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Studi Penggunaan Obat pada Pasien Osteoartritis Usia Lanjut di Instalasi Rawat Jalan Rumah Sakit dr. H Koesnadi Bondowoso Tahun 2013
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Osteoarthritis (OA) is a degenerative bone disease that begin by loss of articulary cartilage (joint). The disease most commonly affects the elder or adult people. Elderly people experiencing degenerative processes in which decreasing organ function. The organ degeneration causes several diseases resulting the patients to receive multi drug for the treatment and causing polypharmacy, thus will increase the risk of drug interactions. This study was conducted to determine the treatment for osteoarthritis and drug interactions that occur in patients with osteoarthritis. The method used was total sampling using the descriptive-retrospective approach. The sample was elderly osteoarthritis patients in outpatient installation which were treated in RSD dr. H Koesnadi Bondowoso during January to December 2013. In this study we found that the main treatment for osteoarthritis was non steroidal anti inflammatory drug (NSAID) that use to relief pain. From 108 samples of elderly osteoarthritis patients, we found that 17 patients (15.74%) indicating the potential for drug interactions.
Keywords: osteoarthritis, outpatient age above 60 years, NSAID, drug interaction
 
Efektivitas Media Promosi “Piring Makanku†Pedoman Gizi Seimbang Sebagai Panduan Sekali Makan (The Effectiveness of Media promotion "Piring Makanku" Balanced Nutrition Guidelines as a Guide Once Packed)
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The problem of nutrition in Indonesia currently has entered a double nutritional problems i.e. less nutritional problems and excess nutritional problems. Is a group of kids who are prone to more nutrition. Department of health’s strategic plan outlines the goals of health promotion 2005-2009 with principal activities the development of health promotion and media communication technology, information and education (KIE). The Government issued a Balanced Nutritional Guidelines contained media promotion "Tumpeng" and "Piring Makanku" in an attempt to lower and maintain the nutritional status of the public. This research aims to analyze the effectiveness of media promotion "Piring Makanku". This research was quantitative research semi experimental at SDN Jember Lor 1. Data analysis was the analysis of the statistical test of Wilcoxon Signed Rank Test and Mann Whitney with α = 0.05. The results showed that the media "Piring Makanku" effective in improving knowledge, attitudes and practice towards a balanced nutrition.
Keywords: The Effectiveness of Media, Piring Makanku, Knowledge, Attitudes, Practic
Sintesis dan Uji Aktivitas Antibakteri Senyawa N-fenil-4-klorobenzamida
Get PDFN-phenylbenzamide is benzamide derivatives, which is potential as an antibacterial agent. N-phenyl-4-chlorobenzamide is N-phenylbenzamide derivative that substitued by chloro to the para position and it was expected to enhance the antibacterial activity. N-phenyl-4-chlorobenzamide was synthesized by reacting 1,3-diphenyilthiourea and 4-chlorobenzoil chloride. This compound has been purified and provided 53% of product with crystal shape, white color, and melting point of 195-197 oC. The purification of this compound was confirmed by TLC and the structure was identified by 1H-NMR, 13C-NMR, and FTIR spectroscopy. This compound was tested for its activity against gram positive bacteria Staphylococcus aureus and gram negative bacteria Pseudomonas aeruginosa, evaluated by well diffusion method and the result showed no activity against both Staphylococcus aureus and Pseudomonas aeruginosa.
Keywords: N-phenyl-4-chlorobenzamide, synthesis, antibacterial activit
Deteksi Protein 270 kDa Plasmodium falciparum Isolat Malang pada Membran Eritrosit Penderita Malaria dengan Komplikasi
Get PDFErythrocyte which is infected by Plasmodium falciparum will have various changes on its architecture, affinity, and biomolecular. Beside that, the infected erythrocyte also forms a knob at its surface. This knob are contained with various parasite proteins, one of them is Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1). Our previous study had been identified a protein with molecular weight 270 kDa at P. falciparum infected erythrocyte from Malang isolate that was playing a role in cytoadherence process. The aim of this study was to detect the possibility of 270 kDa protein expression at complicated malaria falciparum patient erythrocyte membrane. The method that used was immunocytochemistry with polyclonal antibody to 270 kDa protein. The results showed that two (2) erythrocyte samples from healthy people as control had negative reaction, and so did with five (5) erythrocyte samples of uncomplicated malaria patient, but there was positive reaction that shown at two (2) samples of complicated malaria patient erythrocyte. It can be concluded from the results that 270 kDa membrane protein of P. falciparum infected erythrocyte in complicated malaria patient might be a PfEMP-1. This protein can be detected by immunocytochemistry method using polyclonal antibody and can be used for the candidate of complicated malaria diagnostic
Keywords: Plasmodium falciparum, 270 kDA protein, immunocytochemistry, polyclonal antibody
 
Pengaruh Kadar Albumin Serum terhadap Penyembuhan Luka pada Pasien Pascaoperasi Laparotomi dan Lumbotomi di RSD dr. Soebandi Jember
Get PDFWound healing need protein as basis for the formation of collagen network. The important component of protein is albumin. The aim of this study was to investigate albumin serum’s effect on wound healing in patients postoperative laparotomy and lumbotomy at dr. Soebandi Hospital Jember. The method of study was analytic observational with cross sectional design. Total samples in this study were 9 samples. The results showed that the higher albumis, the faster wound healing. Data analysis using bivariate analyzing Spearman's Rho test showed that the significance (p)=0.011 and correlation coefficients (r)=0.791. Thus, it can be concluded that there were a strong albumin serum’s effect of wound healing in patients postoperative laparotomy and lumbotomy at RSD dr. Soebandi Jember.
 
Uji Aktivitas Antidiabetes Ekstrak Teh Hitam dan Teh Hijau secara In Vitro Menggunakan Metode Inhibisi Enzim α-Glukosidase
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Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia. Carbohydrates are metabolized into glucose, in gastrointestinal tract than absorbed into the bloodstream and increase blood glucose level. This absorption process is catalyzed by α-glucosidase enzyme. Previous studies showed that tea (Camellia sinensis) extract have antidiabetic activity in mice induced by streptozotocin. The aim of this study was to compared the in vitro activity of tea extract in inhibiting α-glucosidase. Black tea and green trea extracts were tested for α-glucosidase inhibitory activity. Acarbose was used as positive control. IC50 extract was 54.86 µg/mL for black tea and 44.79 µg/mL for green tea. This study showed that inhibitory effect of green tea was higher than black tea.
Keywords: black tea, green tea, diabetes mellitus, α-glucosidase
 
Perbedaan Ukuran Gigi Molar Pertama Maksila dan Kaninus Mandibula Permanen Antara Mahasiswa Laki-laki dan Perempuan di FKG Universitas Jember
Get PDFMass disaster often happened in Indonesia. Sex identification is one of the important things for determining the identity of the victims. Sex can be identified based on the size of the teeth. The study determine the differences of maxillary first molar and mandibular caninus tooth size between male and female student in Faculty of Dentistry University of Jember. The sample of this study consisted of 34 tooth models of female and 6 tooth models of male that measured in mesiodistal and bucolingual width of maxillary first molar and mandibular caninus with a digital caliper. Data were analyzed using Independent T-test. There were significant differences (p ≤ 0,05) of maxillary first molar and mandibular caninus size between male and female. Mesiodistal and bucolingual width of maxillary first molar respectively are 10.64 mm, 11.90 mm in males, and 10.16 mm, 11.16 mm in females. The mesiodistal and bucolingual width of mandibular caninus are 7.13 mm, 7.85 mm in males, and 6.66 mm, 7.08 mm in females. It can be concluded that there was a difference in size of maxillary first molar and mandibular caninus between male and female.
Keywords: sex identification, masiodistal width, bucolingual width, maxillary first molar, mandibular caninu
Optimasi Zink Oksida Dan Asam Malat dalam Krim Tabir Surya Kombinasi Avobenzone dan Octyl Methoxycinnamate dengan Desain Faktorial
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Ultraviolet rays (UV) has an adverse effect on the skin, which is epidermis damage. One way to prevent the adverse effects of UV rays on the skin can be done by using sunscreen. The sunscreen mechanism of action was divided into chemical absorber and physical blocker. Chemical absorber will be degradated when exposed to UV rays, while ZnO as physical blocker can increase pH value of the sunscreen. The effectiveness of sunscreen was affected by pH value, so malic acid was added into the sunscreen formula to decrease pH value. This study was aimed to determine the optimum composition of ZnO and malic acid on pH, viscosity, SPF, transmission of erythema and transmission of pigmentation using factorial design method. 0,5% ZnO was set as the lowest level and 3% ZnO was set as the highest level; 0,5% malic acid was set as the lowest level and 0,8% malic acid was set as the highest level. Selected optimum formula was 0,5% ZnO and 0,8% malic acid with the predicted SPF value of 21,242; TE of 0,000; TP of 0,000; pH of 4,820; and viscosity of 80,333 dPa.s
Keywords: sunscreen, Zinc Oxide, malic acid, Sun Protector Factor
 
Uji Efektivitas Beras Herbal Forte terhadap Penurunan Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2 (Study of the Herbal Rice Forte Effectiveness on Decreasing Blood Glucose of Diabetes Mellitus Type 2 Patient)
Get PDFDiabetes mellitus is metabolic diseases characterized by hyperglycemia caused by disturbances in insulin secretion or insulin activity. Herbal Forte Rice is rice synthetic material composed of main purple sweet potato and corn flour. It contains antioksidan, fiber, resistant starch and having moderate glycemic index. This study aimed to determine the effectivity of Herbal Forte Rice on decreasing blood glucose levels of patients type 2 DM. It used a cross-over design, the role of research subjects was both as control and treatment groups. Total sample of this research consisted of 60 samples. The treatment group was given Herbal Forte Rice for 7 days in 2 consecutive meals, while the control group did not receive any intervention. The results showed the average level of Fasting Blood Glucose (FBG) beginning and end of the treatment group 179.76 mg/dL and 138.7 mg/dL; FBG beginning and end of the control 180.87 mg/dL and 187.63 mg/dL; 2 hours post prandial Blood Glucose (2hppBG) levels of beginning and end of the treatment group 284.37 mg/dL and 183.8 mg/dL; 2hppBG levels beginning and end of the control 280.57 mg/dL and 284.13 mg/dL. This study concludes that Herbal Forte Rice effective on decreasing blood glucose levels of patients type 2 DM.
Keywords: diabetes mellitus, Rice Herbal Forte, GDP and GD2PP
 
Pengaruh Pendidikan Kesehatan Metode Brainstorming dan Video terhadap Pengetahuan tentang Demam Berdarah pada Keluarga di Wilayah Kerja Puskesmas Puger Kabupaten Jember (The effect of Health Education Brainstorming Method and Video to the Knowledge about
Get PDFThe increasing cases of dengue hemorrhagic fever disease in both children and adults can beinfluenced by several factors. One of that influences increasing of dengue fever is lack of communityknowledge about dengue hemorrhagic fever. Brainstorming is a form of discussion to gather theinformation from all participants. This research was to find out the effect of health educationbrainstorming method and video toward knowledge of dengue fever in the work area of Puger PublicHealth Center the distric of Jember. This was a quasy experiment research with two groups pretestposttesttreatment design. The population were 88 families with 30 respondents as sample,conducted by simple random sampling, and divided into two groups 15 respondents as treatmentgroup and 15 respondents as control group. Treatment group got health education brainstormingmethod combined with video and control group got health education brace method. Data wereanalyzed used t-test dependent and t-test independent with 95% CI (α: 0,05). The result showedthere were significant differences of knowledge before and after in both treatment group and controlgroup (p: 0,000) and there were significant differences between treatment group and control afterhealth education (p: 0,001). Overall, health education by brainstorming method and can improveknowledge of dengue hemorrhagic fever. It is recommended for nurses to do health educationpreventation and treatment about dengue hemorrhagic fever to improve knowledge people.Keywords: health education brainstorming method and video, knowledge, dengue hemorrhagicfeve