which only given vancomycin and 6 other groups which given vancomycin and vitamin C with following concentration 0,4; 0,8; 1,6; 3,2; 6,4; and 12,8 mg/mL. We used microdilution method with 4 repetitions to measure the MIC value. This study revealed that there were no difference between control and other groups, the MIC of vancomycin is 1 µg/mL. Combination effect was measured by Fractional Inhibitory Concentration Index (FICI) calculation which showed indifferent effect to all groups. This study concluded that combination of vancomycin and vitamin C effect has no difference with control group and by adding vitamin C until 12,8 mg/mL did not decrease MRSA growth.
Keywords: MRSA, vancomycin, vitamin C, Minimum Inhibitory Concentration (MIC)
 
Pengaruh Relaksasi Aromaterapi Jasmine terhadap Kualitas Tidur pada Lansia di Karang Werdha
Get PDFDuring the quality of sleep the elderly is good, some changes that will occur to the elderly arenormal as well, but if not, it will cause health problems. This research aims to analyze theeffect of jasmine aromatherapy relaxation on sleeping quality to the elderly at elderlyassociation in Jenggawah Jember. This research used quasy experimental design methodwith pre-post test and control group design. Sleeping quality was measured using a PSQIquestionnaire and interventions which were given for 28 days. The result of dependent t testshowed no significant difference on the average score of control group (p value = 1,000).While in the intervention group there was a decrease in the mean score of PSQI after beinggiven jasmine aromatherapy relaxation, so that there was a significant difference in sleepingquality of the intervention group (p value = 0,001). Independent t tests showed significantdifferences between the control group and the intervention group after jasmine aromatherapyrelaxation (p value = 0,001). Overall, jasmine aromatherapy relaxation can improve sleepingquality in the elderly, so that jasmine aromatherapy relaxation may be used as an alternativenon-pharmacological treatment which has no adverse side effects compared to the use oflong-term sleeping pills that would give negative side effects to its users.
Keywords: aromatherapy, sleeping quality, elderly
Efektivitas Ekstrak Artemisia vulgaris L. sebagai Hepatoprotektor pada sel-sel Hati Tikus yang Diinduksi Niasin
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The niacin in energy drinks has metabolic product that cause oxidative stress and liver damage, while the liver damage can be prevented by hepatoprotective agents. Scoparone in Artemisia vulgaris L. can act as a hepatoprotector by its antioxidant effect. This study aimed to investigate the effectivity of Artemisia vulgaris L. extract as a hepatoprotector in wistar hepatocytes induced by niacin. This study used 25 male rats which were divided into 5 groups: normal, the negative control, the positive control, the treatment group I, and II. Treatment was conducted for 28 days. The samples were terminated and the hepatocyte were prepared for histological examination. Histological appearance was catagorized as mild, moderate, and severe damage with or without inflamatory cells activity. The data analysis by Kruskal Wallis showed significant difference (p<0,001). Further analysis by Mann Whitney revealed significantly difference (p<0,05) between normal group and all groups, negative control group and positive control group, and positive control group and treatment group I, but not significantly difference between negative control group and treatment group I, negative control group and treatment group II, positive control group and treatment group II, and between treatment groups. The study concluded that the effectivity of Artemisia vulgaris L. extract has not been proven as a hepatoprotector but further study is needed to draw a definite conclusion.
Keywords: energy drink, niacin, Artemisia vulgaris L., hepatoprotector
 
Pengaruh Perendaman Nilon Termoplastik Dalam Berbagai Konsentrasi Ekstrak Bunga Cengkeh Terhadap Modulus Elastisitas (The Effect of Thermoplastic Nylon Immersion In Various Concentration of Clove Flower Extract to the Modulus Elasticity)
Get PDFBackground:Thermoplastic nylon is one of denture basic alternative made by resin polyamide because its high flexibility and good translutient, but hard to be smoothed and polished causing food waste accumulation and plaque formation. Clove flower extract proved as antiseptic used to be a denture cleanser material, but its contens of phenol essence can break the thermoplastic nylon chain. Purpose: The aim of this study was to determine the effect of thermoplastic nylon immersion in various concentration: 0,8%, 1%, 1,2%, 1,4% and 1,6%, of clove flower extract to the modulus elasticity. Materials and Methods: This study was an laboratories experimental using post-test only control group design. The samples in 65 mm x 10 mm x 2,5 mm size were 30 samples. Those samples grouped into 6 groups immersed in aquadest and clove flower extract solution that is grouped based on the concentrations: 0,8%, 1%, 1,2%, 1,4% and 1,6% for 23 days. The modulus elasticity of thermoplastic nylon measured with Universal Testing Machine (UTM). Data was analysed using One Way Anova. Result and Conclusions: the conclusion of this study represented that thermoplastic nylon plates immersion in clove flower extract at the concentration 0,8%, 1%, 1,2%, 1,4% and 1,6% was affected the modulus elasticitys. The most effective clove extract concentration to be use as denture cleanser was 1,6% because it has the lowest increasing value of nylon thermoplastic modulus elasticity.
Keyword: Clove flower extract, modulus elasticity, thermoplastic nylon.
 
Efektifitas Penggunaan Pasta Biji Kopi Robusta Sebagai Pembersih Gigi Tiruan Terhadap Kekasaran Permukaan Resin Akrilik Heat Cured
Get PDFThe most used denture base materials is heat cured acrylic resin. The disadvantages of acrylic resin are easy to absorb water and porosity that can increase surface roughness. The surface roughness can facilitate the attachment of microorganisms and accumulation of plaque. The cleansing of mechanical denture use electric toothbrush and denture cleanser paste. This paste uses natural materials from robusta coffee beans that decrease surface roughness. To determine the effectivity of robusta coffee beans paste as a denture cleanser to the surface roughness of heat cured acrylic resin. This study was an experimental laboratory with the research design the post test only control group design. Total sample of 36 samples in size (65 x 10 x 2,5) mm which consisted of 4 groups: control group without brushing, group A brushed with electric toothbrush and a placebo paste, group B brushed with electric toothbrush and robusta coffee beans paste 25%, and group C brushed with electric toothbrush and robusta coffee beans paste 50%. Brushing was done for 22 minutes, then measured the surface roughness of dentures. Robusta coffee bean paste was less effective as a denture cleanser agent against the surface roughness of the heat cured acrylic resin. Robusta coffee beans paste 50% can be used as a denture cleanser.
Keyword: acrylic resin, electric toothbrush, robusta coffee bean paste, surface roughness