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Optimasi Tween 80 dan PEG 400 dalam Self Nanoemulsifying Drug Delivery System Antibakteri dari Minyak Daun Kemangi
Get PDFBasil has antibacterial activity against Salmonella typhi with essential oils as active compounds. However, its volatile and hydrophobic nature makes it difficult to dissolve in the gastrointestinal tract so a self nanoemulsifying drug delivery system (SNEDDS) is needed. The study aimed to determine the effect of changes in the concentration and interaction of Tween 80 and PEG 400 on the percent transmittance response and emulsification time in SNEDDS of basil leaf oil. This research optimized of Tween 80 and PEG 400 using basil leaf oil as the oil phase with the percent transmittance response and emulsification time, then verified, characterized the organoleptic, pH, particle size, size distribution, and antibacterial activity. The concentration of Tween 80 and of PEG 400 would increase the percent transmittance and decrease the emulsification time. The interaction between two substances can decrease the percent transmittance and increase the emulsification time. The prediction software design expert 11 SNEDDS optimum formula namely Tween 80 2.05 ml and PEG 400 1.35 ml. The characteristics of the optimum formula produced were clear yellow with a distinctive basil aroma, pH 6.93±0.02, particle size 183.3±0.21 nm, and PI 0.341±0.02. SNEDDS of basil leaf oil inhibits S. typhi with an inhibition zone of 19.22 ± 0.01 mm
Studi Literatur Pola Makan dan Pola Aktivitas Fisik pada Remaja dengan Obesitas di Indonesia
Get PDFThe nutritional problem in Indonesia in modern times is still complex. One of them is obesity that can occur in children, adolescents, and adults. Obesity can be caused by technological developments and consumption patterns of fast food, which is a lifestyle that causes a decrease in physical activity. This literature aims to describe the diet and physical activity patterns that cause obesity. The sources of journals/ articles used in the search for relevant databases were obtained through PubMed, Science Direct, Sinta, and Google Scholar with the 2015-2020 publication years and were traced using a combination of search terms for adolescent diet, adolescent obesity, and adolescent activity patterns. Then, it was analyzed using the PRISMA diagram method with four stages, namely identification, screening, feasibility, and insertion. This review identified that adolescents have a poor diet and often do light physical activity which causes obesity due to frequent consumption of fast food, high fat, high protein, and carbohydrates, eating at nighttime and excessive portions, not eating breakfast, often doing light activities such as watching tv, mopping and others and rarely exercising. The conclusion is that the energy coverage both the frequency, type, and amount needed with physical activity, both light, moderate and heavy, still needs to be studied more deeply. The importance of imparting nutritional knowledge in early childhood so that they can support life in the future
Optimasi Polyvinilpyrolidone K-30 dan Sodium Starch Glycolate pada Tablet Likuisolid Simvastatin dengan Desain Faktorial
Get PDFThe liquisolid technique is one way to increase the drug dissolution rate, which has low solubility in water and can improve drug flow properties. This research aims to determine the optimum composition of a combination of polymer PVP K-30 and SSG on a liquisolid simvastatin tablet with a factorial design. The factorial design method is used to determine the effect of the concentration of two factors, namely PVP K-30 and SSG, on the response of hardness, friability, disintegration time, and dissolution. PVP K-30 acts as a binder, and SSG works as a disintegration, determines the optimum formula using expert design software version 1. The result showed that all formulas meet the requirements of hardness values (4-8 kg), friability (<1%), disintegration time of no more than 15 minutes, and dissolution in 30 minutes. The use of PVP K-30 concentration of 6 mg and SSG 24 mg indicated the optimum formula with a desirability value of 0,806
Hubungan Lingkar Perut dengan Kadar Gula Darah pada Petani: Analisa Data Posbindu PTM Puskesmas Sukorejo Jember 2020
Get PDFFarmer is the occupation of the majority of Indonesians, and they rank first as a contributor to hyperglycemia (32.4%) and third to diabetes (12.6%) in Indonesia. Diabetic disease is affected by several factors, including abdominal obesity. So, the Indonesian government established a program called Posbindu PTM to screen for non-communicable diseases in Indonesians. This research aimed to analyze the correlation between abdominal circumference and blood sugar levels of farmers in Sukorejo Public Health Center. The cohort retrospective study design was used to analyze data of KMS Posbindu PTM in 2020 using Chi Square analysis with a significance of p<0.05. Data on age, gender, and abdominal circumference for 3 consecutive months (January)-March were collected, and blood sugar levels were measured in the third month (March) from 35 selected samples. The result showed no relationship between abdominal circumference and blood sugar levels (p=0.380), but there is a significant difference between gender and abdominal circumference among farmers (p= 0.019). An insignificant relationship between abdominal circumference and blood sugar levels indicated that abdominal obesity is not the main factor of diabetes, and other factors can influence it. Therefore, the abdominal circumference should be monitored regarding gender to prevent increased blood sugar among farmers
Penyelenggaraan Makanan di Unit Gizi Rumah Sakit X Kabupaten Jember
Get PDFOrganization of hospital meals, namely an activity carried out by the hospital nutrition installation related to the provision of food for patients. Based on the data obtained, it is known that food waste at Hospital X Jember Regency is at a total average of 26.04%; this figure is not in accordance with the maximum standard of food waste, which is approximately 20%. This study aims to determine the implementation of food in the Nutrition Unit of Hospital X Jember Regency. This research is descriptive. The population of this study was 12 people, and we used a sample from a total population unit of 12 people (3 working in the nutrition office, 9 working in the kitchen). Data collection is done through interviews, observation, and documentation. The results showed that there were three parameters for storing food ingredients that were not in accordance with Permenkes Number 07 of 2019, namely that there were two drainages, namely under the wet food storage area (refrigerator) and under the warehouse door for dry food storage, and no samples of finished food samples in the refrigerator of the Nutrition Unit of RS X. It is recommended not to place wet food storage areas and dry food storage areas near drainage or waste water drains and to place finished food samples in food sample storage areas at any time to avoid something happening (disturbance) to patients and related complaints about food served to patients
Gambaran Pengetahuan Petani Tebu tentang Penggunaan Alat Pelindung Diri dalam Meminimalkan Risiko Kecelakaan Kerja di Desa Mojosari Asembagus Situbondo
No full textThe sugarcane farmers have a risk of work accidents, and it can be minimized by using Personal Protective Equipment (PPE). The purpose of this study was to describe the characteristics of the respondents and the knowledge of sugarcane farmers about the use of Personal Protective Equipment (PPE) in minimizing the risk of work accidents in the Mojosari village, Asembagus, Situbondo. This research was a quantitative study with a descriptive approach. The respondents were chosen using purposive sampling with a total sample of 193 respondents. The results showed that the knowledge of sugarcane farmers about PPE was in the good category, namely 153 people (79.3%), and in the bad category, there were 40 people (20.7%). The majority of sugarcane farmers understand the definition of PPE, the types of PPE, the function and purpose of using PPE, the use of PPE is an effort to control hazards, and where and when PPE is used. It is recommended to continuously educate sugarcane farmers regarding the standardization of PPE used, the dangers of direct exposure to sunlight, and the use of PPE to minimize the risk of work accidents
Gambaran Motivasi Orang Tua terhadap Physical Distancing pada Anak Sekolah Dasar di Tengah Pandemi Covid-19 di Kelurahan Karangrejo, Banyuwangi
Get PDFSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an emergence virus in the end of 2019 and causing respiratory system disorders such as severe lung infections, leading to death in all age groups including children. The purpose of this study was to determine the description of parents' motivation towards physical distancing in elementary school children during Covid-19 pandemic in Karangrejo District, Banyuwangi. This research involved 90 parents from elementary schools in Karangrejo which was chosen using purposive sampling technique. Data on parent motivation were collected using a questionnaire consisting of 3 indicators with 11 questions measured by a Likert scale. The study indicate that the motivation of parents towards physical distancing in elementary school during the Covid-19 pandemic is in the very good category, with the value interval of 30.26-35.75, and average 33.21. In conclusion, the motivation of parents towards physical distancing in elementary school children in Karangrejo village is very good. This research is expected to be the basis for child caregivers in the community to identify parents' motivation attitudes
Gambaran Pola Konsumsi Mie Instan Anak Sekolah Dasar pada Keluarga Petani di Wilayah Desa Sumberagung-Jember
Get PDFGiving frequently instant noodles to children will form a habit, making children only want to consume instant noodles. Consuming instant noodles twice or thrice a week increase risk of cardiometabolic syndromes such as heart disease, stroke and diabetes which are the common causes of death worldwide. This study aimed to describe the pattern of instant noodle consumption among elementary school children of farmer families in Sumberagung Village, Jember Regency. The study used a quantitative descriptive design with a sample of 58 elementary school age children grades IV, V, VI who were selected using purposive sampling technique. Data were collected using a Food Frequency Questionnaire (FFQ). The result showed that the consumption pattern of Instant Noodles for elementary school children in farming families was in the category of 3-6x/week, >3x/day, 1x/day, and 1-2x/week were 43.1%, 17.2%, 31%, and 8.6%, respectively. This study concluded that the consumption pattern of instant noodles among elementary school children in farmer families in Sumberagung Village, Jember Regency is in a dangerous risk for health. Therefore, it is expected that health workers improve education on Balanced Nutrition Messages (PGS), so that farmer families, especially mothers can prepare healthy, safe and nutritious meals for children and their families
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Ungu (Graptophyllum pictum (L) Griff) terhadap Pertumbuhan Streptococcus sanguinis
Get PDFStreptococcus sanguinis has strong adhesion with salivary pellicles which causes other oral bacteria to attach more and has contribution in causing caries and periodontal disease. S. sanguinis mediated the adhesion of S. mutans to dental pellicle receptors so inhibiting the interaction between S. sanguinis and S. mutans would prevent the risk of dental caries. Purple leaf (Graptophyllum pictum) is one of the medicinal plants or natural ingredients that are useful as antibacterials. The purpose of this study was to examine antibacterial activity of purple leaf extract against S. sanguinis. This experimental laboratory study with a pre-posttest control group design was conducted by dilution method on treatment groups, purple leaf extract with concentrations of 25%, 12.5%, 6.25% and 3.12%. Visual and spectrophotometer examination was observed before and after incubation.The result showed that purple leaf extract with concentrations of 6.25% and 3.12% and control + groups had not turbidity and decreased absorbance value. Furthermore, the One Way Anova parametric statistical test and also Post-Hoc Least Significant Difference showed that there were significant differences between the study groups. The purple leaf extract (Graptophyllum pictum L. Griff) had antibacterial activity against S. sanguinis. The antibacterial test for extracts that are dark in color can be continued using the TVC (Total Viable Count) method to provide a quantitative estimate of the concentration of bacterial cells in the sample in units of CFU/ml
Pengembangan Pembalut Pintar untuk Deteksi Dini Kondisi Hiperurisemia dan Hiperkolesterolemia
Get PDFHyperuricemia and hypercholesterolemia’s cases are increasing. Noninvasive early detection method should be develope. Development of smart sanitary napkins based on paper chip biosensors using “Whatman†filter paper through screen printing and immobilized with pH 6 citrate buffer and iron (III)-actress- (1,10-phenanthroline) complex reagent for detection of uric acid and cholesterol oxidase enzymes and reagent 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid (ABTS)) for cholesterol detection. The analysis of the paper chip biosensor has a response time of 10 minutes for uric acid detection and 25 minutes for cholesterol detection. Uric acid linearity 2 - 20 mg / dL and cholesterol 50 - 500 mg / dL. The LOD and LOQ detection areas for uric acid were 0.322 mg / dL and 0.965 mg / dL, respectively, while the cholesterol detection areas were 8.740 mg / dL and 26.221 mg / dL, respectively. NaCl interference interfering with the detection of uric acid and cholesterol was 5.746% and 6.388%, respectively and creatinine interference interfering with the detection of uric acid and cholesterol was 5.868% and 5.583%, respectively. The precision for uric acid detection was 1.252% (RSD <3.7%) and cholesterol detection was 0.059% (RSD <2.7%). The accuracy (% recovery) for uric acid detection was 100.333% and for cholesterol, the detection was 100.016%. Smart bandages can be used to analyze the initial conditions of hyperuricemia and hypercholesterolemia