Jurnal Wiyata Penelitian Sains dan Kesehatan
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ANALISIS PEWARNA ALAMI EKSTRAK AQUADES ANGKAK MERAK PADA PENGAMATAN TELUR CACING SOIL TRANSMITTED HELMINTH
No full textLatar Belakang: Kecacingan adalah infeksi yang disebabkan oleh berbagai jenis cacing parasit di usus. Spesies ini termasuk dalam kategori Soil Transmitted Helminth (STH) karena perkembangan telur atau larva spesies tersebut membutuhkan tanah untuk berkembang menjadi bentuk yang infektif. Metode paling sederhana untuk memeriksa telur cacing Nematoda Usus adalah metode natif. Metode ini menggunakan reagen Eosin 2% untuk mengamati berbagai komponen pemeriksaan pada preparat atau sediaan. Dibutuhkan pewarnaan alternatif yang lebih ramah lingkungan untuk menggantikan eosin karena sifatnya yang tidak mudah terurai dan menghasilkan limbah yang berbahaya. Salah pewarna telur cacing STH yaitu angkak merah. Pewarna angkak merah memiliki zat berupa antosianin yang mampu mewarnai telur cacing STH. Tujuan dari penelitian ini adalah untuk mengetahui apakah ekstrak aquades angkak merah dapat berfungsi sebagai zat warna untuk mendeteksi infeksi SHT dalam pemeriksaan feses. Metode : Penelitian ini menggunakan eksperimen laboratorium dengan karakteristik deskriptif kategorikal, dengan memvariasikan konsentrasi ekstrak angkak merah (murni, 1:1, 1:2, dan 1:3) dan pH Pewarna (asam dan basa). Hasil : Hasil penelitian menunjukkan bahwa pewarna yang paling efektif yaitu ekstrak angkak merah dengan perbandingan 1:3 dengan pH asam berfungsi sebagai pengganti yang efektif untuk reagen Eosin 2% dalam pewarnaan telur cacing STH. Kesimpulan : Hal ini dapat disimpulkan bahwa ekstrak aquades angkak merah dapat digunakan sebagai pewarna alami untuk mengidentifikasi telur cacing STH
PRIORITY HEALTH PROBLEM ANALYSIS WITH BPRS AT MAGETAN HEALTH OFFICE IN 20202
No full textBackground: Health issues significantly impact a country\u27s development, and high disease incidence and inadequate handling contribute to these challenges. Determining health priorities can be achieved through various methods, including the Basic Priority Rating System (BPRS), also known as the Hanlon method. Objective: This research aims to identify health problems and suitable solutions using the BPRS method at the Magetan District Health Office. Method: This descriptive observational study was conducted at the Magetan District Health Office, utilizing the BPRS method to prioritize health issues. Result: Based on Questionnaire responses revealed Dengue Fever (DBD) as the top-priority problem with a total score of 8633.52. Subsequently, a health problem analysis involved discussions and brainstorming sessions with stakeholders responsible for the DBD program and the Head of the Communicable Diseases Section to identify root causes and plan interventions. Conclusion: Addressing DBD mortality rates requires several interventions, such as enhancing the effectiveness of health education methods using appropriate media for the community, providing SIARVI training to DBD program personnel, and raising early detection awareness among villagers through village authorities. These measures can lead to effective health interventions and improved overall health outcomes
Preparation of Methanyl Yellow Test Strip Based on Nata De Coco Membrane Immobilized Anthocyanin Extracted from Rosella Flower (Hibiscus Sabdariffa L.)
No full textMethanyl yellow is a synthetic dye used in the textile industry and its use is prohibited in food products. Its abuse is still found in crackers, noodles, tofu, and beverages. Methanyl yellow identification test used color reaction test, thin layer chromatography, paper chromatography, TLC scanner, and UV-Vis spectrophotometry. So, in this study, the methanyl yellow test strip test method was developed using anthocyanin immobilized nata de coco membrane with rosella flower extract. The purpose of this study was to determine the selectivity and sensitivity of the resulting test strips. The test strip consisted of nata de coco membrane and rosella flower extract reagent. The test strip made has an optimum contact time of 10 seconds. In the analysis using FTIR, the functional groups O–H, C–H alkanes, C=O, C=C alkenes, C–O, and C–H alkenes on the test strip indicated anthocyanin compounds. In the test strip which was reacted with methanyl yellow the functional group identified had a weaker absorption than the test strip which had not been reacted. The characterization test includes a detection limit test with detection capability starting at a concentration of 6 ppm and lifetime test results, up to the 21st day the strip test can be used, storage using dark bottles is better than clear bottles. So that the resulting test strips provide good data and can be used for quick measurements
IDENTIFIKASI Candida sp. PADA SWAB VAGINA WANITA HAMIL TRIMESTER I, II, DAN III DI PRAKTEK MANDIRI BIDAN ROCHYANI DI KOTA DEPOK
No full textAbstrakLatar belakang: Kandidiasis vulvovaginalis merupakan infeksi yang disebabkan oleh Candida sp, yang menginfeksi vagina. Spesies yang paling umum ditemukan adalah Candida albicans yang merupakan flora normal vagina dan spesies non albicans yang dapat muncul sebagai penyebab kandidiasis vulvovaginalis adalah Candida krusei, Candida parapsilopsis, Candida tropicalis, dan Candida glabrata. Wanita hamil memiliki resiko lebih besar mengalami kandidiasis vulvovaginalis dibandingkan wanita tidak hamil karena perubahan fisiologis selama kehamilan dapat menghasilkan beberapa perubahan. Tujuan: Penelitian ini untuk mengetahui keberadaan Candida sp. pada swab vagina wanita hamil trimester I, II, dan III. Metode: Penelitian ini deskriptip kualitatif dengan mengamati hasil kultur swab vagina pada media Hicrome Candida Differential Agar. Responden penelitian ini wanita hamil trimester I, II, dan III sebanyak 21 responden, dengan masing-masing trimester berjumlah 7 orang. Hasil: Didapatkan hasil pada trimester I ditemukan C. albicans, C. glabrata, C. tropicalis, dan C.krusei. Trimester II ditemukan C. albicans, C. glabrata, C. krusei. Trimester III ditemukan C. albicans, C. glabrata, C. tropicalis, C. parapsilopsis, C. krusei. Simpulan: Hasil menunjukan terdapat keberadaan Candida sp. pada swab vagina wanita hamil trimester I, II dan III. AbstractBackground: Vulvovaginal candidiasis is an infection caused by Candida sp, which infects the vagina. The most common species found is Candida albicans which is the normal flora of the vagina and non albicans species that can appear as a cause of vulvovaginal candidiasis are Candida krusei, Candida parapsilopsis, Candida tropicalis, and Candida glabrata. Pregnant women have a greater risk of developing vulvovaginal candidiasis than non-pregnant women because physiological changes during pregnancy can produce several changes in the body. Objective: This study was to determine the presence of Candida sp. in vaginal swabs of pregnant women in the first, second, and third trimester.  Methods: This study is qualitative descriptive by observing the results of vaginal swab culture on Hicrome Candida Differential Agar media. Respondents of this study were pregnant women in trimester I, II, and III as many as 21 respondents, with each trimester totaling 7 people. Results: The results obtained in the first trimester found C. albicans, C. glabrata, C. tropicalis, and C. krusei. Trimester II found C. albicans, C. glabrata, C. krusei. Third trimester found C. albicans, C. glabrata, C. tropicalis, C. parapsilopsis, C. krusei. Conclusion: The results showed the presence of Candida sp. in vaginal swabs of pregnant women in the first, second and third trimester.   Â
Survey Karakteristik Demografi Petugas Rekam Medis di Puskesmas Wilayah Kota Mataram
No full textCharacteristics of Medical Record officers consist of religion, age, gender, years of service, education, training, and employment status. This research was conducted at the Public Health Center in the City of Mataram. The purpose of this study was to determine the characteristics of medical record officers at the public health center in the city of Mataram. The design of this research is descriptive. The sample in this study were all medical record officers at the Mataram City of Health Center, totaling 39 medical record officers. The results showed that the medical record officers at the Mataram City of Health Center were mostly Muslim (100.0%), the sex of the officers was female as many as 22 people (56.4%), and the service period of the officers was less than 5 years (48,7%), Officer education is Diploma III of Medical Record and Health Information (MRHI) as many as 12 people (30.8%), training officers who have never attended training as many as 28 people (71.8%), while the staffing status of non-civil servant officers is 23 people (59, 0%). The conclusion is there needs to be an increase in the number and quality of medical record personnel in health centers with a Diploma III MRHI backgroun
THE RELATIONSHIP OF THE IMPLEMENTATION OF THERAPEUTIC COMMUNICATION AND OUTPATIENT PATIENT STATISFACTION AT THE MUARAGEMBONG HEALTH CENTER 2023
No full textBackground: Communication between nurses and patients plays an important role in the health service process for patients and their families. Patient satisfaction with health services is the hope and interest of the general public, especially for patients and their families and of course for the level of service quality of the relevant agencies. This study aims to analyze the application of therapeutic communication with the level of satisfaction of outpatients at the Muaragembong Community Health Center in 2023. Objective: Analyzing the relationship between nurses\u27 therapeutic communication and patient satisfaction levels in the outpatient ward of Muaragembong Community Health Center 2023. Method: This research is an analytical survey with a Cross Sectional Study approach and a sampling technique using Simple Random Sampling. The sample for this study was outpatients at the Muaragembong Community Health Center. The sample size in this study was 223 samples. Researchers used the chi square test to see the relationship between the two variables with a confidence value of α 5%. Conclusions: There is a relationship between the implementation of therapeutic communication and the level of satisfaction of outpatients at the Muaragembong Community Health Center in 2023.
Keywords:Outpatients, Community Health Centers, Therapeutic Communication, Satisfaction Level
Drug Use Patterns In Stroke Patients Ichemic Inpatience In RSUD dr. Soegiri Lamongan
No full textStroke or Cerebrovascular accident is a clinical symptom that develops rapidly as a result of focal or global brain function disturbance due to blockage or rupture of brain blood vessels, with symptoms lasting more than 24 hours. Stroke is the sudden death of several brain cells due to lack of oxygen due to blockage or rupture of a cerebral artery that blocks blood flow to the brain. This study aims to determine the pattern of drug use in inpatient ischemic stroke patients at RSUD dr. Soegiri Lamongan. Non-experimental research method with a descriptive research design in the form of retrospective collection of medical record data. The samples taken in this study were 86 medical record data of patients who met the inclusion criteria. The results showed that the highnest pattern of drug use in ischemic stroke patients used a combination of 2 drugs use that was the neuroprotectant-antiplatelet in 42 patients (48,8%), the combination of 3 drugs use that was the neuroprotectant-antiplatelet-antihypertension in 13 patient (15%), and a combination of 4 combination drug use that was the neuroprotectant-antiplatelet-antihypertension-antidislipidemia in 8 patient (9,3%). The most widely used neuroprotectant group was citicolin in 77 patients (79,38%), the antiplatelet clopidogrel in 67 patients (50,76%) and aspilet in 65 patients (49,24%), the antihypertension amlodipine in 19 patients (31,67%) and candesartan in 17 patients (28,33%), and the antidyslipidemia atorvastatin in 9 patients (64,29%
POTENSI PEWARNAAN ALAMI EKSTRAK BUAH NAGA MERAH Hylocereus polyrhizus SEBAGAI ALTERNATIF EOSIN
No full textProses pewarnaan rutin yang sering digunakan diseluruh laboratorium patologi anatomi dalam pembuatan sediaan sitologi yaitu Papanicolaou dan Diff Quick. Metode pengecatan rutin tersebut dapat menghasilkan gambaran mikroskopik yang menghasilkan hasil yang berbeda-beda, namun bahan yang digunakan dalam pewarnaan tersebut kebanyakan bersifat karsinogenik. Dalam jangka Panjang dapat mempengaruhi petugas yang melakukan proses pewarnaan. Maka dari itu, penelitian ini memiliki Tujuan jangka pendek adalah untuk melihat perbedaan kualitas warna dalam pengecatan sediaan Fine Needle Aspiration Biopsy (FNAB) untuk pemeriksaan kanker payudara yang dibandingkan dengan pewarnaan alami ekstrak buah naga, sedangkan tujuan jangka panjangnya untuk menemukan metode pewarnaan alternatif yang dapat digunakan untuk sampel FNAB payudara yang lebih ramah terhadap lingkungan. Metode penelitian ini adalah metode eksperimen dengan melakukan perbandingan pada 3 jenis pewarnaan. Hasil penelitian menunjukan potensi yang dimiliki oleh ekstrak buah naga merah sebagai alternatif pengganti eosin. Kesimpulan dari penelitian ini adalah ekstrak buah naga merah memiliki potensi sebagai pewarnaan alami sediaan selular
UJI IN SILICO AKTIVITAS ANALGESIK DAN TOKSISITAS SENYAWA TURUNAN N-BENZOIL-N’-4-METOKSIFENILTIOUREA SEBAGAI CALON OBAT ANALGESIK
No full textAbstrak
Latar belakang : Senyawa N-(Benzoil)-N’-4-metoksifeniltiourea mempunyai gugus farmakofor yang sama dengan asam mefenamat yang mempunyai aktivitas sebagai analgesik, sehingga layak dijadikan senyawa induk untuk dikembangkan lebih lanjut melalui modifikasi struktur. Tujuan : Penelitian ini bertujuan untuk memprediksi aktivitas analgesik dan toksisitas dari duapuluh senyawa turunan N-(Benzoil)-N’-4-metoksifeniltiourea sebagai calon obat analgesik. Salah satu mekanisme kerja turunan N-(Benzoil)-N’-4-metoksifeniltiourea sebagai analgesik adalah menghambat COX2, yang berperan penting dalam mengubah asam arakidonat menjadi prostaglandin. Metode : Aktivitas biologis dapat diprediksi melalui pemodelan molekul yang disebut uji in silico,menggunakan program molecular operating environment (MOE) sedangkan toksisitas dapat diprediksi menggunakan program pkCSM. Uji in silico dilakukan dengan melakukan docking senyawa yang akan diprediksi aktivitasnya dengan target reseptor COX2, PDB 5IKR. Hasil : Hasil docking berupa energi ikatan digambarkan dengan nila Score (S). Senyawa dengan nilai S kecil berarti mempunyai ikatan ligan-reseptor yang stabil dan diprediksi mempunyai aktivitas yang besar. Dari hasil uji in silico disimpulkan bahwa turunan N-(benzoil)-N’-4-metoksifeniltiourea diprediksi menimbulkan toksisitas relative rendah, dan mempunyai aktivitas yang lebih besar dibandingkan asam mefenamat. Simpulan : N-(Etoksibenzoil)-N’-4-metoksifeniltiourea diprediksi mempunyai aktivitas analgesik paling besar sehingga senyawa terpilih untuk disintesis dan dikembangkan lebih lanjut.
Abstract
Background: The compound N-(benzoyl)-N\u27-4-methoxyphenylthiourea has the same pharmacophore group as mefenamic acid which has analgesic activity, so it is suitable to be used as a parent compound for further development through structural modification. Objective: This study aims to predict the analgesic activity and toxicity of twenty N-(benzoyl)-N\u27-4-methoxyphenylthiourea derivative compounds as candidate analgesic drugs. One of the mechanisms of action of the N-(benzoyl)-N\u27-4-methoxyphenylthiourea derivative as an analgesic is to inhibit COX2, which plays an important role in converting arachidonic acid into prostaglandins. Method: Biological activity can be predicted through molecular modeling called in silico testing, using the molecular operating environment (MOE) program, while toxicity can be predicted using the pkCSM program. The in silico test is carried out by docking the compound whose activity will be predicted with the target receptor COX2, PDB ID 5IKR. Results: The docking results in the form of bond energy are described by the value Score (S). A compound with a small S value means it has a stable ligand-receptor bond and is predicted to have large activity. From the in silico test results, it was concluded that the N-(benzoyl)-N\u27-4-methoxyphenylthiourea derivative is predicted to cause relatively low toxicity, and has greater activity than mefenamic acid. Conclusion: N-(Ethoxybenzoyl)-N\u27-4-methoxyphenylthiourea are predicted to have the greatest analgesic activity so the compounds were selected for synthesis and further development
FAKTOR RESIKO KEPADATAN HUNIAN, KEBERADAAN PEROKOK, DAN RIWAYAT PEMBERIAN ASI ESKULISIF TERHADAP KEJADIAN PNEUMONIA PADA BALITA DI INDONESIA : META-ANALISIS 2012-2023
No full textLatar Belakang : Pneumonia pada balita masih menjadi masalah kesehatan global yaitu 14% dari semua kematian dan penyebab anak di bawah usia 5 tahun dan menyebabkan 740.180 kematian anak pada tahun 2019. Di Indonesia pneumonia masih menjadi masalah utama yang menyebabkan 14,5% kematian pada anak kelompok usia 29 hari - 11 bulan. Tujuan : Penelitian ini bertujuan untuk menganalisis faktor risiko kepadatan huniaan, keberadaan perokok dan riwayat pemberian ASi ekslusif pada balita di Indonesia. Metode : Penelitian ini menggunakan metode meta-analisis yang menggabungkan beberapa referensi dari hasil penelitian sejenis. Sumber data penelitian ini diperoleh secara online melalui electronic database yaitu Google Scholar. Artikel yang terkumpul akan diseleksi dengan kriteria inkulsi dan eksklusi yang ditentukan. Sehingga diperoleh 20 artikel penelitian. Teknik analisis data menggunakan sofware yaitu JASP Version 0.16.3.0. Hasil analisis data menunjukkan bahwa variabel kepadatan hunian berisiko 2,054 kali, keberadaan perokok berisiko 2,054 kali, dan riwayat pemberian ASI eksklusif berisiko 3,781 kali lebih besar terhadap kejadian pneumonia pada balita. Kesimpulan : dari penelitian meta-analisis ini dapat diketahui bahwa urutan faktor risiko yang paling besar terhadap kejadian pneumonia pada balita diantaranya adalah riwayat pemberian ASI eksklusif, kepadatan hunian dan keberadaan perokok